Alox15

Summary

Gene Symbol: Alox15
Description: arachidonate 15-lipoxygenase
Alias: 12-LOX, 15-LOX, Alox12, Alox12l, arachidonate 15-lipoxygenase, 12/15-LOX, 12/15-lipoxygenase, arachidonate 12-lipoxygenase, leukocyte-type, arachidonate omega-6 lipoxygenase
Species: rat
Products:     Alox15

Top Publications

  1. Watanabe T, Medina J, Haeggstrom J, Radmark O, Samuelsson B. Molecular cloning of a 12-lipoxygenase cDNA from rat brain. Eur J Biochem. 1993;212:605-12 pubmed
    ..Sequencing of parts of the corresponding cDNAs (from leukocytes and lung), and comparison to the brain 12-lipoxygenase sequence, indicated that these mRNAs from the different rat tissues were identical. ..
  2. Lebeau A, Terro F, Rostene W, Pelaprat D. Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide. Cell Death Differ. 2004;11:875-84 pubmed
    ..These data indicate that blockade of 12-LOX expression disrupts a c-Jun-dependent apoptosis pathway, and suggest that 12-LOX may represent a new target for the treatment of AD. ..
  3. Yao L, Nie X, Shi S, Song S, Hao X, Li S, et al. Reciprocal regulation of HIF-1? and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia. Prostaglandins Other Lipid Mediat. 2012;99:96-106 pubmed publisher
    ..The feedback loop between HIF-1? and 15-LO/15-HETE would obviously reinforce hypoxia-induced anti-apoptosis effect and may become a novel target of therapy in PAH...
  4. McDuffie M, Maybee N, Keller S, Stevens B, Garmey J, Morris M, et al. Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes. 2008;57:199-208 pubmed
    ..Since the gene encoding 12/15-LO (gene designation Alox15) lies within the Idd4 diabetes susceptibility interval in NOD mice, we hypothesized that 12/15-LO is also a key ..
  5. Chen X, Kurre U, Jenkins N, Copeland N, Funk C. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994;269:13979-87 pubmed
    ..Antibodies prepared against the two forms of 12-lipoxygenase revealed the differential distribution of the two enzymes throughout the mouse. ..
  6. Li S, Dwarakanath R, Cai Q, Lanting L, Natarajan R. Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs. J Lipid Res. 2005;46:220-9 pubmed
    ..Our results illustrate the functional relevance of 12/15-LO activation in macrophages and VSMCs and its relationship to oxidant stress and inflammation. ..
  7. Collins J, Hu Z, Ranganathan P, Feng D, Garrick L, Garrick M, et al. Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators. Am J Physiol Gastrointest Liver Physiol. 2008;294:G948-62 pubmed publisher
    ..homeostasis, and one gene related to this physiological process, a leukocyte type, arachidonate 12-lipoxygenase (Alox15), was selected for further examination...
  8. Jin G, Arai K, Murata Y, Wang S, Stins M, Lo E, et al. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke. 2008;39:2538-43 pubmed publisher
    ..12/15-LOX inhibitors may thus be effective as both neuroprotectants and vasculoprotectants. ..
  9. Martínez Clemente M, Ferre N, Titos E, Horrillo R, González Périz A, Morán Salvador E, et al. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Hepatology. 2010;52:1980-91 pubmed publisher
    We have shown that Alox15, the gene encoding for 12/15-lipoxygenase (12/15-LO), is markedly up-regulated in livers from apolipoprotein E-deficient (ApoE(-/-)) mice, which spontaneously develop nonalcoholic fatty liver disease secondary to ..

More Information

Publications62

  1. Nigam S, Zafiriou M. Hepoxilin A3 synthase. Biochem Biophys Res Commun. 2005;338:161-8 pubmed
  2. Liu Y, Tang X, Lu C, Han W, Guo S, Zhu D. Expression of 15-lipoxygenases in pulmonary arteries after hypoxia. Pathology. 2009;41:476-83 pubmed
    ..Moreover, the expressions of both 15-LOX isoenzymes increased dramatically after hypoxia. These results suggest that both isoenzymes of 15-LOXs are upregulated after hypoxia. ..
  3. Andersson E, Schain F, Svedling M, Claesson H, Forsell P. Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity. Biochim Biophys Acta. 2006;1761:1498-505 pubmed
    ..Taken together, this report demonstrates that human 15-LO-1 binds to PI(4.5)P(2) and PI(3.4)P(2) and that these phospholipids stimulate enzyme activity in the presence of calcium in a vesicle based assay. ..
  4. Rostkowska Nadolska B, Kapral M, Fraczek M, Kowalczyk M, Gawron W, Mazurek U. A microarray study of gene expression profiles in nasal polyps. Auris Nasus Larynx. 2011;38:58-64 pubmed publisher
    ..In the control group, significantly higher expression of DMBT1, ALOX12 and LTF genes was detected...
  5. Mabalirajan U, Aich J, Leishangthem G, Sharma S, Dinda A, Ghosh B. Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. J Appl Physiol (1985). 2009;107:1285-92 pubmed publisher
    ..In summary, these findings show that Vit-E reduces key mitochondrial dysfunctions and alleviates asthmatic features. ..
  6. Sun L, Xu Y, Han J, Liang H, Wang N, Cheng Y. 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain. J Lipid Res. 2015;56:502-14 pubmed publisher
    ..Thus, the induction of 12(S)- and 15(S)-HETE during brain ischemia suggests that endogenous signals of neuroprotection may be generated. ..
  7. Zuo L, Christofi F, Wright V, Bao S, Clanton T. Lipoxygenase-dependent superoxide release in skeletal muscle. J Appl Physiol (1985). 2004;97:661-8 pubmed
    ..These data show for the first time that arachidonic acid metabolism through LOX activity, is a major source of extracellular O(2)(*-) release in skeletal muscle. ..
  8. Nagasawa K, Kakuda T, Higashi Y, Fujimoto S. Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons. Neurosci Lett. 2007;429:120-5 pubmed
    ..These findings suggested that activation of 12-LOX, but not NADPH oxidase, following to zinc release might play an important role in ROS generation and decrease of viability in GD/R-treated neurons. ..
  9. Gregus A, Dumlao D, Wei S, Norris P, Catella L, Meyerstein F, et al. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013;27:1939-49 pubmed publisher
    ..We detected the following primary intrinsic activities: 12-LOX (Alox12, Alox15), 15-LOX (Alox15b), and HXS (Alox12, Alox15)...
  10. Zarbock A, Distasi M, Smith E, Sanders J, Kronke G, Harry B, et al. Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol. 2009;183:4715-22 pubmed publisher
    ..The vascular permeability increase upon LPS inhalation was abolished in Alox15(-/-) mice lacking 12/15-LO and in wild-type mice after pharmacological blockade of 12/15-LO...
  11. Uderhardt S, Herrmann M, Oskolkova O, Aschermann S, Bicker W, Ipseiz N, et al. 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity. 2012;36:834-46 pubmed publisher
    ..Our data reveal an unexpected key role for enzymatic lipid oxidation during the maintenance of self-tolerance. ..
  12. Klein R, Allard J, Avnur Z, Nikolcheva T, Rotstein D, Carlos A, et al. Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science. 2004;303:229-32 pubmed
    ..Through combined genetic and genomic approaches, we identified the lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice...
  13. Xu Z, Li S, Lanting L, Kim Y, Shanmugam N, Reddy M, et al. Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy. Kidney Int. 2006;69:512-9 pubmed
    ..These new results indicate for the first time that 12/15-LO and COX-2 pathways can cross-talk and activate each other in MC. These novel interactions may amplify their effects on the progression of DN. ..
  14. Pidgeon G, Tang K, Rice R, Zacharek A, Li L, Taylor J, et al. Overexpression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhancing alphavbeta5 expression. Int J Cancer. 2003;105:459-71 pubmed
    ..These results show that the 12-LOX pathway is a regulator of cell survival and apoptosis, by affecting the expression and localization of the alphavbeta5 integrin and actin microfilaments in Walker 256 cells...
  15. Weibel G, Joshi M, Wei C, Bates S, Blair I, Rothblat G. 15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism. J Lipid Res. 2009;50:2371-6 pubmed publisher
    ..We propose that 15-LO-1 is present and functional on cytoplasmic neutral lipid droplets in macrophage foam cells, and these droplets may act to accumulate the anti-inflammatory lipid mediator 15(S)-HETE. ..
  16. Katoh T, Lakkis F, Makita N, Badr K. Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis. Kidney Int. 1994;46:341-9 pubmed
    ..This represents the first demonstration of tandem regulated in vivo gene expression for a lymphokine (IL-4) and a lipoxygenase, both of which promote counter-inflammatory influences in immune complex-mediated injury. ..
  17. Prasad V, Nithipatikom K, Harder D. Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes. Neurochem Int. 2008;53:220-9 pubmed publisher
    ..Induction of 12-LOX pathway by ceramide may have implications in understanding pathophysiology of neurodegenerative diseases involving ROS generation and inflammation. ..
  18. Sloane D, Leung R, Craik C, Sigal E. A primary determinant for lipoxygenase positional specificity. Nature. 1991;354:149-52 pubmed
    ..Other mutations at the neighbouring amino acids 416 and 417 give an enzyme which performs 12- and 15-lipoxygenation in a ratio of 15:1. These results indicate that this region might position the substrate in the active site. ..
  19. Preston I, Hill N, Warburton R, Fanburg B. Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2006;290:L367-74 pubmed
    ..We conclude that 12-LO and its product, 12(S)-HETE, are important intermediates in hypoxia-induced pulmonary artery SMC proliferation and may participate in hypoxia-induced pulmonary hypertension. ..
  20. Li J, Rao J, Liu Y, Cao Y, Zhang Y, Zhang Q, et al. 15-Lipoxygenase promotes chronic hypoxia-induced pulmonary artery inflammation via positive interaction with nuclear factor-?B. Arterioscler Thromb Vasc Biol. 2013;33:971-9 pubmed publisher
    ..Our study revealed a novel mechanism underlying hypoxia-induced pulmonary arterial inflammation and suggested new therapeutic strategies targeting 15-LO/15-HETE and nuclear factor-?B in the treatment of pulmonary arterial hypertension. ..
  21. Tanabe M, Kamitani H, Watanabe T, Radmark O. C-terminus of p47(phox) is required for interaction with leukocyte type rat 12-lipoxygenase. Protein Pept Lett. 2005;12:295-7 pubmed
    ..These results indicate that C-terminus of p47(phox) is important for its interaction to rat 12-LO. ..
  22. Sun D, Funk C. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem. 1996;271:24055-62 pubmed
    ..Thus, 12/15-lipoxygenase-deficient mice will be useful for the study of interaction between lipoxygenase pathways and determination of the in vivo role of 12/15-lipoxygenase-catalyzed oxidation of LDL in atherogenesis. ..
  23. Coffey M, Natarajan R, Chumley P, Coles B, Thimmalapura P, Nowell M, et al. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proc Natl Acad Sci U S A. 2001;98:8006-11 pubmed
  24. Emerson M, Levine S. Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. Brain Res. 2004;1021:140-5 pubmed
    ..Continued analysis will provide insight into the endogenous LO-generated effectors that assist in tempering EAE. ..
  25. Nigam S, Patabhiraman S, Ciccoli R, Ishdorj G, Schwarz K, Petrucev B, et al. The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity. J Biol Chem. 2004;279:29023-30 pubmed
    ..In summary, it may be concluded that naturally occurring 12S-lipoxygenases exhibit an intrinsic hepoxilin A(3) synthase activity that is minimal in lipoxygenase isoforms with different positional specificity. ..
  26. Singh N, Wang D, Kundumani Sridharan V, Van Quyen D, Niu J, Rao G. 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall rem. J Biol Chem. 2011;286:22478-88 pubmed publisher
  27. Obrosova I, Stavniichuk R, Drel V, Shevalye H, Vareniuk I, Nadler J, et al. Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies. Am J Pathol. 2010;177:1436-47 pubmed publisher
    ..This should be considered in the selection of endpoints for future clinical trials of 12/15-lipoxygenase inhibitors. ..
  28. Yang H, Zhuo J, Chu J, Chinnici C, Pratico D. Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Biol Psychiatry. 2010;68:922-9 pubmed publisher
    ..Our findings support the novel hypothesis that blockade of 12/15LO in the central nervous system by modulating BACE proteolytic pathway could be an effective therapy for prevention or treatment of AD. ..
  29. Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Igarashi Y, Kihara A. Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats. J Dermatol Sci. 2017;85:186-196 pubmed publisher
    ..Consistent with the decreases in the 15-LOX metabolites, expression levels of the genes that encode the 15-LOXs, Alox15 and Alox15b, were largely reduced...
  30. Reddy M, Sahar S, Villeneuve L, Lanting L, Natarajan R. Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2009;29:387-93 pubmed publisher
    ..Src kinase signaling plays a central role in the proatherogenic responses mediated by 12/15-LO and its oxidized lipid metabolite 12(S)-HETE in VSMCs. ..
  31. Zhao J, O Donnell V, Balzar S, St Croix C, Trudeau J, Wenzel S. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc Natl Acad Sci U S A. 2011;108:14246-51 pubmed publisher
    ..The results confirm a previously unknown signaling role for 15LO1 and its PE-conjugated eicosanoid product in human airway epithelial cells. This pathway enhances critical inflammatory pathways integral to asthma pathogenesis. ..
  32. SEARS D, Miles P, Chapman J, Ofrecio J, Almazan F, Thapar D, et al. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS ONE. 2009;4:e7250 pubmed publisher
    ..These results demonstrate that 12/15LO mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding. ..
  33. Hajek A, Lindley A, Favoreto S, Carter R, Schleimer R, Kuperman D. 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. J Allergy Clin Immunol. 2008;122:633-9.e3 pubmed publisher
    ..Induction of 15-LO-1 in asthma might contribute to allergic sensitization and airways inflammation, potentially by causing suppression of secretory IgA. ..
  34. Coffey R, Nam H, Knutson M. Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload. PLoS ONE. 2014;9:e86019 pubmed publisher
    ..The most up-regulated transcript in iron-deficient pancreas was arachidonate 15-lipoxygenase (Alox15), which has been implicated in the development of diabetes...
  35. Biteman B, Hassan I, Walker E, Leedom A, Dunn M, Seta F, et al. Interdependence of lipoxin A4 and heme-oxygenase in counter-regulating inflammation during corneal wound healing. FASEB J. 2007;21:2257-66 pubmed
    ..Collectively, results demonstrate a critical role for LXA4 in inflammatory/reparative responses and provide the first evidence that 12/15-LOX and HO systems function in concert to control inflammation. ..
  36. Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I, Takahashi H, et al. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. J Exp Med. 2009;206:1565-74 pubmed publisher
    ..Among the genes analyzed, Alox15 encoding the protein 12/15 lipoxygenase (LOX) was markedly up-regulated in heart failure...
  37. Huang J, Welch J, Ricote M, Binder C, Willson T, Kelly C, et al. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature. 1999;400:378-82 pubmed
    ..These findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands for PPAR-gamma, and suggest a paradigm for the regulation of nuclear receptor function by cytokines. ..
  38. Viita H, Pacholska A, Ahmad F, Tietäväinen J, Naarala J, Hyvärinen A, et al. 15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma. In Vivo. 2012;26:1-8 pubmed
    ..001). Our results support the pro-apoptotic role of 15-lipoxygenase-1 and suggest that 15-lipoxygenase-1 could be a potential new target gene for the therapy of malignant glioma. ..
  39. Cui L, Zhang X, Yang R, Wang L, Liu L, Li M, et al. Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability. Brain Res. 2010;1325:164-73 pubmed publisher
    ..Atorvastatin protected brain from damage caused by MCAO at the early stage; this effect may be through down-regulation of 12/15-LOX, p38MAPK and cPLA2 expressions, and ameliorating BBB permeability. ..
  40. Alonso Galicia M, Maier K, Greene A, Cowley A, Roman R. Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. Am J Physiol Regul Integr Comp Physiol. 2002;283:R60-8 pubmed
  41. Li Q, Mao M, Qiu Y, Liu G, Sheng T, Yu X, et al. Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension. PLoS ONE. 2016;11:e0149164 pubmed publisher
    ..These results indicated that 15-HETE-regulated ROS mediated hypoxia-induced pulmonary vascular remodeling (PVR) via the p38 MAPK pathway. ..
  42. Chang W, Nakao J, Orimo H, Murota S. Effects of reduced glutathione on the 12-lipoxygenase pathways in rat platelets. Biochem J. 1982;202:771-6 pubmed
    ..Fractionation of cell homogenates indicates that the cytosol fraction possesses almost all the 12-lipoxygenase activity, whereas the microsomal fraction exhibits little enzyme activity. ..
  43. Cole B, Kuhn N, Green Mitchell S, Leone K, Raab R, Nadler J, et al. 12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response. Am J Physiol Endocrinol Metab. 2012;302:E654-65 pubmed publisher
    ..Therefore, reduction of 12/15-LO activity or expression could provide a new therapeutic target to reduce ER stress and downstream inflammation linked to obesity...
  44. Tang L, Ding T, Pratico D. Additive anti-atherogenic effect of thromboxane receptor antagonism with 12/15lipoxygenase gene disruption in apolipoprotein E-deficient mice. Atherosclerosis. 2008;199:265-70 pubmed publisher
    ..These results suggest that the 12/15LO- and TxA(2) receptor-mediated pro-atherogenic effects are two distinct pathways and represent two separate therapeutic targets for a better anti-atherogenic strategy. ..
  45. Kuwata H, Nonaka T, Murakami M, Kudo I. Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway. J Biol Chem. 2005;280:25830-9 pubmed
  46. Gronert K, Maheshwari N, Khan N, Hassan I, Dunn M, Laniado Schwartzman M. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J Biol Chem. 2005;280:15267-78 pubmed
    ..Here, we demonstrate that mouse corneas generate endogenous LXA(4) and NPD1. 12/15-LOX (Alox15) and LXA(4) receptor mRNA expression as well as LXA(4) formation were abrogated by epithelial removal and restored ..
  47. Miller Y, Chang M, Funk C, Feramisco J, Witztum J. 12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. J Biol Chem. 2001;276:19431-9 pubmed
    ..These studies suggest that the 12/15-LO enzyme plays a major role in local control of actin polymerization in macrophages in response to interaction with apoptotic cells. ..
  48. Kronke G, Katzenbeisser J, Uderhardt S, Zaiss M, Scholtysek C, Schabbauer G, et al. 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J Immunol. 2009;183:3383-9 pubmed publisher
    ..Taken together, these results support an anti-inflammatory and tissue-protective role of 12/15-LO and its products during chronic inflammatory disorders such as arthritis. ..
  49. Hada T, Hagiya H, Suzuki H, Arakawa T, Nakamura M, Matsuda S, et al. Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA. Biochim Biophys Acta. 1994;1211:221-8 pubmed
    ..The predominant presence of 12-lipoxygenase mRNA in pineal gland was confirmed by in situ hybridization of rat brain. Significant amounts of 12-lipoxygenase mRNA were also detected in rat spleen, aorta, lung and leukocytes. ..
  50. Dioszeghy V, Rosas M, Maskrey B, Colmont C, Topley N, Chaitidis P, et al. 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo. J Immunol. 2008;181:6514-24 pubmed
    ..No changes in neutrophil or lymphocyte numbers were seen. In summary, endogenous 12/15-LOX defines the resident MPhi population and regulates both the recruitment of monocytes/Mphi and cytokine response to bacterial products in vivo. ..
  51. Zheng H, Stratton C, Morozumi K, Jin J, Yanagimachi R, Yan W. Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility. Proc Natl Acad Sci U S A. 2007;104:6852-7 pubmed
    ..Our study reveals that proper cytoplasm removal is a genetically regulated process requiring the participation of Spem1 and that lack of Spem1 causes sperm deformation and male infertility. ..
  52. Andersson K, Florholmen G, Winer L, Tønnessen T, Christensen G. Regulation of neuronal type genes in congestive heart failure rats. Acta Physiol (Oxf). 2006;186:17-27 pubmed
    ..1 (Ddr1), neuronal pentraxin receptor (Nptxr), peripheral myelin protein Pmp-22, leukocyte type 12-lipoxygenase (Alox15), cytochrome P450 4F5 (Cyp4F5) and cardiac Kcne1 were all increased (range 1.6-6.0-fold, P < 0...
  53. Pratico D, Zhukareva V, Yao Y, Uryu K, Funk C, Lawson J, et al. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Am J Pathol. 2004;164:1655-62 pubmed
    ..These data show that the 12/15-LOX metabolic pathway is increased and correlates with an oxidative imbalance in the AD brain, implying that this enzyme might contribute to the pathogenesis of this neurodegenerative disorder. ..