Gene Symbol: Alox12b
Description: arachidonate 12-lipoxygenase, 12R type
Alias: arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, epidermis-type lipoxygenase 12
Species: rat

Top Publications

  1. Krieg P, Siebert M, Kinzig A, Bettenhausen R, Marks F, Furstenberger G. Murine 12(R)-lipoxygenase: functional expression, genomic structure and chromosomal localization. FEBS Lett. 1999;446:142-8 pubmed
    ..5 kb. By interspecific backcross analysis, the 12(R)-lipoxygenase gene was localized to the central region of mouse chromosome 11. ..
  2. Yu Z, Schneider C, Boeglin W, Brash A. Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. Biochim Biophys Acta. 2005;1686:238-47 pubmed
    ..Weissenbach, M. Ozguc, M. Lathrop, J.F. Prud'homme, J. Fischer, Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1, Hum. Mol...
  3. Liska F, Gosele C, Kren V, Hubner N, Krenova D. Molecular analysis of the sex hormone-binding globulin gene in the rat hypodactylous mutation (Hd). Folia Biol (Praha). 2004;50:63-8 pubmed
    ..Whether Shbg expression is upregulated due to a cis-acting mutation in regulatory elements of the Shbg gene or it is a secondary result of spermatogenesis failure remains to be determined. ..
  4. Epp N, Furstenberger G, Müller K, de Juanes S, Leitges M, Hausser I, et al. 12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol. 2007;177:173-82 pubmed
    ..This study indicates that the 12R-LOX-eLOX-3 pathway plays a key role in the process of epidermal barrier acquisition by affecting lipid metabolism, as well as protein processing. ..
  5. Yoshimoto T, Takahashi Y. Arachidonate 12-lipoxygenases. Prostaglandins Other Lipid Mediat. 2002;68-69:245-62 pubmed
    ..There are important roles for the enzymes and their products in several biological systems including those involved in atherosclerosis and neurotransmission. ..
  6. Meruvu S, Walther M, Ivanov I, Hammarstrom S, Furstenberger G, Krieg P, et al. Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. J Biol Chem. 2005;280:36633-41 pubmed
  7. Bogatcheva N, Sergeeva M, Dudek S, Verin A. Arachidonic acid cascade in endothelial pathobiology. Microvasc Res. 2005;69:107-27 pubmed
    ..This review discusses endothelial-specific synthesis and action of arachidonic acid derivatives with a particular focus on the mechanisms of signal transduction and associated intracellular protein targets. ..
  8. Li J, Wang H, Rosenberg P. Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. J Neurosci Res. 2009;87:1997-2005 pubmed publisher
    ..In summary, our data indicate that vitamin K prevents oxidative cell death by blocking activation of 12-LOX and ROS generation. ..
  9. Liska F, Gosele C, Rivkin E, TRES L, Cardoso M, Domaing P, et al. Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus. Biol Reprod. 2009;81:1196-205 pubmed publisher
    ..Cntrob may represent a novel candidate gene for presently unexplained hereditary forms of teratozoospermia and the "easily decapitated sperm syndrome" in humans. ..

More Information


  1. Zheng Y, Yin H, Boeglin W, Elias P, Crumrine D, Beier D, et al. Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope. J Biol Chem. 2011;286:24046-56 pubmed publisher
    ..Our study uncovers a hitherto unknown biochemical pathway in which the enzymic oxygenation of ceramides is involved in building a crucial structure of the epidermal barrier. ..
  2. Garcia Verdugo I, Benmohamed F, Tattermusch S, Leduc D, Charpigny G, Chignard M, et al. A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells. Eur Respir J. 2012;40:714-23 pubmed publisher
    ..Moreover, the 12R-LOX product 12(R)-hydroxyeicosatetraenoic acid, induces MUC5AC expression, ERK activation and Sp1 translocation. 12R-LOX is involved in MUC5AC expression. This occurs via ERK- and Sp1-signalling pathways. ..
  3. Gregus A, Dumlao D, Wei S, Norris P, Catella L, Meyerstein F, et al. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013;27:1939-49 pubmed publisher
    ..Similar to human and mouse orthologs, proteins encoded by rat Alox12b and Alox12e possessed minimal 12-LOX activity with AA as substrate, while eLOX3 (encoded by Aloxe3) exhibited HXS ..