Gene Symbol: Akt3
Description: AKT serine/threonine kinase 3
Alias: Pkbg, RAC-gamma serine/threonine-protein kinase, AKT3 kinase, PKB gamma, RAC-PK-gamma, protein kinase Akt-3, protein kinase B, gamma, thymoma viral proto-oncogene 3, v-akt murine thymoma viral oncogene 3, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Species: rat
Products:     Akt3

Top Publications

  1. Scheving L, Stevenson M, Zhang X, Russell W. Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner. Am J Physiol Gastrointest Liver Physiol. 2008;295:G322-31 pubmed publisher
    ..We hypothesize that the induction and activation of ErbB2 increases the expression of these kinases, enhancing the responsiveness of hepatocytes to EGF as they adapt to culture. ..
  2. Kageyama K, Ihara Y, Goto S, Urata Y, Toda G, Yano K, et al. Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells. J Biol Chem. 2002;277:19255-64 pubmed
    ..These findings indicate a novel mechanism by which cytoplasmic Akt signaling is modulated to cause apoptosis by a resident protein of the endoplasmic reticulum, calreticulin. ..
  3. Hirsch E, Costa C, Ciraolo E. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J Endocrinol. 2007;194:243-56 pubmed
    ..This review will thus focus on the different pathways that converge on PI3K activation, with particular attention to the paradigmatic PI3K involvement in insulin signaling. ..
  4. Borgatti P, Martelli A, Tabellini G, Bellacosa A, Capitani S, Neri L. Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin. J Cell Physiol. 2003;196:79-88 pubmed
  5. Sasaki T, Nakashiro K, Tanaka H, Azuma K, Goda H, Hara S, et al. Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo. Biochem Biophys Res Commun. 2010;399:79-83 pubmed publisher
    The serine/threonine kinase Akt has three highly homologous isoforms in mammals: Akt1, Akt2, and Akt3. Recent studies indicate that Akt is often constitutively active in many types of human malignancy...
  6. Zhang X, Zhang S, Yamane H, Wahl R, Ali A, Lofgren J, et al. Kinetic mechanism of AKT/PKB enzyme family. J Biol Chem. 2006;281:13949-56 pubmed
    ..AKT2 showed the highest Km value for ATP, and AKT3 showed the highest kcat value...
  7. Franke T. PI3K/Akt: getting it right matters. Oncogene. 2008;27:6473-88 pubmed publisher
    ..An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease. ..
  8. Pectasides D, Kotoula V, Papaxoinis G, Alexopoulou Z, Dervenis C, Samantas E, et al. Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer. Anticancer Res. 2016;36:6347-6356 pubmed
    ..thymoma viral oncogene homolog 1 (AKT1), AKT serine/threonine kinase 2 (AKT2), AKT serine/threonine kinase 3 (AKT3), cyclin D1 (CCND1), epidermal growth factor receptor (EGFR), mitogen-activated protein kinase 1 (MAPK1), ..
  9. Shu X, Lin J, Wood C, Tannir N, Wu X. Energy balance, polymorphisms in the mTOR pathway, and renal cell carcinoma risk. J Natl Cancer Inst. 2013;105:424-32 pubmed publisher
    ..08-fold increased risk. Among 190 SNPs in the mTOR pathway, six SNPs located in the AKT3 gene were statistically significantly associated with increased risk, and those with three or more unfavorable ..

More Information


  1. Zhu L, Zhou J, Zhang J, Wang J, Wang Z, Pan M, et al. MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3). Arterioscler Thromb Vasc Biol. 2017;37:957-968 pubmed publisher
    ..We identified AKT3 (protein kinase B-3) as a direct target of miR-15b-5p...
  2. Lee I, Dinudom A, Sanchez Perez A, Kumar S, Cook D. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem. 2007;282:29866-73 pubmed
    ..Together these data suggest that both Akt and Sgk are components of an insulin signaling pathway that increases Na(+) absorption by up-regulating membrane expression of ENaC via a regulatory system that involves inhibition of Nedd4-2. ..
  3. Zheng Y, Xu Z. MicroRNA-22 induces endothelial progenitor cell senescence by targeting AKT3. Cell Physiol Biochem. 2014;34:1547-55 pubmed publisher
    ..b>AKT3 was identified as a direct target of miR-22, and restoration of AKT3 expression attenuated the effects of miR-22 in ..
  4. Song J, Liu Q, Tang H, Tao A, Wang H, Kao R, et al. Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment. Oncotarget. 2016;7:80803-80810 pubmed publisher
    ..Our results suggest that the cardiomyocytes incur an oxidative stress under diabetic condition, which subsequently activates the PI3Kγ/Akt cell-signaling pathway and further increases HMGB1 expression. ..
  5. Easton R, Cho H, Roovers K, Shineman D, Mizrahi M, Forman M, et al. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol. 2005;25:1869-78 pubmed
    ..In mammals, three highly conserved proteins, Akt1, Akt2, and Akt3, comprise the Akt family, of which the first two are required for normal growth and metabolism, respectively...
  6. Morishita A, Gong J, Nomura T, Yoshida H, Izuishi K, Suzuki Y, et al. The use of protein array to identify targetable receptor tyrosine kinases for treatment of human colon cancer. Int J Oncol. 2010;37:829-35 pubmed
    ..In addition, xenograft tumors were also analyzed by phospho-MAPK protein array. The activity of Akt3/PKBgamma was inhibited with 5-FU alone and trastuzumab, indicating that trastuzumab may inhibit colon cancer growth ..
  7. Webster C, Srinivasulu U, Ananthanarayanan M, Suchy F, Anwer M. Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation. J Biol Chem. 2002;277:28578-83 pubmed
  8. Wright G, Maroulakou I, Eldridge J, Liby T, Sridharan V, Tsichlis P, et al. VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. FASEB J. 2008;22:3264-75 pubmed publisher
    ..We show that the serine threonine kinase Akt3 specifically links VEGF to mitochondrial biogenesis. A direct comparison of Akt1 vs...
  9. Turinsky J, Damrau Abney A. Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise. Am J Physiol. 1999;276:R277-82 pubmed
    Activities of Akt1, Akt2, and Akt3 kinases and glucose uptake in hindlimb muscles of the rat in vivo were investigated. The rats were studied either after intravenous injection of 0...
  10. Li P, Liu D, Liu Y, Song S, Wang Q, Chang Y, et al. BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol. 2012;141:290-300 pubmed publisher
    ..Pae had therapeutic effects on rats with CIA. These effects might be relative to regulating PI3K/Akt/mTOR signal mediated by BAFF/BAFF-R, and down regulate the antibodies production further. ..
  11. Konishi H, Kuroda S, Tanaka M, Matsuzaki H, Ono Y, Kameyama K, et al. Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Biochem Biophys Res Commun. 1995;216:526-34 pubmed
    ..These results suggest that the pleckstrin homology domains of RAC protein kinase family could associate more than one protein to regulate the activity and/or intracellular distribution of this enzyme family by different ways. ..
  12. Al Saad S, Donnem T, Al Shibli K, Persson M, Bremnes R, Busund L. Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer. Anticancer Res. 2009;29:4175-83 pubmed
    ..045) was a negative prognosticator. High stromal expression of total Akt3 (p=0.0008) and total PI3K (p=0.0003) correlated with a good prognosis...
  13. Lavender N, Rogers E, Yeyeodu S, Rudd J, Hu T, Zhang J, et al. Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer. BMC Med Genomics. 2012;5:11 pubmed publisher
    ..Nevertheless, we detected a modest synergistic interaction between AKT3 rs2125230-PRKCQ rs571715 and disease aggressiveness using SEN-guided MDR (p = 0.011)...