Akt1

Summary

Gene Symbol: Akt1
Description: AKT serine/threonine kinase 1
Alias: Akt, RAC-alpha serine/threonine-protein kinase, AKT1 kinase, PKB alpha, RAC protein kinase alpha RAC-PK alpha, RAC-PK-alpha, murine thymoma viral (v-akt) oncogene homolog 1, protein kinase B alpha, thymoma viral proto-oncogene 1, v-akt murine thymoma viral oncogene homolog 1
Species: rat
Products:     Akt1

Top Publications

  1. Endo H, Nito C, Kamada H, Yu F, Chan P. Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats. Stroke. 2006;37:2140-6 pubmed
    Apoptotic cell death is associated with acute brain injury after subarachnoid hemorrhage (SAH). The Akt/glycogen synthase kinase-3beta (GSK3beta) pathway plays an important role in the cell death/survival pathway after a variety of cell ..
  2. Carpten J, Faber A, Horn C, Donoho G, Briggs S, Robbins C, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature. 2007;448:439-44 pubmed
    Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer, mutation of AKT1 has not been widely reported...
  3. Xu J, Tu H, Xin W, Liu X, Zhang G, Zhai C. Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats. Exp Neurol. 2007;206:269-79 pubmed
    Several lines of evidence indicate that phosphatidylinositol 3-kinase (PI3K) and PI3K-protein kinase B/Akt (PKB/Akt) signal pathway mediate the pain hypersensitivity induced by intradermal injection of capsaicin or nerve growth factor...
  4. Gao X, Zhang H, Takahashi T, Hsieh J, Liao J, Steinberg G, et al. The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways. J Neurochem. 2008;105:943-55 pubmed publisher
    ..Here, we extend this data by examining long-term protection and exploring underlying mechanisms involving the Akt, mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) signaling pathways...
  5. Zhang B, Peng F, Wu D, Ingram A, Gao B, Krepinsky J. Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cell Signal. 2007;19:1690-700 pubmed
    ..We have recently shown that Akt mediates the stretch-induced production of type I collagen, an important contributor to sclerosis, in MC...
  6. Hong Y, Shao A, Wang J, Chen S, Wu H, McBride D, et al. Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3? signaling pathway. PLoS ONE. 2014;9:e96212 pubmed publisher
    ..we aimed to evaluate whether hydrogen alleviates EBI after SAH, specifically neuronal apoptosis, partially via the Akt/GSK3? signaling pathway...
  7. Ramachandran A, Ranpura S, Gong E, Mulone M, Cannon G, Adam R. An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration. Am J Pathol. 2010;177:119-31 pubmed publisher
    ..Previously, we implicated Akt and activator protein-1 (AP-1) as mediators of growth and gene expression in SMC exposed to cyclic stretch or PDGF...
  8. Chung C, Zhang Q, Qiao L. Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. J Biol Chem. 2010;285:4206-12 pubmed publisher
    ..pathways mediating NGF-induced type I collagen expression in the inflamed bladder during cystitis revealed that Akt, JNK, and ERK1/2 activities were increased in the inflamed bladder, whereas p38 MAPK remained unchanged...
  9. Franke T. PI3K/Akt: getting it right matters. Oncogene. 2008;27:6473-88 pubmed publisher
    The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells...
  10. Arms L, Vizzard M. Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis. Am J Physiol Renal Physiol. 2011;301:F252-62 pubmed publisher
    b>AKT phosphorylation following peripheral nerve injury or inflammation may play a role in somatic pain processes and visceral inflammation...

Detail Information

Publications80

  1. Endo H, Nito C, Kamada H, Yu F, Chan P. Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats. Stroke. 2006;37:2140-6 pubmed
    Apoptotic cell death is associated with acute brain injury after subarachnoid hemorrhage (SAH). The Akt/glycogen synthase kinase-3beta (GSK3beta) pathway plays an important role in the cell death/survival pathway after a variety of cell ..
  2. Carpten J, Faber A, Horn C, Donoho G, Briggs S, Robbins C, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature. 2007;448:439-44 pubmed
    Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer, mutation of AKT1 has not been widely reported...
  3. Xu J, Tu H, Xin W, Liu X, Zhang G, Zhai C. Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats. Exp Neurol. 2007;206:269-79 pubmed
    Several lines of evidence indicate that phosphatidylinositol 3-kinase (PI3K) and PI3K-protein kinase B/Akt (PKB/Akt) signal pathway mediate the pain hypersensitivity induced by intradermal injection of capsaicin or nerve growth factor...
  4. Gao X, Zhang H, Takahashi T, Hsieh J, Liao J, Steinberg G, et al. The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways. J Neurochem. 2008;105:943-55 pubmed publisher
    ..Here, we extend this data by examining long-term protection and exploring underlying mechanisms involving the Akt, mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) signaling pathways...
  5. Zhang B, Peng F, Wu D, Ingram A, Gao B, Krepinsky J. Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cell Signal. 2007;19:1690-700 pubmed
    ..We have recently shown that Akt mediates the stretch-induced production of type I collagen, an important contributor to sclerosis, in MC...
  6. Hong Y, Shao A, Wang J, Chen S, Wu H, McBride D, et al. Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3? signaling pathway. PLoS ONE. 2014;9:e96212 pubmed publisher
    ..we aimed to evaluate whether hydrogen alleviates EBI after SAH, specifically neuronal apoptosis, partially via the Akt/GSK3? signaling pathway...
  7. Ramachandran A, Ranpura S, Gong E, Mulone M, Cannon G, Adam R. An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration. Am J Pathol. 2010;177:119-31 pubmed publisher
    ..Previously, we implicated Akt and activator protein-1 (AP-1) as mediators of growth and gene expression in SMC exposed to cyclic stretch or PDGF...
  8. Chung C, Zhang Q, Qiao L. Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. J Biol Chem. 2010;285:4206-12 pubmed publisher
    ..pathways mediating NGF-induced type I collagen expression in the inflamed bladder during cystitis revealed that Akt, JNK, and ERK1/2 activities were increased in the inflamed bladder, whereas p38 MAPK remained unchanged...
  9. Franke T. PI3K/Akt: getting it right matters. Oncogene. 2008;27:6473-88 pubmed publisher
    The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells...
  10. Arms L, Vizzard M. Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis. Am J Physiol Renal Physiol. 2011;301:F252-62 pubmed publisher
    b>AKT phosphorylation following peripheral nerve injury or inflammation may play a role in somatic pain processes and visceral inflammation...
  11. Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, et al. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells. 2009;27:3021-31 pubmed publisher
    ..The mechanisms contributing to the beneficial effects of Hsp20 were associated with enhanced Akt activation and increased secretion of growth factors (VEGF, FGF-2, and IGF-1)...
  12. Muraski J, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, et al. Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med. 2007;13:1467-75 pubmed
    The serine-threonine kinases Pim-1 and Akt regulate cellular proliferation and survival. Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 has been overlooked...
  13. Wang H, Wang G, Yu Y, Wang Y. The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. Brain Res. 2009;1297:177-84 pubmed publisher
    ..whether propofol could provide postconditioning to ischemic brain injury and the role of phosphoinositide-3-kinase/Akt (PI3K/Akt) pathway in this phenomenon...
  14. Zdychova J, Kazdova L, Pelikanova T, Lindsley J, Anderson S, Komers R. Renal activity of Akt kinase in obese Zucker rats. Exp Biol Med (Maywood). 2008;233:1231-41 pubmed publisher
    Insulin resistance (IR) and consequent hyperinsulinemia are hallmarks of Type 2 diabetes (DM2). Akt kinase (Akt) is an important molecule in insulin signaling, implicated in regulation of glucose uptake, cell growth, cell survival, ..
  15. Horwood J, Dufour F, Laroche S, Davis S. Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci. 2006;23:3375-84 pubmed
    The phosphoinositide 3-kinase (PI3K)/Akt signalling cascade has classically been implicated in promoting cell survival but more recently has been shown to regulate a number of other cellular functions...
  16. Laatikainen L, Incoronato M, Castellone M, Laurila J, Santoro M, Laukkanen M. SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a. PLoS ONE. 2011;6:e24456 pubmed publisher
    ..apoptosis and survival -related phenomena in different pathological conditions, we clarified the impact of SOD3 on Akt and Erk1/2 cell survival pathways in rat hind limb injury model...
  17. Alessi D, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 1996;15:6541-51 pubmed
    Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes, while after transfection into 293 cells PKBalpha was activated 20- and 50-fold in response to insulin and IGF-1 ..
  18. Pallafacchina G, Calabria E, Serrano A, Kalhovde J, Schiaffino S. A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Natl Acad Sci U S A. 2002;99:9213-8 pubmed
    ..Here we report that constitutively active protein kinase B (PKB), also known as Akt, increases fiber size and prevents denervation atrophy in regenerating and adult rat muscles but does not affect ..
  19. Won C, Ha S, Noh H, Kang S, Cho G, Choi W, et al. Estradiol prevents the injury-induced decrease of Akt activation and Bad phosphorylation. Neurosci Lett. 2005;387:115-9 pubmed
    ..This study investigated whether estradiol modulates the anti-apoptotic signal through the activation of Akt and its downstream targets, including Bad, Bcl-x(L), and 14-3-3...
  20. Hahn Windgassen A, Nogueira V, Chen C, Skeen J, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem. 2005;280:32081-9 pubmed
    ..We show that in Akt1/Akt2 DKO cells AMP/ATP ratio is markedly elevated with concomitant increase in AMPK activity, whereas in cells ..
  21. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N, et al. Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res. 2004;121:159-70 pubmed
    Apoptosis as well as necrosis may play an important role in hepatic ischemia/reperfusion (I/R) injury. Akt, a serine-threonine protein kinase, is known to promote cell survival...
  22. Wang Q, Liu L, Pei L, Ju W, Ahmadian G, Lu J, et al. Control of synaptic strength, a novel function of Akt. Neuron. 2003;38:915-28 pubmed
    b>Akt (also known as PKB), a serine/threonine kinase involved in diverse signal-transduction pathways, is highly expressed in the brain...
  23. Brunet A, Bonni A, Zigmond M, Lin M, Juo P, Hu L, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999;96:857-68 pubmed
    ..factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9...
  24. Sakamoto K, Aschenbach W, Hirshman M, Goodyear L. Akt signaling in skeletal muscle: regulation by exercise and passive stretch. Am J Physiol Endocrinol Metab. 2003;285:E1081-8 pubmed
    b>Akt/protein kinase B is a serine/threonine kinase that has emerged as a critical signaling component for mediating numerous cellular responses...
  25. Ghosh Choudhury G, Abboud H. Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells. Cell Signal. 2004;16:31-41 pubmed
    ..We investigated the involvement of tyrosine phosphorylation and the phosphatidylinositol (PI) 3 kinase/Akt signalling pathway in this process...
  26. Adachi M, Katsumura K, Fujii K, Kobayashi S, Aoki H, Matsuzaki M. Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells. FEBS Lett. 2003;554:77-80 pubmed
    b>Akt is activated by growth factors to regulate various aspects of vascular smooth muscle cell function...
  27. Li L, El Kholy W, Rhodes C, Brubaker P. Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia. 2005;48:1339-49 pubmed
    ..05) and reactive oxygen species (by 27%, p<0.05). The results of our study indicate that GLP-1 plays a protective role against cytokine-induced apoptosis and necrosis in beta cells through a PKB-dependent signalling pathway. ..
  28. Qi X, Wildey G, Howe P. Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. J Biol Chem. 2006;281:813-23 pubmed
    ..The appearance of multiple, phosphorylated species of Bim(EL) correlated with Akt, and not ERK, activation...
  29. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher A. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999;399:601-5 pubmed
    ..Here we demonstrate that the serine/threonine protein kinase Akt/PKB mediates the activation of eNOS, leading to increased NO production...
  30. Turinsky J, Damrau Abney A. Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise. Am J Physiol. 1999;276:R277-82 pubmed
    ..Administration of insulin resulted in rapid activation of Akt1 kinase, with peak activity observed 5 min after insulin injection...
  31. Zheng W, Kar S, Quirion R. Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem. 2000;275:39152-8 pubmed
    ..elegans, is an inducer of apoptosis in its unphosphorylated form and was recently reported as a substrate of Akt kinases...
  32. Chen W, Xu P, Gottlob K, Chen M, Sokol K, Shiyanova T, et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001;15:2203-8 pubmed
    ..Here we report the disruption of the most ubiquitously expressed member of the akt family of genes, akt1, in the mouse. Akt1(-/-) mice are viable but smaller when compared to wild-type littermates...
  33. Alexaki V, Charalampopoulos I, Kampa M, Vassalou H, Theodoropoulos P, Stathopoulos E, et al. Estrogen exerts neuroprotective effects via membrane estrogen receptors and rapid Akt/NOS activation. FASEB J. 2004;18:1594-6 pubmed
    ..signaling cascade (2-30 min after E2) has been tested, showing Ca(2+) mobilization-->PI3K activation-->Akt phosporylation-->NOS activation. Inhibition of PI3K or NOS completely reversed the anti-apoptotic effect of E2...
  34. Woodgett J. Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol. 2005;17:150-7 pubmed
  35. Bose S, Chandran S, Mirocha J, Bose N. The Akt pathway in human breast cancer: a tissue-array-based analysis. Mod Pathol. 2006;19:238-45 pubmed
    The Akt pathway, an important regulator of cell proliferation and survival, is deregulated in many cancers...
  36. Muller C, Dünschede F, Koch E, Vollmar A, Kiemer A. Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway. Am J Physiol Gastrointest Liver Physiol. 2003;285:G769-78 pubmed
    ..Preconditioning with LA significantly enhanced Akt phosphorylation. It showed neither effect on endothelial nitric oxide synthase nor on Bad phosphorylation...
  37. Sakamoto K, Hirshman M, Aschenbach W, Goodyear L. Contraction regulation of Akt in rat skeletal muscle. J Biol Chem. 2002;277:11910-7 pubmed
    ..to increasing phosphorylation, contraction in situ significantly increased the activity of all three Akt isoforms (Akt1 > Akt2 > Akt3) with maximal activation occurring at 2...
  38. Cong L, Chen H, Li Y, Zhou L, McGibbon M, Taylor S, et al. Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol. 1997;11:1881-90 pubmed
    ..b>Akt is a serine-threonine kinase recently identified as a direct downstream target of phosphatidylinositol 3-kinase...
  39. Yu F, Sugawara T, Maier C, Hsieh L, Chan P. Akt/Bad signaling and motor neuron survival after spinal cord injury. Neurobiol Dis. 2005;20:491-9 pubmed
    The serine-threonine kinase Akt is a cell survival signaling pathway that inactivates the proapoptotic BCL-2 family protein Bad and promotes cell survival in cerebral ischemia...
  40. Cross D, Alessi D, Cohen P, Andjelkovich M, Hemmings B. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378:785-9 pubmed
    ..conditions, and we demonstrate that it is the product of the proto-oncogene protein kinase B (PKB, also known as Akt/RAC)...
  41. Majewski N, Nogueira V, Bhaskar P, Coy P, Skeen J, Gottlob K, et al. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell. 2004;16:819-30 pubmed
    The serine/threonine kinase Akt inhibits mitochondrial cytochrome c release and apoptosis induced by a variety of proapoptotic stimuli. The antiapoptotic activity of Akt is coupled, at least in part, to its effects on cellular metabolism...
  42. Xu J, Qian J, Xie X, Lin L, Zou Y, Fu M, et al. High density lipoprotein protects mesenchymal stem cells from oxidative stress-induced apoptosis via activation of the PI3K/Akt pathway and suppression of reactive oxygen species. Int J Mol Sci. 2012;13:17104-20 pubmed publisher
    ..Each of the beneficial effects of HDL on MSCs was attenuated by inhibiting the PI3K/Akt pathway...
  43. Romanelli R, Mahajan K, Fulmer C, Wood T. Insulin-like growth factor-I-stimulated Akt phosphorylation and oligodendrocyte progenitor cell survival require cholesterol-enriched membranes. J Neurosci Res. 2009;87:3369-77 pubmed publisher
    Previously we showed that insulin-like growth factor-I (IGF-I) promotes sustained phosphorylation of Akt in oligodendrocyte progenitor cells (OPCs) and that Akt phosphorylation is required for survival of these cells...
  44. Hu N, Kong L, Chen H, Li W, Qian A, Wang X, et al. Autophagy protein 5 enhances the function of rat EPCs and promotes EPCs homing and thrombus recanalization via activating AKT. Thromb Res. 2015;136:642-51 pubmed publisher
    ..Mechanistically, we have shown that ATG5 overexpression enhances psudotube formation via the activation of AKT. These findings suggest that ATG5-AKT signaling plays an essential role in EPC migration and psudotube formation...
  45. Liu L, Zhao X, Pierre S, Askari A. Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Am J Physiol Cell Physiol. 2007;293:C1489-97 pubmed
    ..In view of the known involvement of phosphatidylinositol 3-kinase (PI3K)-Akt pathways in cardiac hypertrophy, the aim of the present study was to determine whether these pathways are also ..
  46. Xiao H, Shi W, Liu S, Wang W, Zhang B, Zhang Y, et al. 1,25-Dihydroxyvitamin D(3) prevents puromycin aminonucleoside-induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-kinase/Akt-signaling pathway. Am J Nephrol. 2009;30:34-43 pubmed publisher
    ..apoptosis, the expression of nephrin protein and mRNA, TGF-beta/Smad and phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway were evaluated, respectively...
  47. Nair V, Olanow C. Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses. J Biol Chem. 2008;283:15469-78 pubmed publisher
    ..apoptosis induced by oxidative stress by activating the D2 receptor-coupled phosphoinositide 3-kinase (PI-3K)/Akt pathway...
  48. Weng Y, Kuo W, Lin Y, Kuo C, Tzang B, Tsai F, et al. Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts. Food Chem Toxicol. 2013;56:28-39 pubmed publisher
    ..We found that Danshen extract treatments significantly enhanced phosphorylated Akt through estrogen receptor activation to inhibit Leu27IGF-II-induced calcineurin activation and block H9c2 cell ..
  49. Lian S, Xia Y, Khoi P, Ung T, Yoon H, Kim N, et al. Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology. 2015;338:104-16 pubmed publisher
    ..Cd also activated the phosphorylation of EGFR, Akt, Erk1/2, and JNK1/2 in addition to promoting NF-кB and AP-1 binding activities...
  50. Mourouzis I, Giagourta I, Galanopoulos G, Mantzouratou P, Kostakou E, Kokkinos A, et al. Thyroid hormone improves the mechanical performance of the post-infarcted diabetic myocardium: a response associated with up-regulation of Akt/mTOR and AMPK activation. Metabolism. 2013;62:1387-93 pubmed publisher
    ..Thus, this study explored the potential effects of TH treatment on the functional status of the postinfarcted diabetic myocardium. Diabetic patients have worse prognosis after acute myocardial infarction (AMI)...
  51. Zhang X, Zanello L. Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblasts. J Bone Miner Res. 2008;23:1238-48 pubmed publisher
    ..We studied activation of an Akt survival cascade downstream of 1,25D nongenomic stimulation of phosphatidylinositide-3'-kinase (PI3K) in ..
  52. Darmellah A, Baetz D, Prunier F, Tamareille S, Rucker Martin C, Feuvray D. Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of Akt. Diabetologia. 2007;50:1335-44 pubmed
    ..Thus, phosphorylation of the extracellular signal-regulated protein kinase (Erk), of the protein kinase Akt (also known as protein kinase B) and of the Ca(2+)/calmodulin-dependent kinase II was increased in GK LV myocytes...
  53. Nazarewicz R, Salazar G, Patrushev N, San Martin A, Hilenski L, Xiong S, et al. Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes. J Biol Chem. 2011;286:2886-95 pubmed publisher
    b>Akt/protein kinase B (PKB) activation/phosphorylation by angiotensin II (Ang II) is a critical signaling event in hypertrophy of vascular smooth muscle cells (VSMCs)...
  54. Yu J, Zhang S, Saito K, Williams S, Arimura Y, Ma Y, et al. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 2009;28:21-33 pubmed publisher
    ..Here, we describe a novel Akt-EGR1-alternate reading frame (ARF)-PTEN axis, in which PTEN activation in vivo requires p14ARF-mediated sumoylation ..
  55. Kayama M, Nakazawa T, Thanos A, Morizane Y, Murakami Y, Theodoropoulou S, et al. Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. Am J Pathol. 2011;178:1080-91 pubmed publisher
    ..We found that HSP70 was up-regulated after RD and associated with phosphorylated Akt, thereby preventing its dephosphorylation and further activation of cell death pathways...
  56. Zhai Y, Lu Q, Liu Y, Cheng Q, Wei Y, Zhang F, et al. Over-production of nitric oxide by oxidative stress-induced activation of the TGF-?1/PI3K/Akt pathway in mesangial cells cultured in high glucose. Acta Pharmacol Sin. 2013;34:507-14 pubmed publisher
    ..NO over-production in rat mesangial cells cultured in high glucose (HG) is related to activation of the TGF-?1/PI3K/Akt pathway. Rat mesangial cells line (HBZY-1) was exposed to HG (24.44 mmol/L) or H2O2 (10 ?mol/L) for 16 h...
  57. Whittington H, Harding I, Stephenson C, Bell R, Hausenloy D, Mocanu M, et al. Cardioprotection in the aging, diabetic heart: the loss of protective Akt signalling. Cardiovasc Res. 2013;99:694-704 pubmed publisher
    ..following IRI is greatly dependent on its innate cardioprotective potential, in which a central role is played by Akt. We aimed to investigate in an aging diabetic rat model, the susceptibility of the heart to IRI, the achievability ..
  58. Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011;12:175-80 pubmed publisher
    ..here, we discuss subsets defined by so-called driver mutations in ALK, HER2 (also known as ERBB2), BRAF, PIK3CA, AKT1, MAP2K1, and MET...
  59. Deng J, Han Y, Yan C, Tian X, Tao J, Kang J, et al. Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt. Apoptosis. 2010;15:463-73 pubmed publisher
    ..Moreover, CREG enhanced Akt phosphorylation and decreased the expression of p53 in MSCs under hypoxic/SD conditions...
  60. Xiong T, Tang J, Zhao J, Chen H, Zhao F, Li J, et al. Involvement of the Akt/GSK-3?/CRMP-2 pathway in axonal injury after hypoxic-ischemic brain damage in neonatal rat. Neuroscience. 2012;216:123-32 pubmed publisher
    b>Akt has been demonstrated as a survival kinase in brain after hypoxia-ischemia (HI)...
  61. Rokudai S, Laptenko O, Arnal S, Taya Y, Kitabayashi I, Prives C. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A. 2013;110:3895-900 pubmed publisher
    ..Moreover, we identified an Akt/protein kinase B recognition sequence in the PML-binding domain of MOZ protein...
  62. Parkhouse W, Cunningham L, McFee I, Miller J, Whitney D, Pelech S, et al. Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2008;9:24-34 pubmed publisher
    ..These data suggest that the debility in the mSOD mouse model of ALS is produced, in part, by impaired retrograde uptake/transport in motor neuron axons in spite of regenerative support from muscle such as elevated expression of PKB...
  63. Peltier J, O Neill A, Schaffer D. PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Dev Neurobiol. 2007;67:1348-61 pubmed
    The phosphoinositide 3-OH kinase (PI3K)/Akt pathway has been implicated in regulating several important cellular processes, including apoptosis, survival, proliferation, and metabolism...
  64. Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J, et al. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2015;116:35-45 pubmed publisher
    ..loss-of-function studies indicated that YAP is necessary and sufficient to activate the phosphoinositol-3-kinase-Akt pathway...
  65. Chan T, Zhang J, Rodeck U, Pascal J, Armen R, Spring M, et al. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. Proc Natl Acad Sci U S A. 2011;108:E1120-7 pubmed publisher
    Phosphorylation of a threonine residue (T308 in Akt1) in the activation loop of Akt kinases is a prerequisite for deregulated Akt activity frequently observed in neoplasia...
  66. Mao J, Xu C, Jiang R. [Expressions of phospho-Erk1/2 and phospho-Akt1 in the corpus cavernosum of aged rats]. Zhonghua Nan Ke Xue. 2010;16:693-7 pubmed
    ..09 +/- 8.45, P < 0.05). But there were no significant differences in the mRNA and protein expressions of P-Akt1 between the two groups (0.97 +/- 0.04 and 11.67 +/- 5.61 vs 0.94 +/- 0.05 and 10.93 +/- 3.06, P > 0.05)...
  67. Shao J, Wan X, Chen Y, Bi C, Chen H, Zhong Y, et al. H2S protects hippocampal neurons from anoxia-reoxygenation through cAMP-mediated PI3K/Akt/p70S6K cell-survival signaling pathways. J Mol Neurosci. 2011;43:453-60 pubmed publisher
    The study aims to investigate the effect of hydrogen sulfide (H(2)S) on the phosphatidylinositol 3-kinase (PI3K)/Akt/p70 ribosomal S6 kinase (p70S6K) signal transduction pathway after oxygen glucose deprivation/reoxygenation (OGD/R) in ..
  68. Rodriguez Blanco J, Martin V, García Santos G, Herrera F, Casado Zapico S, Antolin I, et al. Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells. J Neurosci Res. 2012;90:1850-60 pubmed publisher
    ..Results showed an early increase in oxidants, which drives the modulation of c-Jun N-terminal kinase (JNK) and AKT/mammalian target of rapamycin (mTOR) pathways, mimicking peroxide treatment...
  69. Zhou C, Tu J, Zhang Q, Lu D, Zhu Y, Zhang W, et al. Delayed ischemic postconditioning protects hippocampal CA1 neurons by preserving mitochondrial integrity via Akt/GSK3? signaling. Neurochem Int. 2011;59:749-58 pubmed publisher
    ..of the PI3K inhibitor LY294002, 20min prior to Post C, significantly attenuated Post C-induced elevation of p-Akt and p-GSK3?, as well as prevented Post C enhancement of mitochondrial integrity and Post C neuroprotection...
  70. Linares Palomino J, Husainy M, Lai V, Dickenson J, Galinanes M. Selective blockade of protein kinase B protects the rat and human myocardium against ischaemic injury. J Physiol. 2010;588:2173-91 pubmed publisher
    Protein kinase B (PKB/Akt) plays a critical role in cell survival but the investigation of its involvement has been limited by the lack of specific pharmacological agents...
  71. Elia L, Contu R, Quintavalle M, Varrone F, Chimenti C, Russo M, et al. Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation. 2009;120:2377-85 pubmed publisher
    ..Our results reveal a critical role of miR-1 in mediating the effects of the IGF-1 pathway and demonstrate a feedback loop between miR-1 expression and the IGF-1 signal transduction cascade. ..
  72. Qi J, Yang B, Ren C, Fu J, Zhang J. Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet. J Diabetes Res. 2016;2016:1564386 pubmed
    ..could improve insulin resistance (IR) by regulating tripartite motif family protein 72 (TRIM72) expression and AKT signal pathway in rats fed with high-fat diet...
  73. Zhang J, Zhang W, Sun Y, Liu Y, Song L, Ma Z, et al. Activation of GRs-Akt-nNOs-NR2B signaling pathway by second dose GR agonist contributes to exacerbated hyperalgesia in a rat model of radicular pain. Mol Biol Rep. 2014;41:4053-61 pubmed publisher
    Central Akt, neuronal nitric oxide synthase (nNOS) and N-methyl-D-aspartate receptor subunit 2B (NR2B) play key roles in the development of neuropathic pain...
  74. Chan A, Dolinsky V, Soltys C, Viollet B, Baksh S, Light P, et al. Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. J Biol Chem. 2008;283:24194-201 pubmed publisher
    ..Because studies in cells other than cardiomyocytes revealed that AMP-activated protein kinase (AMPK) and Akt are affected by resveratrol, we hypothesized that resveratrol prevents cardiac myocyte hypertrophy via these two ..
  75. Allard D, Figg N, Bennett M, Littlewood T. Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3. J Biol Chem. 2008;283:19739-47 pubmed publisher
    ..b>Akt mediates the majority of the IGF1R survival signaling, and ectopic activation of Akt was sufficient to protect ..
  76. Romić S, Tepavcevic S, Zakula Z, Milosavljevic T, Stojiljkovic M, Zivkovic M, et al. Does oestradiol attenuate the damaging effects of a fructose-rich diet on cardiac Akt/endothelial nitric oxide synthase signalling?. Br J Nutr. 2013;109:1940-8 pubmed publisher
    Fructose-rich diets (FRD) cause cardiac insulin resistance manifested by impairment of Akt/endothelial NO synthase (eNOS) signalling. In contrast, oestradiol (E2) activates this signalling pathway in the heart...
  77. Yu J, Li J, Zhang S, Xu X, Zheng M, Jiang G, et al. IGF-1 induces hypoxia-inducible factor 1?-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells. Brain Res. 2012;1430:18-24 pubmed publisher
    ..Moreover, IGF-1 stimulated HIF-1? and GLUT3 protein expression through phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR dependent pathways...
  78. Thiselton D, Vladimirov V, Kuo P, McClay J, Wormley B, Fanous A, et al. AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biol Psychiatry. 2008;63:449-57 pubmed
    ..The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the ..