Gene Symbol: Akr7a2
Description: aldo-keto reductase family 7, member A2
Alias: Aiar, aflatoxin B1 aldehyde reductase member 2, SSA reductase, aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), rAFAR2, succinic semialdehyde reductase
Species: rat
Products:     Akr7a2

Top Publications

  1. Nishi N, Shoji H, Miyanaka H, Nakamura T. Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostate. Endocrinology. 2000;141:3194-9 pubmed
    ..The newly identified protein (androgen-inducible aldehyde reductase, AIAR) and rat aflatoxin B1 aldehyde reductase (AFAR) exhibit 80% amino acid sequence homology...
  2. Kelly V, Sherratt P, Crouch D, Hayes J. Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. Biochem J. 2002;366:847-61 pubmed
    ..Further bioinformatic evidence is presented that full-length human AKR7A2 is composed of 359 amino acids and also possesses an additional N-terminal domain...
  3. Praml C, Savelyeva L, Schwab M. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. Oncogene. 2003;22:4765-73 pubmed
    ..6% identical. Knowledge of the AFAR genes and their structure will be essential in genetic and functional studies, where discrimination of the genes and proteins is a prerequisite for evaluating their individual functions. ..
  4. Bains O, Grigliatti T, Reid R, Riggs K. Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. J Pharmacol Exp Ther. 2010;335:533-45 pubmed publisher
    ..significantly decreased V(max) (47% lower) and k(cat) and k(cat)/K(m) (both 43% lower); and the A142T variant of AKR7A2 significantly affected all kinetic parameters (V(max) and k(cat), 61% decrease; K(m), 156% increase; k(cat)/K(m), ..