Gene Symbol: Akr1c2
Description: aldo-keto reductase family 1, member C2
Alias: Akr1c21, aldo-keto reductase family 1 member C21, 17-alpha-HSD, 17-alpha-hydroxysteroid dehydrogenase, 3(or 17)-alpha-hydroxysteroid dehydrogenase, 3-alpha-hydroxysteroid dehydrogenase, aldo-keto reductase family 1, member C21
Species: rat
Products:     Akr1c2

Top Publications

  1. Faucher F, Cantin L, Pereira de Jésus Tran K, Lemieux M, Luu The V, Labrie F, et al. Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. J Mol Biol. 2007;369:525-40 pubmed
  2. Ruiz F, Porté S, Gallego O, Moro A, Ardèvol A, del Rio Espinola A, et al. Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily. Biochem J. 2011;440:335-44 pubmed publisher
    ..All of the enzymes except AKR1C2 showed retinaldehyde reductase activity with low Km values (~1 ?M). The kcat values were also low (0.18-0...
  3. Hara A, Matsuura K, Tamada Y, Sato K, Miyabe Y, Deyashiki Y, et al. Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. Biochem J. 1996;313 ( Pt 2):373-6 pubmed
    ..Refined relationship between dihydrodiol dehydrogenases and their related proteins of human tissues is proposed. ..
  4. Davies N, Hayden R, Simpson P, Birtwistle J, Mayer K, Ride J, et al. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res. 2009;69:4769-75 pubmed publisher
    ..In conclusion, we have identified AKR1C isoforms as a novel target of jasmonates in cancer cells and provide further evidence of the promise of these compounds, or derivatives thereof, as adjunctive therapies in the treatment of cancer. ..
  5. Bains O, Grigliatti T, Reid R, Riggs K. Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. J Pharmacol Exp Ther. 2010;335:533-45 pubmed publisher
    ..These findings suggest that ns-SNPs in human AKR1C3, AKR1C4, and AKR7A2 significantly decrease the in vitro metabolism of DOX and DAUN. ..
  6. Hevir N, Vouk K, Sinkovec J, Ribic Pucelj M, Rizner T. Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis. Chem Biol Interact. 2011;191:217-26 pubmed publisher
    ..significantly decreased mRNA levels of PR-AB, HSD17B2 and SRD5A2, significantly increased mRNA levels of AKR1C1, AKR1C2, AKR1C3 and SRD5A1, and negligible mRNA levels of AKR1D1...
  7. Ishikura S, Usami N, Nakajima S, Kameyama A, Shiraishi H, Carbone V, et al. Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family. Biol Pharm Bull. 2004;27:1939-45 pubmed
    ..sequences of the two isoforms are identical to those of proteins that are predicted to be encoded in a gene for AKR1C21 in the database of the mouse genome...
  8. Faucher F, Pereira de Jésus Tran K, Cantin L, Luu The V, Labrie F, Breton R. Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. J Mol Biol. 2006;364:747-63 pubmed
  9. Wang S, Yang Q, Fung K, Lin H. AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. Mol Cell Endocrinol. 2008;289:60-6 pubmed publisher
    ..11-ketoprostaglandin reductase activity and is capable of converting PGD2 to 9alpha, 11beta-PGF2alpha, whereas AKR1C2-mediated PG metabolism remains unclear...

More Information


  1. Dhagat U, Endo S, Mamiya H, Hara A, El Kabbani O. Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme. Acta Crystallogr D Biol Crystallogr. 2010;66:198-204 pubmed publisher
    Mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) is the only aldo-keto reductase that catalyzes the stereospecific reduction of 3- and 17-ketosteroids to the corresponding 3(17)alpha-hydroxysteroids...