Gene Symbol: Akr1c1
Description: aldo-keto reductase family 1, member C1
Alias: Akr1c6, Hsd17b5, aldo-keto reductase family 1, member C1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), aldo-keto reductase family 1, member C6, type 5 17beta-hydroxysteroid dehydrogenase
Deyashiki Y, Ohshima K, Nakanishi M, Sato K, Matsuura K, Hara A. Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem. 1995;270:10461-7 pubmed
..The liver mRNA content was considerably more abundant than those found in the other tissues, as 17 beta-HSD protein was mainly detected in the liver by Western analysis. ..
Blouin K, Blanchette S, Richard C, Dupont P, Luu The V, Tchernof A. Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women. Am J Physiol Endocrinol Metab. 2005;288:E398-404 pubmed
We examined expression and activity of steroid aldoketoreductase (AKR) 1C enzymes in adipose tissue in women. AKR1C1 (20alpha-hydroxysteroid dehydrogenase; 20alpha-HSD), AKR1C2 (3alpha-HSD-3), and AKR1C3 (17beta-HSD-5) are involved mainly ..
Ishikura S, Matsumoto K, Sanai M, Horie K, Matsunaga T, Tajima K, et al
. Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme. J Biochem. 2006;139:1053-63 pubmed
..In addition, TBER2 was identified as 3alpha-hydroxysteroid dehydrogenase on chromatographic analysis of the enzyme activities in rat liver cytosol and characterization of the recombinant 3alpha-hydroxysteroid dehydrogenase. ..
Azzarello J, Fung K, Lin H. Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. J Histochem Cytochem. 2008;56:853-61 pubmed publisher
..monoclonal antibody against AKR1C3 that does not cross-react with related, >86% sequence identity, human AKR1C1, AKR1C2, or AKR1C4, human aldehyde reductase AKR1A1, or rat 3alpha-hydroxysteroid dehydrogenase (AKR1C9)...
Davies N, Hayden R, Simpson P, Birtwistle J, Mayer K, Ride J, et al
. AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res. 2009;69:4769-75 pubmed publisher
..In conclusion, we have identified AKR1C isoforms as a novel target of jasmonates in cancer cells and provide further evidence of the promise of these compounds, or derivatives thereof, as adjunctive therapies in the treatment of cancer. ..
Ruiz F, Porté S, Gallego O, Moro A, Ardèvol A, del Rio Espinola A, et al
. Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily. Biochem J. 2011;440:335-44 pubmed publisher
Human AKR (aldo-keto reductase) 1C proteins (AKR1C1-AKR1C4) exhibit relevant activity with steroids, regulating hormone signalling at the pre-receptor level...
Bains O, Grigliatti T, Reid R, Riggs K. Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. J Pharmacol Exp Ther. 2010;335:533-45 pubmed publisher
..These findings suggest that ns-SNPs in human AKR1C3, AKR1C4, and AKR7A2 significantly decrease the in vitro metabolism of DOX and DAUN. ..