AKAP 220


Gene Symbol: AKAP 220
Description: A-kinase anchoring protein 11
Alias: Akap, A-kinase anchor protein 11, A kinase (PRKA) anchor protein 11, A-kinase anchor protein 220 kDa, A-kinase anchoring protein 220, AKAP 220, AKAP 220, AKAP-11, PRKA11, protein kinase A-anchoring protein 11
Species: rat
Products:     AKAP 220

Top Publications

  1. Tasken K, Aandahl E. Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev. 2004;84:137-67 pubmed
  2. Okutsu R, Rai T, Kikuchi A, Ohno M, Uchida K, Sasaki S, et al. AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts. Kidney Int. 2008;74:1429-33 pubmed publisher
    ..Forskolin-mediated phosphorylation of AQP2, transiently expressed in COS cells, was increased by AKAP220 co-expression. Our results suggest that AKAP220 may be involved in the phosphorylation of AQP2 by recruiting protein kinase A. ..
  3. Lester L, Coghlan V, Nauert B, Scott J. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. J Biol Chem. 1996;271:9460-5 pubmed
    ..analysis and RII overlay experiments showed that the protein is approximately 220 kDa and was, therefore, named AKAP 220. Immunoprecipitation of AKAP 220 from rat testis extracts resulted in co-purification of the type II PKA ..
  4. Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A. A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J Biol Chem. 2002;277:36955-61 pubmed
    ..These results suggest that PKA and PP1 regulate the activity of GSK-3beta efficiently by forming a complex with AKAP220. ..
  5. Yang L, Nakayama Y, Hattori N, Liu B, Inagaki C. GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. J Pharmacol Sci. 2008;106:578-84 pubmed
    ..PKA activation, association of GABA(C) receptor with A-kinase anchoring proteins (AKAPs) and effect of an AKAP antisense oligonucleotide on the PKA activation were examined in primary cultured rat hippocampal neurons...
  6. Carnegie G, Means C, Scott J. A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB Life. 2009;61:394-406 pubmed publisher
    ..These anchoring proteins form multi-protein complexes that integrate cAMP signaling with other pathways and signaling events. In this review, we focus on recent advances in the elucidation of AKAP function.