Gene Symbol: Agtrap
Description: angiotensin II receptor-associated protein
Alias: type-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein, angiotensin II, type I receptor-associated protein
Species: rat
Products:     Agtrap

Top Publications

  1. Tanaka Y, Tamura K, Koide Y, Sakai M, Tsurumi Y, Noda Y, et al. The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy. FEBS Lett. 2005;579:1579-86 pubmed
    ..These results indicate that ATRAP significantly promotes downregulation of the AT1R and further attenuates certain Ang II-mediated hypertrophic responses in cardiomyocytes. ..
  2. Ji Y, Liu J, Wang Z, Liu N. Angiotensin II induces inflammatory response partly via toll-like receptor 4-dependent signaling pathway in vascular smooth muscle cells. Cell Physiol Biochem. 2009;23:265-76 pubmed publisher
    ..Our results provide the evidence that Ang II induces inflammatory response involved in pathogenesis of atherosclerosis partly via TLR4- dependent signaling pathway in VSMCs. ..
  3. Akishita M, Yamada H, Dzau V, Horiuchi M. Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor. Biochem Biophys Res Commun. 1999;261:345-9 pubmed
    ..These data suggest that the AT2 receptor modulates vascular contractility, which may influence blood pressure. ..
  4. Lu C, Su L, Lee R, Gao Y. Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: the role of adipocyte-derived angiotensin II. Eur J Pharmacol. 2010;634:107-12 pubmed publisher
    ..These results showed that adipocyte-derived angiotensin II is critically involved in PVAT-mediated potentiation of EFS-evoked contraction in rat mesenteric arteries. ..
  5. Huang H, Zhou J, Cui Z, Wang B, Hu Y. Angiotensin II type 1 receptor-associated protein plays a role in regulating the local renin-angiotensin system in HSC-T6 cells. Mol Med Rep. 2015;12:3763-3768 pubmed publisher
    ..In conclusion, it was identified that ATRAP is endogenously expressed in HSC?T6 cells and therefore, may be critical in regulating the local RAS in these cells. ..
  6. Daviet L, Lehtonen J, Tamura K, Griese D, Horiuchi M, Dzau V. Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor. J Biol Chem. 1999;274:17058-62 pubmed
    ..In conclusion, we have isolated a novel protein that interacts specifically with the carboxyl-terminal cytoplasmic domain of the AT1a receptor and affects AT1a receptor signaling. ..
  7. Azuma K, Tamura K, Shigenaga A, Wakui H, Masuda S, Tsurumi Ikeya Y, et al. Novel regulatory effect of angiotensin II type 1 receptor-interacting molecule on vascular smooth muscle cells. Hypertension. 2007;50:926-32 pubmed
  8. Muñoz M, Giani J, Dominici F, Turyn D, Toblli J. Long-term treatment with an angiotensin II receptor blocker decreases adipocyte size and improves insulin signaling in obese Zucker rats. J Hypertens. 2009;27:2409-20 pubmed publisher
  9. Hao S, Ren M, Yang C, Lin D, Chen L, Zhu P, et al. Activation of skin renin-angiotensin system in diabetic rats. Endocrine. 2011;39:242-50 pubmed publisher
    ..Taken together, our results suggest that the local RAS system is activated in diabetic skin and AngII receptor is likely to mediate the pathological changes of diabetic skin. ..

More Information


  1. Wenzel K, Rajakumar A, Haase H, Geusens N, Hubner N, Schulz H, et al. Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats. Hypertension. 2011;58:77-84 pubmed publisher
    ..We show that AT(1)-AB induces Ang II sensitivity. Our mechanistic study supports the existence of an "autoimmune-activating receptor" that could contribute to Ang II sensitivity and possible to preeclampsia. ..
  2. Cui T, Nakagami H, Iwai M, Takeda Y, Shiuchi T, Tamura K, et al. ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth. Biochem Biophys Res Commun. 2000;279:938-41 pubmed
    ..Our results suggest that ATRAP functions as a negative regulator in AT1 receptor-mediated cell proliferation in VSMCs. ..
  3. Gustavsson M, Mallard C, Vannucci S, Wilson M, Johnston M, Hagberg H. Vascular response to hypoxic preconditioning in the immature brain. J Cereb Blood Flow Metab. 2007;27:928-38 pubmed
    ..01), as detected by both techniques. Several vascular genes (Angpt2, Adm, Apln, Vegf, Flt1, Kdr, Pdgfra, Agtrap, Adora2a, Ednra, serpine1, caveolin, Id1, Prrx1, Ero1l, Acvrl1, Egfl7, Nudt6, Angptl4, Anxa2, and NOS3) were ..
  4. Li Z, Wang Z, Chen X, Chen X. Inhibitory effect of angiotensin II type 1 receptor-associated protein on vascular smooth muscle cell growth and neointimal formation. Chin Med Sci J. 2007;22:22-6 pubmed
    ..The growth inhibitory effects of ATRAP might be due to interfering with AT1 receptor-mediated activation of ERK in VSMC growth and neointimal formation. ..
  5. Shigenaga A, Tamura K, Wakui H, Masuda S, Azuma K, Tsurumi Ikeya Y, et al. Effect of olmesartan on tissue expression balance between angiotensin II receptor and its inhibitory binding molecule. Hypertension. 2008;52:672-8 pubmed publisher
  6. Granado M, Fernandez N, Monge L, Figueras J, Carreño Tarragona G, Amor S, et al. Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors. PLoS ONE. 2013;8:e54984 pubmed publisher
    ..However, overfeeding may reduce the impairment of ventricular contractility by I/R. ..