Gene Symbol: Agtr1b
Description: angiotensin II receptor, type 1b
Alias: AT1, AT1B, AT3, AT1R, Agtr1, type-1B angiotensin II receptor, Angiotensin II receptor, type 1 (AT1B), angiotensin II receptor, type-1, angiotensin II type-1 receptor, angiotensin II type-1B receptor, angiotensin receptor 1, angiotensin receptor 1b
Species: rat
Products:     Agtr1b

Top Publications

  1. Razga Z, Nyengaard J. Up- and down-regulation of angiotensin II AT1-A and AT1-B receptors in afferent and efferent rat kidney arterioles. J Renin Angiotensin Aldosterone Syst. 2008;9:196-201 pubmed publisher
    The contractile effect of angiotensin II via AT1 receptors on the kidney arterioles is a crucial element in the kidney microcirculation...
  2. De Gasparo M, Catt K, Inagami T, Wright J, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52:415-72 pubmed
    ..The development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system. ..
  3. Prieto Carrasquero M, Kobori H, Ozawa Y, Gutierrez A, Seth D, Navar L. AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Am J Physiol Renal Physiol. 2005;289:F632-7 pubmed
    ..This study was performed to determine whether the augmentation of distal nephron renin involves ANG II type 1 (AT1) receptor activation...
  4. Lee S, Ji H, Wu Z, Zheng W, Hassan A, Sandberg K. Translational regulation of ANG II type 1 receptors in proliferating vascular smooth muscle cells. Am J Physiol Regul Integr Comp Physiol. 2006;290:R50-6 pubmed
    ..6; n = 4, P < 0.05]. Taken together, these results suggest that AT(1a)R expression is regulated by translation during VSMC proliferation in part by RNA binding proteins that interact within exon 2 in the 5'LS of the AT(1a)R mRNA. ..
  5. Wu Z, Maric C, Roesch D, Zheng W, Verbalis J, Sandberg K. Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation. Endocrinology. 2003;144:3251-61 pubmed
    ..Dysregulation of this posttranscriptional mechanism may contribute to the increased incidence of cardiovascular disease associated with menopause. ..
  6. Roberts L, LaMarca B, Fournier L, Bain J, Cockrell K, Granger J. Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusion. Hypertension. 2006;47:615-8 pubmed
    ..The purpose of this study was to determine the role of angiotensin II type-1 (AT1) receptor activation on endothelin production induced by serum from pregnant rats exposed to reductions in uterine ..
  7. Miura S, Zhang J, Boros J, Karnik S. TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor. J Biol Chem. 2003;278:3720-5 pubmed
    ..Thus, interaction of TM2 and TM7 is important for transmembrane signal transduction in the AT(1) receptor. ..
  8. Ye M, Healy D. Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype. Biochem Biophys Res Commun. 1992;185:204-10 pubmed
    ..cDNA was identical to the previously cloned AT1 receptor (termed here AT1A) whereas the second cDNA (termed here AT1B) was 92% identical at the nucleotide level and 96% identical at the amino acid level...
  9. Doronin S, Potapova I, Lu Z, Cohen I. Angiotensin receptor type 1 forms a complex with the transient outward potassium channel Kv4.3 and regulates its gating properties and intracellular localization. J Biol Chem. 2004;279:48231-7 pubmed
    ..We hypothesize that the angiotensin receptor type 1 provides its internalization molecular scaffold to Kv4.3 and in this way regulates the cell surface representation of the ion channel. ..

More Information


  1. Cheng H, Wang J, Zhang M, Miyazaki Y, Ichikawa I, McKanna J, et al. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. J Clin Invest. 1999;103:953-61 pubmed
    ..Mutant mice homozygous for both Agtr1a and Agtr1b null mutations (Agtr1a-/-,Agtr1b-/-) demonstrated large increases in immunoreactive COX-2 expression inthe cTALH/..
  2. Rodriguez Campos M, Kadarian C, Rodano V, Bianciotti L, Fernandez B, Vatta M. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Cell Mol Neurobiol. 2000;20:747-62 pubmed
    ..2. In rat hypothalamic tissue labeled with [3H]norepinephrine 1, 10, and 100 nM and 1 microM losartan (AT1 receptor antagonist) had no effect on basal neuronal norepinephrine release, whereas 10 and 100 nM and 1 microM ..
  3. Kakinuma Y, Hama H, Sugiyama F, Goto K, Murakami K, Fukamizu A. Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice. Neurosci Lett. 1997;232:167-70 pubmed
    ..These results suggest that the renin-angiotensin system could play a critical role in central nervous system, preventing neuronal cells from apoptosis not only by AII but also AIV. ..
  4. Perez Rojas J, Derive S, Blanco J, Cruz C, Martínez de la Maza L, Gamba G, et al. Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol. 2005;289:F1020-30 pubmed
    ..Finally, our data point to spironolactone as a potential treatment to reduce CsA nephrotoxicity in transplant patients. ..
  5. Deng A, Dene H, Rapp J. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest. 1994;94:431-6 pubmed
    ..The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance. ..
  6. Sandberg K, Ji H, Clark A, Shapira H, Catt K. Cloning and expression of a novel angiotensin II receptor subtype. J Biol Chem. 1992;267:9455-8 pubmed
    ..Recently, the cDNA for an AII receptor (AT1) was cloned from rat smooth muscle and bovine adrenal...
  7. Shah B, Alberto Olivares Reyes J, Yesilkaya A, Catt K. Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes. Mol Endocrinol. 2002;16:610-20 pubmed
    ..Studies on the relationship between endocytosis of the angiotensin II (Ang II) type 1 receptor (AT1-R) and Ang II-induced ERK1/2 activation were performed in clone 9 (C9) rat hepatic cells treated with inhibitors of ..
  8. Tallam L, Jandhyala B. Exaggerated natriuresis after selective AT1 receptor blockade in Dahl salt-sensitive rats. Clin Exp Hypertens. 2001;23:623-31 pubmed
    ..was comparatively evaluated in Dahl salt-sensitive (SS) and salt-resistant (SR) rats, using a selective AT1 receptor antagonist, candesartan...
  9. Castoldi G, di Gioia C, Bombardi C, Catalucci D, Corradi B, Gualazzi M, et al. MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. J Cell Physiol. 2012;227:850-6 pubmed publisher
  10. Hunyady L, Catt K. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol Endocrinol. 2006;20:953-70 pubmed
    Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1 receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium balance and its diverse pathological actions in ..
  11. Esteban V, Heringer Walther S, Sterner Kock A, de Bruin R, van den Engel S, Wang Y, et al. Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE. 2009;4:e5406 pubmed publisher
    ..Therefore, the blockade of the NF-kappaB-activating properties of the receptor Mas could be a new strategy in the therapy of failing kidney. ..
  12. Takao M, Kobari M, Tanahashi N, Tomita M, Yokoyama M, Tomita Y, et al. Dilatation of cerebral parenchymal vessels mediated by angiotensin type 1 receptor in cats. Neurosci Lett. 2002;318:108-12 pubmed
    We report the effects of angiotensin II (ANG-II), as well as angiotensin II type 1 (AT1) and type 2 receptor antagonists (CV-11974 and PD-123319, respectively) on the cerebral parenchymal microvessels in cats using the photoelectric ..
  13. Seta K, Sadoshima J. Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor. J Biol Chem. 2003;278:9019-26 pubmed
    Although tyrosine kinases are critically involved in the angiotensin II (Ang II) type 1 (AT1) receptor signaling, how AT1 receptors activate tyrosine kinases is not fully understood...
  14. Gao B, Hansen H, Chen H, Feener E. Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells. Biochem J. 2006;397:337-44 pubmed a signalling adapter that is phosphorylated and recruits the p85 subunit of PI3K after Ang II stimulation of AT1 (Ang II subtype 1) receptors on VSMCs...
  15. Szaszak M, Gaborik Z, Turu G, McPherson P, Clark A, Catt K, et al. Role of the proline-rich domain of dynamin-2 and its interactions with Src homology 3 domains during endocytosis of the AT1 angiotensin receptor. J Biol Chem. 2002;277:21650-6 pubmed
    ..This mechanism could be of general importance in dynamin-dependent endocytosis of other G protein-coupled receptors in nonneural tissues. ..
  16. Mok K, Sandberg K, Sweeny J, Zheng W, Lee S, Mulroney S. Growth hormone regulation of glomerular AT1 angiotensin receptors in adult uninephrectomized male rats. Am J Physiol Renal Physiol. 2003;285:F1085-91 pubmed
  17. Welch W, Patel K, Modlinger P, Mendonca M, Kawada N, Dennehy K, et al. Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension. Am J Physiol Heart Circ Physiol. 2007;293:H2644-9 pubmed
    ..2K,1C hypertension in rats activates renin, O(2)*(-), and vasoconstrictor PGs. Hypertension is maintained by AT(1)Rs and by COX-1, but not COX-2, products that activate TPRs. ..
  18. Berger A, Stierkorb E, Nickenig G. The role of the AUUUUA hexamer for the posttranscriptional regulation of the AT1 receptor mRNA stability. Biochem Biophys Res Commun. 2005;330:805-12 pubmed
    b>AT1 receptor expression is mainly regulated posttranscriptionally involving modulation of RNA stability which is dependent on protein binding to the cognate sequence bases 2179-2195 within the 3' untranslated region of the AT1 receptor ..
  19. Hennenberg M, Trebicka J, Biecker E, Schepke M, Sauerbruch T, Heller J. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hepatology. 2007;45:495-506 pubmed
    ..Angiotensin II type 1 receptors (AT1-Rs) are coupled to the contraction-mediating RhoA/Rho-kinase pathway and may be desensitized by phosphorylation ..
  20. Kakar S, Sellers J, Devor D, Musgrove L, Neill J. Angiotensin II type-1 receptor subtype cDNAs: differential tissue expression and hormonal regulation. Biochem Biophys Res Commun. 1992;183:1090-6 pubmed
    ..we report the cloning, sequencing, and expression of a previously unsuspected second form of the type 1 receptor (AT1B) in the rat which exhibits high similarity with the AT1A receptor relative to amino acid sequence (95% identity), ..
  21. Krizanova O, Kiss A, Zacikova L, Jezova D. Nitric oxide synthase mRNA levels correlate with gene expression of angiotensin II type-1 but not type-2 receptors, renin or angiotensin converting enzyme in selected brain areas. Physiol Res. 2001;50:473-80 pubmed
    ..of the rat brain renin angiotensin system (renin, angiotensin converting enzyme (ACE) or angiotensin receptors of AT1 and AT2 subtypes)...
  22. Leung P, Lam S, Fung M. Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body. J Endocrinol. 2000;167:517-24 pubmed
    ..This might be important in the modulation of cardiorespiratory functions as well as fluid and electrolyte homeostasis during chronic hypoxia. ..
  23. Chai W, Zhang W, Jin Z, Feng Y, Kuang Y, Zhi J. Angiotensin II type I receptor agonistic autoantibody-induced apoptosis in neonatal rat cardiomyocytes is dependent on the generation of tumor necrosis factor-?. Acta Biochim Biophys Sin (Shanghai). 2012;44:984-90 pubmed publisher
    Angiotensin II type I receptor agonistic autoantibodies (AT1-AA) are related to pre-eclampsia and hypertension and have a direct effect of stimulating the production of tumor necrosis factor-alpha (TNF-?) in the placenta...
  24. Andresen B, Romero G, Jackson E. AT2 receptors attenuate AT1 receptor-induced phospholipase D activation in vascular smooth muscle cells. J Pharmacol Exp Ther. 2004;309:425-31 pubmed
    ..Furthermore, cultured WKY PGSMCs provide an excellent model system to study endogenous AT(2) receptor signal transduction. ..
  25. Igase M, Strawn W, Gallagher P, Geary R, Ferrario C. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2005;289:H1013-9 pubmed
  26. Garrido Gil P, Rodriguez Perez A, Fernandez Rodriguez P, Lanciego J, Labandeira Garcia J. Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells. Brain Struct Funct. 2017;222:2559-2571 pubmed publisher
  27. Harada S, Nakata T, Oguni A, Kido H, Hatta T, Fukuyama R, et al. Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure. Hypertens Res. 2002;25:779-86 pubmed
    ..In addition, the increase of AT2R gene expression in ECs during exposure to pressure may compensate for the reduction of NO. ..
  28. Lu D, Yu K, Raizada M. Retrovirus-mediated transfer of an angiotensin type I receptor (AT1-R) antisense sequence decreases AT1-Rs and angiotensin II action in astroglial and neuronal cells in primary cultures from the brain. Proc Natl Acad Sci U S A. 1995;92:1162-6 pubmed
    ..A retrovirus vector (LNSV) containing an AT1B-R antisense sequence (AT1B-AS) (termed LNSV-AT1B-AS) was constructed and used to determine the feasibility of using ..
  29. Yim H, Kim M, Bae I, Kim J, Choi B, Yoo K, et al. AT1 antagonist modulates activin-like kinase 5 and TGF-beta receptor II in the developing kidney. Pediatr Nephrol. 2006;21:1377-88 pubmed
    ..Blocking of angiotensin II (ANG II) mainly through angiotensin II type 1 receptor (AT1) has been implicated in mediating this ACE inhibition...
  30. Bao J, Zhang L, Ma J. Angiotensinogen and AT1R expression in cerebral and femoral arteries during hindlimb unloading in rats. Aviat Space Environ Med. 2007;78:852-8 pubmed
    ..However, after a 4-wk simulated microgravity, as compared with control, the mRNA expressions of Ao, and AT1a and AT1b in cerebral arterial tissue were significantly increased (1.45 +/- 0.14, 1.30 +/- 0.11, and 1.63 +/- 0...
  31. Kumar V, Knowle D, Gavini N, Pulakat L. Identification of the region of AT2 receptor needed for inhibition of the AT1 receptor-mediated inositol 1,4,5-triphosphate generation. FEBS Lett. 2002;532:379-86 pubmed
    ..IP3) levels in Xenopus oocytes in response to expression and activation of rat angiotensin II (Ang II) receptor AT1 was inhibited by co-expression of rat AT2 receptor...
  32. Jesmin S, Hattori Y, Sakuma I, Mowa C, Kitabatake A. Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model. Am J Physiol Heart Circ Physiol. 2002;283:H1387-97 pubmed
    ..These results suggest a key role of ANG II in the pathogenesis of the coronary capillary remodeling in this NIDDM model. ..
  33. Adams F, Wiedmer P, Gorzelniak K, Engeli S, Klaus S, Boschmann M. Age-related changes of Renin-Angiotensin system genes in white adipose tissue of rats. Horm Metab Res. 2002;34:716-20 pubmed
    ..We conclude that age and depot-specific mechanisms are of more importance for the expression of AGT and AT 1 -receptor genes during the first 12 weeks of age than a short period of overfeeding. ..
  34. Baiardi G, Macova M, Armando I, Ando H, Tyurmin D, Saavedra J. Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat. Regul Pept. 2005;124:7-17 pubmed
    ..Arcuate arteries and veins expressed AT1B mRNA in males and females, and AT2 mRNA in females only...
  35. Takezako T, Gogonea C, Saad Y, Noda K, Karnik S. "Network leaning" as a mechanism of insurmountable antagonism of the angiotensin II type 1 receptor by non-peptide antagonists. J Biol Chem. 2004;279:15248-57 pubmed
  36. Chen F, Liu F, Badoer E. AT1 receptors in the paraventricular nucleus mediate the hyperthermia-induced reflex reduction of renal blood flow in rats. Am J Physiol Regul Integr Comp Physiol. 2011;300:R479-85 pubmed publisher
    ..microinjected bilaterally into the PVN (100 nl/side) with saline (n = 5) or losartan (1 nmol/100 nl) (n = 7), an AT1 receptor antagonist...
  37. Helou C, Imbert Teboul M, Doucet A, Rajerison R, Chollet C, Alhenc Gelas F, et al. Angiotensin receptor subtypes in thin and muscular juxtamedullary efferent arterioles of rat kidney. Am J Physiol Renal Physiol. 2003;285:F507-14 pubmed
    ..tone of pre- and postglomerular arterioles, and thereby glomerular filtration, through binding to either AT1A, AT1B, or AT2 receptors...
  38. Gardemann A, Nguyen Q, Humme J, Stricker J, Katz N, Tillmanns H, et al. Angiotensin II type 1 receptor A1166C gene polymorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of thes. Eur Heart J. 1998;19:1657-65 pubmed
    There is evidence that interaction between angiotensin II type 1 receptor A1166C gene polymorphism and angiotensin I-converting enzyme Insertion/Deletion gene variation might have an effect on the risk of myocardial infarction...
  39. Sugawara A, Takeuchi K, Uruno A, Kudo M, Sato K, Ito S. Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene. Hypertens Res. 2003;26:623-8 pubmed
    ..We previously reported that ligand-activated PPAR-gamma suppressed angiotensin II type 1 receptor (AT1R) gene transcription in vascular smooth muscle cells (VSMCs) by the inhibition of Sp1 binding to ..
  40. Gribouval O, Gonzales M, Neuhaus T, Aziza J, Bieth E, Laurent N, et al. Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat Genet. 2005;37:964-8 pubmed
    ..This is the first identification to our knowledge of a renal mendelian disorder linked to genetic defects in the renin-angiotensin system, highlighting the crucial role of the renin-angiotensin system in human kidney development. ..
  41. Cowling R, Zhang X, Reese V, Iwata M, Gurantz D, Dillmann W, et al. Effects of cytokine treatment on angiotensin II type 1A receptor transcription and splicing in rat cardiac fibroblasts. Am J Physiol Heart Circ Physiol. 2005;289:H1176-83 pubmed
    ..These results provide evidence that cytokines increase AT(1) protein levels by altering both transcription and splicing. ..
  42. Horio N, Clermont A, Abiko A, Abiko T, Shoelson B, Bursell S, et al. Angiotensin AT(1) receptor antagonism normalizes retinal blood flow and acetylcholine-induced vasodilatation in normotensive diabetic rats. Diabetologia. 2004;47:113-23 pubmed
    ..10+/-0.25 nmol/mg, p<0.05). This report provides evidence that angiotensin-converting enzyme inhibition and AT(1) receptor antagonism ameliorates retinal haemodynamic dysfunctions in normotensive diabetic rats. ..
  43. Wang D, Du Y, Yao A, Hu Z. Regulation of type 1 angiotensin II receptor and its subtype gene expression in kidney by sodium loading and angiotensin II infusion. J Hypertens. 1996;14:1409-15 pubmed
    ..that a high salt intake decreases gene expression of both type 1 angiotensin receptor subtypes 1A and 1B (AT1A and AT1B) and diminishes AT1 receptor density in the kidney through an angiotensin II (Ang II)-independent mechanism...
  44. Wang B, Ansari R, Sun Y, Postlethwaite A, Weber K, Kiani M. The scar neovasculature after myocardial infarction in rats. Am J Physiol Heart Circ Physiol. 2005;289:H108-13 pubmed
    ..biology, were developed to quantify vascular structure and function and to explore the role of ANG II receptor AT1 in cardiac remodeling after myocardial infarction (MI)...
  45. Brassard P, Amiri F, Thibault G, Schiffrin E. Role of angiotensin type-1 and angiotensin type-2 receptors in the expression of vascular integrins in angiotensin II-infused rats. Hypertension. 2006;47:122-7 pubmed
    ..Rats were infused subcutaneously with Ang II and received angiotensin type-1 (AT1) receptor blocker losartan, the AT1/angiotensin type-2 (AT2) [Sar1-Ile8]-Ang II, or the vasodilator hydralazine for ..
  46. Morimoto R, Akeda K, Iida R, Nishimura A, Tsujii M, Obata S, et al. Tissue renin-angiotensin system in the intervertebral disc. Spine (Phila Pa 1976). 2013;38:E129-36 pubmed publisher
    ..To elucidate the association between tRAS and the process of IVD degeneration, the expression and function of tRAS in the human degenerated IVD should be examined in a future study. ..
  47. Li Z, Cao Y, Li L, Liang Y, Tian X, Mo N, et al. Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction. Biochem Biophys Res Commun. 2014;449:74-80 pubmed publisher
    ..the present study was to investigate regulation of the brain RAS and the effect of angiotensin II receptor type 1 (AT1) inhibition on surgery-induced cognitive impairment in a well-established rat POCD model...
  48. Tanuma A, Saito S, Ide I, Sasahara H, Yazdani M, Gottschalk S, et al. Caffeine enhances the expression of the angiotensin II Type 2 receptor mRNA in BeWo cell culture and in the rat placenta. Placenta. 2003;24:638-47 pubmed
    ..A significantly increased AT(2)receptor gene expression and a slight decreased AT(1)receptor gene expression demonstrated the caffeine's effect to the placental RAS. ..
  49. O Mahony O, Barker S, Puddefoot J, Vinson G. Synthesis and secretion of angiotensin II by the prostate gland in vitro. Endocrinology. 2005;146:392-8 pubmed
    ..We showed that angiotensin II type 1 (AT1) receptors are present in mammalian sperm, and angiotensin II stimulates sperm motility and capacitation...
  50. Suzuki H, Maehara K, Yaoita H, Maruyama Y. Altered effects of angiotensin ii type 1 and type 2 receptor blockers on cardiac norepinephrine release and inotropic responses during cardiac sympathetic nerve stimulation in aorto-caval shunt rats. Circ J. 2004;68:683-90 pubmed
    ..The effects of A-II via the AT(1)-R and AT(2)-R on the adrenergic drive in the heart were altered significantly in volume overload hypertrophy induced by AV shunting. ..
  51. Garrett M, Dene H, Walder R, Zhang Q, Cicila G, Assadnia S, et al. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Genome Res. 1998;8:711-23 pubmed
    ..Interactions between each QTL and every other locus in the genome scan yielded significant interactions between chromosomes 10 and 4, and between chromosomes 2 and 3. ..
  52. Barta P, Monti J, Maass P, Gorzelniak K, Muller D, Dechend R, et al. A gene expression analysis in rat kidney following high and low salt intake. J Hypertens. 2002;20:1115-20 pubmed
    ..Experiments of this nature have substantial limitations and require detailed verification. However, overall, the utility is promising. ..
  53. Kambe T, Hiruki H, Kubo T. Existence of a mutation of angiotensin AT1 receptor gene promoter region involved in inhibition of AT1 receptor gene transcription in spontaneously hypertensive rats. Hypertens Res. 2003;26:245-50 pubmed
    ..These results suggest that there is one single mutation unique to the SHR AT1a receptor gene promoter region, but that the mutation is not responsible for overexpression of the AT1 a receptor gene in SHR.
  54. Wagner C, Kurtz A. Positive feedback regulation of angiotensin II-AT1B receptor gene expression in rat adrenal glands. Pflugers Arch. 1998;436:323-8 pubmed
    ..ANGII-AT1 receptor antagonist losartan (40 mg/kg per day) for 2 days, and adrenal mRNA levels for ANGII AT1A and AT1B receptors were determined by RNase protection...
  55. Iwai N, Inagami T. Identification of two subtypes in the rat type I angiotensin II receptor. FEBS Lett. 1992;298:257-60 pubmed
    ..Two cDNA clones were identified, designated as AT1B, to have a nucleotide sequence highly homologous to and yet distinct from AT1A...
  56. Villar Cheda B, Dominguez Meijide A, Valenzuela R, Granado N, Moratalla R, Labandeira Garcia J. Aging-related dysregulation of dopamine and angiotensin receptor interaction. Neurobiol Aging. 2014;35:1726-38 pubmed publisher
    ..a major role in the inflammatory response, neuronal oxidative stress, and dopaminergic vulnerability via type 1 (AT1) receptors...
  57. Newton C, Curran B, Victorino G. Angiotensin II type 1 receptor activation increases microvascular hydraulic permeability. Surgery. 2004;136:1054-60 pubmed
    ..We hypothesized that activation of the angiotensin II type 1 receptor (AT1) would increase hydraulic permeability...
  58. Andresen B, Shome K, Jackson E, Romero G. AT2 receptors cross talk with AT1 receptors through a nitric oxide- and RhoA-dependent mechanism resulting in decreased phospholipase D activity. Am J Physiol Renal Physiol. 2005;288:F763-70 pubmed
    ..Furthermore, because AT(2) receptors inhibit AT(1) receptor signaling to PLD via modulating RhoA activity, AT(2) receptor signaling can potentially regulate multiple vasoconstrictive signaling systems through inactivating RhoA. ..
  59. Herzig T, Jobe S, Aoki H, Molkentin J, Cowley A, Izumo S, et al. Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc Natl Acad Sci U S A. 1997;94:7543-8 pubmed
  60. Poumarat J, Houillier P, Rismondo C, Roques B, Lazar G, Paillard M, et al. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Kidney Int. 2002;62:434-45 pubmed
    ..of Ca2+-independent phospholipase A2 (PLA2-dependent endocytosis and recycling of the complex Ang II subtype 1 (AT1) receptor (AT1-R)...
  61. Tissir F, Riviere M, Guo D, Tsuzuki S, Inagami T, Levan G, et al. Localization of the genes encoding the three rat angiotensin II receptors, Agtr1a, Agtr1b, Agtr2, and the human AGTR2 receptor respectively to rat chromosomes 17q12, 2q24 and Xq34, and the human Xq22. Cytogenet Cell Genet. 1995;71:77-80 pubmed
    ..determined the regional localization of the 3 rat genes encoding angiotensin II receptors at 17q12 (Agtr1a), 2q24 (Agtr1b) and Xq34 (Agtr2)...
  62. Ruan X, Wagner C, Chatziantoniou C, Kurtz A, Arendshorst W. Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet. J Clin Invest. 1997;99:1072-81 pubmed
    ..Intrarenal administration of angiotensin II receptor type 1 (AT1) receptor antagonists losartan or EXP-3174 simultaneously with ANG II caused dose-dependent inhibition of ANG II ..
  63. Lindstedt I, Xu C, Zhang Y, Edvinsson L. Increased perfusion pressure enhances the expression of endothelin (ETB) and angiotensin II (AT1, AT2) receptors in rat mesenteric artery smooth muscle cells. Blood Press. 2009;18:78-85 pubmed publisher
    ..that changes in perfusion pressure result in altered expression of mRNA and protein encoding for the ETA-, ETB-, AT1- and AT2-receptors in rat mesenteric vessels...
  64. Thomas M, Hauptfleisch S, Fleissner G, Lemmer B. Localization of angiotensin II (AT1)-receptor-immunoreactive fibres in the hypothalamus of rats: angiotensin II-sensitive tanycytes in the ependyma of the third ventricle?. Brain Res. 2003;967:281-4 pubmed
  65. Sodhi C, Kanwar Y, Sahai A. Hypoxia and high glucose upregulate AT1 receptor expression and potentiate ANG II-induced proliferation in VSM cells. Am J Physiol Heart Circ Physiol. 2003;284:H846-52 pubmed
  66. Correa S, Zalcberg H, Han S, Oliveira L, Costa Neto C, Paiva A, et al. Aliphatic amino acids in helix VI of the AT(1) receptor play a relevant role in agonist binding and activity. Regul Pept. 2002;106:33-8 pubmed
  67. Siragy H, Awad A, Abadir P, Webb R. The angiotensin II type 1 receptor mediates renal interstitial content of tumor necrosis factor-alpha in diabetic rats. Endocrinology. 2003;144:2229-33 pubmed
    ..This finding of a potential antiinflammatory effect for valsartan is new and in addition to its known antihypertensive effects. ..
  68. Butler D, Pak S, Midgely A, Nemati B. AT(1) receptor blockade with losartan during gestation in Wistar rats leads to an increase in thirst and sodium appetite in their adult female offspring. Regul Pept. 2002;105:47-57 pubmed
    ..Plasma electrolytes, blood hematocrit and carotid MABP in the LO group did not differ from the CO group. ..
  69. Konishi M, Nagashima K, Kanosue K. Systemic salt loading decreases body temperature and increases heat-escape/cold-seeking behaviour via the central AT1 and V1 receptors in rats. J Physiol. 2002;545:289-96 pubmed
    ..AII and AVP are involved in the decrease in T(core) observed at neutral ambient temperature and the increase in heat-escape/cold-seeking behaviour in response to osmotic stimulation, via the central AT(1) and V(1) receptors, respectively ..
  70. Miura S, Fujino M, Hanzawa H, Kiya Y, Imaizumi S, Matsuo Y, et al. Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor. J Biol Chem. 2006;281:19288-95 pubmed
    ..the molecular mechanism underlying the inverse agonist activity of olmesartan, a potent angiotensin II type 1 (AT1) receptor antagonist, we performed binding affinity studies and an inositol phosphate production assay...
  71. Zeng C, Yang Z, Wang Z, Jones J, Wang X, Altea J, et al. Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells. Hypertension. 2005;45:804-10 pubmed
    Angiotensin II type 1 (AT1) receptor and D1 and D3 dopamine receptors directly interact in renal proximal tubule (RPT) cells from normotensive Wistar-Kyoto rats (WKY)...
  72. Zhu Z, Zhu S, Zhu J, van der Giet M, Tepel M. Effect of sodium on vasoconstriction and angiotensin II type 1 receptor mRNA expression in cold-induced hypertensive rats. Clin Exp Hypertens. 2004;26:475-83 pubmed
    ..Now, we investigated the effects of sodium on vasoconstriction and angiotensin II type 1 (AT1) and type 2 (AT2) receptor mRNA expression in aortic vessels from cold-induced hypertensive rats...
  73. Razga Z, Kovacs G, Bódi N, Talapka P, Nyengaard J. Heterogeneous downregulation of angiotensin II AT1-A and AT1-B receptors in arterioles in STZ-induced diabetic rat kidneys. Biomed Res Int. 2014;2014:947506 pubmed publisher
    ..Therefore, the number of angiotensin II AT1-A and AT1-B receptors in afferent and efferent arteriole's renin-positive and renin-negative smooth muscle cells (..
  74. Dutil J, Eliopoulos V, Marchand E, Devlin A, Tremblay J, Prithiviraj K, et al. A quantitative trait locus for aortic smooth muscle cell number acting independently of blood pressure: implicating the angiotensin receptor AT1B gene as a candidate. Physiol Genomics. 2005;21:362-9 pubmed a chromosome region not containing a BP QTL, but harboring the locus for the angiotensin II receptor AT1B (Agtr1b)...
  75. Obata J, Nakamura T, Takano H, Naito A, Kimura H, Yoshida Y, et al. Increased gene expression of components of the renin-angiotensin system in glomeruli of genetically hypertensive rats. J Hypertens. 2000;18:1247-55 pubmed
    ..enzyme (ACE), angiotensin II type 1a (AT1a), and type 1b (AT1b) receptors, and intervention with angiotensin II type 1 receptor antagonist candesartan and equihypotensive hydralazine...
  76. Meijering B, Van der Wouden E, Pelgröm V, Henning R, Sharma K, Deelman L. TGF-beta inhibits Ang II-induced MAPK p44/42 signaling in vascular smooth muscle cells by Ang II type 1 receptor downregulation. J Vasc Res. 2009;46:459-68 pubmed publisher
    ..In conclusion, TGF-beta1 attenuates Ang II-mediated MAPK p44/42 kinase signaling in RASMC through downregulation of AT(1) levels, which is mainly caused by the inhibition of transcription of the AT(1) gene. ..
  77. Leong D, Terrón J, Falcón Neri A, Armando I, Ito T, Jöhren O, et al. Restraint stress modulates brain, pituitary and adrenal expression of angiotensin II AT(1A), AT(1B) and AT(2) receptors. Neuroendocrinology. 2002;75:227-40 pubmed
    ..There may be additional roles for adrenal AT(2) receptors during acute stress, possibly related to interaction or cross-talk with AT(1) receptors. ..
  78. Fogarty D, Sánchez Gómez M, Matute C. Multiple angiotensin receptor subtypes in normal and tumor astrocytes in vitro. Glia. 2002;39:304-13 pubmed
    ..Moreover, the untimely expression of this A((1-7)) receptor may represent an important etiological component in the development of brain astrocytomas. ..
  79. Chan J, Wang L, Ou C, Chan S. Downregulation of angiotensin subtype 1 receptor in rostral ventrolateral medulla during endotoxemia. Hypertension. 2003;42:103-9 pubmed
  80. Tan J, Wang H, Leenen F. Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats. Am J Physiol Heart Circ Physiol. 2004;286:H1665-71 pubmed
    ..the peripheral RAS. Angiotensin-converting enzyme (ACE) and angiotensin type 1 (AT1) receptor binding densities were determined by measuring 125I-labeled 351A and 125I-labeled ANG II binding 4 and 8 ..
  81. Zeng C, Wang Z, Asico L, Hopfer U, Eisner G, Felder R, et al. Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats. Kidney Int. 2005;68:623-31 pubmed
    ..ETB receptors regulate AT(1) receptors by direct physical receptor interaction and receptor expression. An impaired ETB receptor regulation of the AT(1) receptor may participate in the pathogenesis of high blood pressure in the SHR. ..
  82. Feng Y, Sun Y, Douglas J. Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1. Proc Natl Acad Sci U S A. 2002;99:12049-54 pubmed
    ..The AT(2)-mediated ITIM-independent activation of SHP-1 that is distinct from the conventional mode of activation, may represent a general paradigm for activation of SHP-1/2-class tyrosine phosphatases by G protein-coupled receptors. ..
  83. Chugh G, Lokhandwala M, Asghar M. Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats. Hypertension. 2012;59:1029-36 pubmed publisher
    ..Perhaps, alterations in both D1R (diminished) and AT(1)R (exaggerated) functions are necessary for the development of age-associated hypertension, as seen in old FBN rats. ..
  84. Zeng C, Wang Z, Hopfer U, Asico L, Eisner G, Felder R, et al. Rat strain effects of AT1 receptor activation on D1 dopamine receptors in immortalized renal proximal tubule cells. Hypertension. 2005;46:799-805 pubmed
    ..We have reported that activation of a D1-like receptor decreases AT1 receptor expression in the mouse kidney and in immortalized RPT cells from Wistar-Kyoto (WKY) rats...