Agtr1a

Summary

Gene Symbol: Agtr1a
Description: angiotensin II receptor, type 1a
Alias: AT1, AT1A, AT1R, Agtr1, type-1A angiotensin II receptor, angiotensin II type-1A receptor, angiotensin receptor 1a, vascular type-1 angiotensin II receptor
Species: rat
Products:     Agtr1a

Top Publications

  1. Ichiki T, Takeda K, Tokunou T, Funakoshi Y, Ito K, Iino N, et al. Reactive oxygen species-mediated homologous downregulation of angiotensin II type 1 receptor mRNA by angiotensin II. Hypertension. 2001;37:535-40 pubmed
    ..The generation of ROS through stimulation of AT(1)-R not only mediates signaling of Ang II but also may play a crucial role in the adaptation process of AT(1)-R to the sustained stimulation of Ang II. ..
  2. Nikiforovich G, Zhang M, Yang Q, Jagadeesh G, CHEN H, Hunyady L, et al. Interactions between conserved residues in transmembrane helices 2 and 7 during angiotensin AT1 receptor activation. Chem Biol Drug Des. 2006;68:239-49 pubmed
    ..Balance of interactions between residues in helix 2 (as D74) and helix 7 (as N294, N295 and N298) in the AT(1) receptors, however, has a crucial role both in determining their functional activity and levels of their expression. ..
  3. Doan T, Farmer P, Cooney T, Ali M. Selective down-regulation of angiotensin II receptor type 1A signaling by protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells. Cell Signal. 2004;16:301-11 pubmed
    ..These data show SHP-2 represents a critical negative regulator of angiotensin II signaling, and further demonstrate a new function for this phosphatase in vascular smooth muscle cells. ..
  4. Lakshmanan A, Harima M, Sukumaran V, Soetikno V, Thandavarayan R, Suzuki K, et al. Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Biochem Pharmacol. 2012;83:653-60 pubmed publisher
  5. Hunton D, Barnes W, Kim J, Ren X, Violin J, Reiter E, et al. Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol Pharmacol. 2005;67:1229-36 pubmed
    ..These data suggest that beta-arrestin 2 can mediate chemotaxis through mechanisms which may be G-protein-independent (Ang II receptors) or -dependent (LPA receptors). ..
  6. Talaia C, Queiroz G, Pinheiro H, Moura D, Goncalves J. Involvement of G-protein ?? subunits on the influence of inhibitory ?2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens. Neurochem Int. 2006;49:698-707 pubmed
    ..II enhanced tritium overflow evoked by trains of 100 pulses at 8 Hz, an effect that was attenuated by the AT1-receptor antagonist losartan (0.3-1 microM), at concentrations suggesting the involvement of the AT1B subtype...
  7. Suzuki K, Han G, Miyauchi N, Hashimoto T, Nakatsue T, Fujioka Y, et al. Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall. Am J Pathol. 2007;170:1841-53 pubmed
    ..ameliorates proteinuria, its pharmacological mechanism and the differential roles of Ang II type 1 receptor (AT1R) and type 2 receptor (AT2R) are not well understood...
  8. Unal H, Jagannathan R, Bhatnagar A, Tirupula K, Desnoyer R, Karnik S. Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor. J Biol Chem. 2013;288:540-51 pubmed publisher
    ..To investigate this, we examined conformational changes in ECL2 of the angiotensin II type 1 receptor (AT1R) by introducing mutations in distant sites that alter the activation state equilibrium of the AT1R...
  9. Koganti S, Snyder R, Gumaste U, Karamyan V, Thekkumkara T. 2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor. Eur J Pharmacol. 2014;723:131-40 pubmed publisher
    Controlling angiotensin AT1 receptor function has been shown to be protective for many pathophysiological disorders...

More Information

Publications103 found, 100 shown here

  1. Ozdemir S, Ugur M, Gurdal H, Turan B. Treatment with AT(1) receptor blocker restores diabetes-induced alterations in intracellular Ca(2+) transients and contractile function of rat myocardium. Arch Biochem Biophys. 2005;435:166-74 pubmed
    ..Thus, angiotensin II receptor blockade protects the heart from the development of cellular alterations typically related with diabetes, and this action of AT(1) receptors seems to be related with the activity of PKC. ..
  2. Igarashi M, Hirata A, Nozaki H, Kadomoto Antsuki Y, Tominaga M. Role of angiotensin II type-1 and type-2 receptors on vascular smooth muscle cell growth and glucose metabolism in diabetic rats. Diabetes Res Clin Pract. 2007;75:267-77 pubmed
    ..The levels of the medial outgrowth rate of VSMCs and Ang II type-1 receptors (AT1R) in aortae from WF were more enhanced than those in aortae from WL, but the level of Ang II type-2 receptors (AT2R) ..
  3. Sampson A, Moritz K, Jones E, Flower R, Widdop R, Denton K. Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats. Hypertension. 2008;52:666-71 pubmed publisher
    ..ventricular AT(2)R mRNA gene expressions were markedly greater in females than in males with a renal angiotensin II type 1a receptor:AT(2)R ratio of approximately 1 in females...
  4. Mertens B, Vanderheyden P, Michotte Y, Sarre S. Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum. Neuropharmacology. 2010;58:1038-44 pubmed publisher
    ..1 and 1 microM) and candesartan (10 nM). Together, these data suggest that AT(1) and AT(2) receptors in the striatum exert an opposite effect on the modulation of DA synthesis rather than DA release. ..
  5. Waseda Y, Yasui M, Nishizawa Y, Inuzuka K, Takato H, Ichikawa Y, et al. Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice. Respir Res. 2008;9:43 pubmed publisher
    ..We examined effects of the AT1 antagonist (AT1A) olmesartan medoxomil (olmesartan) and the AT2 antagonist (AT2A) PD-123319 on BLM-induced pulmonary fibrosis, which ..
  6. Diniz G, Carneiro Ramos M, Barreto Chaves M. Angiotensin type 1 (AT1) and type 2 (AT2) receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac hypertrophy. Pflugers Arch. 2007;454:75-81 pubmed
    ..These results demonstrate for the first time the TH-modulated induction of cardiac TGF-beta1 in cardiac hypertrophy, and that this effect is mediated by ANG II receptors. ..
  7. Naito T, Ma L, Yang H, Zuo Y, Tang Y, Han J, et al. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Am J Physiol Renal Physiol. 2010;298:F683-91 pubmed publisher
    Angiotensin type 1 (AT1) receptor blocker (ARB) ameliorates progression of chronic kidney disease...
  8. Alwasel S, Kaleem I, Sahajpal V, Ashton N. Maternal protein restriction reduces angiotensin II AT(1) and AT(2) receptor expression in the fetal rat kidney. Kidney Blood Press Res. 2010;33:251-9 pubmed publisher
  9. Dolley Hitze T, Jouan F, Martin B, Mottier S, Edeline J, Moranne O, et al. Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma?. Br J Cancer. 2010;103:1698-705 pubmed publisher
    The growth factor Angiotensin-2 signals through Angiotensin receptor type 1 (AT1-R) in a broad range of cell types and tumours and through the type-2 receptor (AT2-R) in a more restricted group of cell types...
  10. Kim J, Ahn S, Rajagopal K, Lefkowitz R. Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. J Biol Chem. 2009;284:11953-62 pubmed publisher
  11. Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, et al. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest. 1998;101:755-60 pubmed
    Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b...
  12. Fogarty D, Sánchez Gómez M, Matute C. Multiple angiotensin receptor subtypes in normal and tumor astrocytes in vitro. Glia. 2002;39:304-13 pubmed
    ..Moreover, the untimely expression of this A((1-7)) receptor may represent an important etiological component in the development of brain astrocytomas. ..
  13. Ishiyama Y, Gallagher P, Averill D, Tallant E, Brosnihan K, Ferrario C. Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension. 2004;43:970-6 pubmed
    ..on the expression of cardiac angiotensin-converting enzymes (ACE and ACE 2) and angiotensin II type-1 receptors (AT1a-R) 28 days after myocardial infarction...
  14. Allen A, Dosanjh J, Erac M, Dassanayake S, Hannan R, Thomas W. Expression of constitutively active angiotensin receptors in the rostral ventrolateral medulla increases blood pressure. Hypertension. 2006;47:1054-61 pubmed
    ..More importantly, they imply that constitutive receptor signaling in glia of the rostral ventrolateral medulla can modulate the activity of adjacent neurons to change blood pressure. ..
  15. Yang W, Zhang J, Wang H, Gao P, Singh M, Shen K, et al. Angiotensin II downregulates catalase expression and activity in vascular adventitial fibroblasts through an AT1R/ERK1/2-dependent pathway. Mol Cell Biochem. 2011;358:21-9 pubmed publisher
    ..The effects were abolished by the angiotensin II type 1 receptor (AT1R) blocker losartan and AT1R small-interfering RNA (siRNA)...
  16. Cao Z, Bonnet F, Candido R, Nesteroff S, Burns W, Kawachi H, et al. Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. J Am Soc Nephrol. 2002;13:1773-87 pubmed
  17. Kim H, Sato T, Rodriguez Iturbe B, Vaziri N. Role of intrarenal angiotensin system activation, oxidative stress, inflammation, and impaired nuclear factor-erythroid-2-related factor 2 activity in the progression of focal glomerulosclerosis. J Pharmacol Exp Ther. 2011;337:583-90 pubmed publisher
    ..Treatment with AT1 blockers (ARBs) ameliorates proteinuria, hyperlipidemia, and nephropathy in this model...
  18. Li L, Fan D, Wang C, Wang J, Cui X, Wu D, et al. Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-?1 pathways in cardiac fibroblasts. Cardiovasc Res. 2011;91:80-9 pubmed publisher
    ..The activation of the Ras/p38 MAPK/CREB pathway is required for AngII-induced periostin expression. ERK1/2 also participates in AngII-induced periostin expression by regulating TGF-?1/Smad signalling. ..
  19. De Gasparo M, Catt K, Inagami T, Wright J, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52:415-72 pubmed
    ..The development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system. ..
  20. Moulder J, Fish B, Cohen E. Impact of angiotensin II type 2 receptor blockade on experimental radiation nephropathy. Radiat Res. 2004;161:312-7 pubmed
    ..We speculate that the beneficial effect of the angiotensin II type 2 receptor blocker is due to a reduction in radiation-induced renal cell proliferation or fibrosis. ..
  21. Batenburg W, Garrelds I, Bernasconi C, Juillerat Jeanneret L, van Kats J, Saxena P, et al. Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries. Circulation. 2004;109:2296-301 pubmed
    ..Most likely, AT2 receptors are located on endothelial cells, and their contribution increases with age. ..
  22. Hunyady L, Catt K. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol Endocrinol. 2006;20:953-70 pubmed
    Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1 receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium balance and its diverse pathological actions in ..
  23. Takeda Y, Zhu A, Yoneda T, Usukura M, Takata H, Yamagishi M. Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats. Am J Hypertens. 2007;20:1119-24 pubmed
    ..Combination therapy normalized BP and further improved cardiac hypertrophy, fibrosis, and EDR. In DS rats, blockade of aldosterone or Ang II protects cardiac hypertrophy and fibrosis by inactivation of the local RAAS in the heart. ..
  24. Bregonzio C, Seltzer A, Armando I, Pavel J, Saavedra J. Angiotensin II AT(1) receptor blockade selectively enhances brain AT(2) receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive rats. Stress. 2008;11:457-66 pubmed publisher
  25. Downie L, Vessey K, Miller A, Ward M, Pianta M, Vingrys A, et al. Neuronal and glial cell expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in the rat retina. Neuroscience. 2009;161:195-213 pubmed publisher
    ..The differential pattern of expression of these receptors across these cell types is similar to that observed in the brain and suggests that a similar functional role for Ang II may also exist within the retina. ..
  26. Esteban V, Lorenzo O, Ruperez M, Suzuki Y, Mezzano S, Blanco J, et al. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. J Am Soc Nephrol. 2004;15:1514-29 pubmed
  27. Razga Z, Nyengaard J. Up- and down-regulation of angiotensin II AT1-A and AT1-B receptors in afferent and efferent rat kidney arterioles. J Renin Angiotensin Aldosterone Syst. 2008;9:196-201 pubmed publisher
    The contractile effect of angiotensin II via AT1 receptors on the kidney arterioles is a crucial element in the kidney microcirculation...
  28. Nunes F, Braga V. Chronic angiotensin II infusion modulates angiotensin II type I receptor expression in the subfornical organ and the rostral ventrolateral medulla in hypertensive rats. J Renin Angiotensin Aldosterone Syst. 2011;12:440-5 pubmed publisher
    ..We tested the hypothesis that increased circulating levels of Ang II activate angiotensin type I (AT1) receptors in the subfornical organ (SFO), increasing the Ang II signalling in the rostral ventrolateral medulla (..
  29. Ansar S, Vikman P, Nielsen M, Edvinsson L. Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol. 2007;293:H3750-8 pubmed
    ..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage. ..
  30. Wamsley Davis A, Padda R, Truong L, Tsao C, Zhang P, Sheikh Hamad D. AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan. Am J Physiol Renal Physiol. 2004;287:F474-80 pubmed
    ..The renoprotective effects afforded by AT(1A)-receptor blockade in obstructive uropathy are consistent with attenuation of JNK1- and SMAD2-mediated renal injury. ..
  31. Tang H, Pavel J, Saavedra J, Brimijoin S. Angiotensin II type 1 receptors may not influence response of spinal autonomic neurons to axonal damage. Neurol Res. 2008;30:751-60 pubmed publisher
    Angiotensin II can promote cell stress, and the expression of its AT1 receptor is characteristic of neuronal populations that die off in multiple systems atrophy and Parkinson's disease...
  32. Cong H, Li X, Ma L, Jiang H, Mao Y, Xu M. Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation. J Thorac Cardiovasc Surg. 2010;140:298-304 pubmed publisher
  33. Michel M, Foster C, Brunner H, Liu L. A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists. Pharmacol Rev. 2013;65:809-48 pubmed publisher
    ..Although there is general consensus that a continuous receptor blockade over a 24-hour period is desirable, the clinical relevance of other pharmacological differences between individual ARBs remains to be assessed. ..
  34. Shan Z, Zubcevic J, Shi P, Jun J, Dong Y, Murça T, et al. Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat. Hypertension. 2013;61:1328-33 pubmed publisher
    ..Transduction of brain neuronal cultures with recombinant adeno-associated virus type 2 (AAV2)-AT1R-small hairpin RNA (shRNA) resulted in a 72% decrease in AT1Ra mRNA and attenuated angiotensin II-induced increase ..
  35. WALCH J, Nedungadi T, Cunningham J. ANG II receptor subtype 1a gene knockdown in the subfornical organ prevents increased drinking behavior in bile duct-ligated rats. Am J Physiol Regul Integr Comp Physiol. 2014;307:R597-607 pubmed publisher
    ..These results indicate that angiotensin signaling through the SFO contributes to increased water intake, but not dilutional hyponatremia, during congestive liver failure. ..
  36. Langford K, Frenzel K, Martin B, Bernstein K. The genomic organization of the rat AT1 angiotensin receptor. Biochem Biophys Res Commun. 1992;183:1025-32 pubmed
    The AT1 receptor subtype modulates all of the hemodynamic effects of the vasoactive peptide, angiotensin II. In this report, we investigate the genomic organization of this important receptor...
  37. Iwai N, Inagami T. Identification of two subtypes in the rat type I angiotensin II receptor. FEBS Lett. 1992;298:257-60 pubmed
    ..cDNA library was screened by colony hybridization using a rat cDNA fragment of type I angiotensin II receptor (AT1A) previously isolated from the kidney...
  38. Filipeanu C, Zhou F, Claycomb W, Wu G. Regulation of the cell surface expression and function of angiotensin II type 1 receptor by Rab1-mediated endoplasmic reticulum-to-Golgi transport in cardiac myocytes. J Biol Chem. 2004;279:41077-84 pubmed
    ..We recently demonstrated that Rab1 is involved in the export of angiotensin II (Ang II) type 1 receptor (AT1R) to the cell surface in HEK293 cells and that transgenic mice overexpressing Rab1 in the myocardium develop cardiac ..
  39. Petersen M, Greene A. Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle. Microcirculation. 2007;14:583-91 pubmed
    ..This study demonstrates an inhibitory effect of high salt intake on prazosin-induced angiogenesis. Further, these results indicate that ANGII acting through the AT(1) receptor is a critical pathway in this model of angiogenesis. ..
  40. Ihara Y, Egashira K, Nakano K, Ohtani K, Kubo M, Koga J, et al. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. J Mol Cell Cardiol. 2007;43:455-64 pubmed
    The receptor for advanced glycation end products (RAGE) and the angiotensin II type I receptor (AT1R) have been separately linked to the pathogenesis of diabetic atherosclerosis...
  41. Hultström M, Helle F, Iversen B. AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats. Am J Physiol Renal Physiol. 2009;297:F163-8 pubmed publisher
    ..In conclusion, CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor. This finding may be of direct importance for NOS and the regulation of preglomerular vascular function. ..
  42. Durst R, Goldstein K, Horowitz Y, Baggish A, Gare M, Hasin Y, et al. Hypothyroid dependent myocardial angiotensin receptor trafficking is involved in improved cardiac performance after heat acclimation. Life Sci. 2010;86:331-6 pubmed publisher
    ..Significantly different patterns of AT1 and AT2 receptor densities (a 50% reduction and a 30% increase in outer cell membrane AT1 and AT2 receptors ..
  43. Chung I, Kim Y, Yoo M, Shin M, Kim C, Suh S. Immobilization stress induces endothelial dysfunction by oxidative stress via the activation of the angiotensin II/its type I receptor pathway. Atherosclerosis. 2010;213:109-14 pubmed publisher
  44. Müller Fielitz H, Landolt J, Heidbreder M, Werth S, Vogt F, Jöhren O, et al. Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPAR? target gene regulation. Endocrinology. 2012;153:1103-15 pubmed publisher
    ..Because the expression of examined PPAR? target genes was not affected, we concluded that improved insulin sensitivity after long-term treatment with AT(1) blockers was not related to a PPAR?-dependent mechanism. ..
  45. Hong K, Zhao G, Hong Z, Sun Z, Yang Y, Clifford P, et al. Mechanical activation of angiotensin II type 1 receptors causes actin remodelling and myogenic responsiveness in skeletal muscle arterioles. J Physiol. 2016;594:7027-7047 pubmed publisher
  46. Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J, et al. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008;28:1263-9 pubmed publisher
    ..It was also reported that inhibition of angiotensin II function by angiotensin II type I receptor (AT1R) antagonist prolonged rat life span...
  47. Hosojima M, Sato H, Yamamoto K, Kaseda R, Soma T, Kobayashi A, et al. Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor- and insulin-mediated signaling cross talk. Endocrinology. 2009;150:871-8 pubmed publisher
    ..This study aimed to investigate the role of angiotensin II type 1A receptor (AT(1A)R)- and insulin-mediated signaling pathways in regulating the expression of megalin, a ..
  48. Igase M, Yokoyama H, Ferrario C. Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7). Ther Adv Cardiovasc Dis. 2011;5:297-304 pubmed publisher
  49. Lawnicka H, Ptasinska Wnuk D, Mucha S, Kunert Radek J, Pawlikowski M, Stepien H. The involvement of angiotensin type 1 and type 2 receptors in estrogen-induced cell proliferation and vascular endothelial growth factor expression in the rat anterior pituitary. ScientificWorldJournal. 2012;2012:358102 pubmed publisher
    ..VEGF immunoreactivity in pituitary cells of DES-treated rats was decreased by AT1 antagonist and not changed by AT2 blocker and ACE inhibitor...
  50. Klimas J, Olvedy M, Ochodnicka Mackovicova K, Kruzliak P, Cacanyiova S, Kristek F, et al. Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats. J Cell Mol Med. 2015;19:1965-74 pubmed publisher
    ..left ventricle of SHR, cardiac expressions of Ace and Mas were decreased while those of AT1 receptor (Agtr1a) and Ace2 were unchanged. Continuous losartan administration reduced LV weight (0.43 ± 0.02; P < 0...
  51. Harikumar K, Augustine M, Lee L, Chow B, Miller L. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. J Biol Chem. 2016;291:17332-44 pubmed publisher
    ..This may provide a more selective means of exploring the physiologic functional impact of this cross-class receptor complex without interfering with the function of either component receptor. ..
  52. Bourassa E, Speth R. Water deprivation increases angiotensin-converting enzyme but not AT(1) receptor expression in brainstem and paraventricular nucleus of the hypothalamus of the rat. Brain Res. 2010;1319:83-91 pubmed publisher
  53. Gong J, Lu Z, Cao J, Xu C, Wang H, Jin X. [Overexpression of angiotensin-converting enzyme 2 inhibits angiotensin II type 1 receptor expression and signal transducer and activator of transcription 3 phosphorylation in cultured smooth muscle cells]. Zhonghua Xin Xue Guan Bing Za Zhi. 2012;40:607-13 pubmed
    ..lentiviral angiotensin-converting enzyme 2 (ACE2) vector transfer on the expression of angiotensin II type 1 (AT1) receptor in cultured vascular smooth muscle cells (VSMCs)...
  54. Villar Cheda B, Dominguez Meijide A, Valenzuela R, Granado N, Moratalla R, Labandeira Garcia J. Aging-related dysregulation of dopamine and angiotensin receptor interaction. Neurobiol Aging. 2014;35:1726-38 pubmed publisher
    ..a major role in the inflammatory response, neuronal oxidative stress, and dopaminergic vulnerability via type 1 (AT1) receptors...
  55. de Lima M, Scabora J, Lopes A, Mesquita F, Torres D, Boer P, et al. Early changes of hypothalamic angiotensin II receptors expression in gestational protein-restricted offspring: effect on water intake, blood pressure and renal sodium handling. J Renin Angiotensin Aldosterone Syst. 2013;14:271-82 pubmed publisher
    ..Also, immunoblotting analysis demonstrated a significantly decreased expression of type 1 AngII receptors (AT1R) in the entire hypothalamic tissue extract of LP rats at 12 days of age compared to age-matched NP offspring...
  56. Li Z, Cao Y, Li L, Liang Y, Tian X, Mo N, et al. Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction. Biochem Biophys Res Commun. 2014;449:74-80 pubmed publisher
    ..the present study was to investigate regulation of the brain RAS and the effect of angiotensin II receptor type 1 (AT1) inhibition on surgery-induced cognitive impairment in a well-established rat POCD model...
  57. Murphy T, Alexander R, Griendling K, Runge M, Bernstein K. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature. 1991;351:233-6 pubmed
    ..Angiotensin II interacts with two pharmacologically distinct subtypes of cell-surface receptors, AT1 and AT2. AT1 receptors seem to mediate the major cardiovascular effects of angiotensin II...
  58. Banday A, Lokhandwala M. Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension. Am J Physiol Renal Physiol. 2008;295:F698-706 pubmed publisher
    ..Most of the known biological actions of angiotensin II can be attributed to AT1 receptors...
  59. LaMarca B, Wallukat G, Llinas M, Herse F, Dechend R, Granger J. Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats. Hypertension. 2008;52:1168-72 pubmed publisher
    Circulating factors, such as agonistic autoantibodies to the angiotensin II type 1 (AT1) receptor (AT1-AAs), and inflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), are suggested to be important links between ..
  60. Long H, Niu H, Li X, Xu Z, Zhang H, Zhong J, et al. [Effects of Shenkangwan on renal expressions of angiotensin II and its type I receptor in rats with early diabetic nephropathy]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:805-9 pubmed
    ..The urinary protein quality in 24 h and plasma and renal contents of AngII were measured. The expressions of AT1R at the protein and mRNA levels in the kidney tissues were measured by immunohistochemistry and reverse ..
  61. Braga V. Differential brain angiotensin-II type I receptor expression in hypertensive rats. J Vet Sci. 2011;12:291-3 pubmed
    ..05). RT-PCR revealed that Ang-II infusion induced increased AT(1) receptor mRNA levels in RVLM and decreased in SFO. Our data suggest that Ang-II-induced hypertension involves differential expression of brain AT(1) receptors. ..
  62. Na L, Chu X, Jiang S, Li C, Li G, He Y, et al. Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPK/PGC-1α/PPARγ pathway in spontaneously hypertensive rats. Eur J Nutr. 2016;55:1245-53 pubmed publisher
    ..of pAMPK, PPARγ coactivator-1α (PGC-1α), and PPARγ while inhibited angiotensin II type 1 receptor (AT1R) expression in SHRs...
  63. Hong K, Li M, Nourian Z, Meininger G, Hill M. Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension. Hypertension. 2017;70:1264-1272 pubmed publisher
  64. Donadio M, Gomes C, Sagae S, Franci C, Anselmo Franci J, Lucion A, et al. Estradiol and progesterone modulation of angiotensin II receptors in the arcuate nucleus of ovariectomized and lactating rats. Brain Res. 2006;1083:103-9 pubmed
    ..In conclusion, present results show that ARC Ang II receptors decreases on day 20 of lactation compared to day 7 and are highly correlated with plasma progesterone, indicating a pivotal role for progesterone in this regulation. ..
  65. Granzow M, Schierwagen R, Klein S, Kowallick B, Huss S, Linhart M, et al. Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology. 2014;60:334-48 pubmed publisher
    Activation of the renin angiotensin system resulting in stimulation of angiotensin-II (AngII) type I receptor (AT1R) is an important factor in the development of liver fibrosis...
  66. Gardemann A, Nguyen Q, Humme J, Stricker J, Katz N, Tillmanns H, et al. Angiotensin II type 1 receptor A1166C gene polymorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of thes. Eur Heart J. 1998;19:1657-65 pubmed
  67. Itoh S, Ding B, Shishido T, Lerner Marmarosh N, Wang N, Maekawa N, et al. Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation. 2006;113:1787-98 pubmed
  68. Oh Y, Gao S, Shah A, Kim J, Park W, Kim S. Endogenous angiotensin II suppresses stretch-induced ANP secretion via AT1 receptor pathway. Peptides. 2011;32:374-81 pubmed publisher
    ..The response of stretch-induced ANP secretion to Ang II and losartan augmented. The expression of AT1 receptor protein and mRNA increased but AT2 and Mas receptor mRNA did not change in 2K1C rat atria...
  69. Chai W, Zhang W, Jin Z, Feng Y, Kuang Y, Zhi J. Angiotensin II type I receptor agonistic autoantibody-induced apoptosis in neonatal rat cardiomyocytes is dependent on the generation of tumor necrosis factor-?. Acta Biochim Biophys Sin (Shanghai). 2012;44:984-90 pubmed publisher
    Angiotensin II type I receptor agonistic autoantibodies (AT1-AA) are related to pre-eclampsia and hypertension and have a direct effect of stimulating the production of tumor necrosis factor-alpha (TNF-?) in the placenta...
  70. Wagner C, Kurtz A. Positive feedback regulation of angiotensin II-AT1B receptor gene expression in rat adrenal glands. Pflugers Arch. 1998;436:323-8 pubmed
    ..with the ANGII-AT1 receptor antagonist losartan (40 mg/kg per day) for 2 days, and adrenal mRNA levels for ANGII AT1A and AT1B receptors were determined by RNase protection...
  71. Snyder R, Thekkumkara T. 13-cis-Retinoic acid specific down-regulation of angiotensin type 1 receptor in rat liver epithelial and aortic smooth muscle cells. J Mol Endocrinol. 2012;48:99-114 pubmed publisher
    ..cis- and trans-acting factors enabling an alternate approach to control angiotensin type 1 receptor (AT1 or AGTR1 as listed in the MGI database) expression has not been studied...
  72. Rasmussen M, Hornbak M, Larsen S, Sheykhzade M, Edvinsson L. Permanent distal occlusion of middle cerebral artery in rat causes local increased ETB, 5-HT?B and AT? receptor-mediated contractility downstream of occlusion. J Vasc Res. 2013;50:396-409 pubmed publisher
    ..This suggests lack of wall stress as an initiating trigger leading to regulation of contractile response after cerebral stroke. ..
  73. Kazama K, Anrather J, Zhou P, Girouard H, Frys K, Milner T, et al. Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res. 2004;95:1019-26 pubmed
    ..We investigated whether Ang II exerts its deleterious actions by activating Ang II type 1 (AT1) receptors on cerebral blood vessels and producing reactive oxygen species (ROS) through NADPH oxidase...
  74. Zhou C, Vignere C, Levitan E. AUF1 is upregulated by angiotensin II to destabilize cardiac Kv4.3 channel mRNA. J Mol Cell Cardiol. 2008;45:832-8 pubmed publisher
    ..Hence, Ang II acts via AT(1) receptors, NADPH oxidase and p38 MAP kinase to upregulate AUF1, which in turn binds to an ARE in the Kv4.3 3'UTR to destabilize the channel mRNA. ..
  75. Azevedo H, Fujita A, Bando S, Iamashita P, Moreira Filho C. Transcriptional network analysis reveals that AT1 and AT2 angiotensin II receptors are both involved in the regulation of genes essential for glioma progression. PLoS ONE. 2014;9:e110934 pubmed publisher
    ..C6 cells were treated with Ang II and specific antagonists of AT1 and AT2 receptors...
  76. Paradis P, Dali Youcef N, Paradis F, Thibault G, Nemer M. Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci U S A. 2000;97:931-6 pubmed
    ..of arterial pressure and volume homeostasis, mainly because of its vascular action via the AII type 1 receptor (AT1R)...
  77. Davisson R, Oliverio M, Coffman T, Sigmund C. Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest. 2000;106:103-6 pubmed
    ..However, the drinking response requires the presence of AT(1B) receptors. To our knowledge, this is the first demonstration of a primary and nonredundant physiological function for AT(1B) receptors. ..
  78. Yatabe J, Sanada H, Midorikawa S, Hashimoto S, Watanabe T, Andrews P, et al. Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin type 1 receptors in rats. Hypertens Res. 2008;31:1455-64 pubmed publisher
    Abnormalities in renal angiotensin type 1 receptor (AT1R), D1 dopamine receptor (D1R) and G protein-coupled receptor kinase 4 (GRK4) are present in polygenic hypertension...
  79. Iwai J, Kanayama Y, Inoue N, Okamura M, Takeda T. Increased endothelial gene expression of angiotensin AT1A receptor in cyclosporine induced hypertensive rats. Eur J Pharmacol. 1993;248:341-4 pubmed
    We examined the gene expression of angiotensin AT1A receptors in aortic endothelial cells of cyclosporine induced hypertensive rats using reverse transcribed polymerase chain reaction method...
  80. Li X, Zhuo J. Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors. Am J Physiol Cell Physiol. 2008;294:C1034-45 pubmed publisher
  81. Shigenaga A, Tamura K, Wakui H, Masuda S, Azuma K, Tsurumi Ikeya Y, et al. Effect of olmesartan on tissue expression balance between angiotensin II receptor and its inhibitory binding molecule. Hypertension. 2008;52:672-8 pubmed publisher
  82. Chen K, Fu C, Chen C, Liu L, Ren H, Han Y, et al. Role of GRK4 in the regulation of arterial AT1 receptor in hypertension. Hypertension. 2014;63:289-96 pubmed publisher
    ..This study provides a mechanism by which GRK4, via regulation of arterial AT(1)R expression and function, participates in the pathogenesis of conduit vessel abnormalities in hypertension. ..
  83. Zhang Y, Yang X, Wu P, Liao G, Yang G, Zhang X, et al. Expression of AT(1a) mRNA in rat hepatic stellate cells and its effects on cell growth collagen production. Chin Med J (Engl). 2004;117:772-4 pubmed
  84. Abdollahi M, Lewis R, Gaunt T, Cumming D, Rodriguez S, Rose Zerilli M, et al. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Hum Mutat. 2007;28:365-73 pubmed
    The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance...
  85. Lymperopoulos A, Rengo G, Zincarelli C, Kim J, Soltys S, Koch W. An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo. Proc Natl Acad Sci U S A. 2009;106:5825-30 pubmed publisher
    ..Thus, inhibition of adrenal betaarr1 activity on AT(1)Rs might be of therapeutic value in pathological conditions characterized and aggravated by hyperaldosteronism...
  86. Arumugam S, Thandavarayan R, Palaniyandi S, Giridharan V, Arozal W, Sari F, et al. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Toxicology. 2012;291:139-45 pubmed publisher
    ..Emerging evidences suggest that, at least, part of the benefits observed with the use of AT1 receptor blockers could be attributed to the increased Ang (1-7) levels observed during administration of these ..
  87. Barnes W, Reiter E, Violin J, Ren X, Milligan G, Lefkowitz R. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem. 2005;280:8041-50 pubmed
    ..the small GTPase RhoA leading to the re-organization of stress fibers following the activation of the angiotensin II type 1A receptor. This angiotensin II type 1A receptor-directed RhoA activation and stress fiber formation also ..
  88. Zhao S, Shen L, Li H, Wang L, Chen H, Wang Y, et al. Down-regulation of the expression of angiotensin II type 1 receptor in neonatal rat cardiac fibroblast by activation of PPARgamma signal pathway. Chin J Physiol. 2008;51:357-62 pubmed
    ..mRNA and protein expression of collagen type I, III and angiotensin II type 1 receptor (AT1-R) were tested by reverse transcription--polymerase chain reaction and Western blotting...
  89. Morimoto R, Akeda K, Iida R, Nishimura A, Tsujii M, Obata S, et al. Tissue renin-angiotensin system in the intervertebral disc. Spine (Phila Pa 1976). 2013;38:E129-36 pubmed publisher
    ..To elucidate the association between tRAS and the process of IVD degeneration, the expression and function of tRAS in the human degenerated IVD should be examined in a future study. ..
  90. Gromotowicz Poplawska A, Stankiewicz A, Kramkowski K, Gradzka A, Wojewódzka Zelezniakowicz M, Dzieciol J, et al. The acute prothrombotic effect of aldosterone in rats is partially mediated via angiotensin II receptor type 1. Thromb Res. 2016;138:114-120 pubmed publisher
    ..the effects of angiotensin II (Ang II), in the present study we investigated the role of Ang II receptor type 1 - AT1 in acute ALDO prothrombotic action...
  91. Wang H, Huang B, White R, Chen A, Ahmad M, Leenen F. Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II - induced hypothalamic reactive oxygen species and hypertension. Neuroscience. 2016;329:112-21 pubmed publisher
    ..The subfornical organ (SFO) contains both MR and angiotensin II type 1 receptors (AT1R) and can relay the signals of circulating Ang II to downstream nuclei such as the paraventricular nucleus (PVN), ..
  92. Iijima K, Geshi E, Nomizo A, Arata Y, Katagiri T. Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats. Jpn Circ J. 1998;62:449-54 pubmed
    ..SR Ca2+-ATPase activity and mRNA (SERCA2a) and AT1 mRNA (AT1a, AT1b) were analyzed...