Agt

Summary

Gene Symbol: Agt
Description: angiotensinogen
Alias: ANRT, Ang, AngII, PAT, angiotensinogen, angiotensin II, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), serpin A8
Species: rat
Products:     Agt

Top Publications

  1. Dikalov S, Dikalova A, Bikineyeva A, Schmidt H, Harrison D, Griendling K. Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med. 2008;45:1340-51 pubmed publisher
    ..We hypothesized that Nox1 and Nox4 play distinct roles in basal and angiotensin II (AngII)-stimulated production of O2*- and H2O2...
  2. Sadoshima J, Izumo S. Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res. 1993;73:413-23 pubmed
    ..Ang II also caused upregulation of the angiotensinogen gene and transforming growth factor-beta 1 gene within 6 hours...
  3. Stuck B, Lenski M, Bohm M, Laufs U. Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase. J Biol Chem. 2008;283:32562-9 pubmed publisher
    b>Angiotensin II induces cardiomyocyte hypertrophy, but its consequences on cardiomyocyte metabolism and energy supply are not completely understood...
  4. He M, Zhang L, Shao Y, Xue H, Zhou L, Wang X, et al. Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal prorenin/renin receptor expression. Mol Cell Endocrinol. 2010;315:188-94 pubmed publisher
    ..lower in the kidney of (DM) rats than that of untreated control animals, meanwhile the plasma and renal angiotensin II (Ang II) levels and Ang II type 2 receptor (AT(2)R) mRNA level, but not Ang II type 1 receptor (AT(1)R) mRNA ..
  5. Tsai C, Lai L, Kuo K, Hwang J, Hsieh C, Hsu K, et al. Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling. Circulation. 2008;117:344-55 pubmed publisher
    ..Another important mediator of the angiotensin II (Ang II) effect is the Janus kinase/signal transducers and activators of transcription (STAT) pathway, which ..
  6. Hunyady L, Catt K. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol Endocrinol. 2006;20:953-70 pubmed
    b>Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1 receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium balance and its diverse pathological actions in ..
  7. Zhang S, Moini B, Ingelfinger J. Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor. J Am Soc Nephrol. 2004;15:1452-65 pubmed
    ..b>Angiotensin II (AngII) upregulated Pax-2 protein and Pax-2 mRNA expression via the AngII type 2 (AT(2)) receptor in MK4 but ..
  8. Prosser H, Forster M, Richards A, Pemberton C. Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics. Cardiovasc Res. 2009;82:40-50 pubmed publisher
    ..renin-angiotensin system, proangiotensin-12 (PA12); and investigate whether PA12 can serve as a substrate for Angiotensin II (AngII) generation...
  9. Tallant E, Ferrario C, Gallagher P. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Am J Physiol Heart Circ Physiol. 2005;289:H1560-6 pubmed
    Peptide hormones such as ANG II and endothelin contribute to cardiac remodeling after myocardial infarction by stimulating myocyte hypertrophy and myofibroblast proliferation...

More Information

Publications100

  1. Wosik K, Cayrol R, Dodelet Devillers A, Berthelet F, Bernard M, Moumdjian R, et al. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. J Neurosci. 2007;27:9032-42 pubmed
    ..We show that angiotensinogen (AGT) produced and secreted by astrocytes is cleaved into angiotensin II (AngII) and acts on type 1 ..
  2. Colmenero J, Bataller R, Sancho Bru P, Bellot P, Miquel R, Moreno M, et al. Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity. Gastroenterology. 2007;132:687-97 pubmed
    ..adenine dinucleotide phosphate (NADPH) oxidase were markedly up-regulated, whereas cytochrome p450 2E1 and angiotensinogen were down-regulated...
  3. Kobori H, Ozawa Y, Suzaki Y, Nishiyama A. Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. J Am Soc Nephrol. 2005;16:2073-80 pubmed
    This study was performed to determine whether augmented intrarenal angiotensinogen may contribute to the enhanced renal angiotensin II (Ang II) and associated tissue injury in spontaneously hypertensive rats (SHR)...
  4. Ohashi N, Urushihara M, Satou R, Kobori H. Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species--ERK/JNK pathways. Hypertens Res. 2010;33:1174-81 pubmed publisher
    Whereas intra-renal angiotensinogen is predominantly localized in proximal tubular cells under basal conditions, it has been previously reported that angiotensinogen expression is induced in glomeruli under pathological conditions...
  5. Yang F, Chung A, Huang X, Lan H. Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3. Hypertension. 2009;54:877-84 pubmed publisher
    Connective tissue growth factor (CTGF) plays a critical role in angiotensin II (Ang II)-mediated hypertensive nephropathy...
  6. Zhang S, Chen X, Wei C, Filep J, Tang S, Ingelfinger J, et al. Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose. Endocrinology. 2002;143:4627-35 pubmed
    The present studies investigated whether insulin inhibits the stimulatory effect of dexamethasone (DEX) on angiotensinogen (ANG) gene expression and induction of hypertrophy in rat immortalized renal proximal tubular cells (IRPTCs) in a ..
  7. Tamura K, Yokoyama N, Sumida Y, Fujita T, Chiba E, Tamura N, et al. Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice. J Endocrinol. 1999;160:401-8 pubmed
    ..II receptor (AT1) and angiotensin-converting enzyme (ACE) mRNAs are regulated during dietary salt loading in angiotensinogen gene-knockout (Atg-/-) mice which are genetically deficient in endogenous production of angiotensin II...
  8. Polichnowski A, Griffin K, Long J, Williamson G, Bidani A. Blood pressure-renal blood flow relationships in conscious angiotensin II- and phenylephrine-infused rats. Am J Physiol Renal Physiol. 2013;305:F1074-84 pubmed publisher
    Chronic ANG II infusion in rodents is widely used as an experimental model of hypertension, yet very limited data are available describing the resulting blood pressure-renal blood flow (BP-RBF) relationships in conscious rats...
  9. Pepperell J, Nemeth G, Yamada Y, Naftolin F, Merino M. Localized accumulation of angiotensin II and production of angiotensin-(1-7) in rat luteal cells and effects on steroidogenesis. Am J Physiol Endocrinol Metab. 2006;291:E221-33 pubmed
    These studies aim to investigate subcellular distribution of angiotensin II (ANG II) in rat luteal cells, identify other bioactive angiotensin peptides, and investigate a role for angiotensin peptides in luteal steroidogenesis...
  10. Wolf G. Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis. Antioxid Redox Signal. 2005;7:1337-45 pubmed
    b>Angiotensin II (ANG II) induces cell-cycle arrest of cultured proximal tubular cells, resulting in cellular hypertrophy...
  11. Jackson E, Gillespie D, Zhu C, Ren J, Zacharia L, Mi Z. Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA. Hypertension. 2008;51:719-26 pubmed publisher
    Alpha(2)-adrenoceptors potentiate renal vascular responses to angiotensin II via coincident signaling at phospholipase C. This leads to increased activation of the phospholipase C/protein kinase C/c-src pathway...
  12. Brosnihan K, Bharadwaj M, Yamaleyeva L, Neves L. Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels. Placenta. 2012;33:17-23 pubmed publisher
    Previous studies showed that angiotensin (Ang) II and Ang-(1-7) concentrations were reduced in the implantation site at day 7 of pregnancy in Sprague-Dawley rats as compared to the site immediately adjacent to it, which does not have the ..
  13. Wang K, Duan S, Wen X, Wang W, Fang S, Qi D, et al. Angiotensin II system in the nucleus tractus solitarii contributes to autonomic dysreflexia in rats with spinal cord injury. PLoS ONE. 2017;12:e0181495 pubmed publisher
    ..Level of angiotensin II (Ang II) in the NTS was significantly increased in the SCI rats than sham...
  14. Yuan Q, Lyu C, Wu C, Lei S, Shao Y, Wang Q. [Valsartan inhibits angiotensin II-Notch signaling of mesangial cells induced by high glucose]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:5-9 pubmed
    To explore the role of angiotensin II (Ang II)-Notch signaling in high glucose-induced secretion of extracellular matrix of rat mesangial cells (RMCs) and to further investigate the protective effect of valsartan (one of Ang II receptor ..
  15. Rodriguez Campos M, Kadarian C, Rodano V, Bianciotti L, Fernandez B, Vatta M. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Cell Mol Neurobiol. 2000;20:747-62 pubmed
    ..PD 123319 (1 microM) did not affect ANG III-induced phosphatidyl inositol hydrolysis enhancement. 5...
  16. Szekeres M, Nadasy G, Turu G, Soltész Katona E, Toth Z, Balla A, et al. Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors. J Biol Chem. 2012;287:31540-50 pubmed publisher
    In the vascular system angiotensin II (Ang II) causes vasoconstriction via the activation of type 1 angiotensin receptors...
  17. Wang S, Cheng M, Hu Z, Hu S, Zou Q, Lai X, et al. Angiotensin II Facilitates Matrix Metalloproteinase-9-Mediated Myosin Light Chain Kinase Degradation in Pressure Overload-Induced Cardiac Hypertrophy. Cell Physiol Biochem. 2017;44:2281-2295 pubmed publisher
    b>Angiotensin II (Ang II) has been shown to promote cardiac remodeling during the process of hypertrophy...
  18. Kazama K, Anrather J, Zhou P, Girouard H, Frys K, Milner T, et al. Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res. 2004;95:1019-26 pubmed
    b>Angiotensin II (Ang II) exerts detrimental effects on cerebral circulation, the mechanisms of which have not been elucidated...
  19. Gao H, Yallampalli U, Yallampalli C. Gestational protein restriction increases angiotensin II production in rat lung. Biol Reprod. 2013;88:64 pubmed publisher
    ..PR) alters the renin-angiotensin system in uterine arteries and placentas and elevates plasma levels of angiotensin II in pregnant rats. To date, how PR increases maternal plasma levels of angiotensin II remains unknown...
  20. Chow L, Tao P, Chen J, Liao R, Chang E, Huang E. A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. Peptides. 2013;39:21-8 pubmed publisher
    In our previous study, we showed that intrathecal (i.t.) administration of angiotensin IV (Ang IV), an insulin-regulated aminopeptidase (IRAP) inhibitor, attenuated inflammatory hyperalgesia in rats...
  21. Mao C, Lv J, Zhu H, Zhou Y, Chen R, Feng X, et al. Fetal functional capabilities in response to maternal hypertonicity associated with altered central and peripheral angiotensinogen mRNA in rats. Peptides. 2007;28:1178-84 pubmed
    ..plasma osmolality and sodium concentrations in maternal rats and fetuses associated with an up-regulation in angiotensinogen gene mRNA in the fetal liver and down-regulation of the same gene in the fetal brain...
  22. Chen Y, Tran S, Chenier I, Chan J, Ingelfinger J, Inagami T, et al. Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis. Pediatr Nephrol. 2008;23:1769-77 pubmed publisher
    We previously demonstrated that angiotensin II (Ang II) stimulates paired homeo box-2 (Pax-2) via the Ang II type 2 receptor (AT(2)R)...
  23. Carver K, Smith T, Gallagher P, Tallant E. Angiotensin-(1-7) prevents angiotensin II-induced fibrosis in cremaster microvessels. Microcirculation. 2015;22:19-27 pubmed publisher
    The effect of the heptapeptide hormone Ang-(1-7) on microvascular fibrosis in rats with Ang II-induced hypertension was investigated, since vascular fibrosis/remodeling plays a prominent role in hypertension-induced end-organ damage and ..
  24. Wang J, He W, Guo L, Zhang Y, Li H, Han S, et al. The ACE2-Ang (1-7)-Mas receptor axis attenuates cardiac remodeling and fibrosis in post-myocardial infarction. Mol Med Rep. 2017;16:1973-1981 pubmed publisher
    ..In addition, telmisartan and olmesartan was indicated to antagonize angiotensin II (Ang II) and upregulate ACE2, MasR, Ang (1‑7) expression in myocardial tissue using immunoassay and ..
  25. Moreau J, Messenger S, Ciriello J. Effects of angiotensin II on leptin and downstream leptin signaling in the carotid body during acute intermittent hypoxia. Neuroscience. 2015;310:430-41 pubmed publisher
    b>Angiotensin II (ANG II) is known to promote leptin production and secretion...
  26. Desong Liu -, Fang Lu -, Songhui Zhai -, Liu Wei -, Shi Ma -, Xiuying Chen -, et al. Renin-angiotensin system gene polymorphisms in children with Henoch-Schönlein purpura in West China. J Renin Angiotensin Aldosterone Syst. 2010;11:248-55 pubmed publisher
    ..001; p(alleo) = .007, OR(alleo) = 1.533, respectively). We also found correlations between ACE-I/D and Agt T174M with multiple organ involvements, with significant differences in ACE-D in renal groups (p < 0...
  27. Goto M, Hoxha N, Osman R, Dell K. The renin-angiotensin system and hypertension in autosomal recessive polycystic kidney disease. Pediatr Nephrol. 2010;25:2449-57 pubmed publisher
    ..Intrarenal renin, ACE and Ang II expression was increased significantly in cystic kidneys; angiotensinogen and Ang II Type I receptor were unchanged. Systemic Ang I and II levels did not differ...
  28. Block K, Eid A, Griendling K, Lee D, Wittrant Y, Gorin Y. Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem. 2008;283:24061-76 pubmed publisher
    Activation of glomerular mesangial cells (MCs) by angiotensin II (Ang II) leads to hypertrophy and extracellular matrix accumulation...
  29. Hering L, Herse F, Geusens N, Verlohren S, Wenzel K, Staff A, et al. Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hypertension. 2010;56:311-8 pubmed publisher
    ..Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human renin gene develop the PE syndrome, whereas those of the ..
  30. Lal H, Verma S, Golden H, Foster D, Smith M, Dostal D. Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases. J Mol Cell Cardiol. 2008;45:770-8 pubmed publisher
    ..However, the intracellular signaling mechanisms responsible for regulation of angiotensinogen (Ao), a substrate of the RAS system, are largely unknown...
  31. Verma S, Lal H, Golden H, Gerilechaogetu F, Smith M, Guleria R, et al. Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts. Cardiovasc Res. 2011;90:88-96 pubmed publisher
    ..including myocardial remodelling, involvement in mediating mechanical stretch-induced regulation of angiotensinogen (Ao), the precursor to Ang II, remains to be determined...
  32. Wu S, Soulez M, Yang Y, Chu C, Shih S, Hébert M, et al. Local Augmented Angiotensinogen Secreted from Apoptotic Vascular Endothelial Cells Is a Vital Mediator of Vascular Remodelling. PLoS ONE. 2015;10:e0132583 pubmed publisher
    ..After the cells were subjected to SS, we found that the mRNA expression of angiotensinogen (AGT) was increased by >3-fold in HUVECs and by approximately 2.5-fold in VSMCs...
  33. Yamagishi S, Takeuchi M, Matsui T, Nakamura K, Imaizumi T, Inoue H. Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression. FEBS Lett. 2005;579:4265-70 pubmed
    Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood...
  34. Drenjancevic Peric I, Lombard J. Reduced angiotensin II and oxidative stress contribute to impaired vasodilation in Dahl salt-sensitive rats on low-salt diet. Hypertension. 2005;45:687-91 pubmed
    This study investigated the role of impaired angiotensin II (Ang II) modulation in contributing to reduced vascular relaxation in isolated middle cerebral arteries (MCA) (100 to 200 microm in diameter) of normotensive Dahl salt-sensitive (..
  35. Ando Y, Takeshita S, Fujimoto K, Shimizu M, Nagata M, Kikuchi T, et al. Genetic mapping of a neurological mutation cerebellar calcification in the rat. Mamm Genome. 2001;12:80-2 pubmed
  36. Xue H, Zhou L, Yuan P, Wang Z, Ni J, Yao T, et al. Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Regul Pept. 2012;177:12-20 pubmed publisher
    ..Co-treatment of the cell with Ang-(1-7) and Ang II, Ang-(1-7) counteracted AngII-induced effects in a concentration dependent manner, but failed to alter the changes induced by endothelin-1...
  37. Descorbeth M, Anand Srivastava M. Role of vasoactive peptides in high glucose-induced increased expression of G?q/11 proteins and associated signaling in vascular smooth muscle cells. Can J Physiol Pharmacol. 2010;88:331-40 pubmed publisher
    ..vasoactive peptides and oxidative stress, the present study was undertaken to investigate the implication of angiotensin II (Ang II), endothelin (ET)-1, and oxidative stress in the high glucose-induced enhanced expression of G(alpha)q/..
  38. Mukuda T, Koyama Y, Hamasaki S, Kaidoh T, Furukawa Y. Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus. Brain Res. 2014;1588:92-103 pubmed publisher
    ..We examined the role of systemic angiotensin (Ang) peptides in exercise-dependent enhancement of neurogenesis in the adult rat hippocampus...
  39. Jaffré F, Bonnin P, Callebert J, Debbabi H, Setola V, Doly S, et al. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ Res. 2009;104:113-23 pubmed publisher
    ..Interestingly, we show that primary cultures of angiotensinogen null adult cardiac fibroblasts are releasing cytokines on stimulation with either angiotensin II or serotonin,..
  40. O Leary R, Penrose H, Miyata K, Satou R. Macrophage-derived IL-6 contributes to ANG II-mediated angiotensinogen stimulation in renal proximal tubular cells. Am J Physiol Renal Physiol. 2016;310:F1000-7 pubmed publisher
    ..Intrarenal renin-angiotensin system (RAS) activation, including proximal tubular angiotensinogen (AGT) stimulation, has also been regarded as a cardinal mechanism contributing to these diseases...
  41. Dab H, Hachani R, Hodroj W, Sakly M, Bricca G, Kacem K. Interaction between sympathetic nervous system and renin angiotensin system on MMPs expression in juvenile rat aorta. Gen Physiol Biophys. 2011;30:271-7 pubmed publisher
    The aim of our present study is to investigate the interaction between angiotensin II (ANG II) and sympathetic nervous system (SNS) on matrix metalloproteinase MMP-2 and MMP-9 expression and activity in juvenile rat aorta under normal ..
  42. Lukkarinen H, Laine J, Lehtonen J, Zagariya A, Vidyasagar D, Aho H, et al. Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration. Pediatr Res. 2004;55:326-33 pubmed
    ..Lung tissue myeloperoxidase activity and expression of angiotensinogen mRNA and endothelial monocyte-activating polypeptide (EMAP) II protein were also analyzed...
  43. Sadjadi J, Kramer G, Yu C, Burress Welborn M, Chappell M, Gregory Modrall J. Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension. J Surg Res. 2005;127:65-9 pubmed
    Tissue angiotensin II (ANG II) levels are elevated in both kidneys in renovascular hypertension (RVH)...
  44. Alvarez S, Fuentes L, Ciuffo G. Angiotensin II mediates Tyr-dephosphorylation in rat fetal kidney membranes. Mol Cell Biochem. 2003;254:137-43 pubmed
    b>Angiotensin II (Ang II) elicits a variety of physiological effects through specific Ang II receptors in numerous tissues...
  45. Isidoro Tavares N, Philip Couderc P, Baertschi A, Lerch R, Montessuit C. Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure. Cardiovasc Res. 2009;83:726-36 pubmed publisher
    b>Angiotensin II (Ang II) and tumour necrosis factor alpha (TNFalpha) are involved in the progression from compensated hypertrophy to heart failure...
  46. Tucker B, Mundy C, Maciejewski A, Printz M, Ziegler M, Pelayo J, et al. Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats. J Clin Invest. 1986;78:680-8 pubmed
    We examined the changes in glomerular hemodynamics produced by angiotensin II (AII) in both normal Munich-Wistar rats and rats which were unilaterally renal denervated (measured kidney) 4-6 d prior to the measurement periods...
  47. Imboden H, Patil J, Nussberger J, Nicoud F, Hess B, Ahmed N, et al. Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia. Regul Pept. 2009;154:23-31 pubmed publisher
    ..II (Ang II) in the sensory system and especially in the trigeminal ganglia, we studied the expression of angiotensinogen (Ang-N)-, renin-, angiotensin converting enzyme (ACE)- and cathepsin D-mRNA, and the presence of Ang II and ..
  48. Greco M, Mitri M, Chiriacò F, Leo G, Brienza E, Maffia M. Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: association to tumor derived alpha-N-acetylgalactosaminidase activity. Cancer Lett. 2009;283:222-9 pubmed publisher
    ..Significant increases of expression were found for transthyretin (TTR) and angiotensinogen (AGT) while vitamin D binding protein (DBP) expression was decreased in presence of melanoma...
  49. Asami R, Ono K, Nakanishi O, Inenaga K. Distinct mechanisms underlie the regulation of body fluid balance by neurokinin B and angiotensin II in the rat brain. Brain Res. 2011;1383:179-86 pubmed publisher
    Although central injections of either neurokinin B (NKB) or angiotensin II (ANGII) induce a pressor response, they show different involvements in fluid intake behaviors...
  50. Yanes L, Sartori Valinotti J, Iliescu R, Romero D, Racusen L, Zhang H, et al. Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2009;296:F771-9 pubmed publisher
    ..to the systemic renin-angiotensin system, which is suppressed in response to HS in male DS, intrarenal angiotensinogen expression is increased, and intrarenal levels of ANG II are not suppressed...
  51. Kramár E, Armstrong D, Ikeda S, Wayner M, Harding J, Wright J. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Brain Res. 2001;897:114-21 pubmed
  52. Riquier Brison A, Leong P, Pihakaski Maunsbach K, McDonough A. Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. Am J Physiol Renal Physiol. 2010;298:F177-86 pubmed publisher
    b>Angiotensin II (ANG II) stimulates proximal tubule (PT) sodium and water reabsorption...
  53. Nakayama T, Nakajima T, Sokabe H. Comparative studies on angiotensins. II. Structure of rat angiotensin and its identification by DNS-method. Chem Pharm Bull (Tokyo). 1972;20:1579-81 pubmed
  54. Jung G, Jeon J, Jung Y, Choi Y, Kim H, Kim J, et al. Clusterin/apolipoprotein J attenuates angiotensin II-induced renal fibrosis. PLoS ONE. 2014;9:e105635 pubmed publisher
    The blockade of angiotensin II (Ang II) is a major therapeutic strategy for diabetic nephropathy. The main roles of Ang II in renal disease are mediated via the Ang type 1 receptor (AT1R)...
  55. Healy D, Printz M. Angiotensinogen levels in the brain and cerebrospinal fluid of the genetically hypertensive rat. Hypertension. 1985;7:752-9 pubmed
    The present experiments were designed to document changes in the regional distribution of angiotensinogen in the rat brain with the development of hypertension in spontaneously hypertensive rats (SHR) relative to age-matched normotensive ..
  56. Lam S, Liu Y, Ng K, Liong E, Tipoe G, Leung P, et al. Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia. Exp Physiol. 2014;99:220-31 pubmed publisher
    ..In situ hybridization showed an elevated expression of angiotensinogen in the CB glomus cells in the hypoxic group when compared with the normoxic control group...
  57. Herrera M, Silva G, Garvin J. Angiotensin II stimulates thick ascending limb superoxide production via protein kinase C(?)-dependent NADPH oxidase activation. J Biol Chem. 2010;285:21323-8 pubmed publisher
    b>Angiotensin II (Ang II) stimulates thick ascending limb (TAL) O? production, but the receptor(s) and signaling mechanism(s)involved are unknown. The effect of Ang II on O?. is generally attributed to the AT?receptor...
  58. de Godoy M, Rattan S. Autocrine regulation of internal anal sphincter tone by renin-angiotensin system: comparison with phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2005;289:G1164-75 pubmed
    ..We determined the presence of ANG II precursor angiotensinogen (Angen), and the enzymes that convert it into ANG II, using functional, molecular biology, and ..
  59. Kopp U, Cicha M, Smith L. Activation of endothelin-a receptors contributes to angiotensin-induced suppression of renal sensory nerve activation. Hypertension. 2007;49:141-7 pubmed
    ..Angiotensin (Ang) II and endothelin (ET)-1 each contributes to the impaired responsiveness of renal mechanosensory nerves in a low-..
  60. Whaley Connell A, Habibi J, Panfili Z, Hayden M, Bagree S, Nistala R, et al. Angiotensin II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin. Am J Nephrol. 2011;34:115-25 pubmed publisher
    Angiotensin (Ang) II contributes to tubulointerstitial fibrosis. Recent data highlight mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling in tubulointerstitial fibrosis; however, the mechanisms remain unclear...
  61. Ma L, Zhang L, Zhang Y, Wang L, Li Z, Cao T, et al. [Renin-angiotensin system in mesenteric adipose tissues in rats with metabolic syndrome]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006;28:770-5 pubmed
    ..The expressions of angiotensinogen, angiotensin converting enzyme, angiotensin II receptor type 1 in mesenteric adipose tissue were ..
  62. Zeng W, Chen W, Leng X, Tang L, Sun X, Li C, et al. Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991. Cardiovasc Ther. 2012;30:152-61 pubmed publisher
    We evaluated effects of the nonpeptide angiotensin (ANG)-(1-7) analog AVE 0991 (AVE) on cardiac function and remodeling as well as transforming growth factor-beta1 (TGF-?1)/tumor necrosis factor-alpha (TNF-?) expression in myocardial ..
  63. Chen Y, Currie R. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. Inflamm Res. 2005;54:338-43 pubmed
    ..treatment (42 degrees C for 15 min) and the expression of heat shock proteins (Hsps) protect against angiotensin (Ang) II-induced inflammation in aorta and heart by suppressing the activation of the pro-inflammatory transcription ..
  64. Shen Y, Wei H, Jin C. [Effects of Chinese herbal medicine Xuefu Zhuyu Decoction on angiotensin II-induced proliferation and extracellular matrix synthesis of rat cardiac fibroblasts]. Zhong Xi Yi Jie He Xue Bao. 2011;9:313-9 pubmed
    ..proliferation and extracellular matrix synthesis of cardiac fibroblasts (CFs) from neonatal rats induced by angiotensin II, and to explore the mechanism of Xuefu Zhuyu Decoction in improving myocardial fibrosis...
  65. Mayer M, Hocht C, Giani J, Munoz M, Carranza A, Taira C, et al. Central insulin-angiotensin II interaction in blood pressure regulation in fructose overloaded rats. Regul Pept. 2013;185:37-43 pubmed publisher
    ..was to determine if insulin is able to modulate the pressor response to intracerebroventricularly administered angiotensin II in insulin resistant fructose overloaded rats...
  66. Kanome T, Watanabe T, Nishio K, Takahashi K, Hongo S, Miyazaki A. Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. Hypertens Res. 2008;31:1801-10 pubmed publisher
    b>Angiotensin II (Ang II) is known to accelerate the progression of macrophage-driven atherosclerotic lesions...
  67. Husková Z, Kramer H, Vanourková Z, Thumová M, Maly J, Opocensky M, et al. Effects of dietary salt load and salt depletion on the course of hypertension and angiotensin II levels in male and female heterozygous Ren-2 transgenic rats. Kidney Blood Press Res. 2007;30:45-55 pubmed
    In the present study we evaluated plasma and kidney angiotensin II (ANG II) levels in female and male Ren-2 transgenic rats (TGR) in comparison to age-matched female and male normotensive Hannover Sprague-Dawley rats...
  68. Low B, Grigor M. Angiotensin II stimulates system y+ and cationic amino acid transporter gene expression in cultured vascular smooth muscle cells. J Biol Chem. 1995;270:27577-83 pubmed
    The effect of angiotensin II (Ang II) on the transport of cationic amino acids has been examined in vascular smooth muscle cells (VSMC) isolated from rat aortae...
  69. Lochard N, Silversides D, van Kats J, Mercure C, Reudelhuber T. Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. J Biol Chem. 2003;278:2184-9 pubmed
    Mice deficient for angiotensinogen (AGT), or other components of the renin-angiotensin system, show a high rate of neonatal mortality correlated with severe renal abnormalities including hydronephrosis, hypertrophy of renal arteries, and ..
  70. Savoia C, Ebrahimian T, He Y, Gratton J, Schiffrin E, Touyz R. Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase. J Hypertens. 2006;24:2417-22 pubmed
    b>Angiotensin II (Ang II) induces vasodilation, in part, through angiotensin type 2 receptor (AT2R)-induced actions in conditions associated with angiotensin type 1 receptor (AT1R) blockade and AT2R upregulation...
  71. Pilbrow A, Palmer B, Frampton C, Yandle T, Troughton R, Campbell E, et al. Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Hypertension. 2007;49:322-7 pubmed
    b>Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy...
  72. Fatini C, Attanasio M, Porciani C, Sticchi E, Padeletti L, Lapini I, et al. AGT and ACE genes influence classic mitral valve prolapse predisposition in Marfan patients. Int J Cardiol. 2008;123:293-7 pubmed
    ..We investigated the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) I/D and angiotensin II type 1 receptor (AT1R) A1166C ..
  73. Gebhard S, Steil L, Peters B, Gesell Salazar M, Hammer E, Kuttler B, et al. Angiotensin II-dependent hypertension causes reversible changes in the platelet proteome. J Hypertens. 2011;29:2126-37 pubmed publisher
    Hypertension is a risk factor for arterial thrombosis. We investigated the effects of angiotensin II (ANG II)-dependent hypertension on the platelet proteome...
  74. Hunyady L, Bor M, Baukal A, Balla T, Catt K. A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor. J Biol Chem. 1995;270:16602-9 pubmed
    ..The role of this sequence (NPLFY) in angiotensin II receptor function was studied in mutant and wild-type rat type 1a angiotensin II receptors transiently ..
  75. Tolpygo S, Pevtsova E, Shoĭbonov B, Kotov A. Comparative study of the effects of free bound and carrier protein angiotensin II in experimental hypoglycemia and hyperglycemia. Bull Exp Biol Med. 2014;156:419-22 pubmed publisher
    Experimental hypoglycemia and hyperglycemia eliminated the differences in the regulatory functions of free angiotensin II and its complexes with carrier proteins (transport protein BSA and neurospecific protein S100b) in rats...
  76. Susic D, Frohlich E, Kobori H, Shao W, Seth D, Navar L. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. J Hypertens. 2011;29:716-23 pubmed publisher
    ..In SHRs on high-salt diet, plasma angiotensin II concentration increased three to four-fold, whereas urinary angiotensinogen excretion increased 10-fold; and these changes were significantly reduced by losartan...
  77. Villarreal R, Alvarez S, Ayub M, Ciuffo G. Angiotensin II modulates tyr-phosphorylation of IRS-4, an insulin receptor substrate, in rat liver membranes. Mol Cell Biochem. 2006;293:35-46 pubmed
    b>Angiotensin II (Ang II), a major regulator of blood pressure, is also involved in the control of cellular proliferation and hypertrophy and might exhibit additional actions in vivo by modulating the signaling of other hormones...
  78. Camargo de Andrade M, Di Marco G, de Paulo Castro Teixeira V, Mortara R, Sabatini R, Pesquero J, et al. Expression and localization of N-domain ANG I-converting enzymes in mesangial cells in culture from spontaneously hypertensive rats. Am J Physiol Renal Physiol. 2006;290:F364-75 pubmed
    ..The N-domain ACE was localized in the glomerulus from Wistar rats and SHR. ANG II and ANG-(1-7) were localized in the cell cytoplasm and nuclei...
  79. Isa K, Garcia Espinosa M, Arnold A, Pirro N, Tommasi E, Ganten D, et al. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2009;297:R111-5 pubmed publisher
    Angiotensin-(1-12) [ANG-(1-12)] is a newly identified peptide detected in a variety of rat tissues, including the brain...
  80. Gao F, Bao J, Xue J, Huang J, Huang W, Wu S, et al. Regional specificity of adaptation change in large elastic arteries of simulated microgravity rats. Acta Physiol Hung. 2009;96:167-87 pubmed publisher
    ..differential remodeling of the two kinds of large arteries by examining the gene and protein expression of angiotensinogen (AO) and angiotensin II receptor type 1 (AT1R) and their localization in the vessel wall...
  81. Pendergrass K, Pirro N, Westwood B, Ferrario C, Brosnihan K, Chappell M. Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats. Am J Physiol Heart Circ Physiol. 2008;295:H10-20 pubmed publisher
    ..congenics exhibited greater circulating renin and angiotensin-converting enzyme (ACE) activities, as well as angiotensinogen, than female littermates...
  82. Sharma N, Zheng H, Mehta P, Li Y, Patel K. Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II. Cardiovasc Res. 2011;92:348-57 pubmed publisher
    ..b>Angiotensin II (Ang II) type I receptor (AT(1)) antagonist losartan (Los) treatment in rats with CHF reduced renal ..
  83. Szentivanyi M, Maeda C, Cowley A. Local renal medullary L-NAME infusion enhances the effect of long-term angiotensin II treatment. Hypertension. 1999;33:440-5 pubmed
    We hypothesized that the relatively high doses of angiotensin (Ang) II required to produce hypertension in rats were related to stimulation of renal medullary nitric oxide production, which in turn blunted reductions in medullary blood ..
  84. Maximino J, Ferrari M, Coelho E, Fior Chadi D. Time course analysis of tyrosine hydroxylase and angiotensinogen mRNA expression in central nervous system of rats submitted to experimental hypertension. Neurosci Res. 2006;55:292-9 pubmed
    ..study analysed the expression of tyrosine hydroxylase (TH), a key enzyme for catecholamine synthesis and of angiotensinogen (AGT), the precursor of angiotensin II (Ang II), in areas of the central nervous system (CNS) involved with ..
  85. Zhang L, Ren Z, Yang Q, Ding G. Csk regulates angiotensin II-induced podocyte apoptosis. Apoptosis. 2016;21:846-55 pubmed publisher
    Increasing data have shown that angiotensin II (Ang II) perpetuates podocyte injury and promotes progression to end-stage kidney disease. The mechanism underlying Ang II-induced podocyte apoptosis has not been established...
  86. Li J, Lu J, Kaur C, Sivakumar V, Wu C, Ling E. Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells. Neuroscience. 2009;158:1488-99 pubmed publisher
    ..This study reports expression of angiotensin II and its receptors namely, angiotensin II receptor type 1 (AT(1)) and angiotensin II receptor type 2 (AT(2)) in ..
  87. Huang J, Siragy H. Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced (Pro)renin receptor expression. Endocrinology. 2009;150:5557-65 pubmed publisher
    ..2 wk followed by PRR small interfering RNA knockdown, IL-1 receptor blockade with IL-1 receptor antagonist or angiotensin II type 1 receptor blockade with valsartan...
  88. Tucker P, Scanlan A, Dalbo V. High Intensity Interval Training Favourably Affects Angiotensinogen mRNA Expression and Markers of Cardiorenal Health in a Rat Model of Early-Stage Chronic Kidney Disease. Biomed Res Int. 2015;2015:156584 pubmed publisher
    ..028), and reduced kidney weight-body weight ratios (p = 0.045). Compared to LIT, HIIT resulted in reduced Agt mRNA expression (p = 0.035), reduced plasma LDL (p = 0.001), triglycerides (p = 0...
  89. Ning W, Hu G, Peng Z, Wang L, Wang W, Chen J, et al. Fluorofenidone inhibits Ang II-induced apoptosis of renal tubular cells through blockage of the Fas/FasL pathway. Int Immunopharmacol. 2011;11:1327-32 pubmed publisher
    The present study was designed to investigate the inhibitory effects of fluorofenidone on Ang II-induced apoptosis in renal tubular cells and the related signaling pathway...
  90. Singh V, Le B, Bhat V, Baker K, Kumar R. High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2007;293:H939-48 pubmed
    ..Western analysis showed increased intracellular levels of angiotensinogen, renin, and chymase in high-glucose-exposed cells...
  91. Jiang T, Yu J, Zhu X, Zhang Q, Tan M, Cao L, et al. Angiotensin-(1-7) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas/eNOS-dependent pathway. Br J Pharmacol. 2014;171:4222-32 pubmed publisher
    As a newer component of the renin-angiotensin system, angiotensin-(1-7) [Ang-(1-7)?] has been shown to facilitate angiogenesis and protect against ischaemic damage in peripheral tissues...