Gene Symbol: Ago1
Description: argonaute 1, RISC catalytic component
Alias: Eif2c1, protein argonaute-1, argonaute RISC catalytic component 1, eukaryotic translation initiation factor 2C, 1
Species: rat
Products:     Ago1

Top Publications

  1. Wu L, Fan J, Belasco J. Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. Curr Biol. 2008;18:1327-32 pubmed publisher
    ..These findings have important implications for the efficacy and specificity of RNA interference. ..
  2. Ghosh U, Adhya S. Non-equivalent Roles of AGO1 and AGO2 in mRNA Turnover and Translation of Cyclin D1 mRNA. J Biol Chem. 2016;291:7119-27 pubmed publisher
    Mammalian Argonaute proteins (AGO1-4), in combination with microRNAs (miRs), bind to target mRNAs to initiate degradation and/or translation repression, but the relationships between these two effects is unclear...
  3. Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell. 2004;15:185-97 pubmed
    ..The human Argonaute family has eight members, four of which (Ago1 through Ago4) are closely related and coexpressed in many cell types...
  4. Höck J, Weinmann L, Ender C, Rüdel S, Kremmer E, Raabe M, et al. Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep. 2007;8:1052-60 pubmed
    ..Here, we analysed Ago1- and Ago2-containing protein complexes in human cells...
  5. Chi S, Zang J, Mele A, Darnell R. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 2009;460:479-86 pubmed publisher
    ..Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions. ..
  6. Yoda M, Kawamata T, Paroo Z, Ye X, Iwasaki S, Liu Q, et al. ATP-dependent human RISC assembly pathways. Nat Struct Mol Biol. 2010;17:17-23 pubmed publisher
    ..RNAs (siRNAs) and microRNAs (miRNAs) are incorporated into RISCs containing the Argonaute (AGO) subfamily proteins Ago1-4...
  7. Ender C, Meister G. Argonaute proteins at a glance. J Cell Sci. 2010;123:1819-23 pubmed publisher
  8. Huang V, Place R, Portnoy V, Wang J, Qi Z, Jia Z, et al. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res. 2012;40:1695-707 pubmed publisher
    ..e. Dicer, Drosha, Ago1 and Ago2). In silico analysis identifies highly-complementary sites for 21 miRNAs in the Ccnb1 promoter...
  9. Gu S, Jin L, Huang Y, Zhang F, Kay M. Slicing-independent RISC activation requires the argonaute PAZ domain. Curr Biol. 2012;22:1536-42 pubmed publisher
    ..the RNA-induced silencing complex (RISC), which, in mammals, contains at its center one of four Argonaute proteins (Ago1-Ago4)...

More Information


  1. Chen Z, Lai T, Jan Y, Lin F, Wang W, Xiao H, et al. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest. 2013;123:1057-67 pubmed publisher
    ..silico bioinformatics and in vitro validation showed that these HRMs are induced by HIF1? and target argonaute 1 (AGO1), which anchors the microRNA-induced silencing complex (miRISC)...
  2. Nakanishi K, Ascano M, Gogakos T, Ishibe Murakami S, Serganov A, Briskin D, et al. Eukaryote-specific insertion elements control human ARGONAUTE slicer activity. Cell Rep. 2013;3:1893-900 pubmed publisher
    ..Evolutionary amino acid changes to hAGO1 were readily reversible, suggesting that loading of guide RNA and pairing of seed-based miRNA and target RNA constrain its sequence drift. ..
  3. Eswarappa S, Potdar A, Koch W, Fan Y, Vasu K, Lindner D, et al. Programmed translational readthrough generates antiangiogenic VEGF-Ax. Cell. 2014;157:1605-18 pubmed publisher
    ..Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets...
  4. Sun S, Ma J, Zhang Q, Wang Q, Zhou L, Bai F, et al. Argonaute proteins in cardiac tissue contribute to the heart injury during viral myocarditis. Cardiovasc Pathol. 2016;25:120-6 pubmed publisher
    ..In this study, we detected the expression of four AGOs in the CVB3-infected mouse heart tissues and found that AGO1 and AGO3 up-regulated significantly at 4 and 8h after CVB3 infection...
  5. Hu J, Wang F, Zhu X, Yuan Y, Ding M, Gao S. Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest. Dev Dyn. 2010;239:407-24 pubmed publisher
    ..When ectopically expressed in somatic cells, ZAR1L colocalized with P-body components including EIF2C1(AGO1), EIF2C2(AGO2), DDX6 and LSM14A, and germline-specific chromatoid body components including PIWIL1, PIWIL2, ..