Ager

Summary

Gene Symbol: Ager
Description: advanced glycosylation end product-specific receptor
Alias: RAGE, advanced glycosylation end product-specific receptor, advanced glycosylation end product-specific receptor variant 2, advanced glycosylation end product-specific receptor variant 3, advanced glycosylation end product-specific receptor variant 4, advanced glycosylation end product-specific receptor variant 5, receptor for advanced glycosylation end products
Species: rat
Products:     Ager

Top Publications

  1. Huang J, Guh J, Chen H, Hung W, Lai Y, Chuang L. Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells. J Cell Biochem. 2001;81:102-13 pubmed
    ..Additionally, AGE increased RAGE (receptor for AGE) protein expression...
  2. Ren X, Shao H, Wei Q, Sun Z, Liu N. Advanced glycation end-products enhance calcification in vascular smooth muscle cells. J Int Med Res. 2009;37:847-54 pubmed
    ..was demonstrated that rat aortic VSMCs incubated with AGEs exhibited an increased expression of the AGE receptor (RAGE) and typical bone proteins, such as osteopontin and alkaline phosphatase...
  3. Fehrenbach H, Kasper M, Tschernig T, Shearman M, Schuh D, Muller M. Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung. Cell Mol Biol (Noisy-le-grand). 1998;44:1147-57 pubmed
    The transmembrane receptor (RAGE) of advanced glycation endproducts (AGEs), is abundantly present in the lung...
  4. Forbes J, Thorpe S, Thallas Bonke V, Pete J, Thomas M, Deemer E, et al. Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy. J Am Soc Nephrol. 2005;16:2363-72 pubmed
    ..and human approaches to explore the potential effects of these agents on the modulation of the receptor for AGE (RAGE)...
  5. Kang P, Tian C, Jia C. Association of RAGE gene polymorphisms with type 2 diabetes mellitus, diabetic retinopathy and diabetic nephropathy. Gene. 2012;500:1-9 pubmed publisher
    A meta-analysis was performed to assess the associations of the receptor for advanced glycation end products (RAGE) gene polymorphisms [Gly82Ser (rs2070600), 1704G/T (rs184003), 429T/C (rs1800625)] with type 2 diabetes mellitus (T2DM), ..
  6. Wang Z, Jiang Y, Liu N, Ren L, Zhu Y, An Y, et al. Advanced glycation end-product N?-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes. Atherosclerosis. 2012;221:387-96 pubmed publisher
    ..Furthermore, CML deposition signals and the expression of receptor for advanced glycation end-products (RAGE) in the aortic wall were mainly restricted in the atherosclerotic plaques...
  7. Huttunen H, Fages C, Rauvala H. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem. 1999;274:19919-24 pubmed
    Receptor for advanced glycation end products (RAGE) mediates neurite outgrowth in vitro on amphoterin-coated substrates...
  8. Balasubbu S, Sundaresan P, Rajendran A, Ramasamy K, Govindarajan G, Perumalsamy N, et al. Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy. BMC Med Genet. 2010;11:158 pubmed publisher
    ..Seven candidate genes (RAGE, PEDF, AKR1B1, EPO, HTRA1, ICAM and HFE) were chosen based on reported association with DR in the literature...
  9. Hanford L, Enghild J, Valnickova Z, Petersen S, Schaefer L, Schaefer T, et al. Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE). J Biol Chem. 2004;279:50019-24 pubmed
    The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface proteins that has been implicated as a progression factor in a number of pathologic conditions from chronic inflammation ..

More Information

Publications75

  1. Yan S, Chen X, Fu J, Chen M, Zhu H, Roher A, et al. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature. 1996;382:685-91 pubmed
    ..Here we present evidence that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia...
  2. Hudson B, Stickland M, Futers T, Grant P. Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy. Diabetes. 2001;50:1505-11 pubmed
    Interactions between advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the vascular complications in diabetes...
  3. Zhang H, Chen L, Wang L, Liao Y, Wu Z, Ye F, et al. Association of 1704G/T and G82S polymorphisms in the receptor for advanced glycation end products gene with diabetic retinopathy in Chinese population. J Endocrinol Invest. 2009;32:258-62 pubmed
    The receptor for advanced glycation end products (RAGE) plays an important role in the pathogenesis of diabetic complications...
  4. Vincent A, Perrone L, Sullivan K, Backus C, Sastry A, Lastoskie C, et al. Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress. Endocrinology. 2007;148:548-58 pubmed
    The receptor for advanced glycation end products (RAGE) may promote diabetic vascular and renal disease through the activation of intracellular signaling pathways that promote oxidative stress...
  5. Ferhani N, Letuve S, Kozhich A, Thibaudeau O, Grandsaigne M, Maret M, et al. Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;181:917-27 pubmed publisher
    ..and repair, interacts with proinflammatory cytokines and with the receptor for advanced glycation end products (RAGE), which is highly expressed in the lung...
  6. Suga T, Iso T, Shimizu T, Tanaka T, Yamagishi S, Takeuchi M, et al. Activation of receptor for advanced glycation end products induces osteogenic differentiation of vascular smooth muscle cells. J Atheroscler Thromb. 2011;18:670-83 pubmed
    ..Receptor for advanced glycation end products (RAGE) and its multiple ligands have been implicated in the pathogenesis of accelerated atherosclerosis; however, little ..
  7. Giunti S, Calkin A, Forbes J, Allen T, Thomas M, Cooper M, et al. The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse. Am J Physiol Renal Physiol. 2010;299:F528-35 pubmed publisher
    ..collagen IV, fibronectin and advanced glycation end products (AGEs), receptor for advanced glycation and products (RAGE), NADPH oxidase 4 (NOX4), and nitrotyrosine was assessed by real-time PCR and/or immunohistochemistry...
  8. Lindholm E, Bakhtadze E, Sjogren M, Cilio C, Agardh E, Groop L, et al. The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients. Diabetologia. 2006;49:2745-55 pubmed
    The receptor for AGE (RAGE) is considered to be mainly an intracellular signal-transducer or pro-inflammatory peptide of possible importance for inflammation and autoimmune diseases...
  9. Wendt T, Tanji N, Guo J, Kislinger T, Qu W, Lu Y, et al. RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol. 2003;162:1123-37 pubmed
    ..b>RAGE, a receptor for advanced glycation endproducts (AGEs) and S100/calgranulins, displays enhanced expression in ..
  10. Hofmann M, Drury S, Fu C, Qu W, Taguchi A, Lu Y, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999;97:889-901 pubmed
    ..We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related ..
  11. Xiang M, Wang J, Zhang Y, Ling J, Xu X. Attenuation of aortic injury by ursolic acid through RAGE-Nox-NF?B pathway in streptozocin-induced diabetic rats. Arch Pharm Res. 2012;35:877-86 pubmed publisher
    Vascular complications are the leading causes of morbidity and mortality in diabetes mellitus (DM). The RAGE (receptor for advanced glycation end products)-NADPH oxidase-NF-?B signal transduction pathway plays an important role in the ..
  12. Li J, Wang W, Huang X, Oldfield M, Schmidt A, Cooper M, et al. Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway. Am J Pathol. 2004;164:1389-97 pubmed
    ..We report here that AGEs signal through the receptor for AGEs (RAGE) to induce TEMT, as determined by de novo expression of a mesenchymal marker (alpha-smooth muscle actin, alpha-SMA) ..
  13. Pachydaki S, Tari S, Lee S, Ma W, Tseng J, Sosunov A, et al. Upregulation of RAGE and its ligands in proliferative retinal disease. Exp Eye Res. 2006;82:807-15 pubmed
    We sought to study the presence of the receptor for advanced glycation endproducts (RAGE) and its ligands, advanced glycation endproducts (AGEs), S100/calgranulins and amphoterin (high mobility group box 1 protein; HMGB1), in the vitreous ..
  14. Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen J, et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem. 1995;270:25752-61 pubmed
    The receptor for advanced glycation end products (RAGE), a newly-identified member of the immunoglobulin superfamily, mediates interactions of advanced glycation end product (AGE)-modified proteins with endothelium and other cell types...
  15. Englert J, Hanford L, Kaminski N, Tobolewski J, Tan R, Fattman C, et al. A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis. Am J Pathol. 2008;172:583-91 pubmed publisher
    ..The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface receptors whose activation has been linked to ..
  16. Abdul Salam V, Wharton J, Cupitt J, Berryman M, Edwards R, Wilkins M. Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension. Circulation. 2010;122:2058-67 pubmed publisher
    ..Increased expression of chloride intracellular channel 4 may be pertinent to the disorganized angiogenesis of plexiform lesions. ..
  17. Uchida T, Shirasawa M, Ware L, Kojima K, Hata Y, Makita K, et al. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med. 2006;173:1008-15 pubmed
    Receptor for advanced glycation end-products (RAGE) is one of the alveolar type I cell-associated proteins in the lung. To test the hypothesis that RAGE is a marker of alveolar epithelial type I cell injury...
  18. dos Santos K, Canani L, Gross J, Tschiedel B, Pires Souto K, Roisenberg I. The -374A allele of the receptor for advanced glycation end products gene is associated with a decreased risk of ischemic heart disease in African-Brazilians with type 2 diabetes. Mol Genet Metab. 2005;85:149-56 pubmed
    Three functional polymorphisms described in the promoter of receptor for advanced glycation end products (RAGE) gene were shown to have a marked effect on transcriptional activity...
  19. Lizotte P, Hanford L, Enghild J, Nozik Grayck E, Giles B, Oury T. Developmental expression of the receptor for advanced glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lung. BMC Dev Biol. 2007;7:15 pubmed
    ..The adult lung is unique in that it expresses high amounts of RAGE under normal conditions while other tissues express low amounts normally and up-regulate RAGE during pathologic ..
  20. Gebhardt C, Riehl A, Durchdewald M, Nemeth J, Furstenberger G, Muller Decker K, et al. RAGE signaling sustains inflammation and promotes tumor development. J Exp Med. 2008;205:275-85 pubmed publisher
    ..We show that mice deficient for the receptor for advanced glycation end-products (RAGE) are resistant to DMBA/TPA-induced skin carcinogenesis and exhibit a severe defect in sustaining inflammation ..
  21. Reiniger N, Lau K, McCalla D, Eby B, Cheng B, Lu Y, et al. Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse. Diabetes. 2010;59:2043-54 pubmed publisher
    ..showed that genetic deletion or pharmacological blockade of the receptor for advanced glycation end products (RAGE) prevents the early structural changes in the glomerulus associated with diabetic nephropathy...
  22. Lander H, Tauras J, Ogiste J, Hori O, Moss R, Schmidt A. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem. 1997;272:17810-4 pubmed
    ..on cells by interacting with specific cellular receptors, the best characterized of which is the receptor for AGE (RAGE)...
  23. Meloche J, Paulin R, Courboulin A, Lambert C, Barrier M, Bonnet P, et al. RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes. Arterioscler Thromb Vasc Biol. 2011;31:2114-24 pubmed publisher
    ..Recently, the activation of the advanced glycation endproducts receptor (RAGE) has been shown to promote VSMC proliferation and resistance to apoptosis in VRD in a signal transducer and ..
  24. Kankova K, Záhejský J, Marova I, Muzik J, Kuhrova V, Blazkova M, et al. Polymorphisms in the RAGE gene influence susceptibility to diabetes-associated microvascular dermatoses in NIDDM. J Diabetes Complications. 2001;15:185-92 pubmed
    To examine genetic polymorphism in the complete sequence of the Receptor of Advanced Glycation End products (RAGE) gene and its possible associations with diabetes-associated microvascular dermatoses (DAMD)...
  25. Ishiguro H, Nakaigawa N, Miyoshi Y, Fujinami K, Kubota Y, Uemura H. Receptor for advanced glycation end products (RAGE) and its ligand, amphoterin are overexpressed and associated with prostate cancer development. Prostate. 2005;64:92-100 pubmed
    ..Recently, some reports indicated that the interaction between AGE and the cognate receptor (RAGE) has a role in cancer dependent...
  26. Renard C, Chappey O, Wautier M, Nagashima M, Lundh E, Morser J, et al. Recombinant advanced glycation end product receptor pharmacokinetics in normal and diabetic rats. Mol Pharmacol. 1997;52:54-62 pubmed
    ..AGEs produce an increase in vascular permeability and generated an oxidant stress after binding to the receptor (RAGE) present on endothelium...
  27. Sorci G, Giovannini G, Riuzzi F, Bonifazi P, Zelante T, Zagarella S, et al. The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation. PLoS Pathog. 2011;7:e1001315 pubmed publisher
    ..Upon forming complexes with TLR2 ligands, S100B inhibited TLR2 via RAGE, through a paracrine epithelial cells/neutrophil circuit that restrained pathogen-induced inflammation...
  28. Bucciarelli L, Kaneko M, Ananthakrishnan R, Harja E, Lee L, Hwang Y, et al. Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury. Circulation. 2006;113:1226-34 pubmed
    ..this context, our laboratory has been investigating the role of the receptor for advanced-glycation end products (RAGE) in myocardial I/R injury...
  29. Harashima A, Yamamoto Y, Cheng C, Tsuneyama K, Myint K, Takeuchi A, et al. Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression. Biochem J. 2006;396:109-15 pubmed
    The cell-surface RAGE [receptor for AGE (advanced glycation end-products)] is associated with the development of diabetic vascular complications, neurodegenerative disorders and inflammation...
  30. Ye X, Chopp M, Liu X, Zacharek A, Cui X, Yan T, et al. Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats. Neuroscience. 2011;190:339-45 pubmed publisher
    High-mobility group box 1 (HMGB1), an active receptor for advanced glycation endproducts (RAGE), functions as a potent proinflammatory cytokine-like factor that contributes to the pathogenesis of vasculature...
  31. Takeda R, Suzuki E, Satonaka H, Oba S, Nishimatsu H, Omata M, et al. Blockade of endogenous cytokines mitigates neointimal formation in obese Zucker rats. Circulation. 2005;111:1398-406 pubmed
    ..It has become clear that advanced glycation end products (AGE) and their receptor (RAGE) are implicated in vascular diseases, especially in diabetes mellitus...
  32. Kim J, Park S, Lee M, Song Y, Han S, Kim S, et al. Plasma levels of soluble receptor for advanced glycation end products (sRAGE) and proinflammatory ligand for RAGE (EN-RAGE) are associated with carotid atherosclerosis in patients with peritoneal dialysis. Atherosclerosis. 2012;220:208-14 pubmed publisher
    ..sRAGE) exerts a protective effect on the development of atherosclerotic vascular complications by inhibiting RAGE-mediated inflammatory response...
  33. Pettersson Fernholm K, Forsblom C, Hudson B, Perola M, Grant P, Groop P. The functional -374 T/A RAGE gene polymorphism is associated with proteinuria and cardiovascular disease in type 1 diabetic patients. Diabetes. 2003;52:891-4 pubmed
    ..end products (AGEs) that predominantly act through specific receptors, particularly the receptor for AGEs (RAGE)...
  34. Wolf R, Howard O, Dong H, Voscopoulos C, Boeshans K, Winston J, et al. Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol. 2008;181:1499-506 pubmed
    ..We define RAGE (receptor for advanced glycation end products) as the hS100A7 receptor, whereas hS100A15 functions through a Gi ..
  35. Zong H, Ward M, Madden A, Yong P, Limb G, Curtis T, et al. Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE). Diabetologia. 2010;53:2656-66 pubmed publisher
    Up-regulation of the receptor for AGEs (RAGE) and its ligands in diabetes has been observed in various tissues...
  36. Deane R, Du Yan S, Submamaryan R, LaRue B, Jovanovic S, Hogg E, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003;9:907-13 pubmed
    ..in genetically manipulated mice show that Abeta interaction with receptor for advanced glycation end products (RAGE)-bearing cells in the vessel wall results in transport of Abeta across the blood-brain barrier (BBB) and expression ..
  37. Palanisamy N, Kannappan S, Anuradha C. Genistein modulates NF-?B-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats. Eur J Pharmacol. 2011;667:355-64 pubmed publisher
    ..B (NF-?B p65), transforming growth factor-?1 (TGF-?1) and receptor for advanced glycation end products (RAGE) in kidney of fructose-fed rats...
  38. Chen J, Jin J, Song M, Dong H, Zhao G, Huang L. C-reactive protein down-regulates endothelial nitric oxide synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced glycation end-products. Gene. 2012;496:128-35 pubmed publisher
    ..CRP can regulate receptor for advanced glycation end-products (RAGE) expression in endothelial progenitor cells (EPCs)...
  39. Mancini J, Ortiz G, Croxatto J, Gallo J. Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet. BMC Ophthalmol. 2013;13:14 pubmed publisher
    ..Primary antibodies against inflammatory and proangiogenic mediators such as RAGE, GFAP, 5-LO, VEGF and TNF-? were used for immunohistochemistry and Western Blot (WB) analyses...
  40. Tian Z, Ji P, Li Y, Zhao S, Wang X. [Influence of human mesenchymal stem cells on hyperoxia-exposed newborn rats by RAGE-NF-?B signaling in lung]. Zhonghua Er Ke Za Zhi. 2012;50:356-60 pubmed
    ..the influence of high oxygen exposure on signaling pathway of the receptor for advanced glycation end products (RAGE)-NF-?B of lung in newborn rats and the mechanisms of protecting lung injury for human mesenchymal stem cells (hMSC)...
  41. Park E, Seo M, Park J. Effects of specific genes activating RAGE on polycystic kidney disease. Am J Nephrol. 2010;32:169-78 pubmed publisher
    ..Receptor of advanced glycation end product (RAGE) is a putative cell surface receptor for s100a8/a9...
  42. Gasparotto J, Senger M, Kunzler A, Degrossoli A, De Simone S, Bortolin R, et al. Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis. Brain Behav Immun. 2015;43:37-45 pubmed publisher
    ..to investigate if peripheral infection of BALB/c mice with Leishmania amazonensis affects tau phosphorylation and RAGE protein content in the brain, which represent biochemical markers of neurodegenerative processes observed in ..
  43. Perrone L, Peluso G, Melone M. RAGE recycles at the plasma membrane in S100B secretory vesicles and promotes Schwann cells morphological changes. J Cell Physiol. 2008;217:60-71 pubmed publisher
    b>RAGE is a multiligand receptor of the immunoglobulin superfamily involved in regeneration of injured peripheral nerve and cell motility...
  44. Zhang J, Zhen Y, Pu Bu Ci Ren -, Song L, Kong W, Shao T, et al. Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behav Brain Res. 2013;244:70-81 pubmed publisher
    ..cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), receptor for advanced glycation end products (RAGE)). Our results confirmed that A?1-40 peptide caused learning and memory deficits in rats...
  45. Zhao Z, Sagare A, Ma Q, Halliday M, Kong P, Kisler K, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015;18:978-87 pubmed publisher
    ..Thus, PICALM regulates Aβ BBB transcytosis and clearance, which has implications for Aβ brain homeostasis and clearance therapy. ..
  46. López Díez R, Rastrojo A, Villate O, Aguado B. Complex tissue-specific patterns and distribution of multiple RAGE splice variants in different mammals. Genome Biol Evol. 2013;5:2420-35 pubmed publisher
    The receptor for advanced glycosylation end products (RAGE) is a multiligand receptor involved in diverse cell signaling pathways. Previous studies show that this gene expresses several splice variants in human, mouse, and dog...
  47. Wei W, Chen M, Zhu Y, Wang J, Zhu P, Li Y, et al. Down-regulation of vascular HMGB1 and RAGE expression by n-3 polyunsaturated fatty acids is accompanied by amelioration of chronic vasculopathy of small bowel allografts. J Nutr Biochem. 2012;23:1333-40 pubmed publisher
    ..The pathway mediated by the receptor for advanced glycation end products (RAGE) and its ligand, high mobility group box-1 (HMGB1), may contribute to the pathogenesis of CAV, given that they were ..
  48. Raposeiras Roubín S, Rodiño Janeiro B, Grigorian Shamagian L, Seoane Blanco A, Moure González M, Varela Roman A, et al. Evidence for a role of advanced glycation end products in atrial fibrillation. Int J Cardiol. 2012;157:397-402 pubmed publisher
    Recent studies suggested that advanced glycation end-products (AGEs) and their receptor (RAGE) interaction may be promoted by inflammation and oxidative stress...
  49. Ng Z, Kuppusamy U, Poh R, Tajunisah I, Koay A, Fong K, et al. Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients. Genet Mol Res. 2012;11:455-61 pubmed publisher
    ..We investigated the association of Gly82Ser, 1704G/T and 2184A/G polymorphisms in the RAGE gene with retinopathy in type 2 diabetic patients in Malaysia...
  50. Kerkeni M, Saïdi A, Bouzidi H, Letaief A, Ben Yahia S, Hammami M. Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients. Diab Vasc Dis Res. 2013;10:239-45 pubmed publisher
    ..may reflect the activity of the advanced glycation end product (AGE)-receptor for advanced glycation end product (RAGE) axis, which has been proposed as a potential mechanism linking hyperglycaemia to vascular complications in ..
  51. Abe R, Shimizu T, Sugawara H, Watanabe H, Nakamura H, Choei H, et al. Regulation of human melanoma growth and metastasis by AGE-AGE receptor interactions. J Invest Dermatol. 2004;122:461-7 pubmed
    ..In this study we investigated the expression levels of their receptor for AGE (RAGE) in human melanoma and subsequently studied the effects of AGE on melanoma growth and migration...
  52. You L, Sheng Z, Tang C, Chen L, Pan L, Chen J. High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats. Acta Pharmacol Sin. 2011;32:1498-504 pubmed publisher
    ..The up-regulated genes were found to code for IL-6 and Ager with bone-resorption functions. Treatment of MC3T3-E1 cells with cholesterol (12...
  53. Jules J, Maiguel D, Hudson B. Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function. PLoS ONE. 2013;8:e78267 pubmed publisher
    The Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand receptor present on most cell types...
  54. Iannitti R, Casagrande A, De Luca A, Cunha C, Sorci G, Riuzzi F, et al. Hypoxia promotes danger-mediated inflammation via receptor for advanced glycation end products in cystic fibrosis. Am J Respir Crit Care Med. 2013;188:1338-50 pubmed publisher
    ..inflammation in murine and human CF, as revealed by functional studies and analysis of the genetic variability of AGER in patients with CF...
  55. Cecil D, Terkeltaub R. Arterial calcification is driven by RAGE in Enpp1-/- mice. J Vasc Res. 2011;48:227-35 pubmed publisher
    ..The multiligand receptor for advanced glycation end-products (RAGE), which promotes atherosclerosis and diabetic cardiovascular and renal complications, also mediates chondrocyte ..
  56. Sbai O, Devi T, Melone M, Feron F, Khrestchatisky M, Singh L, et al. RAGE-TXNIP axis is required for S100B-promoted Schwann cell migration, fibronectin expression and cytokine secretion. J Cell Sci. 2010;123:4332-9 pubmed publisher
    ..The receptor for advanced glycation end products (RAGE) and its ligand S100B, which are secreted by SCs, are required for the repair of the injured peripheral nerve in ..
  57. Li H, Wu W, Sun Q, Liu M, Li W, Zhang X, et al. Expression and cell distribution of receptor for advanced glycation end-products in the rat cortex following experimental subarachnoid hemorrhage. Brain Res. 2014;1543:315-23 pubmed publisher
    ..The receptor for advanced glycation end-products (RAGE) is a transmembrane receptor that senses these molecules and plays central role in inflammatory processes...
  58. Qin W, Lu Y, Zhan C, Shen T, Dou L, Man Y, et al. Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p(53), Bcl-2 and Bcl-xL. Cardiovasc Drugs Ther. 2012;26:23-30 pubmed publisher
    ..kappa B (NF-?B) activation and suppression of the expression of the receptor for advanced glycation end products (RAGE)...
  59. Eun S, Ko Y, Park S, Chang K, Kim H. IL-1β enhances vascular smooth muscle cell proliferation and migration via P2Y2 receptor-mediated RAGE expression and HMGB1 release. Vascul Pharmacol. 2015;72:108-17 pubmed publisher
    ..The equipotent P2Y2R agonists ATP and UTP enhanced proliferation, RAGE expression and HMGB1 secretion in IL-1β-pretreated VSMCs...
  60. Ha T. High-glucose and advanced glycosylation end products increased podocyte permeability via PI3-K/Akt signaling. J Mol Med (Berl). 2010;88:391-400 pubmed publisher
    ..We could also confirm the induction of RAGE (receptor for AGE) and PI3-K/Akt signaling pathway by AGE and HG...
  61. Yan T, Chopp M, Ning R, Zacharek A, Roberts C, Chen J. Intracranial aneurysm formation in type-one diabetes rats. PLoS ONE. 2013;8:e67949 pubmed publisher
    ..Trichrome, Elastica van Gieson, alpha-smooth muscle actin (a-SMA) and receptor of advanced glycation end-products (RAGE), toll-like receptor 4 (TLR4) and matrix metalloproteinase 9 (MMP9) immunostaining were performed...
  62. Wang L, Zhang X, Liu L, Cui L, Yang R, Li M, et al. Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res. 2010;1321:143-51 pubmed publisher
    ..Experiment 1 was used to evaluate the longitudinal expression of HMGB1, RAGE and TLR4 and NF-kappaB in the cerebral ischemia. Experiment 2 was used to detect Tan II A's neuroprotection...
  63. Xu H, Vetri F, Lee H, Ye S, Paisansathan C, Mao L, et al. Estrogen replacement therapy in diabetic ovariectomized female rats potentiates postischemic leukocyte adhesion in cerebral venules via a RAGE-related process. Am J Physiol Heart Circ Physiol. 2009;297:H2059-67 pubmed publisher
    ..diabetes mellitus (DM) is due to an enhanced contribution from the receptor for advanced glycation end products (RAGE). Rhodamine 6G-labeled leukocytes were observed through a closed cranial window in rats...
  64. Li G, Tang J, Du Y, Lee C, Kern T. Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia. Mol Vis. 2011;17:3156-65 pubmed
    The receptor for advanced glycation end products (RAGE) has been implicated in the pathogenesis of numerous complications of diabetes...
  65. Tsoporis J, Izhar S, Leong Poi H, Desjardins J, Huttunen H, Parker T. S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction. Circ Res. 2010;106:93-101 pubmed publisher
    ..the expression and function of S100B and its receptor, the receptor for advanced glycation end products (RAGE) in both postinfarction myocardium and in a rat neonatal myocyte culture model...
  66. Sun N, Yang L, Li Y, Cheng Y, Zhang Z, Cai D. [Advanced oxidation protein products inhibit proliferation and differentiation of rat osteoblasts through oxidative stress]. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:356-9 pubmed
    ..cells were analyzed using 2', 7'-dichlorofluorescin diacetate, and the transcription levels of ALP, collagen I and RAGE were assessed using real-time PCR...