Gene Symbol: Adra1b
Description: adrenoceptor alpha 1B
Alias: alpha-1B adrenergic receptor, Adrenergic alpha 1B- receptor, adrenergic receptor, alpha 1b, adrenergic, alpha-1B-, receptor, alpha-1B adrenoceptor, alpha-1B adrenoreceptor
Species: rat
Products:     Adra1b

Top Publications

  1. Abdulla M, Sattar M, Abdullah N, Hye Khan M, Anand Swarup K, Johns E. The contribution of ?1B-adrenoceptor subtype in the renal vasculature of fructose-fed Sprague-Dawley rats. Eur J Nutr. 2011;50:251-60 pubmed publisher
  2. Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, et al. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol Cell Biol. 2008;28:3424-36 pubmed publisher
    ..These findings indicate that MURC modulates RhoA signaling and that MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias. ..
  3. Day H, Greenwood B, Hammack S, Watkins L, Fleshner M, Maier S, et al. Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J Comp Neurol. 2004;474:364-78 pubmed
    ..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR. ..
  4. Wang X, Zeng W, Soyombo A, Tang W, Ross E, Barnes A, et al. Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol. 2005;7:405-11 pubmed
    ..These findings provide a general mechanism by which RGS proteins recognize GPCRs to confer signalling specificity. ..
  5. Kazi R, Munavvar A, Abdullah N, Khan A, Johns E. Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats. Auton Autacoid Pharmacol. 2009;29:25-31 pubmed publisher
  6. Sathi Z, Anisuzzaman A, Morishima S, Suzuki F, Tanaka T, Yoshiki H, et al. Different affinities of native alpha1B-adrenoceptors for ketanserin between intact tissue segments and membrane preparations. Eur J Pharmacol. 2008;584:222-8 pubmed publisher
    ..The present study reveals that the pharmacological profiles of native alpha 1B-adrenoceptors for ketanserin is strongly influenced by the assay conditions and suggest that antagonist affinity is not necessarily constant. ..
  7. Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, et al. Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates. J Neurosci. 2002;22:2873-84 pubmed
  8. Molina Muñoz T, Romero Avila M, Avendaño Vázquez S, García Sáinz J. Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I. Eur J Pharmacol. 2008;578:1-10 pubmed
    ..Our data show that IGF-I induces alpha(1B)-adrenoceptor desensitization associated to receptor phosphorylation and internalization. ..
  9. Tillinger A, Myslivecek J, Novakova M, Krizanova O, Kvetnansky R. Gene expression of adrenoceptors in the hearts of cold-acclimated rats exposed to a novel stressor. Ann N Y Acad Sci. 2008;1148:393-9 pubmed publisher
    ..A protective role of beta(2)-, beta(3)-AR, and alpha(1B)-AR in the process of heart adaptation to chronic stress exposure is proposed. ..

More Information


  1. Campos M, Morais P, Pupo A. Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens. Eur J Pharmacol. 2003;471:149-55 pubmed
    ..The results suggest that alpha(1B)-adrenoceptors are detectable in vas deferens from at least the 7th through the 30th day after castration and that testosterone prevents this plasticity. ..
  2. Cavalli A, Lattion A, Hummler E, Nenniger M, Pedrazzini T, Aubert J, et al. Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor. Proc Natl Acad Sci U S A. 1997;94:11589-94 pubmed
  3. Spreng M, Cotecchia S, Schenk F. A behavioral study of alpha-1b adrenergic receptor knockout mice: increased reaction to novelty and selectively reduced learning capacities. Neurobiol Learn Mem. 2001;75:214-29 pubmed
    ..The lack of alpha-1b adrenergic receptors in spatial orientation does not seem important in cue-rich tasks but may interfere with orientation in situations providing distant cues only. ..
  4. Hague C, Uberti M, Chen Z, Hall R, Minneman K. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. J Biol Chem. 2004;279:15541-9 pubmed
    ..These observations may be relevant to many other Class I G protein-coupled receptors, where the functional consequences of heterodimerization are still poorly understood. ..
  5. Lindblom J, Petrovska R, Hallberg M, Magnusson K, Nyberg F, Uhlen S. Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells. Eur J Pharmacol. 2005;527:157-62 pubmed
    ..It is concluded that the regulation of alpha1B-adrenoceptor expression by anabolic androgenic steroids is intricate and cell-type specific. ..
  6. Manni L, Holmang A, Lundeberg T, Aloe L, Stener Victorin E. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Auton Neurosci. 2005;118:79-87 pubmed
    ..Overall, our findings suggest that therapeutical approaches aimed at down-regulating the sympathetic tone to the ovary could be useful in the prevention and clinical treatment of PCOS. ..
  7. Casas González P, Ruiz Martínez A, García Sáinz J. Lysophosphatidic acid induces alpha1B-adrenergic receptor phosphorylation through G beta gamma, phosphoinositide 3-kinase, protein kinase C and epidermal growth factor receptor transactivation. Biochim Biophys Acta. 2003;1633:75-83 pubmed
    ..This is the first demonstration of a role of EGF receptor transactivation in the phosphorylation of a G protein-coupled receptor. ..
  8. Wright C, Wu S, Dahl E, Sazama A, O Connell T. Nuclear localization drives ?1-adrenergic receptor oligomerization and signaling in cardiac myocytes. Cell Signal. 2012;24:794-802 pubmed publisher
    ..In summary, our data indicate that ?1-AR nuclear localization can drive the formation of receptor oligomers and regulate signaling in adult cardiac myocytes. ..
  9. Hye Khan M, Sattar M, Abdullah N, Johns E. Influence of combined hypertension and renal failure on functional alpha(1)-adrenoceptor subtypes in the rat kidney. Br J Pharmacol. 2008;153:1232-41 pubmed publisher
    ..In the RFSHR, other alpha(1)-adrenoceptor subtypes, for example, alpha(1B)-adrenoceptors appeared to play a greater role. ..
  10. Battaglia G, Fornai F, Busceti C, Lembo G, Nicoletti F, De Blasi A. Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003;86:413-21 pubmed
    ..Pharmacological blockade of alpha-adrenergic receptors with prazosin also protected wild-type mice against MA toxicity. These results suggests that alpha1b-ARs may play a role in the toxicity of MA on nigro-striatal DA neurons. ..
  11. Turnbull L, McCloskey D, O Connell T, Simpson P, Baker A. Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR. Am J Physiol Heart Circ Physiol. 2003;284:H1104-9 pubmed
    ..Furthermore, alpha(1)-AR inotropic responses depend critically on the experimental conditions. ..
  12. Novakova M, Myslivecek J. Identification of all alpha1-adrenoceptor subtypes in rat lung. Gen Physiol Biophys. 2005;24:349-53 pubmed
    ..We identified three subpopulations of alpha1-adrenoceptor binding sites in the rat lung (alpha1A, alpha1B and alpha1D). ..
  13. Patrão M, Queiroz D, Grossman G, Petrusz P, Lázari M, Avellar M. Cloning, expression and immunolocalization of alpha1-adrenoceptor in different tissues from rhesus monkey and human male reproductive tract. Mol Hum Reprod. 2008;14:85-96 pubmed publisher
    ..Partial nucleotide sequences for rhesus alpha(1B)-(ADRA1B) and alpha(1D)-adrenoceptor (ADRA1D) transcripts were also characterized...
  14. Zhang H, Cotecchia S, Thomas S, Tanoue A, Tsujimoto G, Faber J. Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling. Am J Physiol Heart Circ Physiol. 2004;287:H2106-14 pubmed
    ..These studies suggest that the trophic effects of catecholamines are mediated primarily by alpha1B-ARs in mouse carotid and contribute to hypertrophic growth after vascular injury. ..
  15. Burcelin R, Uldry M, Foretz M, Perrin C, Dacosta A, Nenniger Tosato M, et al. Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype. J Biol Chem. 2004;279:1108-15 pubmed
  16. Díaz Cruz A, Vilchis Landeros M, Guinzberg R, Villalobos Molina R, Piña E. NOX2 activated by ?1-adrenoceptors modulates hepatic metabolic routes stimulated by ?-adrenoceptors. Free Radic Res. 2011;45:1366-78 pubmed publisher
  17. Piascik M, Perez D. Alpha1-adrenergic receptors: new insights and directions. J Pharmacol Exp Ther. 2001;298:403-10 pubmed
    ..We also review the signaling components and aspects of its function and provide new insights into its roles in smooth muscle, growth, neurological, and cardiovascular function. ..
  18. Ogata T, Naito D, Nakanishi N, Hayashi Y, Taniguchi T, Miyagawa K, et al. MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by ?1-adrenergic receptors. Proc Natl Acad Sci U S A. 2014;111:3811-6 pubmed publisher
  19. Tripathi A, Vana P, Chavan T, Brueggemann L, Byron K, Tarasova N, et al. Heteromerization of chemokine (C-X-C motif) receptor 4 with ?1A/B-adrenergic receptors controls ?1-adrenergic receptor function. Proc Natl Acad Sci U S A. 2015;112:E1659-68 pubmed publisher
    ..Compounds targeting the ?1A/B-AR:CXCR4 interaction could provide an alternative pharmacological approach to modulate blood pressure. ..
  20. Lomasney J, Cotecchia S, Lorenz W, Leung W, Schwinn D, Yang Feng T, et al. Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. J Biol Chem. 1991;266:6365-9 pubmed
    ..This study provides definitive evidence for the existence of three alpha 1-adrenergic receptor subtypes. ..
  21. O Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, et al. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 2008;102:1378-88 pubmed publisher
    ..In contrast, alpha(1B)-adrenoceptor interacts with G(o), of which the betagamma-complex might directly inhibit the channel activity at T-tubules...
  22. Gonzalez S, Moreno Delgado D, Moreno E, Pérez Capote K, Franco R, Mallol J, et al. Circadian-related heteromerization of adrenergic and dopamine D? receptors modulates melatonin synthesis and release in the pineal gland. PLoS Biol. 2012;10:e1001347 pubmed publisher
    ..The unanticipated heteromerization between adrenergic and dopamine D? receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs...
  23. Voigt M, Kispert J, Chin H. Sequence of a rat brain cDNA encoding an alpha-1B adrenergic receptor. Nucleic Acids Res. 1990;18:1053 pubmed
  24. Pupo A, Minneman K. Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells. BMC Pharmacol. 2002;2:17 pubmed
    ..These results show that nNOS does interact with full-length alpha1A-ARs, but that this interaction is not subtype-specific and does not require the C-terminal tail, raising questions about its functional significance. ..
  25. García Sáinz J, Casas González P, Romero Avila M, Gonzalez Espinosa C. Characterization of the hepatic alpha 1B-adrenoceptors of rats, mice and hamsters. Life Sci. 1994;54:1995-2003 pubmed
    ..Total RNA obtained from the liver of these species hybridized with the alpha 1B-adrenergic cDNA probe. The data suggest that these receptors correspond to the alpha 1B subtype. ..
  26. Castrejón Sosa M, Villalobos Molina R, Guinzberg R, Piña E. Adrenaline (via alpha(1B)-adrenoceptors) and ethanol stimulate OH* radical production in isolated rat hepatocytes. Life Sci. 2002;71:2469-74 pubmed
    ..It is suggested that adrenaline increases hydroxyl radicals by an alpha(1B)-adrenoceptor-mediated mechanism, while ethanol does so by a receptor-independent mechanism. ..
  27. Xu Z, Hirasawa A, Shinoura H, Tsujimoto G. Interaction of the alpha(1B)-adrenergic receptor with gC1q-R, a multifunctional protein. J Biol Chem. 1999;274:21149-54 pubmed
    ..These observations suggest a new role for the previously identified complement regulatory molecule, gC1q-R, in regulating the cellular localization and expression of the alpha(1B)-adrenergic receptors. ..
  28. Drummond P, Dawson L, Finch P, Drummond E, Wood F, Fear M. Up-regulation of cutaneous α1-adrenoceptors after a burn. Burns. 2015;41:1227-34 pubmed publisher
    ..The heightened expression of α1-adrenoceptors in injured tissue could shape inflammatory and wound healing responses. ..
  29. Simão S, Fraga S, Jose P, Soares da Silva P. Oxidative stress and alpha1-adrenoceptor-mediated stimulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells. Br J Pharmacol. 2008;153:1445-55 pubmed publisher
  30. Pérez Rivera A, Fink G, Galligan J. Alpha-1B adrenoceptors mediate neurogenic constriction in mesenteric arteries of normotensive and DOCA-salt hypertensive mice. Auton Neurosci. 2005;121:64-73 pubmed
    ..Nerve-released NE acts primarily at alpha1B-and to a lesser extent at alpha1A-ARs in SHAM arteries whereas NE mediates neurogenic constrictions in DOCA-salt arteries by acting at alpha1B-ARs. ..
  31. Itoh M, Ishizuka B. alpha1-Adrenergic receptor in rat ovary: presence and localization. Mol Cell Endocrinol. 2005;240:58-63 pubmed
    ..Furthermore, we found that alpha(1)-AR is present in oocyte of large antral follicle, suggesting that noradrenaline acts on oocyte via this receptor. ..
  32. O Connell T, Ishizaka S, Nakamura A, Swigart P, Rodrigo M, Simpson G, et al. The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. J Clin Invest. 2003;111:1783-91 pubmed
    ..Thus, alpha(1)-ARs in male mice are required for the physiological hypertrophy of normal postnatal cardiac development and for an adaptive response to cardiac stress. ..
  33. Kang S, Kim D, Damron D, Baek K, Im M. Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. Biochem Biophys Res Commun. 2002;293:383-90 pubmed
  34. Kanasaki M, Matsubara H, Murasawa S, Masaki H, Nio Y, Inada M. cAMP responsive element-mediated regulation of the gene transcription of the alpha 1B adrenergic receptor by thyrotropin. J Clin Invest. 1994;94:2245-54 pubmed
    To elucidate the molecular mechanism of the stimulatory effect of thyrotropin on the gene regulation of alpha 1B adrenergic receptor in functioning rat thyroid (FRTL-5) cells, we established a competitive reverse-transcriptase (RT) ..
    ..The renal vasoconstrictor responses to adrenergic agonist are blunted in LVH and (αIB adrenergic receptor is functional subtype in renal vasculature in LVH. ..
  36. Liu T, Ding T, Ma Y, Wei W. Selective α1B- and α1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro. Acta Pharmacol Sin. 2014;35:1385-92 pubmed publisher
    ..NA promotes HSC-T6 cell activation, proliferation and secretion of ECM in vitro via activation of Gα-coupled α1B-AR and α1D-AR and the PKC-PI3K-AKT signaling pathway. ..
  37. Gao B, Kunos G. Isolation and characterization of the gene encoding the rat alpha 1B adrenergic receptor. Gene. 1993;131:243-7 pubmed
    Using a rat alpha 1B adrenergic receptor(AR)-encoding cDNA probe, we isolated two genomic clones from a rat liver genomic DNA library...
  38. Quesada A, Etgen A. Functional interactions between estrogen and insulin-like growth factor-I in the regulation of alpha 1B-adrenoceptors and female reproductive function. J Neurosci. 2002;22:2401-8 pubmed
    ..These events may help coordinate the timing of ovulation with the expression of sexual receptivity. ..
  39. Cahová M, Palenickova E, Papackova Z, Dankova H, Skop V, Kazdova L. Epinephrine-dependent control of glucose metabolism in white adipose tissue: the role of ?- and ?-adrenergic signalling. Exp Biol Med (Maywood). 2012;237:211-8 pubmed publisher
    ..The impairment of ?(1)-dependent, epinephrine-stimulated, glycolysis-dependent FFA esterification may contribute to the establishment of dyslipidemia in insulin resistance...
  40. Bruchas M, Toews M, Bockman C, Abel P. Characterization of the alpha1-adrenoceptor subtype activating extracellular signal-regulated kinase in submandibular gland acinar cells. Eur J Pharmacol. 2008;578:349-58 pubmed
    ..These results show only alpha(1B)-adrenoceptors activate ERK1/2 and suggest subtype-specific ERK1/2 signaling by alpha(1B)-adrenoceptors may be determined by localization to cholesterol-rich microdomains in submandibular cells. ..