Adipoq

Summary

Gene Symbol: Adipoq
Description: adiponectin, C1Q and collagen domain containing
Alias: Acdc, Acrp30, adiponectin, adipocyte complement related protein of 30 kDa
Species: rat
Products:     Adipoq

Top Publications

  1. Kloting N, Bluher M, Kloting I. The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue. Diabetes Metab Res Rev. 2006;22:146-54 pubmed
    ..Glucose metabolism, insulin sensitivity, and gene expression of key adipocyte genes, including adiponectin, interleukin 6 (Il6), 11 beta-hydroxysteroid dehydrogenase (11beta Hsd), peroxisome proliferator-activated ..
  2. Wang Y, Lam K, Chan L, Chan K, Lam J, Lam M, et al. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem. 2006;281:16391-400 pubmed
    b>Adiponectin is a multifunctional adipokine that circulates as several oligomeric complexes in the blood stream. However, the molecular basis that regulates the production of the adiponectin oligomers remains largely elusive...
  3. Archanco M, Gomez Ambrosi J, Tena Sempere M, Fruhbeck G, Burrell M. Expression of leptin and adiponectin in the rat oviduct. J Histochem Cytochem. 2007;55:1027-37 pubmed
    ..Leptin and adiponectin are two hormones originally identified in adipocytes that play a critical role not only in the control of ..
  4. Duda M, O Shea K, Lei B, Barrows B, Azimzadeh A, McElfresh T, et al. Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload. Cardiovasc Res. 2007;76:303-10 pubmed
    ..In addition, we studied the effect of omega-3 PUFA on the cardioprotective adipocyte-derived hormone adiponectin, which may alter the pro-growth serine-threonine kinase Akt...
  5. Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2002;106:2767-70 pubmed
    ..We previously reported that adiponectin, an adipocyte-specific plasma protein, accumulated in the injured artery from the plasma and suppressed ..
  6. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116:1784-92 pubmed
    b>Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue and directly sensitizes the body to insulin...
  7. Suzuki S, Wilson Kubalek E, Wert D, Tsao T, Lee D. The oligomeric structure of high molecular weight adiponectin. FEBS Lett. 2007;581:809-14 pubmed
    There is great interest in the structure of adiponectin as its oligomeric state may specify its biological activities. It occurs as a trimer, a hexamer and a high molecular weight complex...
  8. Mao D, Peng H, Li Q, Wang J, Li P, Hu K, et al. Aqueous humor and plasma adiponectin levels in proliferative diabetic retinopathy patients. Curr Eye Res. 2012;37:803-8 pubmed publisher
    To study whether aqueous humor (AH) and plasma adiponectin (APN) levels were altered in proliferative diabetic retinopathy (PDR).
  9. Luvizotto R, Síbio M, Olímpio R, Nascimento A, Lima Leopoldo A, Leopoldo A, et al. Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Horm Metab Res. 2011;43:452-7 pubmed publisher
    ..the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats...

More Information

Publications89

  1. Maruyama S, Shibata R, Ohashi K, Ohashi T, Daida H, Walsh K, et al. Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism. J Biol Chem. 2011;286:32790-800 pubmed publisher
    ..b>Adiponectin is an adipose-derived, cardioprotective factor that is down-regulated in obesity...
  2. Cabanelas A, Cordeiro A, Santos Almeida N, Monteiro de Paula G, Coelho V, Ortiga Carvalho T, et al. Effect of triiodothyronine on adiponectin expression and leptin release by white adipose tissue of normal rats. Horm Metab Res. 2010;42:254-60 pubmed publisher
    Previous studies have shown that alterations in thyroid status may lead to changes in serum leptin and adiponectin, both in humans and rodents. The mechanisms, especially for adiponectin, are unclear...
  3. Hug C, Wang J, Ahmad N, Bogan J, Tsao T, Lodish H. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A. 2004;101:10308-13 pubmed
    Acrp30/adiponectin is reduced in the serum of obese and diabetic individuals, and the genetic locus of adiponectin is linked to the metabolic syndrome...
  4. Cheng C, Lian W, Chen S, Lai P, Li H, Lan Y, et al. Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPAR?-heme oxygenase-1 signaling pathway. J Cell Physiol. 2012;227:239-49 pubmed publisher
    b>Adiponectin (APN), a circulating adipose-derived hormone that regulates inflammation and energy metabolism, has beneficial effects on the cardiovascular disorders...
  5. Phillips S, Kung J, Ciaraldi T, Choe C, Christiansen L, Mudaliar S, et al. Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans. Am J Physiol Endocrinol Metab. 2009;297:E767-73 pubmed publisher
    b>Adiponectin, an insulin-sensitizing factor secreted from adipose tissue, is decreased in individuals with type 2 diabetes (T2D) and increased in response to thiazolidinedione (TZD) therapy...
  6. Scherer P, Williams S, Fogliano M, Baldini G, Lodish H. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995;270:26746-9 pubmed
    We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation...
  7. Berg A, Combs T, Du X, Brownlee M, Scherer P. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001;7:947-53 pubmed
    b>Acrp30 is a circulating protein synthesized in adipose tissue...
  8. Kato K, Osawa H, Ochi M, Kusunoki Y, Ebisui O, Ohno K, et al. Serum total and high molecular weight adiponectin levels are correlated with the severity of diabetic retinopathy and nephropathy. Clin Endocrinol (Oxf). 2008;68:442-9 pubmed
    b>Adiponectin is secreted specifically from adipocytes, and improves insulin sensitivity. Of its isoforms, the high molecular weight (HMW) complex is thought to be the most active...
  9. Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation. 2001;103:1057-63 pubmed
    ..Recently, we discovered an adipocyte-specific plasma protein, adiponectin, that is decreased in patients with coronary artery disease...
  10. Tsao T, Tomas E, Murrey H, Hug C, Lee D, Ruderman N, et al. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem. 2003;278:50810-7 pubmed
    Acrp30/adiponectin is an adipocyte-derived serum protein with important roles in regulation of lipid and glucose metabolism, but which of its isoforms are biologically active remains controversial...
  11. Massip Salcedo M, Zaouali M, Padrissa Altés S, Casillas Ramirez A, Rodés J, Rosello Catafau J, et al. Activation of peroxisome proliferator-activated receptor-alpha inhibits the injurious effects of adiponectin in rat steatotic liver undergoing ischemia-reperfusion. Hepatology. 2008;47:461-72 pubmed
    Hepatic steatosis is a major risk factor in ischemia-reperfusion (I/R). Adiponectin acts as an antiobesity and anti-inflammatory hormone...
  12. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation. 1999;100:2473-6 pubmed
    Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity...
  13. Kaser S, Moschen A, Kaser A, Ludwiczek O, Ebenbichler C, Vogel W, et al. Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis. J Intern Med. 2005;258:274-80 pubmed
    The adipocytokine adiponectin has been proposed to play important roles in the regulation of energy homeostasis, insulin sensitivity and shows anti-inflammatory properties...
  14. van Himbergen T, Beiser A, Ai M, Seshadri S, Otokozawa S, Au R, et al. Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. Arch Neurol. 2012;69:594-600 pubmed
    To investigate the contribution of biomarkers of glucose homeostasis (adiponectin, glucose, glycated albumin, and insulin levels) and inflammation (high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A(2) levels) ..
  15. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002;8:731-7 pubmed
    Here we investigated the biological functions of adiponectin/ACRP30, a fat-derived hormone, by disrupting the gene that encodes it in mice...
  16. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation. 2000;102:1296-301 pubmed
    Among the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity...
  17. Neumeier M, Hellerbrand C, Gabele E, Buettner R, Bollheimer C, Weigert J, et al. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. World J Gastroenterol. 2006;12:5490-4 pubmed
    To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level...
  18. Chen B, Liao W, Xu N, Xu H, Wen J, Yu C, et al. Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action. Brain Res. 2009;1273:129-37 pubmed publisher
    b>Adiponectin (APN), a circulating adipose-derived hormone regulating inflammation and energy metabolism, has beneficial actions on cardio- and cerebrovascular disorders...
  19. Aragão C, Souza L, Cabanelas A, Oliveira K, Pazos Moura C. Effect of experimental hypo- and hyperthyroidism on serum adiponectin. Metabolism. 2007;56:6-11 pubmed
    b>Adiponectin, an adipocyte-derived hormone, has been shown to decrease body weight by increasing thermogenesis and lipid oxidation. Thyroid hormones have similar effects...
  20. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762-9 pubmed
    b>Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine...
  21. Guo Z, Zheng C, Qin Z, Wei P. Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats. J Pharm Pharmacol. 2011;63:87-94 pubmed publisher
    This study investigated the effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats...
  22. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood. 2000;96:1723-32 pubmed
    We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses...
  23. Sharma A, Raikwar S, Kurmi M, Srinivasan B. Gemfibrozil and its combination with metformin on pleiotropic effect on IL-10 and adiponectin and anti-atherogenic treatment in insulin resistant type 2 diabetes mellitus rats. Inflammopharmacology. 2013;21:137-45 pubmed publisher
    ..Gemfibrozil, poor anti-hyperglycemic combined with metformin, evaluated for MMP-9, IL-10 and adiponectin beyond glycemic control. IR type 2 DM induced by administering streptozotocin (90 mg/kg, i.p...
  24. Nakasone H, Binh P, Yamazaki R, Tanaka Y, Sakamoto K, Ashizawa M, et al. Association between serum high-molecular-weight adiponectin level and the severity of chronic graft-versus-host disease in allogeneic stem cell transplantation recipients. Blood. 2011;117:3469-72 pubmed publisher
    Recently, a growing body of evidence has suggested that adiponectin, which is secreted by adipose tissues, plays a critical role in obesity-related and autoimmune diseases...
  25. Peña A, Belobrajdic D, Wiltshire E, Gent R, Hirte C, Couper J. Adiponectin relates to smooth muscle function and folate in obese children. Int J Pediatr Obes. 2010;5:185-91 pubmed publisher
    b>Adiponectin, an adipocyte-specific protein, stimulates nitric oxide production and may mediate associations between visceral obesity and vascular dysfunction...
  26. Bertani S, Carboni L, Criado A, Michielin F, Mangiarini L, Vicentini E. Circadian profile of peripheral hormone levels in Sprague-Dawley rats and in common marmosets (Callithrix jacchus). In Vivo. 2010;24:827-36 pubmed
  27. Liu Y, Chewchuk S, Lavigne C, Brûlé S, Pilon G, Houde V, et al. Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment. Am J Physiol Endocrinol Metab. 2009;297:E657-64 pubmed publisher
    Endocrine effects of adipose-derived adiponectin on skeletal muscle have been shown to account, at least in part, for the anti-diabetic effects of this adipokine...
  28. Hsiao I, Lin K, Chang S, Yen T, Chen T, Yeh T. Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling. J Hepatol. 2010;52:540-9 pubmed publisher
    ..Hepatic adiponectin mRNA surged in MCD rats after PVL, whereas its receptors, AdipoR1 and AdipoR2, were paradoxically down-..
  29. Ljubic S, Boras J, Jazbec A, Lovrencic M, Vidjak V, Erzen D, et al. Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link. Clin Invest Med. 2009;32:E271-9 pubmed
    b>Adiponectin (ApN) is considered to be responsible for reduction of inflammation and is known to be included in lipid metabolism...
  30. Huh J, Seo E, Lee H, Ha H. Glucose-based peritoneal dialysis solution suppresses adiponectin synthesis through oxidative stress in an experimental model of peritoneal dialysis. Perit Dial Int. 2012;32:20-8 pubmed publisher
    ..b>Adiponectin, an adipokine commonly regarded as a negative indicator of metabolic disease, is reported to be downregulated ..
  31. Liu R, He B, Gao F, Liu Q, Yi Q. Relationship between adipokines and coronary artery aneurysm in children with Kawasaki disease. Transl Res. 2012;160:131-6 pubmed publisher
    ..Levels of leptin, adiponectin, and resistin were measured in 165 cases, including 4 groups: the control group (n = 85), KD with normal ..
  32. Wang H, Wu W, Duan J, Ma M, Kong W, Ke Y, et al. Cardioprotection of ischemic preconditioning in rats involves upregulating adiponectin. J Mol Endocrinol. 2017;58:155-165 pubmed publisher
    It has been reported that ischemic preconditioning (IPC) and adiponectin (APN) are cardioprotective in many cardiovascular disorders. However, whether APN mediates the effect of IPC on myocardial injury has not been elucidated...
  33. Lorente Cebrián S, Perez Matute P, Martinez J, Marti A, Moreno Aliaga M. Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes. J Physiol Biochem. 2006;62:61-9 pubmed
    b>Adiponectin, a hormone produced by adipocytes, is involved in glucose metabolism and insulin sensitivity. The production of this adipokine is impaired in obesity and insulin resistance...
  34. Whitehead J, Richards A, Hickman I, Macdonald G, Prins J. Adiponectin--a key adipokine in the metabolic syndrome. Diabetes Obes Metab. 2006;8:264-80 pubmed
    b>Adiponectin is a recently described adipokine that has been recognized as a key regulator of insulin sensitivity and tissue inflammation...
  35. Alim I, Fry W, Walsh M, Ferguson A. Actions of adiponectin on the excitability of subfornical organ neurons are altered by food deprivation. Brain Res. 2010;1330:72-82 pubmed publisher
    b>Adiponectin (ADP) is a peptide produced by adipose tissue, which acts as an insulin sensitizing hormone...
  36. Lihn A, Richelsen B, Pedersen S, Haugaard S, Rathje G, Madsbad S, et al. Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels. Am J Physiol Endocrinol Metab. 2003;285:E1072-80 pubmed
    ..b>Adiponectin, an adipocyte-specific protein, is thought to play an important role in regulating insulin sensitivity...
  37. Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem. 2002;277:25863-6 pubmed
    The adipocyte-derived hormone adiponectin has been proposed to play important roles in the regulation of energy homeostasis and insulin sensitivity, and it has been reported to exhibit putative antiatherogenic properties in vitro...
  38. Szkudelski T, Nogowski L, Szkudelska K. Short-term regulation of adiponectin secretion in rat adipocytes. Physiol Res. 2011;60:521-30 pubmed
    b>Adiponectin belongs to the group of biologically active substances secreted by adipocytes and referred to as adipokines...
  39. Takeshita S, Takabayashi H, Yoshida N. Circulating adiponectin levels in Kawasaki disease. Acta Paediatr. 2006;95:1312-4 pubmed
    To investigate the kinetics of adipocytokine in Kawasaki disease (KD). The plasma levels of adiponectin, IL-6 and TNF-alpha were measured in 20 patients with KD, 15 patients with acute febrile diseases (disease control, DC) and 15 ..
  40. Zhang C, Liao Y, Li Q, Chen M, Zhao Q, Deng R, et al. Recombinant adiponectin ameliorates liver ischemia reperfusion injury via activating the AMPK/eNOS pathway. PLoS ONE. 2013;8:e66382 pubmed publisher
    ..Reducing the inflammatory reaction is an effective way to achieve this goal. Notably, adiponectin (APN) was found to have anti-inflammatory activity in heart and renal I/R injury...
  41. Jenke A, Wilk S, Poller W, Eriksson U, Valaperti A, Rauch B, et al. Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury. Cardiovasc Res. 2013;99:422-31 pubmed publisher
    b>Adiponectin (APN) is an immunomodulatory and cardioprotective adipocytokine. Toll-like receptor (TLR) 4 mediates autoimmune reactions that cause myocarditis resulting in inflammation-induced cardiac injury...
  42. Li H, Feng Q, Hu Y, Chen S, Peng J, Li X, et al. [The role of adiponectin and adiponectin receptor 2 in the pathology of fatty liver]. Zhonghua Gan Zang Bing Za Zhi. 2009;17:826-30 pubmed
    To investigate the role of adiponectin (ADP) and adiponectin receptor 2 (adipoR2) in pathology of fatty liver, and to investigate the effect of Chinese herbal decoction (Qushi Huayu Decoction, QHD) on fatty liver disease...
  43. Oana F, Takeda H, Hayakawa K, Matsuzawa A, Akahane S, Isaji M, et al. Physiological difference between obese (fa/fa) Zucker rats and lean Zucker rats concerning adiponectin. Metabolism. 2005;54:995-1001 pubmed
    ..The aim of this study was to examine the physiological difference concerning adiponectin between obese (fa/fa) Zucker rats and control lean Zucker rats...
  44. Latif H, Assal H, Mahmoud M, Rasheed W. Role of serum adiponectin level in the development of liver cirrhosis in patients with hepatitis C virus. Clin Exp Med. 2011;11:123-9 pubmed publisher
    b>Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis-C-related liver disease...
  45. Zhou G, Liu B. Single nucleotide polymorphisms of metabolic syndrome-related genes in primary open angle glaucoma. Int J Ophthalmol. 2010;3:36-42 pubmed publisher
    ..C-reactive protein (CRP), ectonueleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), hepatic lipase (LIPC), adiponectin (ADIPOQ), paraoxonase 1 (PON1) and serine protease inhibitor E (SERPINE1) genes in POAG (n=37) and normal ..
  46. Altomonte J, Harbaran S, Richter A, Dong H. Fat depot-specific expression of adiponectin is impaired in Zucker fatty rats. Metabolism. 2003;52:958-63 pubmed
    ..We have studied the relative expression of adiponectin in visceral versus subcutaneous fat in Zucker fatty versus lean rats...
  47. Fry M, Smith P, Hoyda T, Duncan M, Ahima R, Sharkey K, et al. Area postrema neurons are modulated by the adipocyte hormone adiponectin. J Neurosci. 2006;26:9695-702 pubmed
    b>Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension...
  48. Qian Y, Xue Y, Li J, Zhu B, Pan Y, Zhang Y. [Effect of Liuweidihuang pills in preventing diabetes mellitus in OLETF rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:21-4 pubmed
    ..At 8, 32 and 40 weeks, the rats were sacrificed and the expression level of adiponectin mRNA in the adipose tissue was detected using RT-PCR...
  49. El Mesallamy H, Hamdy N, Salman T, Mahmoud S. Adiponectin and E-selectin concentrations in relation to inflammation in obese type 2 diabetic patients with coronary heart disease(s). Minerva Endocrinol. 2011;36:163-70 pubmed
    ..and atherogenesis, however, some of them have a protective role against vascular inflammation and/or IR; namely adiponectin and nitric oxide (NO). Adiponectin is a fat derived hormone, which enhances insulin sensitivity...
  50. Selthofer Relatić K, Radić R, Vcev A, Steiner R, Vizjak V, Sram M, et al. Low adiponectin serum level--reduced protective effect on the left ventricular wall thickness. Coll Antropol. 2011;35:787-91 pubmed
    b>Adiponectin, secreted by fat tissue, is down - regulated in obesity and may be involved in obesity-related disorders. It has anti-inflammatory, antiatherosclerotic and antidiabetic effect...
  51. Wang Y, Zhang J, Zhang L, Gao P, Wu X. Adiponectin attenuates high glucose-induced apoptosis through the AMPK/p38 MAPK signaling pathway in NRK-52E cells. PLoS ONE. 2017;12:e0178215 pubmed publisher
    ..Recent evidence suggests that adiponectin (ADPN) protects cells from high glucose induced apoptosis...
  52. Song H, Chan J, Rovin B. Induction of chemokine expression by adiponectin in vitro is isoform dependent. Transl Res. 2009;154:18-26 pubmed publisher
    b>Adiponectin is reported to have both proinflammatory and anti-inflammatory effects...
  53. Tsujimura Y, Matsutani T, Matsuda A, Kutsukake M, Uchida E, Sasajima K, et al. Effects of pioglitazone on survival and omental adipocyte function in mice with sepsis induced by cecal ligation and puncture. J Surg Res. 2011;171:e215-21 pubmed publisher
    ..Serum and omental tissue were collected before, 24, and 48 h after CLP. Serum levels of adiponectin, cytokine, and chemokine were measured with ELISA...
  54. Li Z, Woo J, Chung S, Kwon M, Choi J, Oh H, et al. Therapeutic effect of topical adiponectin in a mouse model of desiccating stress-induced dry eye. Invest Ophthalmol Vis Sci. 2013;54:155-62 pubmed publisher
    To investigate the therapeutic effect of topical adiponectin in a mouse model of experimental dry eye (EDE). EDE was created by desiccating stress in 6- to 8-week old female C57BL/6 mice. Eye drops consisting of 0.0001%, 0.001%, or 0...
  55. Jadhav A, Ndisang J. Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism. Free Radic Biol Med. 2012;53:2277-86 pubmed publisher
    ..These were associated with reduced glycemia, increased insulin, and the insulin-sensitizing protein adiponectin, with corresponding reduction in insulin resistance...
  56. Durazzo M, Niro G, Premoli A, Morello E, Rizzotto E, Gambino R, et al. Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression?. J Gastroenterol. 2009;44:476-82 pubmed publisher
    ..There is some evidence suggesting a link between adiponectin-biliary function and liver disease...
  57. Phan J, Hickey M, Zhang P, Chesselet M, Reue K. Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models. Hum Mol Genet. 2009;18:1006-16 pubmed publisher
    ..In addition, HD mice exhibit reduced levels of leptin and adiponectin, adipose tissue-derived hormones that regulate food intake and glucose metabolism...
  58. Arsenescu V, Narasimhan M, Halide T, Bressan R, Barisione C, Cohen D, et al. Adiponectin and plant-derived mammalian adiponectin homolog exert a protective effect in murine colitis. Dig Dis Sci. 2011;56:2818-32 pubmed publisher
    ..Mesenteric fat hypertrophy and low adiponectin have been described in patients with Crohn's disease...
  59. Jiang Z, Zhou J, Zhou D, Zhu Z, Sun L, Nanji A. The adiponectin-SIRT1-AMPK pathway in alcoholic fatty liver disease in the rat. Alcohol Clin Exp Res. 2015;39:424-33 pubmed publisher
    ..In this study, we used the rat model to investigate the role of adiponectin (Adip), sirtuin 1 (SIRT1), AMPK, and lipin 1 (LIP 1) signaling, a central controlling pathway of lipid ..
  60. Yan Z, Yang Z, Chen F. [Effect of electroacupuncture intervention on blood-lipid, high-sensitivity C-reactive protein and adiponectin levels in hyperlipidemia rats]. Zhen Ci Yan Jiu. 2013;38:365-8, 385 pubmed
    ..ST 36) and "Zhongwan" (CV 12) on blood-lipid, high-sensitivity C-reactive protein (HS-CRP) and adiponectin (ADPN) levels in hyperlipidemia rats, so as to study its mechanisms underlying improvement of hyperlipidemia...
  61. Naderali E, Fatani S, Telles M, Hunter L. The effects of physiological and pharmacological weight loss on adiponectin and leptin mRNA levels in the rat epididymal adipose tissue. Eur J Pharmacol. 2008;579:433-8 pubmed
    ..with obesity, diabetes and coronary artery disease, circulating levels of leptin increased while that of adiponectin is decreased...
  62. Yamaguchi M, Nakagawa T. Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression. Int J Mol Med. 2007;20:323-8 pubmed
    ..b>Adiponectin mRNA levels were not significantly changed in the adipose tissues of 50-week-old regucalcin TG rats, while the ..
  63. Inoue T, Takemori K, Yamamoto K, Ito H. Characterization of Wistar-Kyoto rats showing hyperadiponectinemia. Life Sci. 2010;86:344-50 pubmed publisher
    Wistar-Kyoto rats (HA-WKY) kept in the author's laboratory showed higher levels of serum adiponectin (approximately 4-fold) compared with Wistar-Kyoto/Izm rats (WKY/Izm), a WKY standard strain, at 6weeks old...
  64. Sedova L, Seda O, Kazdova L, Chylíková B, Hamet P, Tremblay J, et al. Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndrome. Am J Physiol Endocrinol Metab. 2007;292:E1318-24 pubmed
    ..On the other hand, their adiponectin concentrations were significantly higher, and insulin sensitivity of skeletal muscle was enhanced compared with ..
  65. Bairwa S, Rajapurohitam V, Gan X, Mangat R, Proctor S, Karmazyn M. Cardiomyocyte Antihypertrophic Effect of Adipose Tissue Conditioned Medium from Rats and Its Abrogation by Obesity is Mediated by the Leptin to Adiponectin Ratio. PLoS ONE. 2016;11:e0145992 pubmed publisher
    ..manner, an effect enhanced by the leptin receptor antagonist and attenuated by an antibody against the adiponectin AdipoR1 receptor...
  66. Takano H, Obata J, Kodama Y, Kitta Y, Nakamura T, Mende A, et al. Adiponectin is released from the heart in patients with heart failure. Int J Cardiol. 2009;132:221-6 pubmed publisher
    Plasma levels of adiponectin are decreased in patients with ischemic heart disease, but increased in patients with heart failure (HF). The source of increased adiponectin levels in patients with HF remains unknown...
  67. Li R, Xu M, Wang X, Wang Y, Lau W, Yuan Y, et al. Reduced vascular responsiveness to adiponectin in hyperlipidemic rats--mechanisms and significance. J Mol Cell Cardiol. 2010;49:508-15 pubmed publisher
    Deficiency of adiponectin (APN), an adipocyte-derived vascular protective molecule, contributes to diabetic vascular injury...
  68. Baldasseroni S, Mannucci E, Orso F, Di Serio C, Pratesi A, Bartoli N, et al. Adiponectin in outpatients with coronary artery disease: independent predictors and relationship with heart failure. Nutr Metab Cardiovasc Dis. 2012;22:292-9 pubmed publisher
    ..A role of metabolic derangement in the pathophysiology of HF has been recently reported. Adiponectin, an adipose-tissue-derived cytokine, seems to play an important role in cardiac dysfunction...
  69. Ebina K, Oshima K, Matsuda M, Fukuhara A, Maeda K, Kihara S, et al. Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice. Biochem Biophys Res Commun. 2009;378:186-91 pubmed publisher
    b>Adiponectin (APN) is a hormone released by adipose tissue with anti-inflammatory properties. The purpose of this study was to examine the therapeutic effects of systemic delivery of APN in murine arthritis model...
  70. Mullen K, Pritchard J, Ritchie I, Snook L, Chabowski A, Bonen A, et al. Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats. Am J Physiol Regul Integr Comp Physiol. 2009;296:R243-51 pubmed publisher
    ..b>Adiponectin (Ad) is an insulin-sensitizing adipokine known to stimulate skeletal muscle FA oxidation and reduce lipid ..
  71. Cammisotto P, Bendayan M. Adiponectin stimulates phosphorylation of AMP-activated protein kinase alpha in renal glomeruli. J Mol Histol. 2008;39:579-84 pubmed publisher
    b>Adiponectin receptor ADIPOR1 activates the intracellular second messenger AMP-activated protein kinase (AMPK) that participates in the control of the oxidative stress and apoptosis...
  72. Wang H. Preventive effects of ophiopogon-polysaccharide on apiponectin in gestational diabetes mellitus rat. Asian Pac J Trop Med. 2013;6:296-9 pubmed publisher
    To investigate the effect of ophiopogon-polysaccharide on adiponectin (APN) in gestational diabetic mellitus rat. The model of gestational diabetes mellitus rat were established with streptozotocin by intraperitoneal injection...
  73. Wang Y, Huang T, Liang H, Su T, Chen S, Wang T. Fasting serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury. Arch Phys Med Rehabil. 2005;86:1964-8 pubmed
    To measure serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury (SCI) and to investigate possible correlations between these serum levels and various factors, such as body mass index (BMI), age, injury level, ..
  74. Ribot J, Rodriguez A, Rodriguez E, Palou A. Adiponectin and resistin response in the onset of obesity in male and female rats. Obesity (Silver Spring). 2008;16:723-30 pubmed publisher
    Studying the sex-dependent response of adiponectin and resistin adipose tissue expression and circulating levels in the onset of dietary obesity...
  75. Guebre Egziabher F, Bernhard J, Funahashi T, Hadj Aissa A, Fouque D. Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. Nephrol Dial Transplant. 2005;20:129-34 pubmed
    b>Adiponectin, a newly discovered collagen-like protein of the collectin family exclusively produced by adipocytes, possesses anti-inflammatory properties...
  76. Ma K, Cabrero A, Saha P, Kojima H, Li L, Chang B, et al. Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002;277:34658-61 pubmed
    Previous reports showed that recombinant fragments of adiponectin (adipo) displayed pharmacological effects when injected into rodents, but the relevance of these observations to the physiological function of adipo is unclear...
  77. Lee E, Warmann G, Dhir R, Ahima R. Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. J Neurosci. 2011;31:14361-6 pubmed publisher
    ..b>Adiponectin is secreted by adipose tissue and acts in the brain and peripheral organs to regulate glucose and lipid ..
  78. Marousi S, Theodorou G, Karakantza M, Papathanasopoulos P, Ellul J. Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role. Acta Neurol Scand. 2010;121:277-84 pubmed publisher
    Past ischemic stroke (IS) patients display suppressed adiponectin (ADPN) levels a few months after disease onset...
  79. Liu J, Shen Y, Liu X, Zhang H, Wu H, Yin M. [Effects of telmisartan on nonalcoholic steatohepatitis rat model by activating peroxisome proliferator-activated receptor r]. Zhonghua Gan Zang Bing Za Zhi. 2011;19:614-8 pubmed publisher
    ..glucose(FBG), fasting insulin(FINS), HOMA-IR(homeostasis model assessment insulin resistance), Serum TNF-a and adiponectin were detected and analyzed...
  80. Wang J, Ma S, Tao R, Xia L, Liu L, Jiang Y. Gene expression profile changes in rat dorsal horn after sciatic nerve injury. Neurol Res. 2017;39:176-182 pubmed publisher
    ..Among the five genes, the first three are specific in adult population, while the latter two are age-independent. They all might function through involvement of these immune or inflammatory pathways. ..