Gene Symbol: Adgrb1
Description: adhesion G protein-coupled receptor B1
Alias: Bai1, adhesion G protein-coupled receptor B1, brain-specific angiogenesis inhibitor 1
Species: rat
Products:     Adgrb1

Top Publications

  1. Kaur B, Brat D, Devi N, Van Meir E. Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor. Oncogene. 2005;24:3632-42 pubmed
    Brain angiogenesis inhibitor 1 (BAI1) is a transmembrane protein with unknown function expressed primarily in normal but not tumoral brain...
  2. Park D, Tosello Trampont A, Elliott M, Lu M, Haney L, Ma Z, et al. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007;450:430-4 pubmed
    ..Here we identify brain-specific angiogenesis inhibitor 1 (BAI1) as a receptor upstream of ELMO and as a receptor that can bind phosphatidylserine on apoptotic cells...
  3. Kaur B, Cork S, Sandberg E, Devi N, Zhang Z, Klenotic P, et al. Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. Cancer Res. 2009;69:1212-20 pubmed publisher
    ..Little is known about how this process is specifically regulated in the brain. Brain angiogenesis inhibitor-1 (BAI1) is a brain-predominant seven-transmembrane protein that contains five antiangiogenic thrombospondin type-1 repeats ..
  4. Das S, Owen K, Ly K, Park D, Black S, Wilson J, et al. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011;108:2136-41 pubmed publisher
    ..Brain angiogenesis inhibitor 1 (BAI1) is a receptor that recognizes apoptotic cells through its conserved type I thrombospondin repeats and triggers ..
  5. Sokolowski J, Nobles S, Heffron D, Park D, Ravichandran K, Mandell J. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun. 2011;25:915-21 pubmed publisher
    Brain-specific angiogenesis inhibitor-1 (BAI1) is a transmembrane protein highly expressed in normal brain that has been ascribed two apparently distinct functions: inhibition of angiogenesis and recognition and engulfment of apoptotic ..
  6. Cork S, Kaur B, Devi N, Cooper L, Saltz J, Sandberg E, et al. A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40?kDa vasculostatin from tumor suppressor BAI1. Oncogene. 2012;31:5144-52 pubmed publisher
    Brain-specific angiogenesis inhibitor 1 (BAI1), an orphan G protein-coupled receptor-type seven transmembrane protein, was recently found mutated or silenced in multiple human cancers and can interfere with tumor growth when overexpressed...
  7. Duman J, Tzeng C, Tu Y, Munjal T, Schwechter B, Ho T, et al. The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013;33:6964-78 pubmed publisher
    ..Here, we identify brain-specific angiogenesis inhibitor 1 (BAI1) as a synaptic adhesion GPCR that is required for spinogenesis and synaptogenesis in mice and rats...
  8. Hochreiter Hufford A, Lee C, Kinchen J, Sokolowski J, Arandjelovic S, Call J, et al. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013;497:263-7 pubmed publisher
    ..Here we report an unexpected discovery that the membrane protein BAI1, previously linked to recognition of apoptotic cells by phagocytes, promotes myoblast fusion...
  9. Stephenson J, Paavola K, Schaefer S, Kaur B, Van Meir E, Hall R. Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density. J Biol Chem. 2013;288:22248-56 pubmed publisher
    Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties...

More Information


  1. Das S, Sarkar A, Ryan K, Fox S, Berger A, Juncadella I, et al. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014;28:2214-24 pubmed publisher
    ..In this study, we assessed the expression and function of brain angiogenesis inhibitor 1 (BAI1) in the engulfment of apoptotic GECs using human tissue and cells. After induction of apoptosis by H...
  2. Zhu D, Li C, Swanson A, Villalba R, Guo J, Zhang Z, et al. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015;125:1497-508 pubmed publisher
    ..Here, we demonstrated that mice lacking brain-specific angiogenesis inhibitor 1 (BAI1) have severe deficits in hippocampus-dependent spatial learning and memory that are accompanied by enhanced long-..
  3. Billings E, Lee C, Owen K, D Souza R, Ravichandran K, Casanova J. The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Sci Signal. 2016;9:ra14 pubmed publisher
    ..We previously characterized brain-specific angiogenesis inhibitor 1 (BAI1), a member of the adhesion family of G protein (heterotrimeric guanine nucleotide-binding protein)-coupled ..