Adcyap1

Summary

Gene Symbol: Adcyap1
Description: adenylate cyclase activating polypeptide 1
Alias: Pacap, pituitary adenylate cyclase-activating polypeptide, adenylate cyclase activating polypeptide 1 (pituitary), pituitary adenylate cyclase activating polypeptide 1, pituitary adenylate cyclase-activating polypeptide precursor (Pacap)
Species: rat
Products:     Adcyap1

Top Publications

  1. Kalamatianos T, Kallo I, Piggins H, Coen C. Expression of VIP and/or PACAP receptor mRNA in peptide synthesizing cells within the suprachiasmatic nucleus of the rat and in its efferent target sites. J Comp Neurol. 2004;475:19-35 pubmed
    ..and PAC(1), receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP), play critical roles in maintaining and entraining circadian rhythms...
  2. Das M, Vihlen C, Legradi G. Hypothalamic and brainstem sources of pituitary adenylate cyclase-activating polypeptide nerve fibers innervating the hypothalamic paraventricular nucleus in the rat. J Comp Neurol. 2007;500:761-76 pubmed
    ..and magnocellular PVN neurons are richly innervated by pituitary adenylate cyclase-activating polypeptide (PACAP) axons...
  3. Ajpru S, McArthur A, Piggins H, Sugden D. Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 2002;105:29-37 pubmed
    The pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in the photic resetting of the rodent circadian clock in the suprachiasmatic nucleus (SCN)...
  4. Pettersson L, Dahlin L, Danielsen N. Changes in expression of PACAP in rat sensory neurons in response to sciatic nerve compression. Eur J Neurosci. 2004;20:1838-48 pubmed
    In the present study, expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in rat dorsal root ganglion (DRG) neurons and sciatic nerve following experimental sciatic nerve compression was studied with the use of ..
  5. Hurley J, Gardiner J, Jones P, Bloom S. Cloning and molecular characterization of complementary deoxyribonucleic acid corresponding to a novel form of pituitary adenylate cyclase-activating polypeptide messenger ribonucleic acid in the rat testis. Endocrinology. 1995;136:550-7 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide that greatly stimulates adenylyl cyclase activity in cultured anterior pituitary cells, was isolated from ovine hypothalamus in 1989...
  6. Pettersson L, Heine T, Verge V, Sundler F, Danielsen N. PACAP mRNA is expressed in rat spinal cord neurons. J Comp Neurol. 2004;471:85-96 pubmed
    This study examines the expression of pituitary adenylate cyclase activating polypeptide (PACAP) mRNA in the rat spinal cord during normal conditions and in response to sciatic nerve transection...
  7. Yaka R, He D, Phamluong K, Ron D. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003;278:9630-8 pubmed
    ..We identified the neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP(1-38)), as a ligand that induced phosphorylation of NR2B and enhanced NMDA receptor ..
  8. Legradi G, Hannibal J, Lechan R. Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat. Neurosci Lett. 1998;246:145-8 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in many regions of the hypothalamus including the paraventricular nucleus (PVN)...
  9. Oride A, Kanasaki H, Mijiddorj T, Sukhbaatar U, Yamada T, Kyo S. Expression and Regulation of Pituitary Adenylate Cyclase-Activating Polypeptide in Rat Placental Cells. Reprod Sci. 2016;23:1080-6 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) was first identified as a hypophysiotropic factor that regulates pituitary cell functions and has been subsequently shown to be widely distributed and have multiple functions...
  10. Ahnaou A, Yon L, Arluison M, Vaudry H, Hannibal J, Hamon M, et al. Immunocytochemical distribution of VIP and PACAP in the rat brain stem: implications for REM sleep physiology. Ann N Y Acad Sci. 2006;1070:135-42 pubmed
    Recent evidence indicates that pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) might play an important role in rapid eye movement sleep (REMS) generation at the pontine level in rats...

Detail Information

Publications62

  1. Kalamatianos T, Kallo I, Piggins H, Coen C. Expression of VIP and/or PACAP receptor mRNA in peptide synthesizing cells within the suprachiasmatic nucleus of the rat and in its efferent target sites. J Comp Neurol. 2004;475:19-35 pubmed
    ..and PAC(1), receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP), play critical roles in maintaining and entraining circadian rhythms...
  2. Das M, Vihlen C, Legradi G. Hypothalamic and brainstem sources of pituitary adenylate cyclase-activating polypeptide nerve fibers innervating the hypothalamic paraventricular nucleus in the rat. J Comp Neurol. 2007;500:761-76 pubmed
    ..and magnocellular PVN neurons are richly innervated by pituitary adenylate cyclase-activating polypeptide (PACAP) axons...
  3. Ajpru S, McArthur A, Piggins H, Sugden D. Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 2002;105:29-37 pubmed
    The pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in the photic resetting of the rodent circadian clock in the suprachiasmatic nucleus (SCN)...
  4. Pettersson L, Dahlin L, Danielsen N. Changes in expression of PACAP in rat sensory neurons in response to sciatic nerve compression. Eur J Neurosci. 2004;20:1838-48 pubmed
    In the present study, expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in rat dorsal root ganglion (DRG) neurons and sciatic nerve following experimental sciatic nerve compression was studied with the use of ..
  5. Hurley J, Gardiner J, Jones P, Bloom S. Cloning and molecular characterization of complementary deoxyribonucleic acid corresponding to a novel form of pituitary adenylate cyclase-activating polypeptide messenger ribonucleic acid in the rat testis. Endocrinology. 1995;136:550-7 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide that greatly stimulates adenylyl cyclase activity in cultured anterior pituitary cells, was isolated from ovine hypothalamus in 1989...
  6. Pettersson L, Heine T, Verge V, Sundler F, Danielsen N. PACAP mRNA is expressed in rat spinal cord neurons. J Comp Neurol. 2004;471:85-96 pubmed
    This study examines the expression of pituitary adenylate cyclase activating polypeptide (PACAP) mRNA in the rat spinal cord during normal conditions and in response to sciatic nerve transection...
  7. Yaka R, He D, Phamluong K, Ron D. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003;278:9630-8 pubmed
    ..We identified the neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP(1-38)), as a ligand that induced phosphorylation of NR2B and enhanced NMDA receptor ..
  8. Legradi G, Hannibal J, Lechan R. Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat. Neurosci Lett. 1998;246:145-8 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in many regions of the hypothalamus including the paraventricular nucleus (PVN)...
  9. Oride A, Kanasaki H, Mijiddorj T, Sukhbaatar U, Yamada T, Kyo S. Expression and Regulation of Pituitary Adenylate Cyclase-Activating Polypeptide in Rat Placental Cells. Reprod Sci. 2016;23:1080-6 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) was first identified as a hypophysiotropic factor that regulates pituitary cell functions and has been subsequently shown to be widely distributed and have multiple functions...
  10. Ahnaou A, Yon L, Arluison M, Vaudry H, Hannibal J, Hamon M, et al. Immunocytochemical distribution of VIP and PACAP in the rat brain stem: implications for REM sleep physiology. Ann N Y Acad Sci. 2006;1070:135-42 pubmed
    Recent evidence indicates that pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) might play an important role in rapid eye movement sleep (REMS) generation at the pontine level in rats...
  11. Fila T, Trazzi S, Crochemore C, Bartesaghi R, Ciani E. Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation. J Biol Chem. 2009;284:15325-38 pubmed publisher
    ..cells with a time course matching the expression of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor, a neuropeptide receptor that plays an important role in the regulation of granule cell proliferation/..
  12. Durr K, Norsted E, Gömüç B, Suarez E, Hannibal J, Meister B. Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) defines a subpopulation of hypothalamic POMC neurons. Brain Res. 2007;1186:203-11 pubmed
    Several lines of evidence support a role for pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of energy balance...
  13. Hegg C, Au E, Roskams A, Lucero M. PACAP is present in the olfactory system and evokes calcium transients in olfactory receptor neurons. J Neurophysiol. 2003;90:2711-9 pubmed
    Pituitary adenylate cyclase activating peptide (PACAP), a neuroregulatory peptide, is found in germinative regions of the CNS, including the olfactory bulb, throughout adulthood...
  14. Riek Burchardt M, Kolodziej A, Henrich Noack P, Reymann K, Hollt V, Stumm R. Differential regulation of CXCL12 and PACAP mRNA expression after focal and global ischemia. Neuropharmacology. 2010;58:199-207 pubmed publisher
    Pituitary adenylate cyclase activating peptide (PACAP) and the chemokine stromal cell-derived factor (SDF-1) have been implicated in neuroprotection, neurogenesis, and regeneration...
  15. Kiss P, Reglodi D, Tamas A, Lubics A, Lengvari I, Jozsa R, et al. Changes of PACAP levels in the brain show gender differences following short-term water and food deprivation. Gen Comp Endocrinol. 2007;152:225-30 pubmed
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide exerting diverse actions in the central and peripheral nervous systems...
  16. King S, Lezak K, O Reilly M, Toufexis D, Falls W, BRAAS K, et al. The Effects of Prior Stress on Anxiety-Like Responding to Intra-BNST Pituitary Adenylate Cyclase Activating Polypeptide in Male and Female Rats. Neuropsychopharmacology. 2017;42:1679-1687 pubmed publisher
    ..In male rodents, chronic variate stress (CVS) has been shown to increase BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate PAC1 receptor transcript, and BNST PACAP signaling may mediate the ..
  17. Aubert N, Falluel Morel A, Vaudry D, Xifro X, Rodriguez Alvarez J, Fisch C, et al. PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression. J Neurochem. 2006;99:1237-50 pubmed
    The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) inhibits C2-ceramide-induced cell death through blockade of the mitochondrial apoptotic pathway in rat cerebellar granule neurones...
  18. Szabo E, Nemeskeri A, Heinzlmann A, Suzuki N, Arimura A, Koves K. Cell immunoblot assay study demonstrating the release of PACAP from individual anterior pituitary cells of rats and the effect of PACAP on LH release. Regul Pept. 2002;109:75-81 pubmed
    The presence of pituitary adenylate cyclase activating polypeptide (PACAP) was previously demonstrated in the anterior pituitary by radioimmunoassay, immunohistochemistry, and reverse transcript-polymerase chain reaction (RT-PCR)...
  19. Tominaga A, Sugawara H, Inoue K, Miyata A. Implication of pituitary adenylate cyclase-activating polypeptide (PACAP) for neuroprotection of nicotinic acetylcholine receptor signaling in PC12 cells. J Mol Neurosci. 2008;36:73-8 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) functions as a neurotrophic factor through PAC1-R, PACAP-specific receptor, in the central nervous system...
  20. Chen W, Tzeng S. Pituitary adenylate cyclase-activating polypeptide prevents cell death in the spinal cord with traumatic injury. Neurosci Lett. 2005;384:117-21 pubmed
    Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a potent factor in the regulation of neurotransmission, neuroprotection, neurogenesis and anti-inflammation...
  21. Lakk M, Szabó B, Volgyi B, Gabriel R, Denes V. Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina. Invest Ophthalmol Vis Sci. 2012;53:7825-32 pubmed publisher
    The ubiquitous pituitary adenylate cyclase-activating peptide (PACAP) has a disparate array of functions in development (e.g., proliferation and apoptosis)...
  22. Missig G, Roman C, Vizzard M, Braas K, Hammack S, May V. Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: implication for the sensory and behavioral effects of pain. Neuropharmacology. 2014;86:38-48 pubmed publisher
    ..represents a convergence of pathways for pain, stress and emotion, and we have identified pituitary adenylate cyclase activating polypeptide (PACAP) immunoreactivity in fiber elements in the lateral capsular division of the CeA (CeLC)..
  23. Han X, Ran Y, Su M, Liu Y, Tang W, Dong Z, et al. Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats. Mol Pain. 2017;13:1744806917720361 pubmed publisher
    ..The selective increase in pituitary adenylate cyclase-activating polypeptide-related receptors suggests that the PAC1 receptor pathway is a novel target for the treatment of migraine. ..
  24. Baeres F, Møller M, Martin F, Baeres M. Origin of PACAP-immunoreactive nerve fibers innervating the subarachnoidal blood vessels of the rat brain. J Cereb Blood Flow Metab. 2004;24:628-35 pubmed
    ..g. pituitary adenylatecyclase activating polypeptide (PACAP)...
  25. Abad C, Martinez C, Leceta J, Juarranz M, Delgado M, Gomariz R. Pituitary adenylate-cyclase-activating polypeptide expression in the immune system. Neuroimmunomodulation. 2002;10:177-86 pubmed
    Although pituitary adenylate-cyclase-activating polypeptide (PACAP) is a multifunctional and pleiotropic neuropeptide with many different immunomodulatory properties, investigations of its source in lymphoid organs are scarce...
  26. Reglodi D, Tamas A, Lengvari I, Toth G, Szalontay L, Lubics A. Comparative study of the effects of PACAP in young, aging, and castrated males in a rat model of Parkinson's disease. Ann N Y Acad Sci. 2006;1070:518-24 pubmed
    We have previously shown that PACAP ameliorates the neurological symptoms and reduces the dopaminergic cell loss in young male rats, in a 6-hydroxydopamine (6-OHDA)-induced lesion of the substantia nigra, a model of Parkinson's disease...
  27. Toda A, Huganir R. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Proc Natl Acad Sci U S A. 2015;112:6712-7 pubmed publisher
    ..Although numerous studies have reported that the neuropeptide pituitary adenylate cyclase activating polypeptide 38 (PACAP38) alters hippocampal CA1 synaptic strength and GluA1 synaptic localization, its ..
  28. Papka R, Workley M, Usip S, Mowa C, Fahrenkrug J. Expression of pituitary adenylate cyclase activating peptide in the uterine cervix, lumbosacral dorsal root ganglia and spinal cord of rats during pregnancy. Peptides. 2006;27:743-52 pubmed
    ..undertaken to determine the expression pattern of the neuropeptide pituitary adenylate cyclase activating peptide (PACAP) in the cervix and its nerves during pregnancy and the influence of estrogen on this expression using ..
  29. Zvara P, Braas K, May V, Vizzard M. A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord injury (SCI). Ann N Y Acad Sci. 2006;1070:622-8 pubmed
    ..b>PACAP may contribute to detrusor hyperreflexia induced by SCI and PACAP antagonists may be a novel approach to reduce ..
  30. Csati A, Tajti J, Kuris A, Tuka B, Edvinsson L, Warfvinge K. Distribution of vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, nitric oxide synthase, and their receptors in human and rat sphenopalatine ganglion. Neuroscience. 2012;202:158-68 pubmed publisher
    ..used for the demonstration of vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating peptide (PACAP), nitric oxide synthase (NOS), glutamine synthetase (GS), glial fibrillary acidic protein (GFAP), VIP and PACAP ..
  31. Shieh P, Tsao C, Li J, Wu H, Wen Y, Kou D, et al. Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes. Neurosci Lett. 2008;434:1-5 pubmed publisher
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) is introduced as a neurotrophic factor to promote cell survival...
  32. Tanida M, Shintani N, Hashimoto H. The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide. Neurosci Res. 2011;70:55-61 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a peptidergic neurotransmitter that is highly expressed in the nervous system...
  33. Njaine B, Martins R, Santiago M, Linden R, Silveira M. Pituitary adenylyl cyclase-activating polypeptide controls the proliferation of retinal progenitor cells through downregulation of cyclin D1. Eur J Neurosci. 2010;32:311-21 pubmed publisher
    ..Previously, we showed that pituitary adenylyl cyclase-activating polypeptide (PACAP) exerts a neuroprotective effect in the developing retina of rats, through the cAMP-cAMP-dependent protein kinase (..
  34. Gaylinn B, Harrison J, Zysk J, Lyons C, Lynch K, Thorner M. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Mol Endocrinol. 1993;7:77-84 pubmed
    ..A specific GHRH antagonist blocked both binding and second messenger response. Northern analysis indicated that GHRH-R mRNA was most abundant in extracts of pituitary and was not detected in other tissues. ..
  35. Abu Hamdan M, Drescher M, Ramakrishnan N, Khan K, Toma V, Hatfield J, et al. Pituitary adenylyl cyclase-activating polypeptide (PACAP) and its receptor (PAC1-R) in the cochlea: evidence for specific transcript expression of PAC1-R splice variants in rat microdissected cochlear subfractions. Neuroscience. 2006;140:147-61 pubmed
    Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a neuropeptide originally isolated from the hypothalamus, named for its high potency in stimulating adenylyl cyclase in pituitary cells...
  36. Legradi G, Das M, Giunta B, Hirani K, Mitchell E, Diamond D. Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Neural Plast. 2007;2007:79102 pubmed
    High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) nerve fibers are present in the central nucleus of amygdala (CeA), a brain region implicated in the control of fear-related behavior...
  37. Jozsa R, Nemeth J, Tamas A, Hollosy T, Lubics A, Jakab B, et al. Short-term fasting differentially alters PACAP and VIP levels in the brains of rat and chicken. Ann N Y Acad Sci. 2006;1070:354-8 pubmed
    The present article investigated the levels of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) in the brains of rats and chickens 12, 36, and 84 h after starvation...
  38. Botia B, Jolivel V, Burel D, Le Joncour V, Roy V, Naassila M, et al. Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum. Neurotox Res. 2011;19:423-34 pubmed publisher
    ..The neuropeptide Pituitary adenylate cyclase-activating polypeptide (PACAP) has previously been shown to prevent the death of cultured neurons in vitro...
  39. Costa L, Santangelo F, Li Volsi G, Ciranna L. Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus. Hippocampus. 2009;19:99-109 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384)...
  40. Chen Y, Zhou Z, Yan W, Wang Z, Gao H, Zheng X. [Effects of analogs of pituitary adenylate cyclase activating polypeptide on acute pancreatitis in rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005;36:64-8 pubmed
    To examine the effects of analogs of pituitary adenylate cyclase activating polypeptide (PACAP)--PACAP6-27 (10, 100 microg/kg) and (4-Cl-D-Phe6, Leu17)VIP (10, 100 microg/kg) on the pancreata of normal rats and on the development of ..
  41. Nguyen T, Heintz G, Wolfe M. Structural characterization of PACAP receptors on rat liver plasma membranes. Am J Physiol. 1993;265:G811-8 pubmed
    Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and PACAP-27 are recently characterized hypothalamic peptides with marked homology with vasoactive intestinal peptide (VIP), which are concentrated in the innervation of ..
  42. Lee F, Rajagopal R, Kim A, Chang P, Chao M. Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. J Biol Chem. 2002;277:9096-102 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide that acts through G protein-coupled receptors, exerts neuroprotective effects upon many neuronal populations...
  43. Kántor O, Heinzlmann A, Suzuki N, Vincze E, Kocsis K, Koves K. Distribution of PACAP and its mRNA in several nonneural tissues of rats demonstrated by sandwich enzyme immunoassay and RT-PCR technique. Regul Pept. 2002;109:103-5 pubmed
    The presence of PACAP in various organs was previously demonstrated using immunohistochemistry and radioimmunoassay...
  44. Engelund A, Fahrenkrug J, Harrison A, Hannibal J. Vesicular glutamate transporter 2 (VGLUT2) is co-stored with PACAP in projections from the rat melanopsin-containing retinal ganglion cells. Cell Tissue Res. 2010;340:243-55 pubmed publisher
    ..have been identified in ipRGCs, glutamate and pituitary adenylate cyclase-activating polypeptide (PACAP). To date, little is known about their release and interplay...
  45. Wang G, Qi C, Fan G, Zhou H, Chen S. PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone. FEBS Lett. 2005;579:4005-11 pubmed
    In vivo and in vitro studies have suggested a neuroprotective role for Pituitary adenylate cyclase activating polypeptide (PACAP) against neuronal insults...
  46. Sandor K, Bölcskei K, McDougall J, Schuelert N, Reglodi D, Elekes K, et al. Divergent peripheral effects of pituitary adenylate cyclase-activating polypeptide-38 on nociception in rats and mice. Pain. 2009;141:143-50 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and its receptors have been shown in the spinal dorsal horn, on capsaicin-sensitive sensory neurons and inflammatory cells...
  47. Koh P, Won C, Ho J. Ethanol decreases the expression of pituitary adenylate cyclase activating polypeptide in rat testes. J Vet Med Sci. 2006;68:635-7 pubmed
    The present study was designed to evaluate the effect of ethanol on pituitary adenylate cyclase activating polypeptide (PACAP) expression in adult rat testes. Ethanol (3 g/kg i.p...
  48. Moore J, Villafuerte B, Unick C, Winters S. Developmental changes in pituitary adenylate cyclase activating polypeptide expression during the perinatal period: possible role in fetal gonadotroph regulation. Endocrinology. 2009;150:4802-9 pubmed publisher
    ..b>Pituitary adenylate cyclase activating polypeptide (PACAP) can differentially regulate the gonadotropins in vitro by stimulating alpha-subunit ..
  49. Bourgault S, Vaudry D, Botia B, Couvineau A, Laburthe M, Vaudry H, et al. Novel stable PACAP analogs with potent activity towards the PAC1 receptor. Peptides. 2008;29:919-32 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38- or 27-amino acid neuropeptide with promising therapeutic applications for the treatment of several pathophysiological states related to neurodegenerative diseases...
  50. Nicot A, Lelievre V, Tam J, Waschek J, Dicicco Bloom E. Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation. J Neurosci. 2002;22:9244-54 pubmed
    ..In the embryo, pituitary adenylate cyclase-activating polypeptide (PACAP) receptor 1 (PAC1) signaling regulates neural precursor proliferation...
  51. Møller M, Baeres F. PACAP-containing intrapineal nerve fibers originate predominantly in the trigeminal ganglion: a combined retrograde tracing- and immunohistochemical study of the rat. Brain Res. 2003;984:160-9 pubmed
    Pituitary adenylate-cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated from the hypothalamus and located in many neuronal systems in both the central and peripheral nervous system...
  52. Salehi A, Qader S, Ekblad E, Ekelund M. Defective insulin secretion during total parenteral nutrition in rat and its normalization by pituitary adenylate cyclase-activating polypeptide 27. Regul Pept. 2004;119:83-91 pubmed
    ..The data suggest that the defective nutrient-stimulated insulin secretion seen after long-term TPN treatment could be normalized by agents stimulating cAMP production possibly through cAMP/PK A-pathway. ..
  53. Sharma N, Marzo S, Jones K, Foecking E. Electrical stimulation and testosterone differentially enhance expression of regeneration-associated genes. Exp Neurol. 2010;223:183-91 pubmed publisher
    ..protein (GAP-43), brain derived neurotrophic factor (BDNF), pituitary adenylate cyclase-activating peptide (PACAP), and neuritin (candidate plasticity-related gene 15)...
  54. Boni L, Ploug K, Olesen J, Jansen Olesen I, Gupta S. The in vivo effect of VIP, PACAP-38 and PACAP-27 and mRNA expression of their receptors in rat middle meningeal artery. Cephalalgia. 2009;29:837-47 pubmed publisher
    ..molecules including vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP), which subsequently stimulate VPAC(1), VPAC(2) and PAC(1) receptors...
  55. Ohnishi T, Okuda Ashitaka E, Matsumura S, Katano T, Nishizawa M, Ito S. Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP. J Neurochem. 2008;105:2271-85 pubmed publisher
    ..We recently demonstrated that pituitary adenylate cyclase activating polypeptide (PACAP) and NMDA synergistically caused the translocation of nNOS to the membrane and ..
  56. Lv C, Cheng D, Zhao W, Zhu H. Pituitary adenylate cyclase-activating polypeptide mRNA expression in rat testis and epididymis during postnatal development and experimental cryptorchidism. Mol Med Rep. 2011;4:793-8 pubmed publisher
    In the present study, the expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA was investigated in rat testis and epididymis during postnatal development and experimental cryptorchidism using reverse ..
  57. Schmidt S, Myskiw J, Furini C, Schmidt B, Cavalcante L, Izquierdo I. PACAP modulates the consolidation and extinction of the contextual fear conditioning through NMDA receptors. Neurobiol Learn Mem. 2015;118:120-4 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) has a broad spectrum of biological functions including neurotransmitter, neurotrophic and neuroprotective...
  58. Horvath G, Racz B, Reglodi D, Kovacs K, Kiss P, Gallyas F, et al. Effects of PACAP on mitochondrial apoptotic pathways and cytokine expression in rats subjected to renal ischemia/reperfusion. J Mol Neurosci. 2010;42:411-8 pubmed publisher
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with highly efficient cytoprotective actions. Its neuroprotective effects are well-known, but PACAP is able to exert similar actions in non-neuronal cells...
  59. Sun C, Song D, Davis Taber R, Barrett L, Scott V, Richardson P, et al. Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. Proc Natl Acad Sci U S A. 2007;104:7875-80 pubmed
    The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G protein-coupled receptor that contributes to many different cellular functions including neurotransmission, neuronal survival, and synaptic ..
  60. Tomimoto S, Hashimoto H, Shintani N, Yamamoto K, Kawabata Y, Hamagami K, et al. Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice. J Pharmacol Exp Ther. 2004;309:796-803 pubmed
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is an intraislet neuropeptide and shares insulinotropic and insulin-sensitizing properties with glucagon-like peptide-1 (GLP-1); however, the pathophysiological significance of ..
  61. Bik W, Wolinska Witort E, Pawlak J, Skwarlo Sonta K, Chmielowska M, Martynska L, et al. PACAP 38 as a modulator of immune and endocrine responses during LPS-induced acute inflammation in rats. J Neuroimmunol. 2006;177:76-84 pubmed
    The effect of PACAP 38 administration on neuroendocrine and immune parameters was examined in rats with LPS-induced peritonitis...
  62. Gasz B, Racz B, Roth E, Borsiczky B, Ferencz A, Tamas A, et al. Pituitary adenylate cyclase activating polypeptide protects cardiomyocytes against oxidative stress-induced apoptosis. Peptides. 2006;27:87-94 pubmed
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) has well-known neuroprotective effects, and one of the main factors leading to neuroprotection seems to be its anti-apoptotic effects...