Adcyap1

Summary

Gene Symbol: Adcyap1
Description: adenylate cyclase activating polypeptide 1
Alias: Pacap, pituitary adenylate cyclase-activating polypeptide, adenylate cyclase activating polypeptide 1 (pituitary), pituitary adenylate cyclase activating polypeptide 1, pituitary adenylate cyclase-activating polypeptide precursor (Pacap)
Species: rat

Top Publications

  1. ncbi Expression of VIP and/or PACAP receptor mRNA in peptide synthesizing cells within the suprachiasmatic nucleus of the rat and in its efferent target sites
    Theodosis Kalamatianos
    Centre for Neuroscience Research, King s College, London SE1 1UL, United Kingdom
    J Comp Neurol 475:19-35. 2004
  2. ncbi Cloning and molecular characterization of complementary deoxyribonucleic acid corresponding to a novel form of pituitary adenylate cyclase-activating polypeptide messenger ribonucleic acid in the rat testis
    J D Hurley
    Department of Medicine, Royal Postgraduate Medical School, London, United Kingdom
    Endocrinology 136:550-7. 1995
  3. ncbi Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat
    G Legradi
    Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine, New England Medical Center and Tupper Research Institute, Boston, MA, USA
    Neurosci Lett 246:145-8. 1998
  4. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    J Biol Chem 278:9630-8. 2003
  5. ncbi PACAP mRNA is expressed in rat spinal cord neurons
    Lina M E Pettersson
    Department of Physiological Sciences, Section for Neuroendocrine Cell Biology, Lund University, SE 221 84 Lund, Sweden
    J Comp Neurol 471:85-96. 2004
  6. ncbi Changes in expression of PACAP in rat sensory neurons in response to sciatic nerve compression
    L M E Pettersson
    Department of Physiological Sciences, Section for Neuroendocrine Cell Biology, BMC F10, Lund University, SE 221 84 Lund, Sweden
    Eur J Neurosci 20:1838-48. 2004
  7. pmc Hypothalamic and brainstem sources of pituitary adenylate cyclase-activating polypeptide nerve fibers innervating the hypothalamic paraventricular nucleus in the rat
    Mahasweta Das
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Comp Neurol 500:761-76. 2007
  8. ncbi Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus
    Supaporn Ajpru
    Endocrinology and Reproduction Research Group, GKT School of Biomedical Sciences, Kings College London, London SE1 1UL, UK
    Brain Res Mol Brain Res 105:29-37. 2002
  9. ncbi Structural characterization of PACAP receptors on rat liver plasma membranes
    T D Nguyen
    Division of Gastroenterology, Duke University, Medical Center, Durham, North Carolina
    Am J Physiol 265:G811-8. 1993
  10. ncbi Pituitary adenylate cyclase-activating polypeptide prevents cell death in the spinal cord with traumatic injury
    Wen Hsin Chen
    Department of Life Sciences, National Cheng Kung University, 1 Ta Hsueh Road, Tainan 70101, Taiwan
    Neurosci Lett 384:117-21. 2005

Research Grants

Scientific Experts

Detail Information

Publications113 found, 100 shown here

  1. ncbi Expression of VIP and/or PACAP receptor mRNA in peptide synthesizing cells within the suprachiasmatic nucleus of the rat and in its efferent target sites
    Theodosis Kalamatianos
    Centre for Neuroscience Research, King s College, London SE1 1UL, United Kingdom
    J Comp Neurol 475:19-35. 2004
    ..and PAC(1), receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP), play critical roles in maintaining and entraining circadian rhythms...
  2. ncbi Cloning and molecular characterization of complementary deoxyribonucleic acid corresponding to a novel form of pituitary adenylate cyclase-activating polypeptide messenger ribonucleic acid in the rat testis
    J D Hurley
    Department of Medicine, Royal Postgraduate Medical School, London, United Kingdom
    Endocrinology 136:550-7. 1995
    Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide that greatly stimulates adenylyl cyclase activity in cultured anterior pituitary cells, was isolated from ovine hypothalamus in 1989...
  3. ncbi Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat
    G Legradi
    Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine, New England Medical Center and Tupper Research Institute, Boston, MA, USA
    Neurosci Lett 246:145-8. 1998
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in many regions of the hypothalamus including the paraventricular nucleus (PVN)...
  4. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    J Biol Chem 278:9630-8. 2003
    ..We identified the neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP(1-38)), as a ligand that induced phosphorylation of NR2B and enhanced NMDA receptor ..
  5. ncbi PACAP mRNA is expressed in rat spinal cord neurons
    Lina M E Pettersson
    Department of Physiological Sciences, Section for Neuroendocrine Cell Biology, Lund University, SE 221 84 Lund, Sweden
    J Comp Neurol 471:85-96. 2004
    This study examines the expression of pituitary adenylate cyclase activating polypeptide (PACAP) mRNA in the rat spinal cord during normal conditions and in response to sciatic nerve transection...
  6. ncbi Changes in expression of PACAP in rat sensory neurons in response to sciatic nerve compression
    L M E Pettersson
    Department of Physiological Sciences, Section for Neuroendocrine Cell Biology, BMC F10, Lund University, SE 221 84 Lund, Sweden
    Eur J Neurosci 20:1838-48. 2004
    In the present study, expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in rat dorsal root ganglion (DRG) neurons and sciatic nerve following experimental sciatic nerve compression was studied with the use of ..
  7. pmc Hypothalamic and brainstem sources of pituitary adenylate cyclase-activating polypeptide nerve fibers innervating the hypothalamic paraventricular nucleus in the rat
    Mahasweta Das
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Comp Neurol 500:761-76. 2007
    ..and magnocellular PVN neurons are richly innervated by pituitary adenylate cyclase-activating polypeptide (PACAP) axons...
  8. ncbi Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus
    Supaporn Ajpru
    Endocrinology and Reproduction Research Group, GKT School of Biomedical Sciences, Kings College London, London SE1 1UL, UK
    Brain Res Mol Brain Res 105:29-37. 2002
    The pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in the photic resetting of the rodent circadian clock in the suprachiasmatic nucleus (SCN)...
  9. ncbi Structural characterization of PACAP receptors on rat liver plasma membranes
    T D Nguyen
    Division of Gastroenterology, Duke University, Medical Center, Durham, North Carolina
    Am J Physiol 265:G811-8. 1993
    Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and PACAP-27 are recently characterized hypothalamic peptides with marked homology with vasoactive intestinal peptide (VIP), which are concentrated in the innervation of ..
  10. ncbi Pituitary adenylate cyclase-activating polypeptide prevents cell death in the spinal cord with traumatic injury
    Wen Hsin Chen
    Department of Life Sciences, National Cheng Kung University, 1 Ta Hsueh Road, Tainan 70101, Taiwan
    Neurosci Lett 384:117-21. 2005
    Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a potent factor in the regulation of neurotransmission, neuroprotection, neurogenesis and anti-inflammation...
  11. ncbi Pituitary adenylate cyclase activating polypeptide messenger RNA in the paraventricular nucleus and anterior pituitary during the rat estrous cycle
    Joseph P Moore
    Division of Endocrinology and Metabolism, Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Biol Reprod 73:491-9. 2005
    The neuropeptide pituitary adenylate cyclase activating polypeptide (ADCYAP 1, or PACAP) has been demonstrated to enhance gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulate gonadotropin subunit gene ..
  12. ncbi Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) defines a subpopulation of hypothalamic POMC neurons
    Katrin Durr
    Department of Neuroscience, Retzius vag 8, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1186:203-11. 2007
    Several lines of evidence support a role for pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of energy balance...
  13. pmc Regulation of spinal dynorphin 1-17 release by endogenous pituitary adenylyl cyclase-activating polypeptide in the male rat: relevance of excitation via disinhibition
    Nai Jiang Liu
    Department of Biochemistry, State University of New York Downstate Medical Center, Brooklyn, New York, USA
    J Pharmacol Exp Ther 336:328-35. 2011
    ..we studied the functional and anatomical relationships between pituitary adenylyl cyclase-activating polypeptide (PACAP) and dynorphin 1-17 (Dyn) in spinal cord...
  14. doi Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP
    Emilie Raoult
    Inserm U982, DC2N, Mont Saint Aignan, France
    J Neurochem 119:920-31. 2011
    Pituitary adenylate cyclase-activating polypeptide (PACAP) and tissue plasminogen activator (tPA) play important roles in neuronal migration and survival...
  15. doi Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide promote the genesis of calcium currents in differentiating mouse embryonic stem cells
    M Chafai
    Inserm U982, IFRMP23, University of Rouen, 76821 Mont Saint Aignan, France
    Neuroscience 199:103-15. 2011
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) are known to be implicated early during ontogenesis in cell ..
  16. doi Distribution of vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, nitric oxide synthase, and their receptors in human and rat sphenopalatine ganglion
    A Csati
    Department of Neurology, University of Szeged, Szeged, Hungary
    Neuroscience 202:158-68. 2012
    ..used for the demonstration of vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating peptide (PACAP), nitric oxide synthase (NOS), glutamine synthetase (GS), glial fibrillary acidic protein (GFAP), VIP and PACAP ..
  17. doi The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway
    Fabrizio Gardoni
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Cell Sci 125:1401-6. 2012
    ....
  18. pmc Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor κB (NF-κB) pathway: involvement of extracellular signal-regulated kinase (ERK), calcium, and c-REL
    Destiny Love Manecka
    INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, 76821 Mont Saint Aignan, France
    J Biol Chem 288:14936-48. 2013
    The pituitary adenylate cyclase-activating polypeptide (PACAP) is a trophic factor that promotes neuronal survival and neurite outgrowth...
  19. pmc Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: implication for the sensory and behavioral effects of pain
    Galen Missig
    Department of Neurological Sciences, University of Vermont College of Medicine, 149 Beaumont Avenue, Burlington, VT 05405, USA
    Neuropharmacology 86:38-48. 2014
    ..represents a convergence of pathways for pain, stress and emotion, and we have identified pituitary adenylate cyclase activating polypeptide (PACAP) immunoreactivity in fiber elements in the lateral capsular division of the CeA (CeLC)..
  20. doi The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation
    Marta Jozwiak-Bebenista
    Department of Pharmacology and Toxicology, The Interfaculty Chair of Basic and Clinical Pharmacology, Medical University of Lodz, Łódź, Poland Electronic address
    Pharmacol Rep 67:332-8. 2015
    Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are endogenous peptides, widely expressed in the central and peripheral nervous system...
  21. pmc Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)
    H Hashimoto
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University Medical School, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 98:13355-60. 2001
    Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably during evolution and is widely expressed in the mammalian brain...
  22. ncbi Distribution of PACAP and its mRNA in several nonneural tissues of rats demonstrated by sandwich enzyme immunoassay and RT-PCR technique
    Orsolya Kántor
    Department of Human Morphology and Developmental Biology, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    Regul Pept 109:103-5. 2002
    The presence of PACAP in various organs was previously demonstrated using immunohistochemistry and radioimmunoassay...
  23. pmc Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus
    Stephan Michel
    Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Neurosci 7:15. 2006
    ..of retinal ganglion cells that contain both glutamate and pituitary adenylyl cyclase activating peptide (PACAP)...
  24. ncbi Postinjury administration of pituitary adenylate cyclase activating polypeptide (PACAP) attenuates traumatically induced axonal injury in rats
    Andrea Tamas
    Department of Anatomy Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, University of Pecs, Medical Faculty, Pecs, Hungary
    J Neurotrauma 23:686-95. 2006
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) has several different actions in the nervous system. Numerous studies have shown its neuroprotective effects both in vitro and in vivo...
  25. ncbi A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord injury (SCI)
    Peter Zvara
    University of Vermont College of Medicine, Department of Neurology, D411 Given Building, Burlington, VT 05405, USA
    Ann N Y Acad Sci 1070:622-8. 2006
    ..b>PACAP may contribute to detrusor hyperreflexia induced by SCI and PACAP antagonists may be a novel approach to reduce ..
  26. doi Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    FEBS J 275:5542-51. 2008
    ..could attenuate streptozotocin cytotoxicity, and especially pituitary adenylate cyclase-activating polypeptide (PACAP), at a concentration of 10(-7) M, exhibited 34% attenuation of lactate dehydrogenase release from streptozotocin-..
  27. doi Vesicular glutamate transporter 2 (VGLUT2) is co-stored with PACAP in projections from the rat melanopsin-containing retinal ganglion cells
    Anna Engelund
    Department of Clinical Biochemistry, Bispebjerg Hospital, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, DK 2400, Copenhagen, Denmark
    Cell Tissue Res 340:243-55. 2010
    ..have been identified in ipRGCs, glutamate and pituitary adenylate cyclase-activating polypeptide (PACAP). To date, little is known about their release and interplay...
  28. doi The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide
    Mamoru Tanida
    Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1 1 1 Nojihigashi, Kusatsu, Shiga 525 8577, Japan
    Neurosci Res 70:55-61. 2011
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a peptidergic neurotransmitter that is highly expressed in the nervous system...
  29. doi Peripheral and central alterations of pituitary adenylate cyclase activating polypeptide-like immunoreactivity in the rat in response to activation of the trigeminovascular system
    Bernadett Tuka
    Department of Neurology, Faculty of Medicine, University of Szeged, H 6725 Szeged, Semmelweis u 6, Hungary
    Peptides 33:307-16. 2012
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) is present in the cranial arteries and trigeminal sensory neurons...
  30. ncbi Involvement of PACAP/ADNP signaling in the resistance to cell death in malignant peripheral nerve sheath tumor (MPNST) cells
    Alessandro Castorina
    Department of Bio Medical Sciences, University of Catania, Via S Sofia 87, 95123, Catania, Italy
    J Mol Neurosci 48:674-83. 2012
    ..Both pituitary adenylate cyclase-activating polypeptide (PACAP) and activity-dependent neuroprotective protein (ADNP) have glioprotective potential...
  31. ncbi Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat
    Z Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Hungary
    Peptides 28:1847-55. 2007
    Inhibitory actions of pituitary adenylate cyclase activating polypeptide (PACAP) have been described on cellular/vascular inflammatory components, but there are few data concerning its role in neurogenic inflammation...
  32. ncbi PACAP stimulates the release of interleukin-6 in cultured rat Müller cells
    T Seki
    Ophthalmology, Kozawa Eye Hospital Eye Research Center, 2 2 11 Gokencho, Mito, Ibaraki 310 0063, Japan
    Ann N Y Acad Sci 1070:535-9. 2006
    We have investigated the in vivo effect of PACAP on rat Müller cells that are the predominant glial element in the retina...
  33. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the oxygen sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK-like K+ current
    Fenglian Xu
    Department of Pharmacology and Center for Neurosciences, 9 70 Medical Science Building, University of Alberta, Edmonton, Alberta, Canada
    J Neurochem 101:1284-93. 2007
    Pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice are prone to sudden neonatal death and have reduced respiratory response to hypoxia...
  34. pmc Interferon-gamma produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells
    Johanna Mäkelä
    Minerva Medical Research Institute, Biomedicum 2 Helsinki, Helsinki, Finland
    PLoS ONE 5:e11091. 2010
    ..of putative factors for rescue showed that the neuropeptide, Pituitary adenylate cyclase-activating polypeptide (PACAP) increased cell viability, the levels of p-Bad and reduced caspase-3 activation in the NPCs...
  35. doi Pituitary adenylyl cyclase-activating polypeptide controls the proliferation of retinal progenitor cells through downregulation of cyclin D1
    Brian Njaine
    Instituto de Biofisica Carlos Chagas Filho UFRJ, Edifício do Centro de Ciencias da Saude, Ilha do Fundao, Rio de Janeiro, Brazil
    Eur J Neurosci 32:311-21. 2010
    ..Previously, we showed that pituitary adenylyl cyclase-activating polypeptide (PACAP) exerts a neuroprotective effect in the developing retina of rats, through the cAMP-cAMP-dependent protein kinase (..
  36. ncbi [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]
    Wei Zhao
    Department of Physiology, Harbin Medical University, Harbin 150086, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 26:313-7. 2010
    To investigate the expression changes and regulation of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in corpus luteum during pregnancy.
  37. pmc Age-related decrease in cerebrovascular-derived neuroprotective proteins: effect of acetaminophen
    Debjani Tripathy
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Microvasc Res 84:278-85. 2012
    ..factor (VEGF), pigment epithelium-derived factor (PEDF), and pituitary adenylate cyclase activating peptide (PACAP) are important for maintaining neuronal viability, especially in the face of injury and disease...
  38. doi Upregulation of pituitary adenylate cyclase activating polypeptide and its receptor expression in the rat carotid body in chronic and intermittent hypoxia
    S Y Lam
    Department of Physiology, University of Hong Kong, Pokfulam, Hong Kong, China
    Adv Exp Med Biol 758:301-6. 2012
    ..b>Pituitary adenylate cyclase activating polypeptide (PACAP) is involved in the regulation of respiratory chemoresponse...
  39. doi Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina
    Mónika Lakk
    Department of Experimental Zoology and Neurobiology, University of Pecs, Pecs, Hungary
    Invest Ophthalmol Vis Sci 53:7825-32. 2012
    The ubiquitous pituitary adenylate cyclase-activating peptide (PACAP) has a disparate array of functions in development (e.g., proliferation and apoptosis)...
  40. ncbi Molecular cloning and characterization of cDNA for the precursor of rat pituitary adenylate cyclase activating polypeptide (PACAP)
    K Ogi
    Tsukuba Research Laboratories, Takeda Chemical Industries Ltd, Ibaraki, Japan
    Biochem Biophys Res Commun 173:1271-9. 1990
    We have isolated and cloned a cDNA for rat pituitary adenylate cyclase activating polypeptide (PACAP) precursor protein from the brain...
  41. ncbi Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells
    A Miyata
    U S Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, LA 70037
    Biochem Biophys Res Commun 164:567-74. 1989
    ..Whether these hypophysiotropic effects are the primary actions of the peptide or what physiological action in the pituitary is linked with the stimulation of adenylate cyclase by this peptide remains to be determined...
  42. ncbi The augmentation of pituitary adenylate cyclase-activating polypeptide (PACAP) in streptozotocin-induced diabetic rats
    H Tamakawa
    National Cardiovascular Center Research Institute, Suita City, Osaka, Japan
    Peptides 19:1497-502. 1998
    b>Pituitary adenylate cyclase activating polypeptide (PACAP), which was isolated from ovine hypothalamic extract, has been shown to have a physiological role in the regulation of insulin or islet functions...
  43. ncbi Pituitary adenylate cyclase-activating polypeptide gene expression regulated by a testis-specific promoter in germ cells during spermatogenesis
    P B Daniel
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, and Harvard Medical School, Boston 02114, USA
    Endocrinology 141:1218-27. 2000
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the glucagon-related family of hormones that is widely expressed in various tissues...
  44. ncbi Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons
    Marcel Miampamba
    CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System and Department of Medicine, University of California, Los Angeles, 90073, USA
    Regul Pept 105:145-54. 2002
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to regulate gastric acid secretion and intestinal motility...
  45. ncbi Pituitary adenylate cyclase activating polypeptide regulates the basal production of nitric oxide in PC12 cells
    Satomi Onoue
    Health Science Division, Itoham Foods Inc, 1 2, Kubogaoka, Moriya, Ibaraki 302 0104, Japan
    Life Sci 71:205-14. 2002
    Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP), two members of the VIP/secretin/glucagon family, modulate neurotransmission via stimulation of protein kinases including cAMP-dependent ..
  46. ncbi Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor
    Min Sung Kim
    Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan 680 749, South Korea
    J Biol Chem 277:36863-71. 2002
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is an important hypophysiotrophic factor as well as a regulator for immune, reproductive, and neural tissues...
  47. ncbi Cell immunoblot assay study demonstrating the release of PACAP from individual anterior pituitary cells of rats and the effect of PACAP on LH release
    E Szabo
    Department of Human Morphology and Developmental Biology, Faculty of Medicine, Semmelweis University, Tuzolto u 58, H 1094, Budapest, Hungary
    Regul Pept 109:75-81. 2002
    The presence of pituitary adenylate cyclase activating polypeptide (PACAP) was previously demonstrated in the anterior pituitary by radioimmunoassay, immunohistochemistry, and reverse transcript-polymerase chain reaction (RT-PCR)...
  48. ncbi Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation
    Arnaud Nicot
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 22:9244-54. 2002
    ..In the embryo, pituitary adenylate cyclase-activating polypeptide (PACAP) receptor 1 (PAC1) signaling regulates neural precursor proliferation...
  49. ncbi PC12 cells as a model to study the neurotrophic activities of PACAP
    David Vaudry
    Section on Molecular Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 971:491-6. 2002
  50. ncbi Pituitary adenylate-cyclase-activating polypeptide expression in the immune system
    Catalina Abad
    Department of Cellular Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Neuroimmunomodulation 10:177-86. 2002
    Although pituitary adenylate-cyclase-activating polypeptide (PACAP) is a multifunctional and pleiotropic neuropeptide with many different immunomodulatory properties, investigations of its source in lymphoid organs are scarce...
  51. ncbi Pituitary adenylate cyclase-activating polypeptide-immunoreactive nerve fibers in rat and human tooth pulps
    H Ichikawa
    Department of Oral Function and Anatomy, and Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 980:288-92. 2003
    The distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) was examined in the tooth pulp...
  52. ncbi PACAP-containing intrapineal nerve fibers originate predominantly in the trigeminal ganglion: a combined retrograde tracing- and immunohistochemical study of the rat
    M Møller
    Institute of Medical Anatomy, Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200, Copenhagen, Denmark
    Brain Res 984:160-9. 2003
    Pituitary adenylate-cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated from the hypothalamus and located in many neuronal systems in both the central and peripheral nervous system...
  53. ncbi Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice
    Shuhei Tomimoto
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    J Pharmacol Exp Ther 309:796-803. 2004
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is an intraislet neuropeptide and shares insulinotropic and insulin-sensitizing properties with glucagon-like peptide-1 (GLP-1); however, the pathophysiological significance of ..
  54. ncbi Defective insulin secretion during total parenteral nutrition in rat and its normalization by pituitary adenylate cyclase-activating polypeptide 27
    Albert Salehi
    Department of Physiological Sciences, Division of Pharmacology, University of Lund, BMC F13, S 221 84 Lund, Sweden
    Regul Pept 119:83-91. 2004
    ..The data suggest that the defective nutrient-stimulated insulin secretion seen after long-term TPN treatment could be normalized by agents stimulating cAMP production possibly through cAMP/PK A-pathway...
  55. ncbi Origin of PACAP-immunoreactive nerve fibers innervating the subarachnoidal blood vessels of the rat brain
    Florian Martin Moesgaard Baeres
    Institute of Medical Anatomy, University of Copenhagen, Denmark
    J Cereb Blood Flow Metab 24:628-35. 2004
    ..g. pituitary adenylatecyclase activating polypeptide (PACAP)...
  56. ncbi Activity-dependent transcriptional activation and mRNA stabilization for cumulative expression of pituitary adenylate cyclase-activating polypeptide mRNA controlled by calcium and cAMP signals in neurons
    Mamoru Fukuchi
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 931 0194, Japan
    J Biol Chem 279:47856-65. 2004
    ..The expression of pituitary adenylate cyclase activating polypeptide (PACAP), a neuropeptide, is controlled by Ca(2+) signals evoked via membrane depolarization ..
  57. pmc Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats
    You Dai Chen
    Instistute of Digestive Surgery Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:538-44. 2005
    Pituitary adenylate cyclase activating-peptide (PACAP) is a late member of the secretin/glucagon/vasoactive intestinal peptide (VIP) family of brain-gut peptides...
  58. ncbi [Effects of analogs of pituitary adenylate cyclase activating polypeptide on acute pancreatitis in rats]
    You Dai Chen
    Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 36:64-8. 2005
    To examine the effects of analogs of pituitary adenylate cyclase activating polypeptide (PACAP)--PACAP6-27 (10, 100 microg/kg) and (4-Cl-D-Phe6, Leu17)VIP (10, 100 microg/kg) on the pancreata of normal rats and on the development of ..
  59. ncbi Pituitary adenylyl cyclase-activating polypeptide 38 reduces astroglial proliferation by inhibiting the GTPase RhoA
    Dieter K Meyer
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Zentrum für Neurowissenschaften, Albert Ludwigs Universitat, D 79104 Freiburg, Germany
    J Biol Chem 280:25258-66. 2005
    ..In contrast, expression of constitutively active RhoA prevented the effect of PACAP38. Our data show a novel signal transduction pathway by which the neuropeptide influences cell proliferation...
  60. ncbi PAC1 receptors mediate pituitary adenylate cyclase-activating polypeptide- and progesterone-facilitated receptivity in female rats
    Ede Marie Apostolakis
    Department of Molecular and Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 19:2798-811. 2005
    Pituitary adenylate cyclase-activating polypeptide (PACAP) acts as a feed-forward, paracrine/autocrine factor in the hypothalamic ventromedial nucleus (VMN) for receptivity and sensitizes pituitary hormone release for ovulation...
  61. ncbi PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    FEBS Lett 579:4005-11. 2005
    In vivo and in vitro studies have suggested a neuroprotective role for Pituitary adenylate cyclase activating polypeptide (PACAP) against neuronal insults...
  62. ncbi Pituitary adenylate cyclase activating polypeptide protects cardiomyocytes against oxidative stress-induced apoptosis
    B Gasz
    Department of Surgical Research and Techniques, Medical Faculty, Pecs University, Hungary
    Peptides 27:87-94. 2006
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) has well-known neuroprotective effects, and one of the main factors leading to neuroprotection seems to be its anti-apoptotic effects...
  63. ncbi Pituitary adenylate cyclase-activating polypeptide neurons of the ventromedial hypothalamus project to the midbrain central gray
    Fumihiko Maekawa
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi, Japan
    Neuroreport 17:221-4. 2006
    The pituitary adenylate cyclase-activating polypeptide (PACAP) and brain-derived neurotrophic factor (BDNF) neurons have recently been established as markers of the ventromedial hypothalamic nucleus (VMH)...
  64. ncbi PACAP--a multifacetted neuropeptide
    Jan Fahrenkrug
    Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Copenhagen, NV, Denmark
    Chronobiol Int 23:53-61. 2006
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) was originally isolated from ovine hypothalamus based on its ability to stimulate cAMP production in pituitary cell cultures...
  65. ncbi Ethanol decreases the expression of pituitary adenylate cyclase activating polypeptide in rat testes
    Phil Ok Koh
    Department of Anatomy, College of Veterinary Medicine, Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju, South Korea
    J Vet Med Sci 68:635-7. 2006
    The present study was designed to evaluate the effect of ethanol on pituitary adenylate cyclase activating polypeptide (PACAP) expression in adult rat testes. Ethanol (3 g/kg i.p...
  66. ncbi Pituitary adenylyl cyclase-activating polypeptide (PACAP) and its receptor (PAC1-R) are positioned to modulate afferent signaling in the cochlea
    M J Drescher
    Laboratory of Bio Otology, Department of Otolaryngology, Wayne State University School of Medicine, 261 Lande Medical Research Building, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Neuroscience 142:139-64. 2006
    Pituitary adenylyl cyclase-activating polypeptide (PACAP), via its specific receptor pituitary adenylyl cyclase-activating polypeptide receptor 1 (PAC1-R), is known to have roles in neuromodulation and neuroprotection associated with ..
  67. ncbi Immunocytochemical distribution of VIP and PACAP in the rat brain stem: implications for REM sleep physiology
    Abdel Ahnaou
    Stanford University, Department of Biological Sciences, 371 Serra Mall, Stanford, CA 94305 5020, USA
    Ann N Y Acad Sci 1070:135-42. 2006
    Recent evidence indicates that pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) might play an important role in rapid eye movement sleep (REMS) generation at the pontine level in rats...
  68. ncbi Search for the optimal monosodium glutamate treatment schedule to study the neuroprotective effects of PACAP in the retina
    Norbert Babai
    Department of Experimental Zoology and Neurobiology, University of Pecs, 7624 Pecs, Hungary
    Ann N Y Acad Sci 1070:149-55. 2006
    We have previously shown the protective effects of pituitary adenylate cyclaseactivating polypeptide (PACAP) in monosodium glutamate (MSG)-induced retinal degeneration...
  69. ncbi Changes in PACAP levels in the central nervous system after ovariectomy and castration
    Jozsef Nemeth
    Department of Anatomy, University of Pecs, 7624 Pecs, Szigeti u 12 Hungary
    Ann N Y Acad Sci 1070:468-73. 2006
    ..article was to investigate the influence of gonadectomy on pituitary adenylate cyclase-activating polypeptide (PACAP) levels in different brain areas...
  70. ncbi Growth factor-dependent actions of PACAP on oligodendrocyte progenitor proliferation
    Vincent Lelievre
    David Geffen School of Medicine, Department of Psychiatry, Semel Institute for Neuroscience and Mental Retardation Research Center, University of California, Los Angeles 90095, USA
    Regul Pept 137:58-66. 2006
    ..rat oligodendrocyte progenitors (OLP) express receptors for the pituitary adenylyl cyclase-activating peptide (PACAP) in vivo and in vitro...
  71. ncbi PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression
    Nicolas Aubert
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, University of Rouen, Mont Saint Aignan, France
    J Neurochem 99:1237-50. 2006
    The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) inhibits C2-ceramide-induced cell death through blockade of the mitochondrial apoptotic pathway in rat cerebellar granule neurones...
  72. ncbi Bone morphogenetic protein down-regulation of neuronal pituitary adenylate cyclase-activating polypeptide and reciprocal effects on vasoactive intestinal peptide expression
    Kristen A Pavelock
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Neurochem 100:603-16. 2007
    ..factor beta superfamily have reciprocal effects on neuronal pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) expression...
  73. pmc Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test
    Gabor Legradi
    Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Neural Plast 2007:79102. 2007
    High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) nerve fibers are present in the central nucleus of amygdala (CeA), a brain region implicated in the control of fear-related behavior...
  74. pmc Weaning and the developmental changes in follicle-stimulating hormone, pituitary adenylate cyclase-activating polypeptide, and inhibin B in the male rat
    Joseph P Moore
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Biol Reprod 78:752-60. 2008
    ..8-fold); pituitary adenylate cyclase-activating polypeptide (Adcyap1, 4.2-fold), total follistatin (Fst, 3.5-fold), and Fst isoform 288 (5...
  75. doi Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion
    Luca Grumolato
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, UA CNRS, University of Rouen 76821 Mont St Aignan, France
    FASEB J 22:1756-68. 2008
    ..we have identified as a novel target gene of the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) during PC12 cell differentiation...
  76. doi PACAP is expressed in sympathoexcitatory bulbospinal C1 neurons of the brain stem and increases sympathetic nerve activity in vivo
    Melissa M J Farnham
    Australian School of Advanced Medicine, Macquarie University, New South Wales 2109, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1304-11. 2008
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is an excitatory neuropeptide present in the rat brain stem...
  77. doi Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes
    Po Chuen Shieh
    Department of Pharmacy, Tajen University, Yen Pou, Ping Tung Shien 90701, Taiwan, ROC
    Neurosci Lett 434:1-5. 2008
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP) is introduced as a neurotrophic factor to promote cell survival...
  78. doi Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP
    Takayuki Ohnishi
    Department of Medical Chemistry, Kansai Medical University, Fumizono, Moriguchi, Japan
    J Neurochem 105:2271-85. 2008
    ..We recently demonstrated that pituitary adenylate cyclase activating polypeptide (PACAP) and NMDA synergistically caused the translocation of nNOS to the membrane and ..
  79. pmc PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 36:310-20. 2008
    Pituitary adenylate cyclase-activating peptide (PACAP) peptides are expressed in micturition pathways, and PACAP expression is regulated by urinary bladder inflammation...
  80. doi Survival-promoting activity of pituitary adenylate cyclase-activating polypeptide in the presence of phosphodiesterase inhibitors on rat motoneurons in culture: cAMP-protein kinase A-mediated survival
    Naoko Tomimatsu
    Clinical Research Center, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Neurochem 107:628-35. 2008
    Pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to be neurotrophic or neuroprotective in various neurons in culture...
  81. doi Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus
    L Costa
    Dipartimento di Scienze Fisiologiche, Universita di Catania, Viale Andrea Doria 6, 95125 Catania, Italy
    Hippocampus 19:99-109. 2009
    Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384)...
  82. doi PACAP and VIP prevent apoptosis in schwannoma cells
    Alessandro Castorina
    Department of Anatomy, Diagnostic Pathology, Legal Medicine, Hygiene and Public Health, University of Catania, Catania, Italy
    Brain Res 1241:29-35. 2008
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are structurally endogenous peptides showing rich profile of biological activities...
  83. doi GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner
    Weishi Zhang
    Department of Biochemistry, Yong Loo Lin of Medicine, The National University of Singapore, 8 Medical Drive, Singapore, 117597, Singapore
    Cell Signal 21:237-45. 2009
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neurotrophic peptide...
  84. doi Divergent peripheral effects of pituitary adenylate cyclase-activating polypeptide-38 on nociception in rats and mice
    Katalin Sandor
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7624, Pecs, Szigeti u 12, Hungary
    Pain 141:143-50. 2009
    Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and its receptors have been shown in the spinal dorsal horn, on capsaicin-sensitive sensory neurons and inflammatory cells...
  85. pmc Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior
    Sayamwong E Hammack
    Department of Psychology, University of Vermont, Burlington, VT 05405, USA
    Psychoneuroendocrinology 34:833-43. 2009
    ..b>Pituitary adenylate cyclase activating polypeptide (PACAP) and its specific G protein-coupled PAC(1) receptor have been associated with many of ..
  86. doi The in vivo effect of VIP, PACAP-38 and PACAP-27 and mRNA expression of their receptors in rat middle meningeal artery
    L J Boni
    Department of Neurology, Glostrup Research Institute, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 29:837-47. 2009
    ..molecules including vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP), which subsequently stimulate VPAC(1), VPAC(2) and PAC(1) receptors...
  87. pmc GnRH stimulates expression of PACAP in the pituitary gonadotropes via both the PKA and PKC signaling systems
    Constance M Grafer
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 23:1022-32. 2009
    Recent studies have demonstrated a clear role for pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of gonadotropin biosynthesis and secretion, both alone and in conjunction with GnRH...
  88. pmc Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation
    Tatiana Fila
    Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, Bologna, Italy
    J Biol Chem 284:15325-38. 2009
    ..cells with a time course matching the expression of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor, a neuropeptide receptor that plays an important role in the regulation of granule cell proliferation/..
  89. pmc Developmental changes in pituitary adenylate cyclase activating polypeptide expression during the perinatal period: possible role in fetal gonadotroph regulation
    Joseph P Moore
    Department of Anatomical Sciences, ivision of Endocrinology and Metabolism, University of Louisville, School of Medicine, Louisville, Kentucky 40292, USA
    Endocrinology 150:4802-9. 2009
    ..b>Pituitary adenylate cyclase activating polypeptide (PACAP) can differentially regulate the gonadotropins in vitro by stimulating alpha-subunit ..
  90. doi Differential regulation of CXCL12 and PACAP mRNA expression after focal and global ischemia
    Monika Riek-Burchardt
    Leibniz Institute for Neurobiology, Brenneckestr 6, 39118 Magdeburg, Germany
    Neuropharmacology 58:199-207. 2010
    Pituitary adenylate cyclase activating peptide (PACAP) and the chemokine stromal cell-derived factor (SDF-1) have been implicated in neuroprotection, neurogenesis, and regeneration...
  91. doi Inhibitory effect of pituitary adenylate cyclase activating polypeptide on the initial stages of rat follicle development
    Stefania Latini
    Department of Histology and Medical Embryology, La Sapienza University of Rome, Via A Scarpa, 16, Rome 00161, Italy
    Mol Cell Endocrinol 320:34-44. 2010
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) is transiently expressed in preovulatory follicles of different species and positively affects parameters correlated with the ovulatory process...
  92. doi Effects of PACAP on mitochondrial apoptotic pathways and cytokine expression in rats subjected to renal ischemia/reperfusion
    Gabriella Horvath
    Department of Anatomy, School of Medicine, University of Pecs, Szigeti u 12, Pecs, Hungary
    J Mol Neurosci 42:411-8. 2010
    b>Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with highly efficient cytoprotective actions. Its neuroprotective effects are well-known, but PACAP is able to exert similar actions in non-neuronal cells...
  93. doi Presence of pituitary adenylate cyclase activating polypeptide and its type I receptor in the rat kidney
    R Brubel
    Department of Anatomy, University of Pecs, Pecs, Hungary
    Transplant Proc 43:1297-9. 2011
    b>Pituitary adenylate cyclase activating polypeptide (PACAP), a multifunctional neuropeptide, has 2 active forms, PACAP38 and PACAP27...
  94. doi Pituitary adenylate cyclase-activating polypeptide mRNA expression in rat testis and epididymis during postnatal development and experimental cryptorchidism
    Chun Mei Lv
    Department of Physiology, Harbin Medical University, Harbin 150081, P R China
    Mol Med Rep 4:793-8. 2011
    In the present study, the expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA was investigated in rat testis and epididymis during postnatal development and experimental cryptorchidism using reverse ..
  95. ncbi Regulation of neurotrophic peptide expression in sympathetic neurons: quantitative analysis using radioimmunoassay and real-time quantitative polymerase chain reaction
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Regul Pept 109:89-101. 2002
    ..peptide and transcript levels of the neurotrophic peptides, pituitary adenylate cyclase-activating polypeptide (PACAP), galanin and vasoactive intestinal peptide (VIP) were examined in sympathetic neurons of the rat superior ..
  96. ncbi Differential expression of the pituitary gonadotropin subunit genes during male rat sexual maturation: reciprocal relationship between hypothalamic pituitary adenylate cyclase-activating polypeptide and follicle-stimulating hormone beta expression
    Joseph P Moore
    Division of Endocrinology and Metabolism, Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Biol Reprod 69:234-41. 2003
    The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to differentially regulate the expression of the gonadotropin subunit genes in cultures of rat pituitary cells...
  97. ncbi Pituitary adenylate cyclase-activating peptide: a pivotal modulator of steroid-induced reproductive behavior in female rodents
    Ede Marie Apostolakis
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 18:173-83. 2004
    Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates the secretion of GnRH into the hypothalamic hypophysial portal system and sensitizes the pituitary for release of hormones that trigger ovulation...
  98. ncbi Role of pituitary adenylate cyclase-activating peptide (PACAP) in the cyclic recruitment of immature follicles in the rat ovary
    Søren Gräs
    Department of Obstetrics and Gynecology, University of Copenhagen, Herlev Amtssygehus, DK 2730 Denmark
    Regul Pept 128:69-74. 2005
    Following the midcyclic gonadotropin surge, PACAP is transiently expressed for approximately 12 h in the cyclic adult rat ovary...
  99. ncbi PACAP regulation of secretion and proliferation of pure populations of gastric ECL cells
    David S Oh
    Division of Gastroenterology and Hepatology, Dept of Research and Development, VA Greater Los Angeles Healthcare System and CURE VA UCLA Digestive Disease Research Center, Dept of Medicine, David Geffen School of Medicine at UCLA, CA 90073, USA
    J Mol Neurosci 26:85-97. 2005
    ..We have previously described that Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is present on myenteric neurons in the rat and colocalizes with its high-affinity receptor, PAC1, expressed on ..
  100. ncbi Expression of pituitary adenylate cyclase activating peptide in the uterine cervix, lumbosacral dorsal root ganglia and spinal cord of rats during pregnancy
    R E Papka
    Northeastern Ohio Universities College of Medicine, Department of Neurobiology, 4209 State Route 44, P O Box 95, Rootstown OH 44272, USA
    Peptides 27:743-52. 2006
    ..undertaken to determine the expression pattern of the neuropeptide pituitary adenylate cyclase activating peptide (PACAP) in the cervix and its nerves during pregnancy and the influence of estrogen on this expression using ..
  101. ncbi Changes of dopamine content and cell proliferation by dexamethsone via pituitary adenylate cyclase-activating polypeptide in PC12 cell
    Ting Ting Yang
    Department of Medicine, College of Medicine, China Medical University, Taichung City 40401, Taiwan
    Neurosci Lett 426:45-8. 2007
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous neuropeptide observed in adrenal gland and sympathetic ganglia to regulate catecholamine synthesis and release...

Research Grants4

  1. A PR-Induced Autocrine/Paracrine Pathway in Female Brain
    EDE APOSTOLAKIS; Fiscal Year: 2004
    ..Since cAMP increases synthesis and release of constitutive pituitary adenylyl cyclase-activating polypeptide (PACAP) in other tissue for local binding to PACAP receptors, the goal of this proposal is to determine whether E-induced ..
  2. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
    ..Finally, knowledge of estrogen responsive sensory neurons has important implications for understanding neuropathic pain syndromes influenced by estrogen levels. ..
  3. Regulation of Neurotrophin Receptor Trafficking
    Francis Lee; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  4. Adenylyl Cyclase Signaling in Ear Sensory Eipthelia
    MARIAN DRESCHER; Fiscal Year: 2009
    ..The elucidation of these AC-mediated signal transduction pathways in inner ear sensory epithelia may allow eventual pharmacological amelioration of tinnitus, sensorinetiral deafness and vertigo. ..