Gene Symbol: Adcy4
Description: adenylate cyclase 4
Alias: adenylate cyclase type 4, ATP pyrophosphate-lyase 4, adenylate cyclase type IV, adenylyl cyclase 4
Zimmermann G, Taussig R. Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and betagamma subunits. J Biol Chem. 1996;271:27161-6 pubmed publisher
Gao B, Gilman A. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci U S A. 1991;88:10178-82 pubmed
..R. (1991) Proc. Natl. Acad. Sci. USA 88, 10173-10177] in its amino acid sequence, lack of response to calmodulin, and synergistic activation by a combination of the Gs alpha subunit and the G-protein beta gamma subunit complex. ..
Baker L, Nielsen M, Impey S, Hacker B, Poser S, Chan M, et al
. Regulation and immunohistochemical localization of betagamma-stimulated adenylyl cyclases in mouse hippocampus. J Neurosci. 1999;19:180-92 pubmed
Cote M, Guillon G, Payet M, Gallo Payet N. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. J Clin Endocrinol Metab. 2001;86:4495-503 pubmed
..adenylyl cyclases 3 and 2 in both the cytoplasm and the plasma membrane, whereas adenylyl cyclase 5/6 and adenylyl cyclase 4 were found mainly in cytoplasm...
Rhim J, Jang I, Yeo E, Song K, Park S. Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts. Aging Cell. 2006;5:451-61 pubmed
Serazin Leroy V, Morot M, De Mazancourt P, Giudicelli Y. Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes. Biochim Biophys Acta. 2001;1550:37-51 pubmed
Sadana R, Dessauer C. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Neurosignals. 2009;17:5-22 pubmed publisher
..In this review we explore the latest on AC knockout and overexpression studies to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart. ..
Wang H, Burns L. Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. J Neurobiol. 2006;66:1302-10 pubmed
Ostrom R, Naugle J, Hase M, Gregorian C, Swaney J, Insel P, et al
. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J Biol Chem. 2003;278:24461-8 pubmed