Ada

Summary

Gene Symbol: Ada
Description: adenosine deaminase
Alias: adenosine deaminase, adenosine aminohydrolase
Species: rat
Products:     Ada

Top Publications

  1. Tofovic S, Kusaka H, Li P, Jackson E. Effects of adenosine deaminase inhibition on blood pressure in old spontaneously hypertensive rats. Clin Exp Hypertens. 1998;20:329-44 pubmed
    ..The objective of this study was to determine whether inhibition of adenosine deaminase lowers blood pressure in spontaneously hypertensive rats (SHR)...
  2. Singh L, Sharma R. Alloxan diabetes regulates adenosine deaminase activity in mice: tissue- and age-specific correlation. Biochem Mol Biol Int. 1998;46:55-61 pubmed
    Effect of alloxan induced diabetes on the activity of adenosine deaminase (ADA) was studied in the liver, spleen, stomach and small intestine of mice at two different postnatal ages (preweaned, 15-day and postweaned, 60-day)...
  3. Kurtul N, Pence S, Akarsu E, Kocoglu H, Aksoy Y, Aksoy H. Adenosine deaminase activity in the serum of type 2 diabetic patients. Acta Medica (Hradec Kralove). 2004;47:33-5 pubmed
    b>Adenosine deaminase (ADA) is suggested to be an important enzyme for modulating the bioactivity of insulin, but its clinical significance in diabetes mellitus (DM) is not yet characterized...
  4. Miura Y, Kano M, Abe K, Urano S, Suzuki S, Toda T. Age-dependent variations of cell response to oxidative stress: proteomic approach to protein expression and phosphorylation. Electrophoresis. 2005;26:2786-96 pubmed
    ..expression of annexin VII, S-adenosyl-L-homocysteine hydrolase, elongation factor II fragment (EF-II), and adenosine deaminase was increased by H2O2-exposure in astrocytes from variously aged rats...
  5. Blackburn M, Datta S, Wakamiya M, Vartabedian B, Kellems R. Metabolic and immunologic consequences of limited adenosine deaminase expression in mice. J Biol Chem. 1996;271:15203-10 pubmed
    b>Adenosine deaminase (ADA; EC 3.5.4.4) deficiency in humans is an autosomal recessive genetic disorder that results in severe combined immunodeficiency disease...
  6. Blackburn M, Wakamiya M, Caskey C, Kellems R. Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice. J Biol Chem. 1995;270:23891-4 pubmed
    b>Adenosine deaminase (ADA, EC 3.5.4.4) is an essential enzyme of purine metabolism that is expressed at very high levels in the murine placenta where it accounts for over 95% of the ADA present at the fetal gestation site...
  7. Blackburn M, Datta S, Kellems R. Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency. J Biol Chem. 1998;273:5093-100 pubmed
    b>Adenosine deaminase (ADA) deficiency in humans leads to a combined immunodeficiency...
  8. Wakamiya M, Blackburn M, Jurecic R, McArthur M, Geske R, Cartwright J, et al. Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. Proc Natl Acad Sci U S A. 1995;92:3673-7 pubmed
    We have generated mice with a null mutation at the Ada locus, which encodes the purine catabolic enzyme adenosine deaminase (ADA, EC 3.5.4.4). ADA-deficient fetuses exhibited hepatocellular impairment and died perinatally...
  9. Migchielsen A, Breuer M, van Roon M, te Riele H, Zurcher C, Ossendorp F, et al. Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Nat Genet. 1995;10:279-87 pubmed
    We report the generation and characterization of mice lacking adenosine deaminase (ADA). In humans, absence of ADA causes severe combined immunodeficiency...

More Information

Publications62

  1. Lee J, Hempel J, Deng J. Anti-adenosine deaminase antibodies in lupus erythematosus. Lupus. 2002;11:168-74 pubmed
    b>Adenosine deaminase (ADA) is an enzyme involved in purine metabolism and has a major role in the development and function of lymphoid cells. Congenital deficiency of ADA results in severe immunodeficiency...
  2. Schmatz R, Schetinger M, Spanevello R, Mazzanti C, Stefanello N, Maldonado P, et al. Effects of resveratrol on nucleotide degrading enzymes in streptozotocin-induced diabetic rats. Life Sci. 2009;84:345-50 pubmed publisher
    ..activities, on NTPDase, ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP), 5'-nucleotidase and adenosine deaminase (ADA) activities in platelets from streptozotocin (STZ)-induced diabetic rats...
  3. Jinnah H, Page T, Friedmann T. Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem. 1993;60:2036-45 pubmed
    ..This increase in the synthesis of purines may protect the HPRT- mice from potential depletion of brain purines despite complete impairment of HPRT-mediated purine salvage. ..
  4. Tonin A, Pimentel V, Da Silva A, de Azevedo M, Souza V, Wolkmer P, et al. Adenosine deaminase activity in serum, erythrocytes and lymphocytes of rats infected with Leptospira icterohaemorrhagiae. Res Vet Sci. 2012;92:197-201 pubmed publisher
    ..icterohaemorrhagiae). The enzyme adenosine deaminase (ADA) plays an important role in the production and differentiation of blood cells...
  5. Da Silva A, Bellé L, Bitencourt P, Souza V, Costa M, Oliveira C, et al. Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi. Parasitology. 2011;138:201-8 pubmed publisher
    In Trypanosoma evansi infections changes in the haemogram are commonly observed, and the enzyme adenosine deaminase (ADA) plays an important role in the production and differentiation of blood cells...
  6. Martin M, Huguet J, Centelles J, Franco R. Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule. J Immunol. 1995;155:4630-43 pubmed
    The expression of surface adenosine deaminase (ADA) and CD26 in activated human T cells was studied by flow cytometry...
  7. Aldrich M, Chen W, Blackburn M, Martinez Valdez H, Datta S, Kellems R. Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol. 2003;171:5562-70 pubmed
    Mice deficient in the enzyme adenosine deaminase (ADA) have small lymphoid organs that contain reduced numbers of peripheral lymphocytes, and they are immunodeficient...
  8. Takahashi T, Otsuguro K, Ohta T, Ito S. Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats. Br J Pharmacol. 2010;161:1806-16 pubmed publisher
    ..Inhibitors of adenosine deaminase or the equilibrative nucleoside transporter (ENT) abolished the hypoxia-evoked increase in inosine but not ..
  9. Alencar N, Cavalcante C, Vasconcelos M, Leite K, Aragão K, Assreuy A, et al. Anti-inflammatory and antimicrobial effect of lectin from Lonchocarpus sericeus seeds in an experimental rat model of infectious peritonitis. J Pharm Pharmacol. 2005;57:919-22 pubmed
    ..process was monitored by total and differential count of cells from blood and peritoneal washing liquid, adenosine deaminase activity, antibiogram and the number of viable bacteria of the peritoneal cavity...
  10. Newsholme E, Blomstrand E, Newell J, Pitcher J. Maximal activities of enzymes involved in adenosine metabolism in muscle and adipose tissue of rats under conditions of variations in insulin sensitivity. FEBS Lett. 1985;181:189-92 pubmed
    The maximal activities of 5'-nucleotidase, adenosine deaminase and adenosine kinase were measured in quadriceps or soleus muscle from animals in which the sensitivity to insulin was changed...
  11. Apasov S, Blackburn M, Kellems R, Smith P, Sitkovsky M. Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest. 2001;108:131-41 pubmed
    b>Adenosine deaminase (ADA) deficiency in humans results in a severe combined immunodeficiency (SCID). This immunodeficiency is associated with severe disturbances in purine metabolism that are thought to mediate lymphotoxicity...
  12. Jiang C, Hong R, Horowitz S, Kong X, Hirschhorn R. An adenosine deaminase (ADA) allele contains two newly identified deleterious mutations (Y97C and L106V) that interact to abolish enzyme activity. Hum Mol Genet. 1997;6:2271-8 pubmed
    Genetic deficiency of the purine salvage enzyme adenosine deaminase (ADA) results in varying degrees of immunodeficiency, ranging from neonatal onset Severe Combined Immunodeficiency (SCID) to an adult onset immunodeficiency disorder...
  13. Bodine D, Moritz T, Donahue R, Luskey B, Kessler S, Martin D, et al. Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood. 1993;82:1975-80 pubmed
    ..Deficiency of the enzyme adenosine deaminase (ADA) results in depletion of T lymphocytes, causing severe combined immunodeficiency syndrome (SCIDS)...
  14. Blackburn M, Volmer J, Thrasher J, Zhong H, Crosby J, Lee J, et al. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. J Exp Med. 2000;192:159-70 pubmed
    b>Adenosine deaminase (ADA) is a purine catabolic enzyme that manages levels of the biologically active purines adenosine and 2'-deoxyadenosine in tissues and cells. ADA-deficient mice die at 3 wk of age from severe respiratory distress...
  15. de Azevedo M, Ferreiro L, Da Silva A, Tonin A, Ruchel J, Rezer J, et al. E-NTPDase and E-ADA activities in rats experimental infected by Cryptococcus neoformans. Vet Microbiol. 2014;174:206-13 pubmed publisher
    ..The aim of this study was to evaluate the activities of E-NTPDase and E-ADA in rats experimentally infected by C. neoformans var. grubii...
  16. Kocic G, Djordjevic V, Vlahovic P, Kocic R, Pavlovic D, Jevtovic T. Antioxidants modulate adenosine metabolism in rat mesangial cells cultured under high glucose conditions. Ren Fail. 2002;24:691-701 pubmed
    ..The activity of adenosine metabolizing enzymes: 5'-nucleotidease (5'-NU) responsible for its production and adenosine deaminase (ADA) responsible for its degradation were investigated...
  17. Kaminsky Y, Kosenko E. AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis. Brain Res. 2010;1311:175-81 pubmed publisher
    Cytosolic enzymes AMP deaminase and adenosine deaminase (ADA) catalyze AMP and adenosine deamination, constitute rate-limiting steps of adenine nucleotide catabolism and play important roles in cellular energy metabolism...
  18. Sun C, Zhong H, Mohsenin A, Morschl E, Chunn J, Molina J, et al. Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest. 2006;116:2173-2182 pubmed
    ..b>Adenosine deaminase-deficient (ADA-deficient) mice develop pulmonary inflammation and injury that are dependent on increased ..
  19. Akeson A, Wiginton D, Dusing M, States J, Hutton J. Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts. J Biol Chem. 1988;263:16291-6 pubmed
    b>Adenosine deaminase (ADA) deficiency in humans is one cause of severe combined immunodeficiency disease...
  20. Lu Q, Harrington E, Newton J, Casserly B, Radin G, Warburton R, et al. Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement. Am J Physiol Lung Cell Mol Physiol. 2010;298:L755-67 pubmed publisher
    ..We further demonstrated that elevation of cellular adenosine by inhibition of adenosine deaminase with Pentostatin significantly enhanced endothelial basal barrier function, an effect that was also ..
  21. Kosenko E, Kaminsky Y. Activation of AMP deaminase and adenosine deaminase in the liver during ammonia poisoning and hepatitis. Bull Exp Biol Med. 2010;150:36-8 pubmed
    ..effect of acute ammonia poisoning and CCl4-induced subacute hepatitis on activities of AMP deaminase and adenosine deaminase in rat liver...
  22. Knudsen T, Blackburn M, Chinsky J, Airhart M, Kellems R. Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies. Biol Reprod. 1991;44:171-84 pubmed
    This study has determined the cellular site of adenosine deaminase (ADA) expression in the mouse during development from Days 5 through 13 (day vaginal plug was found = Day 0) of gestation...
  23. Correia de Sá P, Adães S, Timóteo M, Vieira C, Magalhães Cardoso T, Nascimento C, et al. Fine-tuning modulation of myenteric motoneurons by endogenous adenosine: on the role of secreted adenosine deaminase. Auton Neurosci. 2006;126-127:211-24 pubmed
    ..Surprisingly, bath samples collected after stimulating the LM-MP exhibited a relatively high adenosine deaminase (ADA) activity (0.60+/-0...
  24. Willems L, Reichelt M, Molina J, Sun C, Chunn J, Ashton K, et al. Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts. Cardiovasc Res. 2006;71:79-87 pubmed
    b>Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality...
  25. Winston J, Hanten G, Overbeek P, Kellems R. 5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice. J Biol Chem. 1992;267:13472-9 pubmed
    b>Adenosine deaminase (ADA), an enzyme of purine metabolism, is highly expressed in four tissues of the mouse: the maternal decidua, the fetal placenta, the keratinizing epithelium of the upper alimentary tract (tongue, esophagus, and ..
  26. Hunt S, Hoffee P. Adenosine deaminase from deoxycoformycin-sensitive and -resistant rat hepatoma cells. Purification and characterization. J Biol Chem. 1982;257:14239-44 pubmed
    Deoxycoformycin-resistant rat hepatoma cells exhibit up to 300-fold increase in adenosine deaminase activity compared to the sensitive parental cells...
  27. Mackiewicz M, Nikonova E, Zimmerman J, Galante R, Zhang L, Cater J, et al. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. J Neurochem. 2003;85:348-57 pubmed
    ..We examined, in rats, the activity of the major metabolic enzymes for adenosine - adenosine deaminase, adenosine kinase, ecto- and cytosolic 5'-nucleotidase - in sleep/wake regulatory regions as well as ..
  28. Sun C, Young H, Molina J, Volmer J, Schnermann J, Blackburn M. A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. J Clin Invest. 2005;115:35-43 pubmed
    ..contribution of A(1) adenosine receptor (A(1)AR) signaling to the pulmonary inflammation and injury seen in adenosine deaminase-deficient (ADA-deficient) mice, which exhibit elevated adenosine levels...
  29. Mohsenin A, Mi T, Xia Y, Kellems R, Chen J, Blackburn M. Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2007;293:L753-61 pubmed
    ..Mice deficient in the purine catabolic enzyme adenosine deaminase (ADA) develop pulmonary inflammation and mucous metaplasia in association with adenosine elevations making ..
  30. DeGraw R, Anderson B. Enhanced oral bioavailability of 2'- beta-fluoro-2',3'-dideoxyadenosine (F-ddA) through local inhibition of intestinal adenosine deaminase. Pharm Res. 2001;18:1270-6 pubmed
    ..2-Beta-fluoro-2',3'-dideoxyadenosine (F-ddA) is an adenosine deaminase (ADA) activated prodrug of 2-beta-fluoro-2',3'-dideoxyinosine (F-ddI) with enhanced delivery to the central ..
  31. Gao X, Blackburn M, Knudsen T. Activation of apoptosis in early mouse embryos by 2'-deoxyadenosine exposure. Teratology. 1994;49:1-12 pubmed
    b>Adenosine deaminase (ADA) catalyzes the irreversible hydrolytic deamination of adenosine and deoxyadenosine to nontoxic derivatives...
  32. Pimentel V, Bellé L, Pinheiro F, De Bona K, Da Luz S, Moretto M. Adenosine deaminase activity, lipid peroxidation and astrocyte responses in the cerebral cortex of rats after neonatal hypoxia ischemia. Int J Dev Neurosci. 2009;27:857-62 pubmed publisher
    ..The aim of this study was to describe the chronological sequence of adenosine deaminase (ADA) activity, the oxidative damage changes and astrocyte response using the classic model of neonatal HI...
  33. Kubota M, Katagiri M, Imasaki T, Yanase N, Soma K, Tomita T. [Adenosine deaminase activity in bronchoalveolar lavage fluid of sarcoidosis patients]. Nihon Kokyuki Gakkai Zasshi. 1999;37:374-9 pubmed
    We studied adenosine deaminase (ADA) activity in bronchoalveolar lavage fluid (BALF) specimens from 24 patients with sarcoidosis. Mean BALF-ADA activity was significantly (p < 0.0001) elevated in patients with sarcoidosis (1.02 +/- 1...
  34. Molinos L, Fernandez R, Dominguez M, Riesgo C, Escudero C, Martinez J. Adenosine deaminase activity in the aetiological diagnosis of community-acquired pneumonia. Scand J Infect Dis. 1997;29:287-90 pubmed
    A prospective study was undertaken to assess the usefulness of serum adenosine deaminase (ADA) activity in the aetiological diagnosis of 75 patients (mean age 58 years) with community-acquired pneumonia who required hospitalization...
  35. Van De Wiele C, Joachims M, Fesler A, Vaughn J, Blackburn M, McGee S, et al. Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture. J Immunol. 2006;176:5925-33 pubmed
    Murine fetal thymic organ culture (FTOC) was used to investigate the mechanism by which a lack of adenosine deaminase (ADA) leads to a failure of T cell production in the thymus...
  36. Pimentel V, Moretto M, Oliveira M, Zanini D, Sebastião A, Schetinger M. Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult. Mol Cell Biochem. 2015;403:169-77 pubmed publisher
    ..Thus, the aim of this study was to identify the isoforms of adenosine deaminase (ADA) responsible for the enzymatic activity as well as the adenosine kinase (ADK) and A1 adenosine ..
  37. Nelson A, Battersby A, Baghdoyan H, Lydic R. Opioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminase. Anesthesiology. 2009;111:1327-33 pubmed publisher
    ..containing morphine (0, 10, 30, 100, or 300 microm), fentanyl (100 microm), morphine (100 microm) and the adenosine deaminase inhibitor EHNA (100 microm), or naloxone (10 microm) and morphine (100 microm)...
  38. Eltzschig H, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, et al. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood. 2006;108:1602-10 pubmed
    ..Guided by microarray results revealing induction of endothelial adenosine deaminase (ADA) mRNA in hypoxia, we used in vitro and in vivo models of adenosine signaling, confirming induction of ..
  39. MacKiewicz M, Nikonova E, Bell C, Galante R, Zhang L, Geiger J, et al. Activity of adenosine deaminase in the sleep regulatory areas of the rat CNS. Brain Res Mol Brain Res. 2000;80:252-5 pubmed
    ..b>Adenosine deaminase (ADA) is a key enzyme involved in the metabolism of ADO...
  40. Chunn J, Young H, Banerjee S, Colasurdo G, Blackburn M. Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice. J Immunol. 2001;167:4676-85 pubmed
    ..levels of adenosine as a result of the partial expression of the enzyme that metabolizes adenosine, adenosine deaminase (ADA)...
  41. Santisteban I, Arredondo Vega F, Kelly S, Debre M, Fischer A, Perignon J, et al. Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5' splice site. Hum Mutat. 1995;5:243-50 pubmed
    ..A179D) and a new splicing defect (573 + IG-->A) in the 5' splice site of intron 5 were among six mutant adenosine deaminase (ADA) alleles found in three unrelated patients with severe combined immunodeficiency disease, the most ..
  42. Mi T, Abbasi S, Zhang H, Uray K, Chunn J, Xia L, et al. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest. 2008;118:1491-501 pubmed publisher
    ..Here we report that mice lacking adenosine deaminase (ADA), an enzyme necessary for the breakdown of adenosine, displayed unexpected priapic activity...
  43. Sideraki V, Mohamedali K, Wilson D, Chang Z, Kellems R, Quiocho F, et al. Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase. Biochemistry. 1996;35:7862-72 pubmed
    Two adjacent aspartates, Asp 295 and Asp 296, playing major roles in the reaction catalyzed by mouse adenosine deaminase (mADA) were altered using site-directed mutagenesis...
  44. Blackburn M, Knudsen T, Kellems R. Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development. Development. 1997;124:3089-97 pubmed
    b>Adenosine deaminase (ADA) is an essential enzyme of purine metabolism that is enriched at the maternal-fetal interface of mice throughout postimplantation development...
  45. Pull I, McIlwain H. Rat cerebral-cortex adenosine deaminase activity and its subcellular distribution. Biochem J. 1974;144:37-41 pubmed
    A radioisotopic assay for adenosine deaminase (EC 3.5.4.4) is described together with its application in investigating the activity of the enzyme in rat cerebral cortex...
  46. Pruitt K, Maglott D. RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Res. 2001;29:137-40 pubmed
    ..Additional information about LocusLink and RefSeq is available at http://www.ncbi.nlm.nih.gov/LocusLink/. ..
  47. Migchielsen A, Breuer M, Hershfield M, Valerio D. Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene. Hum Mol Genet. 1996;5:1523-32 pubmed
    We have shown recently that adenosine deaminase (ADA)-deficient mice die perinatally with severe liver cell degeneration...
  48. Lindley E, Pisoni R. Demonstration of adenosine deaminase activity in human fibroblast lysosomes. Biochem J. 1993;290 ( Pt 2):457-62 pubmed
    Human fibroblast lysosomes, purified on Percoll density gradients, contain an adenosine deaminase (ADA) activity that accounts for approximately 10% of the total ADA activity in GM0010A human fibroblasts...
  49. Pereira R, Medeiros Y, Fröde T. Antiinflammatory effects of Tacrolimus in a mouse model of pleurisy. Transpl Immunol. 2006;16:105-11 pubmed
    ..Tacrolimus is an antibiotic macrolide with immunosuppressant properties isolated from Streptomyces tsukubaensis...
  50. Liu Y, Saccucci P, Qi H, Wu H, Zhao F, Dai Y, et al. ADA polymorphisms and asthma: a study in the Chinese Han population. J Asthma. 2006;43:203-6 pubmed
    ..Three polymorphic sites: ADA(1), ADA(2), and ADA(6), within the ADA gene have been examined...
  51. Young H, Molina J, Dimina D, Zhong H, Jacobson M, Chan L, et al. A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice. J Immunol. 2004;173:1380-9 pubmed
    ..the role(s) of the A(3) adenosine receptor in adenosine-dependent pulmonary inflammation observed in adenosine deaminase (ADA)-deficient mice...
  52. Franco M, Bautista R, Pérez Méndez O, González L, Pacheco U, Sanchez Lozada L, et al. Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats. Am J Physiol Renal Physiol. 2008;294:F84-92 pubmed
    ..kg(-1) x min(-1)). 5'-Nucleotidase and adenosine deaminase (ADA) activities were measured in the cytosolic and membrane fractions...
  53. Van De Wiele C, Vaughn J, Blackburn M, Ledent C, Jacobson M, Jiang H, et al. Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation. J Clin Invest. 2002;110:395-402 pubmed
    Thymocyte development past the CD4(-)CD8(-) stage is markedly inhibited in adenosine deaminase-deficient (ADA-deficient) murine fetal thymic organ cultures (FTOCs) due to the accumulation of ADA substrates derived from thymocytes failing ..