Gene Symbol: Actn1
Description: actinin, alpha 1
Alias: alpha-actinin-1, F-actin cross-linking protein, alpha-actinin cytoskeletal isoform, non-muscle alpha-actinin-1
Species: rat
Products:     Actn1

Top Publications

  1. Kunishima S, Okuno Y, Yoshida K, Shiraishi Y, Sanada M, Muramatsu H, et al. ACTN1 mutations cause congenital macrothrombocytopenia. Am J Hum Genet. 2013;92:431-8 pubmed publisher
    ..In 13 Japanese CMTP-affected pedigrees, we identified six (46%) affected by ACTN1 variants cosegregating with CMTP. In the entire cohort, ACNT1 variants accounted for 5...
  2. Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, et al. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol Cell Biol. 2008;28:3424-36 pubmed publisher
    ..These findings indicate that MURC modulates RhoA signaling and that MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias. ..
  3. Sung M, Schulz C, Wang W, Sawicki G, Bautista López N, Schulz R. Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury. J Mol Cell Cardiol. 2007;43:429-36 pubmed
    ..Cardiac dysfunction induced by peroxynitrite involves degradation of alpha-actinin that may be mediated by the proteolytic action of MMP-2. ..
  4. Kremerskothen J, Kindler S, Finger I, Veltel S, Barnekow A. Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. J Neurochem. 2006;96:1659-66 pubmed
    ..Its nuclear localization capacity further points to a function in retrograde signaling from the synapse to the nucleus. ..
  5. Ziane R, Huang H, Moghadaszadeh B, Beggs A, Levesque G, Chahine M. Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction. Biochemistry. 2010;49:166-78 pubmed publisher
    ..Our data suggest that alpha-actinin-2, which is known to regulate the functional expression of the potassium channels, may play a role in anchoring Na(v)1.5 to the membrane by connecting the channel to the actin cytoskeleton network. ..
  6. Beqqali A, Monshouwer Kloots J, Monteiro R, Welling M, Bakkers J, Ehler E, et al. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J Cell Sci. 2010;123:1141-50 pubmed publisher
    ..These findings suggest that CHAP is a critical component of the sarcomere with an important role in muscle development. ..
  7. Keicher C, Gambaryan S, Schulze E, Marcus K, Meyer H, Butt E. Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem Biophys Res Commun. 2004;324:308-16 pubmed
    ..Immunoblotting of LASP-1 in various mouse and human tissues detected a similar prominent expression in non-muscle tissue. Altogether, our data suggest so far no functional differences between human and mouse LASP-1. ..
  8. Ooshio T, Irie K, Morimoto K, Fukuhara A, Imai T, Takai Y. Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. J Biol Chem. 2004;279:31365-73 pubmed
    ..These results indicate that LMO7 is an afadin- and alpha-actinin-binding protein that connects the nectin-afadin and E-cadherin-catenin systems through alpha-actinin. ..
  9. Miyazaki K, Ohno K, Tamura N, Sasaki T, Sato K. CLP36 and RIL recruit ?-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts. Exp Cell Res. 2012;318:1716-25 pubmed publisher
    ..Our findings indicate that CLP36 and RIL have a redundant role in the formation of stress fibers, but have different effects on stress fiber dynamics in F2408 cells...

More Information


  1. Dhavan R, Greer P, Morabito M, Orlando L, Tsai L. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. J Neurosci. 2002;22:7879-91 pubmed
  2. Chen H, Huang X, Yan W, Chen K, Guo L, Tummalapali L, et al. Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Lab Invest. 2005;85:1342-56 pubmed
    ..These results suggest that the IPAP1 complex plays an important role in mediating integrin-signaling pathways that regulate cardiac myocyte hypertrophy and resistance to apoptosis. ..
  3. Triplett J, Pavalko F. Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis. Am J Physiol Cell Physiol. 2006;291:C909-21 pubmed
    ..Thus we conclude that alpha-actinin plays a role in regulating cell survival through stabilization of focal adhesions and regulation of TNF-alpha-induced survival signaling. ..
  4. Mirzoev T, Shenkman B, Ushakov I, Ogneva I. Desmin and ?-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading. Dokl Biochem Biophys. 2012;444:144-6 pubmed publisher
  5. Sakane A, Alamir Mahmoud Abdallah A, Nakano K, Honda K, Kitamura T, Imoto I, et al. Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. Genes Cells. 2013;18:810-22 pubmed publisher
    ..However, actinin-1/-4 have no effect on the cell spreading regulated by JRAB?CC. These data suggest that JRAB contributes to the rearrangement of the actin cytoskeleton during cell spreading via filamins. ..
  6. Torrado M, Senatorov V, Trivedi R, Fariss R, Tomarev S. Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Invest Ophthalmol Vis Sci. 2004;45:3955-63 pubmed
    ..These results suggest that Pdlim2, like other ALP subfamily members, may act as an adapter that directs other proteins to the cytoskeleton. ..
  7. Gokhin D, Lewis R, McKeown C, Nowak R, Kim N, Littlefield R, et al. Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J Cell Biol. 2010;189:95-109 pubmed publisher
    ..Thus, Tmod3 and -4 compensate for the absence of Tmod1 structurally but not functionally. We conclude that Tmod1 is a novel regulator of skeletal muscle physiology. ..
  8. Hao J, Galindo C, Tran T, Sawyer D. Neuregulin-1? induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem J. 2014;458:335-41 pubmed publisher
    ..In summary, we report a previously unrecognized role for NRG-1?/ErbB3/CREB signalling at the pre-mesoderm stage for stem cell cardiac differentiation. ..
  9. Burgueno J, Blake D, Benson M, Tinsley C, Esapa C, Canela E, et al. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. J Biol Chem. 2003;278:37545-52 pubmed
    ..These findings suggest an alpha-actinin-dependent association between the actin cytoskeleton and A2AR trafficking. ..
  10. Khurana S, Chakraborty S, Lam M, Liu Y, Su Y, Zhao X, et al. Familial focal segmental glomerulosclerosis (FSGS)-linked ?-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors. J Biol Chem. 2012;287:12027-35 pubmed publisher
    ..Our data provide the first link between FSGS-linked ACTN4 mutants and transcriptional activation by nuclear receptor such as RAR? and peroxisome proliferator-activated receptor ?. ..
  11. Choi C, Vicente Manzanares M, Zareno J, Whitmore L, Mogilner A, Horwitz A. Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol. 2008;10:1039-50 pubmed publisher
    ..From these studies, we have developed a model for adhesion assembly that clarifies the relative contributions of myosin II and actin polymerization and organization. ..
  12. Guéguen P, Rouault K, Chen J, Raguenes O, Fichou Y, Hardy E, et al. A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family. PLoS ONE. 2013;8:e74728 pubmed publisher
    ..137GA; p.Arg46Gln) in the alpha-actinin 1 gene (ACTN1) that segregated with macrothrombocytopenia in this large pedigree...
  13. Sherniakov M. [Organization of the activities of the medical-sanitary battalion]. Voen Med Zh. 1978;:20-2 pubmed
  14. Gluck U, Ben Ze ev A. Modulation of alpha-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells. J Cell Sci. 1994;107 ( Pt 7):1773-82 pubmed
  15. Ridinger H, Rutenberg C, Lutz D, Buness A, Petersen I, Amann K, et al. Expression and tissue localization of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 is modulated during rat and human left ventricular hypertrophy. Exp Mol Pathol. 2009;86:23-31 pubmed publisher
    ..Our results show that the parallel investigation of rat and human cardiac tissue as well as human cellular models in vitro represents a promising strategy to identify reliable biomarkers of LVH. ..
  16. Chi R, Simon A, Bienkiewicz E, Felix A, Keller T. Smooth muscle titin Zq domain interaction with the smooth muscle alpha-actinin central rod. J Biol Chem. 2008;283:20959-67 pubmed publisher
    ..We present a model in which two sm-titin Zq domains interact with each other and with the two R2-R3 sites in the alpha-actinin central rod. ..
  17. Greene D, Tumova S, Couchman J, Woods A. Syndecan-4 associates with alpha-actinin. J Biol Chem. 2003;278:7617-23 pubmed
    ..We now demonstrate by Triton X-100 extraction immunoprecipitation and in vitro binding assays that the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner. ..
  18. Kontrogianni Konstantopoulos A, Frye C, Benz E, Huang S. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. J Biol Chem. 2001;276:20679-87 pubmed
    ..1G are distributed underneath the plasma membrane in PC12 cells. Collectively, these observations suggest that brain 4.1R and 4.1G may modulate the membrane mechanical properties of neuronal cells by promoting fodrin/actin association. ..
  19. Edlund M, Lotano M, Otey C. Dynamics of alpha-actinin in focal adhesions and stress fibers visualized with alpha-actinin-green fluorescent protein. Cell Motil Cytoskeleton. 2001;48:190-200 pubmed
    ..Additionally, the exchange rates revealed by video-microscopy and FRAP analysis of alpha AGFP are more rapid than those reported previously, which were obtained using microinjection of large excesses of fluorescently-tagged protein. ..
  20. Bois P, Borgon R, Vonrhein C, Izard T. Structural dynamics of alpha-actinin-vinculin interactions. Mol Cell Biol. 2005;25:6112-22 pubmed
    ..The data suggest a model where vinculin's Vh1 domain acts as a molecular switch that undergoes distinct structural changes provoked by talin and alpha-actinin binding in focal adhesions versus adherens junctions, respectively. ..
  21. Bunn R, Jensen M, Reed B. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Mol Biol Cell. 1999;10:819-32 pubmed
  22. Li Q, Dai X, Shen P, Wu Y, Long W, Chen C, et al. Direct binding of alpha-actinin enhances TRPP3 channel activity. J Neurochem. 2007;103:2391-400 pubmed
    ..It remains to be determined whether the TRPP3-alpha-actinin interaction is relevant to acid sensing and other functions in neuronal and non-neuronal cells. ..
  23. Yang N, Schindeler A, McDonald M, Seto J, Houweling P, Lek M, et al. ?-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone. 2011;49:790-8 pubmed publisher
    ..Given the high frequency of R577X in the general population, the potential role of ACTN3 R577X as a factor influencing variations in BMD in elderly humans warrants further study. ..
  24. Vallenius T, Scharm B, Vesikansa A, Luukko K, Schafer R, Makela T. The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin. Exp Cell Res. 2004;293:117-28 pubmed
    ..These results implicate the RIL PDZ-LIM protein as a regulator of actin stress fiber turnover. ..
  25. Kremerskothen J, Teber I, Wendholt D, Liedtke T, Bockers T, Barnekow A. Brain-specific splicing of alpha-actinin 1 (ACTN1) mRNA. Biochem Biophys Res Commun. 2002;295:678-81 pubmed
    Two isoforms of alpha-actinin 1 (ACTN1) known to be generated by tissue-specific alternative splicing of mutually exclusive exons have been described...
  26. Ogneva I, Biryukov N, Leinsoo T, Larina I. Possible role of non-muscle alpha-actinins in muscle cell mechanosensitivity. PLoS ONE. 2014;9:e96395 pubmed publisher
    ..At the same time, the concentration of the abovementioned proteins decreased in the soleus muscle fibers. ..
  27. Li Q, Montalbetti N, Shen P, Dai X, Cheeseman C, Karpinski E, et al. Alpha-actinin associates with polycystin-2 and regulates its channel activity. Hum Mol Genet. 2005;14:1587-603 pubmed
    ..Thus, physical and functional interactions between PC2 and alpha-actinin may play an important role in abnormal cell adhesion, proliferation and migration observed in ADPKD. ..
  28. Zhang J, Elzey B, Williams G, Lu S, Law D, Horowits R. Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry. 2001;40:14898-906 pubmed
    ..These results demonstrate that N-RAP remains tightly bound to myofibrils and fasciae adherentes during biochemical purification and may be a key constituent in the mechanical link between these two structures. ..
  29. Baldini G, Martelli A, Tabellini G, Horn C, Machaca K, Narducci P, et al. Rabphilin localizes with the cell actin cytoskeleton and stimulates association of granules with F-actin cross-linked by {alpha}-actinin. J Biol Chem. 2005;280:34974-84 pubmed
    ..These results suggest that rabphilin, by interacting with alpha-actinin, organizes the cell cytoskeleton to facilitate granule localization within F-actin-rich regions. ..
  30. Heineke J, Ruetten H, Willenbockel C, Gross S, Naguib M, Schaefer A, et al. Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc Natl Acad Sci U S A. 2005;102:1655-60 pubmed
    ..Our study reveals a link between the stress sensor MLP and the calcineurin-NFAT pathway at the sarcomeric Z-disk in cardiomyocytes and indicates that reduced MLP-calcineurin signaling predisposes to adverse remodeling after MI. ..