Gene Symbol: Actg1
Description: actin, gamma 1
Alias: Actg, actin, cytoplasmic 2, actin, gamma, cytoplasmic 1, gamma-actin
Species: rat
Products:     Actg1

Top Publications

  1. Akamizu T, Saji M, Kohn L. A microsequencing approach to identify proteins which appear to interact with thyrotropin in rat FRTL-5 thyroid cells. Biochem Biophys Res Commun. 1990;170:351-8 pubmed
  2. Papponen H, Kaisto T, Leinonen S, Kaakinen M, Metsikkö K. Evidence for gamma-actin as a Z disc component in skeletal myofibers. Exp Cell Res. 2009;315:218-25 pubmed publisher
    ..The results emphasize the role of gamma-actin as a Z disc component but fail to reveal an actin-based sub-sarcolemmal cytoskeleton in skeletal muscle cells. ..
  3. Li Y, Zhang Y, Qiu F, Qiu Z. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis. 2011;32:1976-83 pubmed publisher
    ..The LRG1 was found to be expressed at higher levels in urinary exosomes and lung tissue of NSCLC patients. These results suggested that LRG1 may be a candidate biomarker for non-invasive diagnosis of NSCLC in urine. ..
  4. Brown C, McHugh K, Lessard J. A cDNA sequence encoding cytoskeletal gamma-actin from rat. Nucleic Acids Res. 1990;18:5312 pubmed
  5. Chen Y, Derin R, Petralia R, Li M. Actinfilin, a brain-specific actin-binding protein in postsynaptic density. J Biol Chem. 2002;277:30495-501 pubmed publisher
    ..The results showed the postsynaptic density distribution of actinfilin. Together, these results indicate that actinfilin may be a key player in the actin-based neuronal function...
  6. Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, et al. Parkin interacts with Ambra1 to induce mitophagy. J Neurosci. 2011;31:10249-61 pubmed publisher
    ..These data identify interaction of Parkin with Ambra1 as a key mechanism for induction of the final clearance step of Parkin-mediated mitophagy. ..
  7. Rainger J, Williamson K, Soares D, Truch J, Kurian D, Gillessen Kaesbach G, et al. A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum Mutat. 2017;38:942-946 pubmed publisher
    ..Three of these genes encoded proteins associated with actin cytoskeleton dynamics: ACTG1, TWF1, and LCP1...
  8. Weinstock R, Saville C, Messina J. Role of cytosolic calcium in regulation of cytoskeletal gene expression by insulin. Am J Physiol. 1993;264:E519-25 pubmed
    ..This suggests that the regulation of gene transcription by insulin may include calcium-dependent pathways but strongly implies that calcium-independent pathways are also utilized...
  9. Mandai K, Nakanishi H, Satoh A, Obaishi H, Wada M, Nishioka H, et al. Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol. 1997;139:517-28 pubmed
    ..These results suggest that l-afadin serves as a linker of the actin cytoskeleton to the plasma membrane at cell-to-cell AJ. ..

More Information


  1. Lloyd C, Berendse M, Lloyd D, Schevzov G, Grounds M. A novel role for non-muscle gamma-actin in skeletal muscle sarcomere assembly. Exp Cell Res. 2004;297:82-96 pubmed
    ..Consequently, a modified model is proposed which describes the role of gamma-actin in skeletal sarcomere assembly. ..
  2. Ogneva I, Biryukov N, Leinsoo T, Larina I. Possible role of non-muscle alpha-actinins in muscle cell mechanosensitivity. PLoS ONE. 2014;9:e96395 pubmed publisher
    ..At the same time, the concentration of the abovementioned proteins decreased in the soleus muscle fibers. ..
  3. Legendre K, Safieddine S, Küssel Andermann P, Petit C, El Amraoui A. alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. J Cell Sci. 2008;121:3347-56 pubmed publisher
    ..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin. ..