Gene Symbol: Actg1
Description: actin, gamma 1
Alias: Actg, actin, cytoplasmic 2, actin, gamma, cytoplasmic 1, gamma-actin
Akamizu T, Saji M, Kohn L. A microsequencing approach to identify proteins which appear to interact with thyrotropin in rat FRTL-5 thyroid cells. Biochem Biophys Res Commun. 1990;170:351-8 pubmed
Papponen H, Kaisto T, Leinonen S, Kaakinen M, Metsikkö K. Evidence for gamma-actin as a Z disc component in skeletal myofibers. Exp Cell Res. 2009;315:218-25 pubmed publisher
..The results emphasize the role of gamma-actin as a Z disc component but fail to reveal an actin-based sub-sarcolemmal cytoskeleton in skeletal muscle cells. ..
Li Y, Zhang Y, Qiu F, Qiu Z. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis. 2011;32:1976-83 pubmed publisher
..The LRG1 was found to be expressed at higher levels in urinary exosomes and lung tissue of NSCLC patients. These results suggested that LRG1 may be a candidate biomarker for non-invasive diagnosis of NSCLC in urine. ..
Brown C, McHugh K, Lessard J. A cDNA sequence encoding cytoskeletal gamma-actin from rat. Nucleic Acids Res. 1990;18:5312 pubmed
Chen Y, Derin R, Petralia R, Li M. Actinfilin, a brain-specific actin-binding protein in postsynaptic density. J Biol Chem. 2002;277:30495-501 pubmed publisher
..The results showed the postsynaptic density distribution of actinfilin. Together, these results indicate that actinfilin may be a key player in the actin-based neuronal function...
Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, et al
. Parkin interacts with Ambra1 to induce mitophagy. J Neurosci. 2011;31:10249-61 pubmed publisher
..These data identify interaction of Parkin with Ambra1 as a key mechanism for induction of the final clearance step of Parkin-mediated mitophagy. ..
Rainger J, Williamson K, Soares D, Truch J, Kurian D, Gillessen Kaesbach G, et al
. A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum Mutat. 2017;38:942-946 pubmed publisher
..Three of these genes encoded proteins associated with actin cytoskeleton dynamics: ACTG1, TWF1, and LCP1...
Weinstock R, Saville C, Messina J. Role of cytosolic calcium in regulation of cytoskeletal gene expression by insulin. Am J Physiol. 1993;264:E519-25 pubmed
..This suggests that the regulation of gene transcription by insulin may include calcium-dependent pathways but strongly implies that calcium-independent pathways are also utilized...
Mandai K, Nakanishi H, Satoh A, Obaishi H, Wada M, Nishioka H, et al
. Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol. 1997;139:517-28 pubmed
..These results suggest that l-afadin serves as a linker of the actin cytoskeleton to the plasma membrane at cell-to-cell AJ. ..