Gene Symbol: Acot7
Description: acyl-CoA thioesterase 7
Alias: Bach, cytosolic acyl coenzyme A thioester hydrolase, ACH1, ACT, CTE-II, CTE-IIa, CTE-IIb, LACH1, MTE-II, brain acyl-CoA hydrolase, long chain acyl-CoA thioester hydrolase
Broustas C, Larkins L, Uhler M, Hajra A. Molecular cloning and expression of cDNA encoding rat brain cytosolic acyl-coenzyme A thioester hydrolase. J Biol Chem. 1996;271:10470-6 pubmed
The cDNA encoding rat brain cytosolic acyl-CoA thioester hydrolase (ACT) has been cloned and sequenced, and the primary structure of the enzyme has been deduced...
Engberg S, Aoyama T, Alexson S, Hashimoto T, Svensson L. Peroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells. Biochem J. 1997;323 ( Pt 2):525-31 pubmed
..Both the specific activity and the acyl-CoA chain length specificity were very similar to those of the purified rat liver enzyme. ..
Yamada J, Kuramochi Y, Takagi M, Watanabe T, Suga T. Human brain acyl-CoA hydrolase isoforms encoded by a single gene. Biochem Biophys Res Commun. 2002;299:49-56 pubmed
..The human brain acyl-CoA hydrolase (BACH) gene comprises 13 exons, generating several isoforms through the alternative use of exons...
Yamada J, Matsumoto I, Furihata T, Sakuma M, Suga T. Purification and properties of long-chain acyl-CoA hydrolases from the liver cytosol of rats treated with peroxisome proliferator. Arch Biochem Biophys. 1994;308:118-25 pubmed
Two long-chain acyl-CoA hydrolases, referred to as ACH1 and ACH2, were purified from the liver cytosol of rats fed a diet containing di(2-ethylhexyl)phthalate, a peroxisome proliferator...
Hunt M, Alexson S. The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism. Prog Lipid Res. 2002;41:99-130 pubmed
Kuramochi Y, Takagi Sakuma M, Kitahara M, Emori R, Asaba Y, Sakaguchi R, et al
. Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. Brain Res Mol Brain Res. 2002;98:81-92 pubmed
..mBACH encoded a 338-amino-acid polypeptide with >95% identity to the human and rat homologs, indicating that the BACH gene is highly conserved among species...
Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, et al
. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J Biochem. 1999;126:1013-9 pubmed
..In human brain cytosol, 85% of palmitoyl-CoA hydrolase activity was titrated by an anti-BACH antibody, which accounted for over 75% of the enzyme activity found in the brain tissue...
Hunt M, Yamada J, Maltais L, Wright M, Podesta E, Alexson S. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. 2005;46:2029-32 pubmed
..The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged. ..
Forwood J, Thakur A, Guncar G, Marfori M, Mouradov D, Meng W, et al
. Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proc Natl Acad Sci U S A. 2007;104:10382-7 pubmed
..We present a comprehensive structural and functional characterization of mouse acyl-CoA thioesterase 7 (Acot7)...