Gene Symbol: Acot12
Description: acyl-CoA thioesterase 12
Alias: Cach, rACH, acyl-coenzyme A thioesterase 12, CACH-1, acyl-CoA thioester hydrolase 12, cytoplasmic acetyl-CoA hydrolase 1, cytosolic acetyl-CoA hydrolase, rCACH-1
Species: rat
Products:     Acot12

Top Publications

  1. Suematsu N, Okamoto K, Shibata K, Nakanishi Y, Isohashi F. Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase. Eur J Biochem. 2001;268:2700-9 pubmed
    A cytosolic acetyl-CoA hydrolase (CACH) was purified from rat liver to homogeneity by a new method using Triton X-100 as a stabilizer...
  2. Hunt M, Yamada J, Maltais L, Wright M, Podesta E, Alexson S. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. 2005;46:2029-32 pubmed
    ..The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12...
  3. Yamashita H, Itsuki A, Kimoto M, Hiemori M, Tsuji H. Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase activity is demonstrated by 3-ketoacyl-CoA thiolase. Biochim Biophys Acta. 2006;1761:17-23 pubmed
    ..These findings suggested that acetate generation in liver mitochondria is a side reaction of this known enzyme, 3-ketoacyl-CoA thiolase, and this enzyme may regulate its activities depending on each substrate level. ..
  4. Suematsu N, Okamoto K, Isohashi F. Mouse cytosolic acetyl-CoA hydrolase, a novel candidate for a key enzyme involved in fat metabolism: cDNA cloning, sequencing and functional expression. Acta Biochim Pol. 2002;49:937-45 pubmed
    A cytosolic acetyl-CoA hydrolase (CACH) cDNA has been isolated from mouse liver cDNA library and sequenced. Recombinant expression of the cDNA in insect cells resulted in overproduction of active acetyl-CoA hydrolyzing enzyme protein...
  5. Horibata Y, Ando H, Itoh M, Sugimoto H. Enzymatic and transcriptional regulation of the cytoplasmic acetyl-CoA hydrolase ACOT12. J Lipid Res. 2013;54:2049-59 pubmed publisher
    Acyl-CoA thioesterase 12 (ACOT12) is the major enzyme known to hydrolyze the thioester bond of acetyl-CoA in the cytosol in the liver...