Gene Symbol: Acot1
Description: acyl-CoA thioesterase 1
Alias: Cte1, acyl-coenzyme A thioesterase 1, ACH2, CTE-I, LACH2, acyl-CoA thioesterase 1, cytosolic, cytosolic acyl-CoA thioesterase 1, inducible cytosolic acyl-coenzyme A thioester hydrolase, long chain acyl-CoA hydrolase, long chain acyl-CoA thioester hydrolase
Species: rat

Top Publications

  1. Hunt M, Yamada J, Maltais L, Wright M, Podesta E, Alexson S. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. 2005;46:2029-32 pubmed
    ..The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12...
  2. Momose A, Fujita M, Ohtomo T, Umemoto N, Tanonaka K, Toyoda H, et al. Regulated expression of acyl-CoA thioesterases in the differentiation of cultured rat brown adipocytes. Biochem Biophys Res Commun. 2011;404:74-8 pubmed publisher
    ..Immunocytochemistry suggested that cytosolic ACOT1 was present in the preadipocytes, while mitochondrial ACOT2 was additionally expressed as the cells differentiated,..
  3. Yamada J, Matsumoto I, Furihata T, Sakuma M, Suga T. Purification and properties of long-chain acyl-CoA hydrolases from the liver cytosol of rats treated with peroxisome proliferator. Arch Biochem Biophys. 1994;308:118-25 pubmed
    Two long-chain acyl-CoA hydrolases, referred to as ACH1 and ACH2, were purified from the liver cytosol of rats fed a diet containing di(2-ethylhexyl)phthalate, a peroxisome proliferator...
  4. Yang S, Chen C, Wang H, Rao X, Wang F, Duan Q, et al. Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPAR?/PGC1? signaling. PLoS ONE. 2012;7:e50376 pubmed publisher
    ..By microarray analysis of metabolic gene expression, acyl-CoA thioesterase 1 (acot1) was clearly upregulated in the myocardia of db/db mice, compared with normal control C57BL/Ks...
  5. Ohtomo T, Hoshino A, Yajima M, Tsuchiya A, Momose A, Tanonaka K, et al. Expression and distribution of acyl-CoA thioesterases in the white adipose tissue of rats. Histochem Cell Biol. 2013;140:223-32 pubmed publisher
    ..In this study, we show that a cytosolic isoform, Acot1, is expressed and distributed in immature adipocytes located in the perivascular region of the white adipose ..
  6. Svensson L, Engberg S, Aoyama T, Usuda N, Alexson S, Hashimoto T. Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver. Biochem J. 1998;329 ( Pt 3):601-8 pubmed
  7. Lindquist P, Svensson L, Alexson S. Molecular cloning of the peroxisome proliferator-induced 46-kDa cytosolic acyl-CoA thioesterase from mouse and rat liver--recombinant expression in Escherichia coli, tissue expression, and nutritional regulation. Eur J Biochem. 1998;251:631-40 pubmed
    ..Dietary regulation and tissue-specific expression suggest that CTE-I and MTE-I play important roles in lipid metabolism. ..
  8. Yamada J, Suga K, Furihata T, Kitahara M, Watanabe T, Hosokawa M, et al. cDNA cloning and genomic organization of peroxisome proliferator-inducible long-chain acyl-CoA hydrolase from rat liver cytosol. Biochem Biophys Res Commun. 1998;248:608-12 pubmed
    ..A putative peroxisome proliferator response element (AGGTCATGGTTCA) was identified in the 5'-flanking region, suggesting the involvement of peroxisome proliferator-activated receptors in the regulation of rLACH2 gene expression. ..