Acan

Summary

Gene Symbol: Acan
Description: aggrecan
Alias: Agc, Agc1, CSPCP, aggrecan 1, aggrecan core protein, aggrecan, structural proteoglycan of cartilage, cartilage-specific proteoglycan core protein
Species: rat

Top Publications

  1. doi Localization and developmental expression patterns of CSPG-cs56 (aggrecan) in normal and dystrophic retinas in two rat strains
    Li Feng Chen
    Southwest Hospital Southwest Eye Hospital, Third Military Medical University, Chongqing 400038, China
    Exp Neurol 234:488-98. 2012
  2. pmc Retinoic acid and the transcription factor MafB act together and differentially to regulate aggrecan and matrix metalloproteinase gene expression in neonatal chondrocytes
    Yao Zhang
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Cell Biochem 114:471-9. 2013
  3. ncbi Expression of alternatively spliced epidermal growth factor-like domains in aggrecans of different species. Evidence for a novel module
    C Fulop
    Department of Biochemistry, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612
    J Biol Chem 268:17377-83. 1993
  4. pmc Perinatal exposure to vitamin A differentially regulates chondrocyte growth and the expression of aggrecan and matrix metalloprotein genes in the femur of neonatal rats
    Yao Zhang
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    J Nutr 142:649-54. 2012
  5. pmc PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc
    Chin Chang Cheng
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Physiol 221:668-76. 2009
  6. pmc Microarray cluster analysis of irradiated growth plate zones following laser microdissection
    Timothy A Damron
    SUNY Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 74:949-56. 2009
  7. pmc MSC response to pH levels found in degenerating intervertebral discs
    Karin Wuertz
    School of Engineering, University of Vermont, Burlington, Vermont, USA
    Biochem Biophys Res Commun 379:824-9. 2009
  8. doi Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix
    Mathilde Cancel
    Department of Mechanical Engineering, Ecole Polytechnique de Montreal, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    Bone 44:306-15. 2009
  9. pmc Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc
    Karin Wuertz
    Spine Bioengineering Lab, School of Engineering, University of Vermont, VT 05401, USA
    Spine (Phila Pa 1976) 33:1843-9. 2008
  10. doi Influence of aging on chondroitin sulfate proteoglycan expression and neural stem/progenitor cells in rat brain and improving effects of a herbal medicine, yokukansan
    Y Tanaka
    Section of Oriental Medicine, Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neuroscience 164:1224-34. 2009

Research Grants

Scientific Experts

  • Kosei Ando
  • Ppy Lui
  • Karin Wuertz
  • Hiroki Yasuoka
  • Kurt Doege
  • R T Matthews
  • T A Damron
  • Mathilde Cancel
  • Yao Zhang
  • James W Fawcett
  • Daniela Carulli
  • A Catharine Ross
  • Li Feng Chen
  • Yue Hui Zhang
  • Yun Feng Rui
  • Helena Brisby
  • Minal Patel
  • Fardad T Afshari
  • Y Tanaka
  • Chin Chang Cheng
  • Irving M Shapiro
  • Clare M Galtrey
  • Ruth Schäfer
  • Makarand V Risbud
  • Huiling Ji
  • Huina Zhang
  • Kate E Rhodes
  • Amit Agrawal
  • Anna Lundell
  • Michele L Lemons
  • Susanna Popp
  • John D Sandy
  • Juan Carlos Rodriguez-Manzaneque
  • Thomas FitzGibbon
  • Jian Rong He
  • R A Sobel
  • Zheng Qin Yin
  • Amanda E Wray
  • Chang Qing Zhao
  • Li Yang Dai
  • Lei Sheng Jiang
  • Yuk Wa Lee
  • Sylvia A Chung
  • Tim Molloy
  • Thomas A Dunn
  • Kai Ming Chan
  • George A Murrell
  • Gang Li
  • Sarah Tostanoski
  • Ai Qun Wei
  • John P Fisher
  • Linda White
  • Jessica C Kwok
  • Sai Chuen Fu
  • Ashish D Diwan
  • Sachin Gajghate
  • K Mizoguchi
  • Akihiko Hiyama
  • Yoshiyasu Uchiyama
  • Edward K Chien
  • Vit Long
  • Tanya L Dailey
  • Jessica C F Kwok
  • Doris Dehn
  • Guido J Burbach
  • Thomas Deller
  • Chia Ying Lin
  • Asha Guttapalli
  • Todd J Albert
  • Srinivas Narayan
  • Derek T Logan
  • Salam al-Karadaghi
  • Matthias Morgelin
  • Anders Aspberg
  • Anders I Olin
  • H Watanabe
  • Douglas K Anderson
  • Dena R Howland
  • Richard U Margolis
  • Julie S Andersen
  • Patrice Maurel
  • K Kimata
  • Vera Knauper
  • Gillian Murphy
  • R Perris
  • Alfonso Luque
  • M Luisa Iruela-Arispe
  • Shelley N M Thai
  • Jennifer Westling
  • A S Ahmed

Detail Information

Publications36

  1. doi Localization and developmental expression patterns of CSPG-cs56 (aggrecan) in normal and dystrophic retinas in two rat strains
    Li Feng Chen
    Southwest Hospital Southwest Eye Hospital, Third Military Medical University, Chongqing 400038, China
    Exp Neurol 234:488-98. 2012
    ....
  2. pmc Retinoic acid and the transcription factor MafB act together and differentially to regulate aggrecan and matrix metalloproteinase gene expression in neonatal chondrocytes
    Yao Zhang
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Cell Biochem 114:471-9. 2013
    ..These results support a role for MafB as a regulator of chondrocyte gene expression and matrix formation via control of aggrecan, MMP3 and MMP13 expression, and indicate an important role for RA in the regulation of MafB...
  3. ncbi Expression of alternatively spliced epidermal growth factor-like domains in aggrecans of different species. Evidence for a novel module
    C Fulop
    Department of Biochemistry, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612
    J Biol Chem 268:17377-83. 1993
    ..Although the function of these domains is not understood, the uniform expression of the EGF2 domain may indicate a general role of this aggrecan module, while the expression of the EGF1 domain may reflect species specificity...
  4. pmc Perinatal exposure to vitamin A differentially regulates chondrocyte growth and the expression of aggrecan and matrix metalloprotein genes in the femur of neonatal rats
    Yao Zhang
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    J Nutr 142:649-54. 2012
    ..These results suggest that moderately high maternal VA intake combined with neonatal VARA supplementation can reduce the ratio of aggrecan:MMP, which may unfavorably alter early bone development...
  5. pmc PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc
    Chin Chang Cheng
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Physiol 221:668-76. 2009
    ..Results of these studies demonstrate for the first time that PI3K/AKT signaling controls aggrecan gene expression, in part by modulating Sox9 expression and activity in cells of the nucleus pulposus...
  6. pmc Microarray cluster analysis of irradiated growth plate zones following laser microdissection
    Timothy A Damron
    SUNY Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 74:949-56. 2009
    ..Genes and pathways involved in early growth plate chondrocyte recovery after fractionated irradiation were sought as potential targets for selective radiorecovery modulation...
  7. pmc MSC response to pH levels found in degenerating intervertebral discs
    Karin Wuertz
    School of Engineering, University of Vermont, Burlington, Vermont, USA
    Biochem Biophys Res Commun 379:824-9. 2009
    ..As acidic pH levels are typical of increasingly degenerated discs, our findings demonstrate the importance of early interventions and predifferentiation when planning to use MSCs for reparative treatments...
  8. doi Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix
    Mathilde Cancel
    Department of Mechanical Engineering, Ecole Polytechnique de Montreal, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    Bone 44:306-15. 2009
    ....
  9. pmc Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc
    Karin Wuertz
    Spine Bioengineering Lab, School of Engineering, University of Vermont, VT 05401, USA
    Spine (Phila Pa 1976) 33:1843-9. 2008
    ..OBJECTIVE.: To determine the microenvironmental conditions of the IVD that are critical for MSC-based tissue repair and to determine whether MSCs from different age groups respond differently...
  10. doi Influence of aging on chondroitin sulfate proteoglycan expression and neural stem/progenitor cells in rat brain and improving effects of a herbal medicine, yokukansan
    Y Tanaka
    Section of Oriental Medicine, Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neuroscience 164:1224-34. 2009
    ..These findings help to understand the physiology and pathology of the aged brain and provide an anti-aging strategy for the brain...
  11. doi Sustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model
    Pauline Po Yee Lui
    Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Rheumatology (Oxford) 49:231-9. 2010
    ....
  12. pmc Effect of dynamic compressive loading and its combination with a growth factor on the chondrocytic phenotype of 3-dimensional scaffold-embedded chondrocytes
    Kosei Ando
    Department of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan
    Acta Orthop 80:724-33. 2009
    ..We investigated the effect of mechanical loading and growth factors on reactivation of the 3D-embedded chondrocytes...
  13. doi Isolation and characterization of multipotent rat tendon-derived stem cells
    Yun Feng Rui
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Tissue Eng Part A 16:1549-58. 2010
    ....
  14. doi Cyclic acetal hydroxyapatite composites and endogenous osteogenic gene expression of rat marrow stromal cells
    Minal Patel
    Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA
    J Tissue Eng Regen Med 4:422-36. 2010
    ..Furthermore, we propose that studying gene expression patterns induced by the surrounding biomaterials environment is a fundamental step in the creation of engineered tissues...
  15. doi Schwann cell migration is integrin-dependent and inhibited by astrocyte-produced aggrecan
    Fardad T Afshari
    Department of Clinical Neurosciences, Cambridge University Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, United Kingdom
    Glia 58:857-69. 2010
    ..We further show aggrecan mediates its effect by disruption of integrin function in Schwann cells, and that the inhibitory effects of aggrecan can overcome by activation of Schwann cell integrins...
  16. doi The effect of running exercise on intervertebral disc extracellular matrix production in a rat model
    Helena Brisby
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden
    Spine (Phila Pa 1976) 35:1429-36. 2010
    ..Using a running rat model, the effects of physical exercise on cellular function and intervertebral disc (IVD) extracellular matrix were studied...
  17. doi Substrate stiffness regulates apoptosis and the mRNA expression of extracellular matrix regulatory genes in the rat annular cells
    Yue Hui Zhang
    Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, China
    Matrix Biol 30:135-44. 2011
    ....
  18. doi Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway
    Huina Zhang
    Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Spine (Phila Pa 1976) 33:E525-31. 2008
    ..In vitro experiment to study the effect of simvastatin on rat intervertebral disc (IVD) cells...
  19. doi Differential regulation of chondroitin sulfate proteoglycan mRNAs in the denervated rat fascia dentata after unilateral entorhinal cortex lesion
    Ruth Schäfer
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neurosci Lett 439:61-5. 2008
    ....
  20. doi Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord
    Clare M Galtrey
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge, CB2 2PY, UK
    Eur J Neurosci 27:1373-90. 2008
    ..During postnatal development the expression of link protein and aggrecan mRNA is up-regulated at the time of PNN formation, and these molecules may therefore trigger their formation...
  21. ncbi Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones
    K Doege
    Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, Bethesda, Maryland 20892
    J Biol Chem 262:17757-67. 1987
    ..The first pattern is the more highly conserved, and may have given rise to the second. The carboxyl-terminal domain is a third globule which has homology with animal lectins...
  22. ncbi Cartilage proteoglycan aggregates. The link protein and proteoglycan amino-terminal globular domains have similar structures
    P J Neame
    Department Medicine, University of Alabama, Birmingham 35294
    J Biol Chem 262:17768-78. 1987
    ..We have deduced the positions of all of the disulfide bonds in the hyaluronic acid binding region and find them to be in the same positions as would be expected from comparison of these sequences with link protein...
  23. ncbi Inhibitory effects of PG-H/aggrecan and PG-M/versican on avian neural crest cell migration
    R Perris
    Reference Center for Oncology, Division of Experimental Oncology 2, Aviano, Italy
    FASEB J 10:293-301. 1996
    ....
  24. pmc Dwarfism and age-associated spinal degeneration of heterozygote cmd mice defective in aggrecan
    H Watanabe
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Proc Natl Acad Sci U S A 94:6943-7. 1997
    ..Electron microscopy showed a degeneration of disc chondrocytes in the heterozygotes. These findings may facilitate the identification of mutations in humans predisposed to spinal degeneration...
  25. ncbi White matter extracellular matrix chondroitin sulfate/dermatan sulfate proteoglycans in multiple sclerosis
    R A Sobel
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    J Neuropathol Exp Neurol 60:1198-207. 2001
    ..Thus, ECM PG alterations are specific, temporally dynamic, and widespread in MS patients and may play critical roles in lesion pathogenesis and CNS dysfunction...
  26. ncbi A remote upstream element regulates tissue-specific expression of the rat aggrecan gene
    Kurt Doege
    Department of Biochemistry, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Biol Chem 277:13989-97. 2002
    ..This is the first report of a gene control region which confers authentic tissue-specific regulation of aggrecan in vitro or in vivo and should greatly facilitate understanding the coordinate regulation of chondrocytic genes...
  27. ncbi ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors
    Juan Carlos Rodriguez-Manzaneque
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, University of California at Los Angeles, 611, Charles E Young Drive, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 293:501-8. 2002
    ..Finally, we developed an activity assay using an artificial peptide substrate based on the interglobular domain cleavage site (E(373)-A) of rat aggrecan...
  28. ncbi Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets
    Russell T Matthews
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 22:7536-47. 2002
    ..These results have important implications for the role of regulated microheterogeneity of glycosylation in the CNS...
  29. ncbi Localization of aggrecan and versican in the developing rat central nervous system
    Susanna Popp
    Department of Pharmacology, New York University Medical Center, New York, New York 10016, USA
    Dev Dyn 227:143-9. 2003
    ..Differences in the localization and temporal expression patterns of these chondroitin sulfate proteoglycans suggest that, like neurocan and phosphacan, they have partially complementary roles during central nervous system development...
  30. ncbi Intact aggrecan and chondroitin sulfate-depleted aggrecan core glycoprotein inhibit axon growth in the adult rat spinal cord
    Michele L Lemons
    Department of Pharmacology and Therapeutics and Center for Research in Pediatric Orthopedics, Shriners Hospital, University of South Florida, Tampa, FL 33612, USA
    Exp Neurol 184:981-90. 2003
    ....
  31. ncbi Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins
    Anna Lundell
    Department of Molecular Biophysics, Lund University, Box 124, S 221 00 Lund, Sweden
    Structure 12:1495-506. 2004
    ..Comparison of the protein interaction surface with that of P-selectin in complex with the PGSL-1 peptide suggests that direct protein-protein interactions of Ca(2+)-binding CLDs may be more widespread than previously appreciated...
  32. ncbi Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum
    Daniela Carulli
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
    J Comp Neurol 501:83-94. 2007
    ..These data suggest that aggrecan, HA, and, particularly, Crtll might be crucial elements for the initial assembly of PNNs...
  33. ncbi Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk
    Amit Agrawal
    Dept of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Cell Physiol 293:C621-31. 2007
    ..Results of this study indicate that oxygen-independent stabilization of HIF-1alpha in nucleus pulposus cells is a metabolic adaptation that drives glycolysis and aggrecan expression...
  34. doi Effects of reloading after simulated microgravity on proteoglycan metabolism in the nucleus pulposus and anulus fibrosus of the lumbar intervertebral disc: an experimental study using a rat tail suspension model
    Hiroki Yasuoka
    Department of Orthopedic Surgery, National Defense Medical College, Saitama, Japan
    Spine (Phila Pa 1976) 32:E734-40. 2007
    ..An experiment to measure proteoglycan (PG) content and PG-related gene mRNA expressions in the lumbar intervertebral disc (IVD) of rats tail-suspended (TS) for up to 6 weeks with subsequent reloading...
  35. doi Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis
    Huiling Ji
    Section of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island, Brown University, Providence, RI, USA
    Am J Obstet Gynecol 198:543.e1-9. 2008
    ..Evidence suggests that androgens may play a role in the cervix. We hypothesized that androgens directly regulate cervical remodeling by altering both collagen structure and proteoglycan composition...
  36. ncbi Partial cDNA sequence encoding a globular domain at the C terminus of the rat cartilage proteoglycan
    K Doege
    J Biol Chem 261:8108-11. 1986
    ..The clone extends into a region where serines are clustered, probably the start of the chondroitin sulfate-rich region...

Research Grants7

  1. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2003
    ..abstract_text> ..
  2. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2007
    ..abstract_text> ..