Gene Symbol: Acadvl
Description: acyl-CoA dehydrogenase, very long chain
Alias: VLCAD, very long-chain specific acyl-CoA dehydrogenase, mitochondrial, VLCAD very-long-chain acyl-CoA dehydrogenase, Very long chain Acyl-Coa dehydrogenase, acyl-Coenzyme A dehydrogenase, very long chain
Species: rat
Products:     Acadvl

Top Publications

  1. Aoyama T, Souri M, Ueno I, Kamijo T, Yamaguchi S, Rhead W, et al. Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients. Am J Hum Genet. 1995;57:273-83 pubmed
    ..736 bp, respectively) encoding the precursor of human mitochondrial very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) were cloned and sequenced...
  2. Choi J, Ravipati A, Nimmagadda V, Schubert M, Castellani R, Russell J. Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes. Mitochondrion. 2014;18:41-8 pubmed publisher
    ..of two key enzymes of the mitochondrial β-oxidation machinery, acyl-coenzyme A dehydrogenase, very long chain (ACADVL) and mitochondrial trifunctional enzyme subunit α are significantly decreased in AD and diabetic brains...
  3. Aoyama T, Ueno I, Kamijo T, Hashimoto T. Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cD. J Biol Chem. 1994;269:19088-94 pubmed
    cDNA encoding the precursor of rat very-long-chain acyl-CoA dehydrogenase (VLCAD) was cloned and sequenced. The longest cDNA insert had 2117 bases...
  4. Chouchani E, Hurd T, Nadtochiy S, Brookes P, Fearnley I, Lilley K, et al. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation. Biochem J. 2010;430:49-59 pubmed publisher
    ..More generally, the development of SNO-DIGE facilitates robust investigation of protein S-nitrosation across the proteome. ..
  5. Ghisla S, Thorpe C. Acyl-CoA dehydrogenases. A mechanistic overview. Eur J Biochem. 2004;271:494-508 pubmed
    ..These views are also discussed in the context of the accompanying paper on the three-dimensional properties of acyl-CoA dehydrogenases. ..
  6. Kim J, Choi S, Lee H, Hwang I, Lee Y, An B, et al. Selenium significantly inhibits adipocyte hypertrophy and abdominal fat accumulation in OLETF rats via induction of fatty acid ?-oxidation. Biol Trace Elem Res. 2012;150:360-70 pubmed publisher
    ..metabolism-related factors, including abdominal fat, adiponectin, cholesterol, very long chain dehydrogenase (VLCAD), and medium chain acyl-CoA dehydrogenase (MCAD) in 20-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats ..
  7. Mason K, Stofan D, Szweda L. Inhibition of very long chain acyl-CoA dehydrogenase during cardiac ischemia. Arch Biochem Biophys. 2005;437:138-43 pubmed
    ..Very long chain acyl-CoA dehydrogenase (VLCAD) activity declined 34% during 30 min of ischemia...
  8. Goetzman E, Tian L, Wood P. Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice. Mol Genet Metab. 2005;84:39-47 pubmed
    Mice deficient for either long-chain acyl-CoA dehydrogenase (LCAD-/-) or very-long-chain acyl-CoA dehydrogenase (VLCAD-/-) develop hepatic steatosis upon fasting, due to disrupted mitochondrial fatty acid oxidation...
  9. Bem Z, Birecka A. [A rare type of bone involvement in scleroderma (author's transl)]. Pol Przegl Radiol Med Nukl. 1978;42:115-7 pubmed

Scientific Experts

More Information


  1. Pruitt K, Maglott D. RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Res. 2001;29:137-40 pubmed
    ..Additional information about LocusLink and RefSeq is available at ..
  2. Exil V, Silva Avila D, Benedetto A, Exil E, Adams M, Au C, et al. Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. PLoS ONE. 2010;5:e14228 pubmed publisher
    ..elegans). We have previously documented a mouse model of mitochondrial very-long chain acyl-CoA dehydrogenase (VLCAD) deficiency...
  3. Przkora R, Haslbeck M, Jeschke M, Heyde C, Ertel W, Herndon D, et al. Heat stress modulates hepatocyte membrane proteins during endotoxemia. Burns. 2007;33:628-33 pubmed
    ..The majority of the spots developed 24h after injection. Membrane proteins; Wnt 13, ribosomal protein L14, VLCAD, BHMT and HIT-40 were found only in HS-LPS. Protein profiles of the groups returned to normal after 72 h...
  4. Jia X, Naito H, Yetti H, Tamada H, Kitamori K, Hayashi Y, et al. The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model. Life Sci. 2012;90:934-43 pubmed publisher
    ..Additionally, this study provides new insights into the roles of EPA in hepatic ATP depletion and subsequent hepatocellular injury during severe fibrosis. ..
  5. Bána J, Kralik J. [1st experiences with complex analysis of urinary calculi]. Rozhl Chir. 1978;57:813-20 pubmed
  6. Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T. Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase. J Biol Chem. 1992;267:1027-33 pubmed
    ..The specific enzyme activity was greater than 10 times that of long-chain acyl-CoA dehydrogenase when palmitoyl-CoA was used as substrate. We propose the name "very-long-chain acyl-CoA dehydrogenase" for this enzyme. ..
  7. Fujikawa T, Hirata T, Hosoo S, Nakajima K, Wada A, Yurugi Y, et al. Asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of Eucommia leaves with anti-obesity activity. J Nutr Sci. 2012;1:e10 pubmed publisher
  8. Sauer S, Okun J, Schwab M, Crnic L, Hoffmann G, Goodman S, et al. Bioenergetics in glutaryl-coenzyme A dehydrogenase deficiency: a role for glutaryl-coenzyme A. J Biol Chem. 2005;280:21830-6 pubmed
    ..In conclusion, our results demonstrate that bioenergetic impairment may play an important role in the pathomechanisms underlying neurodegenerative changes in glutaryl-CoA dehydrogenase deficiency. ..
  9. Ensenauer R, He M, Willard J, Goetzman E, Corydon T, Vandahl B, et al. Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial beta-oxidation of unsaturated fatty acids. J Biol Chem. 2005;280:32309-16 pubmed
    ..Because of the substrate specificity and abundance of ACAD-9 in brain, we speculate that it may play a role in the turnover of lipid membrane unsaturated fatty acids that are essential for membrane integrity and structure. ..