Gene Symbol: Acads
Description: acyl-CoA dehydrogenase short chain
Alias: Scad, short-chain specific acyl-CoA dehydrogenase, mitochondrial, acetyl-Coenzyme A dehydrogenase, short chain, acyl-CoA dehydrogenase, C-2 to C-3 short chain, acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain, acyl-Coenzyme A dehydrogenase, short chain, butyryl-CoA dehydrogenase, short chain acyl-coenzyme A dehydrogenase, short-chain acyl-CoA dehydrogenase
Species: rat
Products:     Acads

Top Publications

  1. Huang Q, Huang J, Zeng Z, Luo J, Liu P, Chen S, et al. Effects of ERK1/2/PPAR?/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine. Life Sci. 2015;124:41-9 pubmed publisher
    Short-chain acyl-CoA dehydrogenase (SCAD) is a key enzyme in fatty acid oxidation. In the present study we aim to investigate the changes in SCAD between pathological and physiological cardiomyocyte hypertrophy...
  2. Zeng Z, Huang Q, Shu Z, Liu P, Chen S, Pan X, et al. Effects of short-chain acyl-CoA dehydrogenase on cardiomyocyte apoptosis. J Cell Mol Med. 2016;20:1381-91 pubmed publisher
    Short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid ?-oxidation, plays an important role in cardiac hypertrophy. However, its effect on the cardiomyocyte apoptosis remains unknown...
  3. Finocchiaro G, Ito M, Tanaka K. Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver. J Biol Chem. 1987;262:7982-9 pubmed
    ..The pattern of substrate specificity for these enzymes determined using ETF as electron acceptor significantly differed from that determined using PMS. All of them were severely inhibited by (methylenecyclopropyl)acetyl-CoA. ..
  4. Battaile K, Mohsen A, Vockley J. Functional role of the active site glutamate-368 in rat short chain acyl-CoA dehydrogenase. Biochemistry. 1996;35:15356-63 pubmed
    ..changing the position of the catalytic carboxylate on substrate specificity in short chain acyl-CoA dehydrogenase (SCAD)...
  5. Coulson A. Treatment of metritis in cattle with prostaglandin F2 alpha. Vet Rec. 1978;103:359 pubmed
  6. Battaile K, Molin Case J, Paschke R, Wang M, Bennett D, Vockley J, et al. Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases. J Biol Chem. 2002;277:12200-7 pubmed publisher
    ..Ten reported pathogenic human mutations and two polymorphisms have been mapped onto the structure of short chain acyl-CoA dehydrogenase. None of the mutations directly affect the binding cavity or intersubunit interactions...
  7. Botham K, Maldonado E, Chico Y, Zheng X, Avella M, Ochoa B. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Biochim Biophys Acta. 2001;1534:96-109 pubmed
  8. Nagao M, Parimoo B, Tanaka K. Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and alpha-subunit of electron transfer flavoprotein in rat. J Biol Chem. 1993;268:24114-24 pubmed
    Short chain (SCAD), medium chain (MCAD), and long chain acyl-CoA dehydrogenases (LCAD) catalyze the first step of fatty acid oxidation, while isovaleryl-CoA dehydrogenase (IVD) is involved in leucine oxidation...
  9. Ikeda Y, Keese S, Fenton W, Tanaka K. Biosynthesis of four rat liver mitochondrial acyl-CoA dehydrogenases: in vitro synthesis, import into mitochondria, and processing of their precursors in a cell-free system and in cultured cells. Arch Biochem Biophys. 1987;252:662-74 pubmed
    ..On the other hand, when the chase was performed in the presence of the inhibitor, the labeled precursors disappeared with t1/2 of greater than 4 h for long chain acyl-CoA dehydrogenase and 1-2 h for the other three enzyme precursors. ..

More Information


  1. Matsubara Y, Indo Y, Naito E, Ozasa H, Glassberg R, Vockley J, et al. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase famil. J Biol Chem. 1989;264:16321-31 pubmed
    ..encoding the entire coding regions of the precursors (p) of rat long chain acyl-CoA (LCAD), short chain acyl-CoA (SCAD) and isovaleryl-CoA dehydrogenase (IVD) have been cloned and sequenced...
  2. Dabrowski Z, Gregorczyk J, Samochowiec L, Wojcicki J, Lawczynski L, Antoszczyk M, et al. [Effect of truncal vagotomy on the exocrine function of the pancreas in the dog]. Pol Tyg Lek. 1978;33:1093-5 pubmed
  3. Dakoji S, Shin I, Battaile K, Vockley J, Liu H. Redesigning the active-site of an acyl-CoA dehydrogenase: new evidence supporting a one-base mechanism. Bioorg Med Chem. 1997;5:2157-64 pubmed
    ..These results, in conjunction with molecular modeling of the native and double mutant SCAD indicate that the catalytic base in the E1 and E2 sites are topologically similar and catalytically competent...
  4. Ghisla S, Thorpe C. Acyl-CoA dehydrogenases. A mechanistic overview. Eur J Biochem. 2004;271:494-508 pubmed
    ..These views are also discussed in the context of the accompanying paper on the three-dimensional properties of acyl-CoA dehydrogenases. ..
  5. Lamhonwah A, Tein I. Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. Biochem Biophys Res Commun. 2006;345:1315-25 pubmed
    ..This suggests an important yet different role for OCTN1 from other OCTN family members in intracellular carnitine homeostasis. ..
  6. Kitayama K, Tanimoto T, Koga T, Terasaka N, Fujioka T, Inaba T. Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe. Eur J Pharmacol. 2006;540:121-30 pubmed
    ..Despite similar cholesterol lowering, fatty streak area reduction was greater by 10 mg/kg. These results suggest that ACAT1/2 dual inhibitor pactimibe has anti-atherosclerotic potential beyond its plasma cholesterol-lowering activity. ..
  7. Huang J, Xu L, Huang Q, Luo J, Liu P, Chen S, et al. Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress. J Cell Mol Med. 2015;19:1672-88 pubmed publisher
    This study was designed to investigate the expression of short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid β-oxidation, during rat heart development and the difference of SCAD between pathological and physiological ..
  8. Ikeda Y, Okamura Ikeda K, Tanaka K. Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. J Biol Chem. 1985;260:1311-25 pubmed
    ..In the presence of electron-transfer flavoprotein or phenazine methosulfate, 2-enoyl-CoAs were identified as products from the corresponding enzyme/acyl-CoA reactions. ..