Gene Symbol: Acadl
Description: acyl-CoA dehydrogenase, long chain
Alias: ACOADA, LCAD, long-chain specific acyl-CoA dehydrogenase, mitochondrial, Acyl Coenzyme A dehydrogenase, long chain, LCAD long chain acyl-CoA dehydrogenase, acetyl-Coenzyme A dehydrogenase, long-chain, acyl-Coenzyme A dehydrogenase, long-chain, long-chain acyl-CoA dehydrogenase
Species: rat
Products:     Acadl

Top Publications

  1. Kurtz D, Rinaldo P, Rhead W, Tian L, Millington D, Vockley J, et al. Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci U S A. 1998;95:15592-7 pubmed
    ..Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the initial step in mitochondrial fatty acid oxidation (FAO)...
  2. Goetzman E, Tian L, Wood P. Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice. Mol Genet Metab. 2005;84:39-47 pubmed
    Mice deficient for either long-chain acyl-CoA dehydrogenase (LCAD-/-) or very-long-chain acyl-CoA dehydrogenase (VLCAD-/-) develop hepatic steatosis upon fasting, due to disrupted mitochondrial fatty acid oxidation...
  3. Exil V, Silva Avila D, Benedetto A, Exil E, Adams M, Au C, et al. Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. PLoS ONE. 2010;5:e14228 pubmed publisher
    ..The data obtained from our experiments suggest that TMEM135 is part of a regulatory circuit that plays a critical role in the survival of VLCAD-deficient mice and perhaps in other mitochondrial genetic defects of fat metabolism as well. ..
  4. Matsubara Y, Indo Y, Naito E, Ozasa H, Glassberg R, Vockley J, et al. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase famil. J Biol Chem. 1989;264:16321-31 pubmed
    cDNAs encoding the entire coding regions of the precursors (p) of rat long chain acyl-CoA (LCAD), short chain acyl-CoA (SCAD) and isovaleryl-CoA dehydrogenase (IVD) have been cloned and sequenced...
  5. Hainline B, Kahlenbeck D, Grant J, Strauss A. Tissue specific and developmental expression of rat long-and medium-chain acyl-CoA dehydrogenases. Biochim Biophys Acta. 1993;1216:460-8 pubmed
    ..the tissue distribution and developmental profile of the rat long- and medium-chain acyl-CoA dehydrogenase (LCAD and MCAD) mRNAs were compared...
  6. Pruitt K, Maglott D. RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Res. 2001;29:137-40 pubmed
    ..Additional information about LocusLink and RefSeq is available at ..
  7. Ghisla S, Thorpe C. Acyl-CoA dehydrogenases. A mechanistic overview. Eur J Biochem. 2004;271:494-508 pubmed
    ..These views are also discussed in the context of the accompanying paper on the three-dimensional properties of acyl-CoA dehydrogenases. ..
  8. Ikeda Y, Keese S, Fenton W, Tanaka K. Biosynthesis of four rat liver mitochondrial acyl-CoA dehydrogenases: in vitro synthesis, import into mitochondria, and processing of their precursors in a cell-free system and in cultured cells. Arch Biochem Biophys. 1987;252:662-74 pubmed
    ..On the other hand, when the chase was performed in the presence of the inhibitor, the labeled precursors disappeared with t1/2 of greater than 4 h for long chain acyl-CoA dehydrogenase and 1-2 h for the other three enzyme precursors. ..
  9. Ikeda Y, Okamura Ikeda K, Tanaka K. Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme. J Biol Chem. 1985;260:1311-25 pubmed
    ..In the presence of electron-transfer flavoprotein or phenazine methosulfate, 2-enoyl-CoAs were identified as products from the corresponding enzyme/acyl-CoA reactions. ..

Scientific Experts

More Information


  1. Willard J, Vicanek C, Battaile K, Van Veldhoven P, Fauq A, Rozen R, et al. Cloning of a cDNA for short/branched chain acyl-Coenzyme A dehydrogenase from rat and characterization of its tissue expression and substrate specificity. Arch Biochem Biophys. 1996;331:127-33 pubmed
    ..Northern blotting of mRNA shows ubiquitous tissue expression of both the rat and human enzyme. Further study of these enzymes will be helpful in understanding structure/function relationships in this gene family. ..