Gene Symbol: Acaa2
Description: acetyl-CoA acyltransferase 2
Alias: 3-ketoacyl-CoA thiolase, mitochondrial, acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase), beta-ketothiolase, mitochondrial 3-oxoacyl-CoA thiolase
Species: rat
Products:     Acaa2

Top Publications

  1. Yamashita H, Itsuki A, Kimoto M, Hiemori M, Tsuji H. Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase activity is demonstrated by 3-ketoacyl-CoA thiolase. Biochim Biophys Acta. 2006;1761:17-23 pubmed
    ..These findings suggested that acetate generation in liver mitochondria is a side reaction of this known enzyme, 3-ketoacyl-CoA thiolase, and this enzyme may regulate its activities depending on each substrate level. ..
  2. Cao W, Liu N, Tang S, Bao L, Shen L, Yuan H, et al. Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines. Biochim Biophys Acta. 2008;1780:873-80 pubmed publisher
    ..membrane yeast two-hybrid system was constructed and used to identify acetyl-Coenzyme A acyltransferase 2 (ACAA2) as a new BNIP3 binding partner...
  3. Silva M, Ruiter J, Overmars H, Bootsma A, van Gennip A, Jakobs C, et al. Complete beta-oxidation of valproate: cleavage of 3-oxovalproyl-CoA by a mitochondrial 3-oxoacyl-CoA thiolase. Biochem J. 2002;362:755-60 pubmed
    ..Our data should lead to a re-evaluation of the generally accepted concept that the biotransformation of VPA by mitochondrial beta-oxidation is incomplete. ..
  4. Arakawa H, Takiguchi M, Amaya Y, Nagata S, Hayashi H, Mori M. cDNA-derived amino acid sequence of rat mitochondrial 3-oxoacyl-CoA thiolase with no transient presequence: structural relationship with peroxisomal isozyme. EMBO J. 1987;6:1361-6 pubmed
    ..Two portions in the mitochondrial thiolase that may serve as a mitochondrial targeting signal are presented. ..