Gene Symbol: Acaa1a
Description: acetyl-CoA acyltransferase 1A
Alias: Acaa, Acaa1, Pktaa, 3-ketoacyl-CoA thiolase A, peroxisomal, Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A peroxisomal, acetyl-CoA acyltransferase 1, acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A 1 peroxisomal, acetyl-CoA acyltransferase A, acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A, acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase), acetyl-Coenzyme A acyltransferase 1A, beta-ketothiolase A, peroxisomal 3-oxoacyl-CoA thiolase A
Species: rat
Products:     Acaa1a

Top Publications

  1. Swinkels B, Gould S, Bodnar A, Rachubinski R, Subramani S. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J. 1991;10:3255-62 pubmed
    ..These results imply the existence of two different routes for targeting proteins into the peroxisomal matrix. ..
  2. Litwin J, Volkl A, Müller Höcker J, Fahimi H. Immunocytochemical demonstration of peroxisomal enzymes in human kidney biopsies. Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;54:207-13 pubmed
    ..The immunocytochemical procedure described herein provides a simple approach for the investigation of peroxisomal structure and function in human renal biopsies processed for ultrastructural studies. ..
  3. Kabir Y, Ide T. Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid. Biochim Biophys Acta. 1996;1304:105-19 pubmed
    ..Thus, compared to linoleic acid and saturated fatty acids, dietary alpha-18:3 caused characteristic changes in the activity of hepatic enzymes in fatty acid and glucose metabolism in rats. ..
  4. Nenicu A, Lüers G, Kovacs W, David M, Zimmer A, Bergmann M, et al. Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol Reprod. 2007;77:1060-72 pubmed
    ..Our results suggest a cell type-specific metabolic function of peroxisomes in the testis and point to an important role for peroxisomes in spermiogenesis and in the lipid metabolism of Sertoli cells. ..
  5. Hijikata M, Wen J, Osumi T, Hashimoto T. Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes. J Biol Chem. 1990;265:4600-6 pubmed
    ..Several common sequences were noted in the 5'-flanking regions of the B gene and in the genes of two other peroxisomal beta-oxidation enzymes, induced in parallel by peroxisome proliferators. ..
  6. Andoh Y, Kuramoto T, Yokoi N, Maihara T, Kitada K, Serikawa T. Correlation between genetic and cytogenetic maps of the rat. Mamm Genome. 1998;9:287-93 pubmed
    ..Thus, we provide here a new base for rat genetic maps. ..
  7. Schram A, Goldfischer S, van Roermund C, Brouwer Kelder E, Collins J, Hashimoto T, et al. Human peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency. Proc Natl Acad Sci U S A. 1987;84:2494-6 pubmed
  8. Hijikata M, Ishii N, Kagamiyama H, Osumi T, Hashimoto T. Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. J Biol Chem. 1987;262:8151-8 pubmed
    ..Acyl-CoA binding sites were also located on primary structures of the two thiolases. The occurrence of interrupting sequences in several clones likely originates from intron sequences. ..
  9. Espeel M, Van Limbergen G. Immunocytochemical localization of peroxisomal proteins in human liver and kidney. J Inherit Metab Dis. 1995;18 Suppl 1:135-54 pubmed

More Information


  1. Khan S, Nyce J. Effects of ubiquinone and mevalonic acid on hepatic peroxisomal enzymes induced by dehydroepiandrosterone. Pharmacol Toxicol. 1997;80:118-21 pubmed
    ..These data suggest that exogenous administration of ubiquinone or mevalonic acid can modulate the induction of the enzymes involved in peroxisome proliferation. ..
  2. Ferdinandusse S, Denis S, Mooijer P, Zhang Z, Reddy J, Spector A, et al. Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. J Lipid Res. 2001;42:1987-95 pubmed
    ..These findings are of importance for the treatment of patients with a defect in peroxisomal beta-oxidation. ..
  3. Heikoop J, Ossendorp B, Wanders R, Wirtz K, Tager J. Subcellular localisation and processing of non-specific lipid transfer protein are not aberrant in Rhizomelic Chondrodysplasia Punctata fibroblasts. FEBS Lett. 1992;299:201-4 pubmed
    ..Thus the component of the import machinery defective in RCDP is not required for the import of nsLTP into peroxisomes. ..
  4. Bodnar A, Rachubinski R. Cloning and sequence determination of cDNA encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase. Gene. 1990;91:193-9 pubmed
    ..1.7 kb in size. The mRNA encoding thiolase 2 is induced approx. twofold upon treatment of rats with the peroxisome-proliferating drug, clofibrate. In contrast, the thiolase 1 mRNA is induced more than tenfold under similar conditions. ..
  5. Clayton P, Patel E, Lawson A, Carruthers R, Collins J. Bile acid profiles in peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency. J Clin Invest. 1990;85:1267-73 pubmed
    ..The results provide evidence for peroxisomal pathways for cholic acid synthesis in man via THCA, delta 24-THCA and varanic acid and show that bile acid analyses can be used to diagnose peroxisomal thiolase deficiency. ..
  6. Heikoop J, van Roermund C, Just W, Ofman R, Schutgens R, Heymans H, et al. Rhizomelic chondrodysplasia punctata. Deficiency of 3-oxoacyl-coenzyme A thiolase in peroxisomes and impaired processing of the enzyme. J Clin Invest. 1990;86:126-30 pubmed
    ..However, the capacity of the peroxisomes to oxidize very-long-chain fatty acids must be sufficient to prevent excessive accumulation of these compounds in vivo...
  7. Onay Besikci A, Guner S, Arioglu E, Ozakca I, Ozcelikay A, Altan V. The effects of chronic trimetazidine treatment on mechanical function and fatty acid oxidation in diabetic rat hearts. Can J Physiol Pharmacol. 2007;85:527-35 pubmed
    ..A detailed kinetic analysis of 3-KAT using different concentrations of fatty acid will determine the fatty acid inhibitory concentration of TMZ in diabetic state where plasma fatty acid levels are increased. ..