Abl1

Summary

Gene Symbol: Abl1
Description: ABL proto-oncogene 1, non-receptor tyrosine kinase
Alias: Abl, tyrosine-protein kinase ABL1, Abelson murine leukemia viral (v-abl) oncogene homolog 1, c-abl oncogene 1, non-receptor tyrosine kinase, c-abl oncogene 1, receptor tyrosine kinase, v-abl Abelson murine leukemia viral oncogene 1
Species: rat
Products:     Abl1

Top Publications

  1. Roig J, Tuazon P, Zipfel P, Pendergast A, Traugh J. Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci U S A. 2000;97:14346-51 pubmed
    ..We report herein that gamma-PAK is associated in vivo with the nonreceptor protein tyrosine kinase c-Abl. gamma-PAK phosphorylates c-Abl on sites located in the kinase domain, in a region that is implicated in protein-..
  2. Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan Z, et al. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature. 1997;386:732-5 pubmed
    How DNA damage is converted into intracellular signals that can control cell behaviour is unknown. The c-Abl protein tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents, whereas the DNA-dependent ..
  3. Perez de Arce K, de Arce K, Varela Nallar L, Farias O, Cifuentes A, Bull P, et al. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J Neurosci. 2010;30:3728-38 pubmed publisher
    The c-Abl tyrosine kinase is present in mouse brain synapses, but its precise synaptic function is unknown. We found that c-Abl levels in the rat hippocampus increase postnatally, with expression peaking at the first postnatal week...
  4. Cao C, Leng Y, Huang W, Liu X, Kufe D. Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem. 2003;278:39609-14 pubmed
    The c-Abl and Arg tyrosine kinases are activated in the cellular response to oxidative stress...
  5. Woodring P, Litwack E, O Leary D, Lucero G, Wang J, Hunter T. Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol. 2002;156:879-92 pubmed
    The nonreceptor tyrosine kinase encoded by the c-Abl gene has the unique feature of an F-actin binding domain (FABD)...
  6. Kain K, Klemke R. Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes. J Biol Chem. 2001;276:16185-92 pubmed
    c-Abl and the Abl-related gene product (Arg) are nonreceptor tyrosine kinases that regulate the actin cytoskeleton of cells by direct association with F-actin and localization to focal contacts...
  7. Cancino G, Toledo E, Leal N, Hernandez D, Yévenes L, Inestrosa N, et al. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain. 2008;131:2425-42 pubmed publisher
    ..We have previously reported that c-Abl kinase activation involved in cell signalling regulates the neuronal death response to Abeta fibrils (Abeta(f))...
  8. Jones S, Lu H, Lu Q. Abl tyrosine kinase promotes dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho family small GTPases in hippocampal neurons. J Neurosci. 2004;24:8510-21 pubmed
    Nonreceptor tyrosine kinase Abl is an actin-binding protein and a key regulator of neuronal axonal development...
  9. Sun X, Wu F, Datta R, Kharbanda S, Kufe D. Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J Biol Chem. 2000;275:7470-3 pubmed
    ..that treatment of cells with hydrogen peroxide (H(2)O(2)) induces binding of the PKCdelta isoform and the c-Abl protein-tyrosine kinase. The results show that c-Abl phosphorylates PKCdelta in the H(2)O(2) response...

More Information

Publications81

  1. Koleske A, Gifford A, Scott M, Nee M, Bronson R, Miczek K, et al. Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron. 1998;21:1259-72 pubmed
    The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions...
  2. Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C. Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J Exp Med. 2014;211:1167-83 pubmed publisher
    ..NRP1 formed a complex with ABL1 that was responsible for FN-dependent PXN activation and actin remodeling...
  3. Yuan Z, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kharbanda S, et al. Regulation of Rad51 function by c-Abl in response to DNA damage. J Biol Chem. 1998;273:3799-802 pubmed
    ..The c-Abl tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents...
  4. Yoshida K, Komatsu K, Wang H, Kufe D. c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol Cell Biol. 2002;22:3292-300 pubmed
    The ubiquitously expressed c-Abl tyrosine kinase is activated in the apoptotic response of cells to DNA damage. The mechanisms by which c-Abl signals the induction of apoptosis are not understood...
  5. Westphal R, Soderling S, Alto N, Langeberg L, Scott J. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. EMBO J. 2000;19:4589-600 pubmed
    ..for rat brain A kinase-anchoring proteins (AKAPs), which bind to the SH3 domain of the Abelson tyrosine kinase (Abl)...
  6. Alvarez A, Klein A, Castro J, Cancino G, Amigo J, Mosqueira M, et al. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. FASEB J. 2008;22:3617-27 pubmed publisher
    ..The purpose of this study was to analyze the relevance of apoptosis and particularly the proapoptotic c-Abl/p73 system in cerebellar neuron degeneration in NPC disease...
  7. Alvarez A, Sandoval P, Leal N, Castro P, Kosik K. Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species. Neurobiol Dis. 2004;17:326-36 pubmed
    ..c-Abl kinase is involved in the regulation of apoptosis and its pro-apoptotic function is in part mediated by its ..
  8. Michael M, Vehlow A, Navarro C, Krause M. c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis. Curr Biol. 2010;20:783-91 pubmed publisher
    ..Drosophila Abl negatively regulates the actin cytoskeleton effector protein Ena during neuronal development in flies, and it has ..
  9. Cheng W, Von Kobbe C, Opresko P, Fields K, Ren J, Kufe D, et al. Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol. 2003;23:6385-95 pubmed
    The Werner syndrome protein (WRN) is a caretaker of the human genome, and the Abl kinase is a regulator of the DNA damage response. Aberrant DNA repair has been linked to the development of cancer...
  10. Chislock E, Ring C, Pendergast A. Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival. Proc Natl Acad Sci U S A. 2013;110:12432-7 pubmed publisher
    ..Here, we show a previously unappreciated role for the Abelson (Abl) family kinases (Abl and Arg) in endothelial function and the regulation of angiogenic factor pathways important ..
  11. Escalante M, Courtney J, Chin W, Teng K, Kim J, Fajardo J, et al. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. J Biol Chem. 2000;275:24787-97 pubmed
    ..PC12 cell line as a model system for neuronal morphogenesis, we demonstrate that the non-receptor tyrosine kinase c-Abl is an intermediary for NGF-inducible c-Crk II phosphorylation on the negative regulatory Tyr(222)...
  12. Kua H, Liu H, Leong W, Li L, Jia D, Ma G, et al. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression. Nat Cell Biol. 2012;14:727-37 pubmed publisher
    ..Here we show that the tyrosine kinase c-Abl plays an important role in osteoprogenitor expansion...
  13. Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, et al. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc Natl Acad Sci U S A. 1999;96:11976-81 pubmed
    ..In 293 cells expressing recombinant BRDG1 and various PTKs, Tec and Pyk2, but not Btk, Bmx, Lyn, Syk, or c-Abl, induced marked phosphorylation of BRDG1 on tyrosine residues...
  14. Kitao H, Yuan Z. Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. J Biol Chem. 2002;277:48944-8 pubmed
    ..How the process is functionally regulated in response to DNA damage, however, remains elusive. We show here that c-Abl tyrosine kinase associates with and phosphorylates Rad52 on tyrosine 104...
  15. Wang S, Wilkes M, Leof E, Hirschberg R. Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis. Am J Physiol Renal Physiol. 2010;298:F142-9 pubmed publisher
    ..novel non-smad TGF-beta targets including p21-activated kinase-2 (PAK2), the abelson nonreceptor tyrosine kinase (c-Abl), and the mammalian target of rapamycin (mTOR) that are activated by TGF-beta in mesenchymal cells, specifically in ..
  16. Wang X, Charng W, Chen C, Rosenfeld J, Al Shamsi A, Al Gazali L, et al. Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations. Nat Genet. 2017;49:613-617 pubmed publisher
    b>ABL1 is a proto-oncogene well known as part of the fusion gene BCR-ABL1 in the Philadelphia chromosome of leukemia cancer cells. Inherited germline ABL1 changes have not been associated with genetic disorders...
  17. Jena N, Deng M, Sicinska E, Sicinski P, Daley G. Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells. Cancer Res. 2002;62:535-41 pubmed
    Chronic myeloid leukemia is caused by the tyrosine kinase oncoprotein BCR/ABL. Using oligonucleotide arrays to assay mRNAs at different phases of the cell cycle in BCR/ABL-transformed cells, we found that cyclin D2 mRNA was ..
  18. McCarron S, O Connor L, Langabeer S, Conneally E. BCR-ABL1 kinase domain mutation analysis in an Irish cohort of chronic myeloid leukemia patients. Genet Test Mol Biomarkers. 2013;17:170-3 pubmed publisher
    ..to TKI therapy through a number of cellular and molecular mechanisms of which acquired mutations in the BCR-ABL1 kinase domain (KD) are the most common...
  19. Engel U, Zhan Y, Long J, Boyle S, Ballif B, Dorey K, et al. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. Cytoskeleton (Hoboken). 2014;71:195-209 pubmed publisher
    The Abelson (Abl) non-receptor tyrosine kinase regulates the cytoskeleton during multiple stages of neural development, from neurulation, to the articulation of axons and dendrites, to synapse formation and maintenance...
  20. Chislock E, Pendergast A. Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS ONE. 2013;8:e85231 pubmed publisher
    ..Use of the pharmacological inhibitor imatinib, which targets the Abl family of non-receptor tyrosine kinases (Abl and Arg), as well as other tyrosine kinases including the platelet-..
  21. Habib M, Ganea D, Katz I, Lamprecht R. ABL1 in thalamus is associated with safety but not fear learning. Front Syst Neurosci. 2013;7:5 pubmed publisher
    ..The levels of ABL1, Bog, IL1B, and Tau proteins in thalamus were found to be lower in the group trained for safety learning compared ..
  22. Ito Y, Pandey P, Mishra N, Kumar S, Narula N, Kharbanda S, et al. Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis. Mol Cell Biol. 2001;21:6233-42 pubmed
    The ubiquitously expressed c-Abl tyrosine kinase localizes to the nucleus and cytoplasm. Using confocal microscopy, we demonstrated that c-Abl colocalizes with the endoplasmic reticulum (ER)-associated protein grp78...
  23. Wetzel D, MCMAHON PRATT D, Koleske A. The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection. Mol Cell Biol. 2012;32:3176-86 pubmed publisher
    ..The mechanisms mediating uptake are not well understood. Here we show that Abl family kinases mediate both phagocytosis and the uptake of Leishmania amazonensis by macrophages (Ms)...
  24. Mitra S, Beach C, Feng G, Plattner R. SHP-2 is a novel target of Abl kinases during cell proliferation. J Cell Sci. 2008;121:3335-46 pubmed publisher
    Previously, we showed that Abl family tyrosine kinases are activated by growth factors, and Abl is required for transition from G1 to S phase during PDGF-mediated proliferation...
  25. Jia L, Tang D. Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle. Am J Physiol Cell Physiol. 2010;299:C630-7 pubmed publisher
    b>Abl is a nonreceptor tyrosine kinase that is required for smooth muscle contraction. However, the mechanism by which Abl regulates smooth muscle contraction is not completely understood...
  26. Taagepera S, McDonald D, Loeb J, Whitaker L, McElroy A, Wang J, et al. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A. 1998;95:7457-62 pubmed
    The ubiquitously expressed nonreceptor tyrosine kinase c-Abl contains three nuclear localization signals, however, it is found in both the nucleus and the cytoplasm of proliferating fibroblasts...
  27. Codelia V, Cisterna M, Alvarez A, Moreno R. p73 participates in male germ cells apoptosis induced by etoposide. Mol Hum Reprod. 2010;16:734-42 pubmed publisher
    ..We found an important increase in p73 protein levels, along with the c-Abl kinase, its physiological activator, in response to etoposide...
  28. Marin D, Khorashad J, Foroni L, Milojkovic D, Szydlo R, Reid A, et al. Does a rise in the BCR-ABL1 transcript level identify chronic phase CML patients responding to imatinib who have a high risk of cytogenetic relapse?. Br J Haematol. 2009;145:373-5 pubmed publisher
    BCR-ABL1 transcript numbers were monitored in 161 patients who started treatment with imatinib early after diagnosis of chronic myeloid leukaemia in chronic phase and achieved complete cytogenetic responses (CCyR)...
  29. Sun B, Jiang G, Zaydan M, La Russa V, Safah H, Ehrlich M. ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors. Cancer Res. 2001;61:6931-7 pubmed
    Formation of the hybrid BCR-ABL gene is responsible for >95% of chronic myeloid leukemia (CML)...
  30. Mihara K, Maeda S, Takahashi R, Hatanaka M, Sugiyama T. Detection of hypermethylation of the c-abl genomic locus in the spleen of juvenile LE rats. Biochem Biophys Res Commun. 1988;154:1061-6 pubmed
    ..In our present communication we have examined the c-abl expression in the leukemic cell line as well as in the LE rats at different ages...
  31. Chen A, Lee S, Gao B, Shannon S, Zhu Z, Fang D. c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation. Mol Cell Biol. 2011;31:3445-56 pubmed publisher
    The tyrosine kinase c-Abl is required for full activation of T cells, while its role in T-cell differentiation has not been characterized...
  32. Mertz P, Backman T, Bernards A, Kousvelari E. Two novel c-abl mRNAs are expressed in rat parotid salivary glands during in vivo beta-adrenergic receptor stimulation. Biochim Biophys Acta. 1990;1049:272-7 pubmed
    The c-abl proto-oncogene is transcribed in most cell lines and tissues into two mRNAs of 6.5 and 5.3 kb, which have different 5' ends and encode two 150 kDa proteins that are largely colinear, but have different N-termini...
  33. Xiao L, Chen D, Hu P, Wu J, Liu W, Zhao Y, et al. The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death. J Neurosci. 2011;31:9611-9 pubmed publisher
    ..In the present study, we demonstrate that the protein kinase c-Abl phosphorylates MST1 at Y433, which triggers the stabilization and activation of MST1...
  34. Donaldson L, Gish G, Pawson T, Kay L, Forman Kay J. Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. Proc Natl Acad Sci U S A. 2002;99:14053-8 pubmed
    On phosphorylation of Y221 by Abelson (Abl) kinase, the Crk-II adapter protein undergoes an intramolecular reorganization initiated by the binding of its own Src homology 2 (SH2) domain to the pY221 site...
  35. Lu Q, Mukhopadhyay N, Griffin J, Paredes M, Medina M, Kosik K. Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors. J Neurosci Res. 2002;67:618-24 pubmed
    ..1999). Here we show that delta-catenin colocalizes with actin filaments and Abl tyrosine kinase in the growth cones of cultured hippocampal neurons...
  36. Gallazzini M, Yu M, Gunaratne R, Burg M, Ferraris J. c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP. FASEB J. 2010;24:4325-35 pubmed publisher
    ..c-Abl seemed likely to be the kinase that phosphorylates TonEBP/OREBP because Y143 is in a consensus c-Abl ..
  37. Wang S, Wilkes M, Leof E, Hirschberg R. Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB J. 2005;19:1-11 pubmed
    ..p21-activated kinase-2 (PAK2) and activation of abelson nonreceptor tyrosine kinase (c-abl) have been shown recently to be smad-independent, fibroblast-specific targets downstream of the activated TGF-beta ..
  38. Han L, Wong D, Dhaka A, Afar D, White M, Xie W, et al. Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc Natl Acad Sci U S A. 1997;94:4954-9 pubmed
    ..This RIN1 sequence shows preferential binding to the ABL-SH3 domain in vitro...
  39. Kawai H, Nie L, Yuan Z. Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl. Mol Cell Biol. 2002;22:6079-88 pubmed
    Using a system that expresses a constitutively kinase-active c-Abl protein [c-Abl(KA)], we identified the protein IkappaBalpha as a novel substrate of c-Abl...
  40. Chan W, Wise S, Kaufman M, Ahn Y, Ensinger C, Haack T, et al. Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell. 2011;19:556-68 pubmed publisher
    Acquired resistance to ABL1 tyrosine kinase inhibitors (TKIs) through ABL1 kinase domain mutations, particularly the gatekeeper mutant T315I, is a significant problem for patients with chronic myeloid leukemia (CML)...
  41. Kobashigawa Y, Sakai M, Naito M, Yokochi M, Kumeta H, Makino Y, et al. Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat Struct Mol Biol. 2007;14:503-10 pubmed
    ..Together, these data suggest that the linker region modulates the binding of CRKII to its targets, thus regulating cell growth and motility. ..
  42. Klein A, Maldonado C, Vargas L, Gonzalez M, Robledo F, Perez de Arce K, et al. Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons. Neurobiol Dis. 2011;41:209-18 pubmed publisher
    ..We have previously reported the activation of the c-Abl/p73 proapoptotic pathway in the cerebellum of NPC mice; however, upstream signals underlying the engagement of this ..
  43. Li B, Boast S, de los Santos K, Schieren I, Quiroz M, Teitelbaum S, et al. Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Nat Genet. 2000;24:304-8 pubmed
    The c-Abl protein is a non-receptor tyrosine kinase involved in many aspects of mammalian development...
  44. Yuan Z, Huang Y, Ishiko T, Kharbanda S, Weichselbaum R, Kufe D. Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci U S A. 1997;94:1437-40 pubmed
    Activation of the c-Abl protein tyrosine kinase by certain DNA-damaging agents contributes to downregulation of Cdk2 and G1 arrest by a p53-dependent mechanism...
  45. Beckerman R, Prives C. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol. 2010;2:a000935 pubmed publisher
    ..How p53 is able to discriminate between these different loci is the subject of intense research. Here, we describe key aspects of the fundamentals of p53-mediated transcriptional regulation and target gene promoter selectivity. ..
  46. Muppirala M, Gupta V, Swarup G. Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway. Biochim Biophys Acta. 2012;1823:2109-19 pubmed publisher
    ..c-Abl was identified as one of the kinases, which phosphorylates syntaxin 17 in MIN6 cells...
  47. Greuber E, Pendergast A. Abl family kinases regulate Fc?R-mediated phagocytosis in murine macrophages. J Immunol. 2012;189:5382-92 pubmed publisher
    ..b>Abl and Arg define a family of nonreceptor tyrosine kinases that regulate actin-dependent processes in a variety of ..
  48. Whang Y, Tran C, Henderson C, Syljuasen R, Rozengurt N, McBride W, et al. c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency. Proc Natl Acad Sci U S A. 2000;97:5486-91 pubmed
    The c-Abl tyrosine kinase and the p53 tumor suppressor protein interact functionally and biochemically in cellular genotoxic stress response pathways and are implicated as downstream mediators of ATM (ataxia-telangiectasia mutated)...
  49. Mahul Mellier A, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, et al. c-Abl phosphorylates ?-synuclein and regulates its degradation: implication for ?-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum Mol Genet. 2014;23:2858-79 pubmed publisher
    Increasing evidence suggests that the c-Abl protein tyrosine kinase could play a role in the pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders...
  50. Levy D, Adamovich Y, Reuven N, Shaul Y. Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell. 2008;29:350-61 pubmed publisher
    ..Under this condition, p73 is phosphorylated and activated by c-Abl. The transcription coactivator Yap1 binds p73 to generate a complex that escapes p73 proteasomal degradation and ..
  51. Singh J, Yanfeng W, Grumolato L, Aaronson S, Mlodzik M. Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation. Genes Dev. 2010;24:2157-68 pubmed publisher
    ..Strikingly, mouse embryonic fibroblasts (MEFs) deficient for Abl1 and Abl2/Arg genes also show reduced Dvl2 phosphorylation as compared with control MEFs, and this correlates with a ..
  52. Liberatore R, Goff S. c-Abl-deficient mice exhibit reduced numbers of peritoneal B-1 cells and defects in BCR-induced B cell activation. Int Immunol. 2009;21:403-14 pubmed publisher
    A role for c-Abl in B cell development and signaling has been suggested by previous work showing that c-Abl-deficient mice have defects in bone marrow B cell development and that c-Abl-deficient B cells are hypoproliferative in response ..
  53. Imam S, Indig F, Cheng W, Saxena S, Stevnsner T, Kufe D, et al. Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. Nucleic Acids Res. 2007;35:4941-51 pubmed
    ..c-Abl kinase also plays a role in DNA repair as a regulator/coordinator of the DNA damage response...
  54. Cobbaut M, Derua R, Döppler H, Lou H, Vandoninck S, Storz P, et al. Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep. 2017;7:887 pubmed publisher
    ..In this report, we identify Abl-mediated phosphorylation of a highly conserved Tyr residue in the P?+?1 loop of protein kinase D2 (PKD2) during ..
  55. Takahashi R, Mihara K, Maeda S, Yamaguchi T, Chen H, Aoyama N, et al. Secondary activation of c-abl may be related to translocation to the nucleolar organizer region in an in vitro cultured rat leukemia cell line (K3D). Proc Natl Acad Sci U S A. 1986;83:1079-83 pubmed
    ..Enhanced transcription of the cellular homolog (c-abl) of the transforming sequence of Abelson murine leukemia virus was observed in K3D, which was one of the cloned ..
  56. Gu J, Zhang N, He Y, Koleske A, Pendergast A. Defective T cell development and function in the absence of Abelson kinases. J Immunol. 2007;179:7334-43 pubmed
    ..In this study, we show for the first time that the Abelson (Abl) kinases regulate proximal signaling downstream of the pre-TCR...
  57. Baskaran R, Wood L, Whitaker L, Canman C, Morgan S, Xu Y, et al. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature. 1997;387:516-9 pubmed
    ..One of the known responses to ionizing radiation is the activation of a nuclear tyrosine kinase encoded by the c-abl proto-oncogene...
  58. Cao H, Schroeder B, Chen J, Schott M, McNiven M. The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase. J Biol Chem. 2016;291:16424-37 pubmed publisher
    ..be regulated by additional kinase-dependent cascades, and we observed a significant endocytic block by inhibiting c-Abl kinase by a variety of methods...
  59. Ren R, Mayer B, Cicchetti P, Baltimore D. Identification of a ten-amino acid proline-rich SH3 binding site. Science. 1993;259:1157-61 pubmed
    ..Identification of the SH3 binding site provides a basis for understanding the interaction between the SH3 domains and their targets. ..
  60. Zipfel P, Grove M, Blackburn K, Fujimoto M, Tedder T, Pendergast A. The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. J Immunol. 2000;165:6872-9 pubmed
    c-Abl is a nonreceptor tyrosine kinase that we have recently linked to growth factor receptor signaling. The c-Abl kinase is ubiquitously expressed and localizes to the cytoplasm, plasma membrane, cytoskeleton, and nucleus...
  61. Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, et al. Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase. J Biol Chem. 2003;278:21685-92 pubmed
    ..Enabled (Mena) is a mammalian homologue of Drosophila Enabled (Ena), which genetically interacts with Drosophila Abl tyrosine kinase. The signaling pathway involving c-Abl and Mena (Ena) is not fully understood...
  62. Qiu Z, Cang Y, Goff S. Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum. J Neurosci. 2010;30:14430-9 pubmed publisher
    The Abl family nonreceptor tyrosine kinases, consisting of closely related Abl and Arg (Abl-related gene), play essential roles in mouse neurulation, but their functions in the subsequent development of CNS are poorly understood...
  63. Wen S, Jackson P, Van Etten R. The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J. 1996;15:1583-95 pubmed
    c-Abl is a non-receptor protein-tyrosine kinase lacking a clear physiological role. A clue to its normal function is suggested by overexpression of Abl in fibroblasts, which leads to inhibition of cell growth...
  64. Dai Z, Pendergast A. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev. 1995;9:2569-82 pubmed
    ..that interacts specifically with both the Src homologous 3 (SH3) domain and carboxy-terminal sequences of the c-Abl tyrosine kinase...
  65. Raina D, Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, et al. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem. 2005;280:11147-51 pubmed
    ..The c-Abl tyrosine kinase is also involved in the apoptotic response to DNA damage...
  66. Jia L, Wang R, Tang D. Abl regulates smooth muscle cell proliferation by modulating actin dynamics and ERK1/2 activation. Am J Physiol Cell Physiol. 2012;302:C1026-34 pubmed publisher
    b>Abl is a nonreceptor tyrosine kinase that has a role in regulating migration and adhesion of nonmuscle cells as well as smooth muscle contraction. The role of Abl in smooth muscle cell proliferation has not been investigated...
  67. Hardin J, Boast S, Schwartzberg P, Lee G, Alt F, Stall A, et al. Bone marrow B lymphocyte development in c-abl-deficient mice. Cell Immunol. 1995;165:44-54 pubmed
    Mice homozygous for a mutation in the c-abl tyrosine kinase gene have multiple defects including high postnatal mortality, runting, morphological abnormalities, susceptibility to infections, and reductions in lymphocytes and their ..
  68. Tybulewicz V, Crawford C, Jackson P, Bronson R, Mulligan R. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 1991;65:1153-63 pubmed
    The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes...
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