Abcg2

Summary

Gene Symbol: Abcg2
Description: ATP binding cassette subfamily G member 2
Alias: BCRP1, ATP-binding cassette sub-family G member 2, ATP binding cassette subfamily G member 2 (Junior blood group), ATP-binding cassette protein G2, ATP-binding cassette, sub-family G (WHITE), member 2, ATP-binding cassette, subfamily G (WHITE), member 2, breast cancer resistance protein 1 homolog, urate exporter
Species: rat
Products:     Abcg2

Top Publications

  1. Woodward O, Köttgen A, Coresh J, Boerwinkle E, Guggino W, Köttgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A. 2009;106:10338-42 pubmed publisher
    ..Here we show using functional assays that human ATP-binding cassette, subfamily G, 2 (ABCG2), encoded by the ABCG2 gene contained in this region, is a hitherto unknown urate efflux transporter...
  2. Dehghan A, Kottgen A, Yang Q, Hwang S, Kao W, Rivadeneira F, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008;372:1953-61 pubmed publisher
    ..0 x 10(-168) and 2.9 x 10(-18) for white and black participants, respectively); missense rs2231142 in ABCG2 (p=2.5 x 10(-60) and 9.8 x 10(-4)), and rs1165205 in SLC17A3 (p=3.3 x 10(-26) and 0.33)...
  3. Yue W, Abe K, Brouwer K. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Mol Pharm. 2009;6:134-43 pubmed publisher
    ..This approach may be useful in predicting drug-drug interactions in biliary excretion and the consequence of impaired BCRP function on the hepatic exposure of drugs/derived metabolites...
  4. Takeuchi R, Shinozaki K, Nakanishi T, Tamai I. Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart. Drug Metab Dispos. 2016;44:68-74 pubmed publisher
    ..cilostazol at efflux transporters such as P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2), which are expressed in many tissues including the heart, and our study tested this hypothesis...
  5. Turner J, Gump J, Zhang C, Cook J, Marchion D, Hazlehurst L, et al. ABCG2 expression, function, and promoter methylation in human multiple myeloma. Blood. 2006;108:3881-9 pubmed
    We investigated the role of the breast cancer resistance protein (BCRP/ABCG2) in drug resistance in multiple myeloma (MM)...
  6. He L, Yang Y, Guo C, Yao D, Liu H, Sheng J, et al. Opposite regulation of hepatic breast cancer resistance protein in type 1 and 2 diabetes mellitus. Eur J Pharmacol. 2014;724:185-92 pubmed publisher
    ..Alternations in d-glucose, insulin, and free fatty acid levels in plasma might contribute to the changes in h/rBCRP expression and functions...
  7. Yue W, Lee J, Abe K, Sugiyama Y, Brouwer K. Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR?) rats. Drug Metab Dispos. 2011;39:441-7 pubmed publisher
    ..TR(-) and EHBR rats in combination may be useful in differentiating the role of Mrp2 and Bcrp in drug/metabolite disposition...
  8. Hofman J, Kučera R, Neumanova Z, Klimes J, Ceckova M, Staud F. Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs). Xenobiotica. 2016;46:416-23 pubmed publisher
    ..II and purvalanol A in rat focusing on possible role of p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and/or multidrug resistance-associated proteins (ABCCs)...
  9. Yasuda S, Itagaki S, Hirano T, Iseki K. Expression level of ABCG2 in the placenta decreases from the mid stage to the end of gestation. Biosci Biotechnol Biochem. 2005;69:1871-6 pubmed
    The aim of this study was to elucidate the expression pattern of ABCG2 in the placenta from the mid stage to the end of gestation. rABCG2 expression was investigated in rats on the 14th gestation day (gd) and the 20th gd...

More Information

Publications75

  1. Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, et al. Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism. Kidney Int. 2017;91:658-670 pubmed publisher
    ..excretion in the intestine and kidney decreased, presumably due to down-regulation of the expression of the urate exporter ABCG2 in intestinal and renal epithelial membranes...
  2. Yousif S, Chaves C, Potin S, Margaill I, Scherrmann J, Declèves X. Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation. J Neurochem. 2012;123:491-503 pubmed publisher
    ..Thus, morphine does not directly stimulate P-gp and Bcrp expression by the brain endothelium, but glutamate released during morphine withdrawal may do so by activating the NMDA/cyclo-oxygenase-2 cascade...
  3. Rosenberg M, Bikadi Z, Chan J, Liu X, Ni Z, Cai X, et al. The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone. Structure. 2010;18:482-93 pubmed publisher
    BCRP/ABCG2 mediates efflux of drugs and xenobiotics. BCRP was expressed in Pichia pastoris, purified to > 90% homogeneity, and subjected to two-dimensional (2D) crystallization...
  4. Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, et al. Estrogen receptor ? induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells. J Pharm Sci. 2013;102:3364-72 pubmed publisher
    Substrate-induced upregulation of ATP-binding cassette subfamily G member 2 (ABCG2) has been well studied in cancer cells, but it is also important to understand whether ABCG2 is upregulated by its substrates in tissues in which it is ..
  5. Reichel V, Burghard S, John I, Huber O. P-glycoprotein and breast cancer resistance protein expression and function at the blood-brain barrier and blood-cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats. Brain Res. 2011;1370:238-45 pubmed publisher
    ..ATP-binding cassette transport proteins P-glycoprotein (Pgp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) at the blood-brain barrier and the blood-cerebrospinal fluid barrier formed by the choroid plexus...
  6. Goncalves P, Gregório I, Martel F. The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein. Am J Physiol Cell Physiol. 2011;301:C984-94 pubmed publisher
    ..So, interaction of BT with BCRP and with other BCRP substrates/inhibitors is clearly of major importance...
  7. Hartz A, Madole E, Miller D, Bauer B. Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein. J Pharmacol Exp Ther. 2010;334:467-76 pubmed publisher
    ..These in vitro and in vivo findings imply that E2-mediated down-regulation of blood-brain barrier BCRP has the potential to increase brain uptake of chemotherapeutics that are BCRP substrates...
  8. Dahan A, Amidon G. Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009;297:G371-7 pubmed publisher
    ..To our knowledge, this is the first demonstration of intestinal efflux acting in favor of oral drug delivery...
  9. Yano H, Tamura Y, Kobayashi K, Tanemoto M, Uchida S. Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease. Clin Exp Nephrol. 2014;18:50-5 pubmed publisher
    ..We evaluated the expression of the UA transporter in the intestinal tract--the ATP-binding cassette transporter G2 (ABCG2)--in a 5/6 nephrectomy rat model of CKD.
  10. Uno S, Uraki M, Ito A, Shinozaki Y, Yamada A, Kawase A, et al. Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat. Biopharm Drug Dispos. 2009;30:49-54 pubmed publisher
    ..These results raise the possibility of a functional change of the transporters of liver and intestine in AA rats...
  11. Au A, Aziz Baba A, Goh A, Wahid Fadilah S, Teh A, Rosline H, et al. Association of genotypes and haplotypes of multi-drug transporter genes ABCB1 and ABCG2 with clinical response to imatinib mesylate in chronic myeloid leukemia patients. Biomed Pharmacother. 2014;68:343-9 pubmed publisher
    ..of three common single nucleotide polymorphisms (SNPs) of ABCB1 (T1236C, G2677T/A and C3435T) and two SNPs of ABCG2 (G34A and C421A) genes in mediating resistance and/or good response among 215 CML patients on IM therapy were ..
  12. Staud F, Vackova Z, Pospechova K, Pavek P, Ceckova M, Libra A, et al. Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell line. J Pharmacol Exp Ther. 2006;319:53-62 pubmed
    Breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette transporter family that recognizes a variety of chemically unrelated compounds...
  13. Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009;5:e1000504 pubmed publisher
    ..2x10(-201)), abcg2 (p = 3.1x10(-26)), slc17a1 (p = 3.0x10(-14)), slc22a11 (p = 6.7x10(-14)), slc22a12 (p = 2...
  14. Suvannasankha A, Minderman H, O Loughlin K, Nakanishi T, Ford L, Greco W, et al. Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival. Br J Haematol. 2004;127:392-8 pubmed
    ..of adult acute lymphoblastic leukaemia (ALL) are substrates for breast cancer resistance protein (BCRP, MXR, ABCG2), which may thus play a role in resistance in this disease...
  15. Narang V, Fraga C, Kumar N, Shen J, Throm S, Stewart C, et al. Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Am J Physiol Cell Physiol. 2008;295:C440-50 pubmed publisher
    ..induced significantly higher levels of drug efflux transporters such as breast cancer resistance protein (abcg2), P-glycoprotein (P-gp; abcb1a/abcb1b), and MDR protein 2 (Mrp2; abcc2) as indicted by protein and mRNA levels as ..
  16. Zhang F, Chen X, Jing K, Zhang W, Li G, Dong H, et al. [Expressions of ATP binding cassette transporter genes in rat hepatic oval cells]. Zhonghua Gan Zang Bing Za Zhi. 2007;15:529-33 pubmed
    ..ATP binding cassette transporters are cytoprotective efflux pumps that may contribute to the protection of these cells. The aim of this study was to determine the ABC transporter expressions in hepatic oval cells...
  17. Campos C, Schroter C, Wang X, Miller D. ABC transporter function and regulation at the blood-spinal cord barrier. J Cereb Blood Flow Metab. 2012;32:1559-66 pubmed publisher
    ..of P-glycoprotein (Abcb1), multidrug resistance protein 2 (Mrp2, Abcc2), and breast cancer-related protein (Bcrp, Abcg2)...
  18. Yang C, Xiong F, Dou J, Xue J, Zhan X, Shi F, et al. Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model. Oncotarget. 2015;6:27714-24 pubmed publisher
    Multiple myeloma (MM) remains to be an incurable disease. The purpose of this study was to evaluate the effect of ABCG2 monoclonal antibody (McAb) combined with paclitaxel (PTX) conjugated with Fe3O4 nanoparticles (NPs) on MM progressed ..
  19. Campa D, Butterbach K, Slager S, Skibola C, de Sanjose S, Benavente Y, et al. A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. Int J Cancer. 2012;131:803-12 pubmed publisher
    ..ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP) affect susceptibility to many hematopoietic malignancies...
  20. Thorn C, Oshiro C, Marsh S, Hernandez Boussard T, McLeod H, Klein T, et al. Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet Genomics. 2011;21:440-6 pubmed publisher
  21. Cerveny L, Neumanova Z, Karbanova S, Havlova I, Staud F. Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs. J Pharm Pharmacol. 2016;68:84-92 pubmed publisher
    ..of two widely described pharmacokinetic determinants, P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2), in maternal or fetal biological tissues. For this purpose, pregnant Wistar rats were administered tenofovir (2...
  22. MacLean C, Moenning U, Reichel A, Fricker G. Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats. Drug Metab Dispos. 2008;36:1249-54 pubmed publisher
    ..expression, relative expression levels of P-glycoprotein (Pgp; ABCB1), breast cancer resistance protein (Bcrp; ABCG2), and multidrug resistance-associated protein (Mrp) 2 (ABCC2) were determined using quantitative real-time-..
  23. Delord M, Rousselot P, Cayuela J, Sigaux F, Guilhot J, Preudhomme C, et al. High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients. Oncotarget. 2013;4:1582-91 pubmed
    ..Three of them, all located within the ABCG2 gene, were validated in patients included in the 400 mg/d arm of the SPIRIT trial...
  24. Korenaga Y, Naito K, Okayama N, Hirata H, Suehiro Y, Hamanaka Y, et al. Association of the BCRP C421A polymorphism with nonpapillary renal cell carcinoma. Int J Cancer. 2005;117:431-4 pubmed
    ..Carriers with the C/C genotype of the BCRP C421A polymorphism are at risk of developing nonpapillary RCC. These data suggest that BCRP is a candidate RCC susceptibility gene...
  25. Qian X, Mruk D, Wong E, Cheng C. Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis. Am J Physiol Endocrinol Metab. 2013;304:E757-69 pubmed publisher
    ..Indeed, a knockdown of Bcrp by RNAi in the testis perturbed the apical ES function, disrupting spermatid polarity and adhesion. In summary, Bcrp is a regulator of the F-actin-rich apical ES in the testis...
  26. Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, et al. Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen. Biochem Pharmacol. 2015;97:89-98 pubmed publisher
    ..ROS derived from XO may cause the suppression of function of the ileum for the excretion of uric acid with aging. The results of our study provide a new insight into the causes of increasing hyperuricemia/gout prevalence with aging. ..
  27. Jin Q, Shim W, Choi M, Tian G, Song I, Yang S, et al. Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp. Xenobiotica. 2009;39:711-21 pubmed publisher
  28. Liu Y, Liu H, Yang H, Wen T, Shang Y, Liu X, et al. Impaired expression and function of breast cancer resistance protein (Bcrp) in brain cortex of streptozocin-induced diabetic rats. Biochem Pharmacol. 2007;74:1766-72 pubmed
    ..All results gave a conclusion that STZ-induced DM may induce the impairment of function and expression of Bcrp in brain cortex, and lower levels of insulin may mainly contribute to Bcrp dysfunction in brain...
  29. Bridges C, Zalups R, Joshee L. Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells. Toxicol Appl Pharmacol. 2015;285:110-7 pubmed publisher
    ..These findings suggest that Bcrp may be involved in the cellular export of select mercuric species and that its role in this export may differ from that of Mrp2. ..
  30. Steinbach D, Sell W, Voigt A, Hermann J, Zintl F, Sauerbrey A. BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. Leukemia. 2002;16:1443-7 pubmed
    ..or placenta ABC protein (ABC-P), is the second member of the ABCG subfamily of ABC transport proteins (gene symbol ABCG2)...
  31. Ogura J, Kobayashi M, Itagaki S, Hirano T, Iseki K. Post-transcriptional regulation of breast cancer resistance protein after intestinal ischemia-reperfusion. Biol Pharm Bull. 2008;31:1032-5 pubmed
    Breast cancer resistance protein (BCRP), the product of the ABCG2 gene, is a recently identified ATP binding cassette half-transporter. BCRP is expressed in a variety of tumor cells and many normal human tissues...
  32. Adachi Y, Suzuki H, Schinkel A, Sugiyama Y. Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen. Mol Pharmacol. 2005;67:923-8 pubmed
    ..multidrug resistance protein 2 (Mrp2/Abcc2) is hereditarily defective and breast cancer resistance protein (Bcrp1/Abcg2) knockout mice...
  33. Shimano K, Satake M, Okaya A, Kitanaka J, Kitanaka N, Takemura M, et al. Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1. Am J Pathol. 2003;163:3-9 pubmed
    ..The ATP-binding cassette transporter ABCG2/BCRP1 mediates the SP phenotype...
  34. Shukla S, Zaher H, Hartz A, Bauer B, Ware J, Ambudkar S. Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009;26:480-7 pubmed publisher
    ..of curcumin as an inhibitor of the multidrug-resistance-linked ATP Binding Cassette (ABC) drug transporter, ABCG2. Photoaffinity labeling with [125I]-iodoarylazidoprazosin was used to characterize the interaction of ..
  35. Erdilyi D, Kamory E, Csokay B, Andrikovics H, Tordai A, Kiss C, et al. Synergistic interaction of ABCB1 and ABCG2 polymorphisms predicts the prevalence of toxic encephalopathy during anticancer chemotherapy. Pharmacogenomics J. 2008;8:321-7 pubmed
    Polymorphisms of the ABCB1 (MDR1) and ABCG2 (BCRP) genes were reported to alter the expression and function of these drug transporters. Both proteins are present at the main pharmacokinetic barriers including the blood-brain barrier...
  36. Roma M, Hocht C, Chiappetta D, Di Gennaro S, Minoia J, Bramuglia G, et al. Tetronic® 904-containing polymeric micelles overcome the overexpression of ABCG2 in the blood-brain barrier of rats and boost the penetration of the antiretroviral efavirenz into the CNS. Nanomedicine (Lond). 2015;10:2325-37 pubmed publisher
    To assess the involvement of ABCG2 in the pharmacokinetics of efavirenz in the blood-brain barrier (BBB) and investigate a nanotechnology strategy to overcome its overexpression under a model of chronic oral administration...
  37. Zamek Gliszczynski M, Bedwell D, Bao J, Higgins J. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Drug Metab Dispos. 2012;40:1825-33 pubmed publisher
  38. Xu P, Ling Z, Zhang J, Li Y, Shu N, Zhong Z, et al. Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats. Acta Pharmacol Sin. 2016;37:1129-40 pubmed publisher
    ..UCB elevation in BDL rats impairs the function and expression of BCRP at the BBB, thus contributing to hepatic encephalopathy. ..
  39. Engel T, Bode G, Lueken A, Knop M, Kannenberg F, Nofer J, et al. Expression and functional characterization of ABCG1 splice variant ABCG1(666). FEBS Lett. 2006;580:4551-9 pubmed
    ..Our results support that ABCG1(666) may in fact be the most prominent form of functional ABCG1 expressed in the human...
  40. Salimizand H, Amini S, Abdi M, Ghaderi B, Azadi N. Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia. Tumour Biol. 2016;37:791-8 pubmed publisher
    ..study, the concurrent effects of three polymorphisms affecting the integrity of DNA consist of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp on development of chronic myeloid leukemia were studied...
  41. Akashi T, Nishimura T, Takaki Y, Takahashi M, Shin B, Tomi M, et al. Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents. Reprod Toxicol. 2016;65:375-381 pubmed publisher
    ..localizations of multidrug resistance protein 1 (MDR1)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 in the rodent placental SynT bilayer, i.e., a maternal-facing (SynT-I) layer and a fetal-facing (SynT-II) layer...
  42. Toyoki D, Shibata S, Kuribayashi Okuma E, Xu N, Ishizawa K, Hosoyamada M, et al. Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2. Am J Physiol Renal Physiol. 2017;313:F826-F834 pubmed publisher
    ..transporter 1 (URAT1) was significantly decreased, whereas that of ATP-binding cassette subfamily G member 2 (ABCG2) was increased, consistent with the increased renal UA clearance...
  43. Nicken P, Schröder B, von Keutz A, Breves G, Steinberg P. The colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is actively secreted in the distal colon of the rat: an integrated view on the role of PhIP transport and metabolism in PhIP-induced colon carcinogenesis. Arch Toxicol. 2013;87:895-904 pubmed publisher
    ..The potential role of PhIP transport in colon carcinogenesis is discussed...
  44. Hosomi A, Nakanishi T, Fujita T, Tamai I. Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PLoS ONE. 2012;7:e30456 pubmed publisher
    ..b>Bcrp1 knockout mice exhibited significantly decreased intestinal secretion and an increased plasma concentration of uric ..
  45. van Vliet E, Redeker S, Aronica E, Edelbroek P, Gorter J. Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats. Epilepsia. 2005;46:1569-80 pubmed
    ..In the present study, we investigated the expression of different multidrug transporters during epileptogenesis in the rat. In addition, we determined whether these transporters affected phenytoin (PHT) distribution in the brain...
  46. Huang L, Li X, Roberts J, Janosky B, Lin M. Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats. Xenobiotica. 2015;45:547-55 pubmed publisher
    ..was designed to evaluate how the absence of P-glycoprotein (Pgp, Mdr1a), breast cancer-resistance protein (Bcrp, Abcg2) or both affects drug distribution into sciatic nerves, brain and cerebrospinal fluid (CSF) in rats. 2...
  47. McGill M, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013;30:2174-87 pubmed publisher
    ..Recent advances in the diagnostic use of serum adducts are covered. ..
  48. Huang L, Be X, Tchaparian E, Colletti A, Roberts J, Langley M, et al. Deletion of Abcg2 has differential effects on excretion and pharmacokinetics of probe substrates in rats. J Pharmacol Exp Ther. 2012;343:316-24 pubmed publisher
    This study was designed to characterize breast cancer resistance protein (Bcrp) knockout Abcg2(-/-) rats and assess the effect of ATP-binding cassette subfamily G member 2 (Abcg2) deletion on the excretion and pharmacokinetic properties ..
  49. Hori S, Ohtsuki S, Tachikawa M, Kimura N, Kondo T, Watanabe M, et al. Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s). J Neurochem. 2004;90:526-36 pubmed
    ..the present study was to clarify the expression, transport properties and regulation of ATP-binding cassette G2 (ABCG2) transporter at the rat blood-brain barrier (BBB)...
  50. Petrovic V, Wang J, Piquette Miller M. Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats. Drug Metab Dispos. 2008;36:1944-50 pubmed publisher
    ..results demonstrated a significant time- and dose-dependent down-regulation of breast cancer resistance protein/Abcg2 mRNA in the placentas of endotoxin-treated rats with a corresponding decrease in protein levels...
  51. Bhattacharya S, Das A, Mallya K, Ahmad I. Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling. J Cell Sci. 2007;120:2652-62 pubmed
    b>ABCG2 belongs to the ATP-binding cassette superfamily of transmembrane proteins and is ubiquitously expressed in stem cells including those in the developing nervous system...
  52. Collins J, Franck C, Kowdley K, Ghishan F. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2005;288:G964-71 pubmed
    ..motif protein 27, aquaporin 4, lipocalin-interacting membrane receptor, and the breast cancer-resistance protein (ABCG2)...
  53. Campbell P, Zong Y, Yang S, Zhou S, Rubnitz J, Sorrentino B. Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia. Leuk Res. 2011;35:1321-9 pubmed publisher
    b>ABCG2 encodes a transporter protein that is associated with multidrug-resistant phenotypes in many cancers, including acute myeloid leukemia (AML); high levels of expression are generally associated with a poor prognosis...
  54. Pan G, Giri N, Elmquist W. Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine. Drug Metab Dispos. 2007;35:1165-73 pubmed
    ..of this study was to characterize the interaction of these nucleoside reverse transcriptase inhibitors with the Abcg2/Bcrp1 transporter, the murine homolog of human breast cancer resistance protein (BCRP), using a Bcrp1-transfected ..
  55. Liu H, Liu L, Li J, Mei D, Duan R, Hu N, et al. Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus. Drug Metab Dispos. 2012;40:1104-12 pubmed publisher
    ..All results yielded the conclusion that impaired hepatic CYP2C11 and intestinal BCRP expression and activity induced by diabetes contributed to the increased exposure of orally administered GLB...
  56. Peroni R, Di Gennaro S, Hocht C, Chiappetta D, Rubio M, Sosnik A, et al. Efavirenz is a substrate and in turn modulates the expression of the efflux transporter ABCG2/BCRP in the gastrointestinal tract of the rat. Biochem Pharmacol. 2011;82:1227-33 pubmed publisher
    ..The breast cancer resistant protein (BCRP, ABCG2) is known to be inhibited by EFV in vitro...
  57. Sauerbrey A, Sell W, Steinbach D, Voigt A, Zintl F. Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute lymphoblastic leukaemia. Br J Haematol. 2002;118:147-50 pubmed
    ..or placenta ABC protein (ABC-P), is the second member of the ABCG subfamily of ABC transport proteins (gene symbol ABCG2)...
  58. Brandstätter A, Lamina C, Kiechl S, Hunt S, Coassin S, Paulweber B, et al. Sex and age interaction with genetic association of atherogenic uric acid concentrations. Atherosclerosis. 2010;210:474-8 pubmed publisher
    High serum uric acid levels are associated with gout, atherosclerosis and cardiovascular disease. Three genes (SLC2A9, ABCG2, and SLC17A3) were reported to be involved in the regulation of uric acid levels.
  59. Lee G, Babakhanian K, Ramaswamy M, Prat A, Wosik K, Bendayan R. Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems. Pharm Res. 2007;24:1262-74 pubmed
    The function of ABCG2 (BCRP), a member of the ATP-binding cassette (ABC) superfamily of membrane-associated drug transporters, at the blood-brain barrier remains highly controversial...
  60. Ahmad Najar R, Rahat B, Hussain A, Thakur S, Kaur J, Kaur J, et al. Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation. Mol Nutr Food Res. 2016;60:1501-13 pubmed publisher
    ..decreased expression levels of reduced folate carrier (RFC) and increased expression levels of folate exporter (ABCG2) at both mRNA and protein levels, which in turn regulated by promoter hypermethylation of RFC and promoter ..
  61. Faneyte I, Kristel P, Maliepaard M, Scheffer G, Scheper R, Schellens J, et al. Expression of the breast cancer resistance protein in breast cancer. Clin Cancer Res. 2002;8:1068-74 pubmed
    ..The aim of this study was to investigate the role of BCRP in resistance of breast cancer to anthracycline treatment...
  62. Bartholomae S, Gruhn B, Debatin K, Zimmermann M, Creutzig U, Reinhardt D, et al. Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia. Pediatr Blood Cancer. 2016;63:242-7 pubmed publisher
    ..ABCB1 encoding multidrug resistance protein 1, ABCC3 encoding multidrug resistance-associated protein 3, and ABCG2 encoding breast cancer resistance protein) was measured by TaqMan real time polymerase chain reaction in ..
  63. Hartz A, Mahringer A, Miller D, Bauer B. 17-?-Estradiol: a powerful modulator of blood-brain barrier BCRP activity. J Cereb Blood Flow Metab. 2010;30:1742-55 pubmed publisher
    ..We speculate that this nongenomic E2-signaling pathway could potentially be used for targeting BCRP at the blood-brain barrier, in brain tumors, and in brain tumor stem cells to improve chemotherapy of the central nervous system...
  64. McDevitt C, Collins R, Conway M, Modok S, Storm J, Kerr I, et al. Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2. Structure. 2006;14:1623-32 pubmed
    b>ABCG2 is a multidrug efflux pump associated with resistance of cancer cells to a plethora of unrelated drugs. ABCG2 is a "half-transporter," and previous studies have indicated that it forms homodimers and higher oligomeric species...
  65. Harati R, Benech H, Villegier A, Mabondzo A. P-glycoprotein, breast cancer resistance protein, Organic Anion Transporter 3, and Transporting Peptide 1a4 during blood-brain barrier maturation: involvement of Wnt/?-catenin and endothelin-1 signaling. Mol Pharm. 2013;10:1566-80 pubmed publisher
    ..These findings shed light on the role of an interaction between ?-catenin and endothelin-1 signaling in the regulation of these transporters at the BBB...
  66. Rong Z, Xu Y, Zhang C, Xiang D, Li X, Liu D. Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability. Life Sci. 2013;92:245-51 pubmed publisher
    ..The purpose of the present study was to investigate the role of efflux transporters on the intestinal absorption of amtolmetin guacyl (MED-15)...