Gene Symbol: Abcg1
Description: ATP binding cassette subfamily G member 1
Alias: Abc8, ATP-binding cassette sub-family G member 1, ATP-binding cassette, sub-family G (WHITE), member 1, ATP-binding cassette, subfamily G (WHITE), member 1
Species: rat
Products:     Abcg1

Top Publications

  1. Wang N, Lan D, Chen W, Matsuura F, Tall A. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A. 2004;101:9774-9 pubmed
    ..We show that two ABC transporters of unknown function, ABCG1 and ABCG4, mediate isotopic and net mass efflux of cellular cholesterol to HDL...
  2. Klucken J, Büchler C, Orso E, Kaminski W, Porsch Ozcurumez M, Liebisch G, et al. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci U S A. 2000;97:817-22 pubmed
    ..We report here that the ATP-binding cassette (ABC) transporter ABCG1 (ABC8) is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density ..
  3. Olivier M, BottG R, Frisdal E, Nowick M, Plengpanich W, Desmarchelier C, et al. ABCG1 is involved in vitamin E efflux. Biochim Biophys Acta. 2014;1841:1741-51 pubmed
    ..aim was to investigate the possible participation of another cholesterol transporter in cellular vitamin E efflux: ABCG1. In Abcgl-deficient mice, vitamin E concentration was reduced in plasma lipoproteins whereas most tissues ..
  4. Kobayashi A, Takanezawa Y, Hirata T, Shimizu Y, Misasa K, Kioka N, et al. Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. J Lipid Res. 2006;47:1791-802 pubmed
    ..b>ABCG1, one of the half-type ABC proteins, is thought to be involved in cholesterol homeostasis...
  5. Iborra R, Machado Lima A, Castilho G, Nunes V, Abdalla D, Nakandakare E, et al. Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. Lipids Health Dis. 2011;10:172 pubmed publisher
  6. Hirayama T, Honda A, Matsuzaki Y, Miyazaki T, Ikegami T, Doy M, et al. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hepatology. 2006;44:602-11 pubmed
    ..Protein and mRNA expression of the ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) was markedly higher in tumors than in livers...
  7. Matsuo M, Campenot R, Vance D, Ueda K, Vance J. Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. Biochim Biophys Acta. 2011;1811:31-8 pubmed publisher
    ..Over-expression of ABCG1 in rat cortical glial cells resulted in production of LpE that increased the rate of axonal extension to a greater ..
  8. Kennedy M, Venkateswaran A, Tarr P, Xenarios I, Kudoh J, Shimizu N, et al. Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J Biol Chem. 2001;276:39438-47 pubmed
    The human ABCG1 gene encodes a member of the ATP-binding cassette (ABC) superfamily of transporter proteins and is highly induced when macrophages are incubated with oxysterols...
  9. Hoekstra M, Kruijt J, Van Eck M, Van Berkel T. Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells. J Biol Chem. 2003;278:25448-53 pubmed
    ..endothelial cells show a high expression of cholesterol 27-hydroxylase, liver X receptor (LXR)beta, PPARdelta, and ABCG1, suggesting a novel specific role for these genes in endothelial cells...

More Information


  1. Nakamura K, Kennedy M, Baldán A, Bojanic D, Lyons K, Edwards P. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J Biol Chem. 2004;279:45980-9 pubmed
    The murine Abcg1 gene is reported to consist of 15 exons that encode a single mRNA (herein referred to as Abcg1-a) and protein...
  2. Wang N, Ranalletta M, Matsuura F, Peng F, Tall A. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL. Arterioscler Thromb Vasc Biol. 2006;26:1310-6 pubmed
    This study examines the ABCG1-mediated cholesterol efflux and intracellular cholesterol transport by studying the ABCG1 localization and function in macrophages.
  3. Engel T, Kannenberg F, Fobker M, Nofer J, Bode G, Lueken A, et al. Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol. FEBS Lett. 2007;581:1673-80 pubmed
    ..In the current study, we investigated whether ABC transporter family member G1 (ABCG1) may be involved in oxysterol transport, since its gene expression is highly responsive to oxysterol loading...
  4. Lou J, Zhou H, Li C, Hu L, Lu X, Li J, et al. ABCA1 and ABCG1 expression in the small intestine of type 2 diabetic rats. Lab Med. 2014;45:17-24 pubmed
    ..This study aimed to investigate whether ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) were altered in chronic inflammation of the small intestine of type 2 diabetic rats.
  5. Ji A, Meyer J, Cai L, Akinmusire A, de Beer M, Webb N, et al. Scavenger receptor SR-BI in macrophage lipid metabolism. Atherosclerosis. 2011;217:106-12 pubmed publisher
    ..SR-BI, the other scavenger receptors SRA and CD36 and the ATP-binding cassette transporters ABCA1 and ABCG1 were each distinctly regulated during BMM differentiation...
  6. Tarr P, Edwards P. ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. J Lipid Res. 2008;49:169-82 pubmed
    Here, we describe the initial characterization of Abcg4(-/-) mice and identify overlapping functions of ABCG4 and ABCG1 in the brain...
  7. Wang X, Collins H, Ranalletta M, Fuki I, Billheimer J, Rothblat G, et al. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest. 2007;117:2216-24 pubmed
    Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular acceptors in vitro and influence atherosclerosis in mice, but ..
  8. Tansley G, Burgess B, Bryan M, Su Y, Hirsch Reinshagen V, Pearce J, et al. The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein. J Lipid Res. 2007;48:1022-34 pubmed
    ..The cholesterol transporter ABCG1 facilitates cholesterol efflux to HDL and is expressed in brain...
  9. Schmitz G, Langmann T, Heimerl S. Role of ABCG1 and other ABCG family members in lipid metabolism. J Lipid Res. 2001;42:1513-20 pubmed
    ..ATP-binding cassette transporter A1 (ABCA1) molecule, ABC transporters belonging to the ABCG (White) subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be critically involved in the regulation of lipid-trafficking mechanisms in ..
  10. Lin C, Lee T, Chen C, Chang C, Lin Y, Hsu Y, et al. Endothelin-1 exacerbates lipid accumulation by increasing the protein degradation of the ATP-binding cassette transporter G1 in macrophages. J Cell Physiol. 2011;226:2198-205 pubmed publisher
    ..The results of Western blotting show that ET-1 markedly decreased the ABCG1 levels via ET type A and B receptors and activation of the phosphatidylinositol 3-kinase pathway; however, ET-1 ..
  11. Uhlen M, Oksvold P, Algenäs C, Hamsten C, Fagerberg L, Klevebring D, et al. Antibody-based protein profiling of the human chromosome 21. Mol Cell Proteomics. 2012;11:M111.013458 pubmed publisher
    ..The path to generate a chromosome-specific resource, including integrated data from complementary assay platforms, such as mass spectrometry and gene tagging analysis, is discussed. ..
  12. Vaughan A, Oram J. ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins. J Biol Chem. 2005;280:30150-7 pubmed
    ATP binding cassette transporter G1 (ABCG1) mediates the transport of cholesterol from cells to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein A-I...
  13. Machado J, Iborra R, Fusco F, Castilho G, Pinto R, Machado Lima A, et al. N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1. Atherosclerosis. 2014;237:343-52 pubmed publisher
    ..NAC may contribute to attenuate the deleterious effects of CKD-albumin on lipid accumulation in macrophages helping to prevent atherogenesis in CKD. ..
  14. Xue X, Shi F, Chen T, Wei W, Zhou X, Chen L. Inhibition of ERK1/2 improves lipid balance in rat macrophages via ABCA1/G1 and CD36. Mol Med Rep. 2016;13:1533-40 pubmed publisher
    ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1), and macrophage scavenger receptor, cluster of differentiation (CD)36, function as key mediators of cholesterol efflux and influx from macrophages...
  15. Cho K, Kim H, Kamanna V, Vaziri N. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010;1800:6-15 pubmed publisher
    ..Present study sought to determine efficacy of niacin supplementation on renal tissue lipid metabolism in CRF...
  16. Sporstøl M, Mousavi S, Eskild W, Roos N, Berg T. ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. BMC Mol Biol. 2007;8:5 pubmed
    Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport...
  17. Engel T, Bode G, Lueken A, Knop M, Kannenberg F, Nofer J, et al. Expression and functional characterization of ABCG1 splice variant ABCG1(666). FEBS Lett. 2006;580:4551-9 pubmed
    The ATP-binding cassette transporter ABCG1 mediates the transport of excess cholesterol from macrophages and other cell types to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein AI...