Abcc4

Summary

Gene Symbol: Abcc4
Description: ATP binding cassette subfamily C member 4
Alias: Mrp4, RGD1565953, multidrug resistance-associated protein 4, ABC-tranporter, ATP-binding cassette protein C4, ATP-binding cassette, sub-family C (CFTR/MRP), member 4, ATP-binding cassette, subfamily C (CFTR/MRP), member 4
Species: rat
Products:     Abcc4

Top Publications

  1. Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev V, Hatem S, Cohen Aubart F, et al. Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. J Clin Invest. 2008;118:2747-57 pubmed publisher
    ..superfamily or by active efflux transporters, namely the multidrug resistance-associated proteins (MRPs) MRP4 and MRP5...
  2. Hagenbuch B, Gao B, Meier P. Transport of xenobiotics across the blood-brain barrier. News Physiol Sci. 2002;17:231-4 pubmed
    ..Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain. ..
  3. Prasad V, Achanta S, Tammineni Y, Alla G, Thirtham M, Rao G. Effect of Multi Drug Resistance Protein 4 (MRP4) Inhibition on the Pharmacokinetics and Pharmacodynamics of Ciprofloxacin in Normal and Rats with LPS-Induced Inflammation. Eur J Drug Metab Pharmacokinet. 2016;41:733-741 pubmed
    ..However, the effects of inhibition of multidrug resistance protein 4 (MRP4) on pharmacokinetics and pharmacodynamics are poorly understood in normal and inflamed conditions...
  4. Cheng D, Ren J, Jackson E. Multidrug resistance protein 4 mediates cAMP efflux from rat preglomerular vascular smooth muscle cells. Clin Exp Pharmacol Physiol. 2010;37:205-7 pubmed publisher
    ..3. Both reverse transcription-polymerase chain reaction and real-time polymerase chain reaction detected MRP4 mRNA in PGVSMC in culture...
  5. Rius M, Nies A, Hummel Eisenbeiss J, Jedlitschky G, Keppler D. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003;38:374-84 pubmed
    ..In this study we have localized the multidrug resistance protein 4 (MRP4; ABCC4) to the basolateral membrane of human, rat, and mouse hepatocytes and human hepatoma HepG2 cells...
  6. Ibbotson K, Yell J, Ronaldson P. Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress. Fluids Barriers CNS. 2017;14:6 pubmed publisher
    ..Our goal was to investigate, in vivo, regulation of Abcc1, Abcc2, and Abcc4 mRNA expression (i.e...
  7. McGill M, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013;30:2174-87 pubmed publisher
    ..and GSH conjugates are excreted by transporters in the canalicular (Mrp2 and Bcrp) and basolateral (Mrp3 and Mrp4) hepatocyte membranes...
  8. Okumura H, Katoh M, Minami K, Nakajima M, Yokoi T. Change of drug excretory pathway by CCl4-induced liver dysfunction in rat. Biochem Pharmacol. 2007;74:488-95 pubmed
    ..such as Ntcp, Oct1, and Oatp2 were decreased and basolateral ATP-binding cassette transporters such as Mrp3 and Mrp4 were increased by the CCl(4) treatment...
  9. Merrell M, Augustine L, Slitt A, Cherrington N. Induction of drug metabolism enzymes and transporters by oltipraz in rats. J Biochem Mol Toxicol. 2008;22:128-35 pubmed publisher
    ..Similarly, the transporters Mdr1a, Mdr1b, Mrp3, and Mrp4 were induced by OPZ without any apparent difference between genders...

More Information

Publications21

  1. Miura T, Kimura N, Yamada T, Shimizu T, Nanashima N, Yamana D, et al. Sustained repression and translocation of Ntcp and expression of Mrp4 for cholestasis after rat 90% partial hepatectomy. J Hepatol. 2011;55:407-14 pubmed publisher
    ..To clarify the mechanism of persistent cholestasis after massive hepatectomy, the relationship between such cholestasis and the expression and localization of organic anion transporters for bile acids was examined in a rat model...
  2. Rodriguez M, Diez F, Ventimiglia M, Morales V, Copsel S, Vatta M, et al. Atrial natriuretic factor stimulates efflux of cAMP in rat exocrine pancreas via multidrug resistance-associated proteins. Gastroenterology. 2011;140:1292-302 pubmed publisher
    ..b>MRP4 was knocked down in AR42J cells by small interfering RNA. In vivo studies were performed in rats...
  3. Jedlitschky G, Tirschmann K, Lubenow L, Nieuwenhuis H, Akkerman J, Greinacher A, et al. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood. 2004;104:3603-10 pubmed
    ..proteins mediating accumulation of these mediators in granules include multidrug resistance protein 4 (MRP4, ABCC4), a transport pump for cyclic nucleotides and nucleotide analogs...
  4. Chen C, Klaassen C. Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. Biochem Biophys Res Commun. 2004;317:46-53 pubmed
    In the present study, we report cloning of the rat Mrp4 cDNA. The cDNA is 4526 bp, containing a 3975 bp open reading frame...
  5. Nicken P, Schröder B, von Keutz A, Breves G, Steinberg P. The colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is actively secreted in the distal colon of the rat: an integrated view on the role of PhIP transport and metabolism in PhIP-induced colon carcinogenesis. Arch Toxicol. 2013;87:895-904 pubmed publisher
    ..The potential role of PhIP transport in colon carcinogenesis is discussed...
  6. Umapathy A, Li B, Donaldson P, Lim J. Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens. Invest Ophthalmol Vis Sci. 2015;56:5256-68 pubmed publisher
    ..Multidrug resistance-associated proteins 1 and 5 localized to the epithelium and peripheral fiber cells, whereas Mrp4 strongly labeled the nuclei...
  7. van Aubel R, Smeets P, Peters J, Bindels R, Russel F. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol. 2002;13:595-603 pubmed
    ..Here the expression, localization, and functional properties of human multidrug resistance protein 4 (MRP4) are reported...
  8. Denk G, Soroka C, Takeyama Y, Chen W, Schuetz J, Boyer J. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol. 2004;40:585-91 pubmed
    Multidrug resistance-associated protein 4 (Mrp4, ABCC4) transports cyclic nucleotides, anti-retroviral compounds, and sulfated bile acids. Mrp4 expression is increased in farnesyl/bile acid receptor knockout mice...
  9. Roberts L, Black D, Raman C, Woodford K, Zhou M, Haggerty J, et al. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience. 2008;155:423-38 pubmed publisher
    ..We detected P-glycoprotein (Pgp) (Abcb1), ATP-binding cassette (Abc) g2, multidrug resistance protein (Mrp) 4 (Abcc4), glucose transporter 1 (Glut1) (Slc2a1), Lat1 (Slc7a5), and monocarboxylate transporter-1 (Mct1) (Slc16a1) on the ..
  10. Smeets P, van Aubel R, Wouterse A, van den Heuvel J, Russel F. Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol. 2004;15:2828-35 pubmed
    ..1 +/- 0.6 mM). Human MRP4 (ABCC4), which has recently been localized to the apical membrane, expressed in Sf9 cells had a much higher affinity for ..
  11. Jin D, Ni T, Sun J, Wan H, Amack J, Yu G, et al. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nat Cell Biol. 2014;16:841-51 pubmed publisher
    ..leakytail (lkt) mutants show ciliogenesis defects, and the lkt locus encodes an ATP-binding cassette transporter (ABCC4)...
  12. Klein D, Wright S, Cherrington N. Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis. Drug Metab Dispos. 2014;42:89-93 pubmed publisher
    ..IHC), we determined the site of expression of the MRP transporters expressed in the testis, namely, MRP1, MRP4, MRP5, and MRP8, from immature and mature rats, rhesus macaques, and adult humans...