Gene Symbol: Abcc3
Description: ATP binding cassette subfamily C member 3
Alias: Mlp2, Mrp3, canalicular multispecific organic anion transporter 2, ATP-binding cassette sub-family C member 3, ATP-binding cassette, sub-family C (CFTR/MRP), member 3, ATP-binding cassette, subfamily C (CFTR/MRP), member 3, MLP-2, MRP-like protein 2, multidrug resistance protein 3, multidrug resistance-associated protein 3, organic anion transporter
Species: rat
Products:     Abcc3

Top Publications

  1. Naud J, Michaud J, Boisvert C, Desbiens K, Leblond F, Mitchell A, et al. Down-regulation of intestinal drug transporters in chronic renal failure in rats. J Pharmacol Exp Ther. 2007;320:978-85 pubmed
    ..Pgp, MRP2, MRP3, Oatp2, and Oatp3 protein expression and Pgp, MRP2, and Oatp3 mRNA expression were assessed in the intestine of CRF ..
  2. Muguruma M, Kawai M, Dewa Y, Nishimura J, Saegusa Y, Yasuno H, et al. Threshold dose of piperonyl butoxide that induces reactive oxygen species-mediated hepatocarcinogenesis in rats. Arch Toxicol. 2009;83:183-93 pubmed publisher
    ..25 and 0.5% PBO. Real-time RT-PCR showed that the expression of the CYP1A1, UDPGTr-2, and Mrp3 genes was significantly upregulated in rats given 0.03% PBO or higher. These results suggest that 0...
  3. Villanueva S, Ruiz M, Ghanem C, Luquita M, Catania V, Mottino A. Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats. Drug Metab Dispos. 2008;36:475-80 pubmed
    ..glucuronide (APAP-GLU), a common substrate for multidrug resistance-associated proteins 2 and 3 (Mrp2 and Mrp3), was assessed in bile duct-ligated rats (BDL) 7 days after surgery using an in vivo perfused jejunum model with ..
  4. Hirohashi T, Suzuki H, Ito K, Ogawa K, Kume K, Shimizu T, et al. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Mol Pharmacol. 1998;53:1068-75 pubmed
    The biliary excretion of several organic anions is mediated by the canalicular multispecific organic anion transporter (cMOAT), which is hereditarily defective in mutant rats such as Eisai hyperbilirubinemic rats (EHBR)...
  5. Nishimura M, Koeda A, Suzuki E, Kawano Y, Nakayama M, Satoh T, et al. Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes. Drug Metab Pharmacokinet. 2006;21:297-307 pubmed
  6. Li T, Ito K, Horie T. Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells. Am J Physiol Gastrointest Liver Physiol. 2003;285:G602-10 pubmed
    ..b>Mrp3 mRNA was readily detectable, and the protein was localized on the basolateral membrane...
  7. Hasegawa Y, Kishimoto S, Shibatani N, Nomura H, Ishii Y, Onishi M, et al. The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver. J Pharm Pharmacol. 2010;62:310-4 pubmed publisher
    ..The aim was to investigate the pharmacokinetics of morphine and its metabolite, morphine-3-glucuronide (M3G), in a rat model of streptozotocin (STZ)-induced diabetes...
  8. Tamai M, Ito Y, Mirura H, Tsukada H, Yokogawa K, Nomura M, et al. Conjugated bilirubin induces multidrug resistance-associated protein 2 mRNA expression and in vivo cisplatin resistance in rat hepatoma AH66 cells. Anticancer Res. 2003;23:4781-7 pubmed
    ..These results indicated that conjugated bilirubin, a component of ASF, induces the mRNA expression of MRP2, which is a determinant of the in vivo cisplatin resistance of AH66 cells...
  9. Tanaka Y, Yoshikawa M, Kobayashi Y, Kuroda M, Kaito M, Shiroi A, et al. Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells. Biochem Biophys Res Commun. 2003;309:324-30 pubmed
    ..of organic anion transporting polypeptide 1 (oatp1), multidrug resistance-associated protein 1 (mrp1), mrp2, mrp3, and ugt1a1 was not seen in the undifferentiated HNF-3beta-ES cells by RT-PCR, whereas all were expressed in ..

More Information


  1. Konig J, Hartel M, Nies A, Martignoni M, Guo J, Buchler M, et al. Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma. Int J Cancer. 2005;115:359-67 pubmed
    ..and analyzed the mRNA level of the transporters most abundantly expressed in pancreatic tissue, BCRP, MRP1, MRP3, MRP4 and MRP5, in 37 tissue samples...
  2. Thorn C, Oshiro C, Marsh S, Hernandez Boussard T, McLeod H, Klein T, et al. Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet Genomics. 2011;21:440-6 pubmed publisher
  3. Petrovic V, Wang J, Piquette Miller M. Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats. Drug Metab Dispos. 2008;36:1944-50 pubmed publisher
    ..Likewise, the mRNA levels of several other ABC transporters (Abcb1a, Abcb1b, Abcc1, Abcc2, Abcc3) and members of the organic anion-transporting polypeptides (Slco1a4, Slco2b1, Slco4a1) were down-regulated...
  4. Ortiz D, Li S, Iyer R, Zhang X, Novikoff P, Arias I. MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte. Am J Physiol. 1999;276:G1493-500 pubmed
    ..Antibodies raised against MRP3 recognize a polypeptide of 190-200 kDa, which is reduced in size to 155-165 kDa after treatment with ..
  5. Chang T, Hakamada K, Toyoki Y, Tsuchida S, Sasaki M. Expression of MRP2 and MRP3 during liver regeneration after 90% partial hepatectomy in rats. Transplantation. 2004;77:22-7 pubmed
    ..the bile canaliculus by means of multidrug resistance protein (MRP) 2 and, in particular circumstances, by means of MRP3 to the sinusoidal space...
  6. Thiebaud N, Menetrier F, Belloir C, Minn A, Neiers F, Artur Y, et al. Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium. Neurosci Lett. 2011;505:180-5 pubmed publisher
    ..As previously reported, Mrp1 was mainly found in the supranuclear portions of supporting cells. In addition, Mrp3 and Mrp5 proteins, which were detected for the first time in olfactory epithelium, were localized to the olfactory ..
  7. Okumura H, Katoh M, Minami K, Nakajima M, Yokoi T. Change of drug excretory pathway by CCl4-induced liver dysfunction in rat. Biochem Pharmacol. 2007;74:488-95 pubmed
    ..transporters such as Ntcp, Oct1, and Oatp2 were decreased and basolateral ATP-binding cassette transporters such as Mrp3 and Mrp4 were increased by the CCl(4) treatment...
  8. Lickteig A, Fisher C, Augustine L, Aleksunes L, Besselsen D, Slitt A, et al. Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. Drug Metab Dispos. 2007;35:1970-8 pubmed
    ..Whereas APAP-sulfate levels were also decreased in MCD rat plasma, the levels of the Mrp3 substrate APAP-GLUC were elevated...
  9. Bartholomae S, Gruhn B, Debatin K, Zimmermann M, Creutzig U, Reinhardt D, et al. Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia. Pediatr Blood Cancer. 2016;63:242-7 pubmed publisher
    ..four ABC-transporter genes (ABCA3 encoding drug transporter ABCA3, ABCB1 encoding multidrug resistance protein 1, ABCC3 encoding multidrug resistance-associated protein 3, and ABCG2 encoding breast cancer resistance protein) was ..
  10. Zúñiga García V, Chávez López M, Quintanar Jurado V, Gabiño López N, Hernández Gallegos E, Soriano Rosas J, et al. Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development. Dig Dis Sci. 2015;60:2373-83 pubmed publisher
    ..the mRNA expression of Na(+), K(+) and Ca(2+) channels and ABC transporters during rat HCC development, as well as Abcc3 protein in human liver biopsies...
  11. Nishiya T, Kataoka H, Mori K, Goto M, Sugawara T, Furuhama K. Tienilic acid enhances hyperbilirubinemia in Eisai hyperbilirubinuria rats through hepatic multidrug resistance-associated protein 3 and heme oxygenase-1 induction. Toxicol Sci. 2006;91:651-9 pubmed
    ..In analyses of mRNA expression of the hepatic transporters, elevated Mrp3 expression in EHBR correlated with an increase in serum total bilirubin, suggesting increased bilirubin transport ..
  12. Hagenbuch B, Gao B, Meier P. Transport of xenobiotics across the blood-brain barrier. News Physiol Sci. 2002;17:231-4 pubmed
    ..Members of the drug transporter families MDR, MRP, and OATP have been identified in the BBB, and a detailed characterization of the involved proteins is now required to target drugs more efficiently to the brain. ..
  13. Tzeng S, Huang J. Transcriptional regulation of the rat Mrp3 promoter in intestine cells. Biochem Biophys Res Commun. 2002;291:270-7 pubmed
    The promoter of rat multidrug resistance protein 3 (Mrp3) has been cloned and analyzed in the rat intestinal cell line (IEC-18 cells)...
  14. Akita H, Suzuki H, Hirohashi T, Takikawa H, Sugiyama Y. Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharm Res. 2002;19:34-41 pubmed
    Multidrug resistance-associated protein 3 (MRP3) was initially cloned as a hepatic transporter induced under cholestatic/ hyperbilirubinemic conditions...
  15. Aleksandrova M, Kushnareva N, Smirnova O. Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia. Bull Exp Biol Med. 2013;154:508-11 pubmed
    ..with semiquantitative image analysis showed that cholestasis induced an increase in the manifestation of mrp3 in cholangiocytes of female rats, but did not affect this parameter in the studied structures of kidney...
  16. Carrasco Torres G, Fattel Fazenda S, López Alvarez G, García Román R, Villa Treviño S, Vásquez Garzón V. The transmembrane transporter ABCC3 participates in liver cancer progression and is a potential biomarker. Tumour Biol. 2016;37:2007-14 pubmed publisher
    ..ATP-binding cassette sub-family C member 3 (Abcc3) is overexpressed in different cancers and is associated with multidrug resistance and a carcinogenic stem cell ..
  17. Lu H, Klaassen C. Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats. Drug Metab Dispos. 2008;36:16-23 pubmed
    ..remained unchanged; hepatic expression of most transporters was not altered, except increases in Mdr1a, Mrp3, and Abcg8...
  18. Merrell M, Augustine L, Slitt A, Cherrington N. Induction of drug metabolism enzymes and transporters by oltipraz in rats. J Biochem Mol Toxicol. 2008;22:128-35 pubmed publisher
    ..Similarly, the transporters Mdr1a, Mdr1b, Mrp3, and Mrp4 were induced by OPZ without any apparent difference between genders...
  19. Kuroda M, Kobayashi Y, Tanaka Y, Itani T, Mifuji R, Araki J, et al. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. J Gastroenterol Hepatol. 2004;19:146-53 pubmed
    ..The aim of the present study was to investigate adaptive expressions of mrp1, mrp3, mrp6, organic anion transporting polypeptide 1 (oatp1) and oatp2 in liver and kidney of EHBR.
  20. Ruiz M, Rigalli J, Arias A, Villanueva S, Banchio C, Vore M, et al. Induction of hepatic multidrug resistance-associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor. Drug Metab Dispos. 2013;41:275-80 pubmed publisher
    Multidrug resistance-associated protein 3 (Mrp3; Abcc3) expression and activity are up-regulated in rat liver after in vivo repeated administration of ethynylestradiol (EE), a cholestatic synthetic estrogen, whereas multidrug resistance-..
  21. McGill M, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013;30:2174-87 pubmed publisher
    ..sulfate, and GSH conjugates are excreted by transporters in the canalicular (Mrp2 and Bcrp) and basolateral (Mrp3 and Mrp4) hepatocyte membranes...
  22. Bodo A, Bakos E, Szeri F, Varadi A, Sarkadi B. Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. J Biol Chem. 2003;278:23529-37 pubmed
    The multidrug resistance proteins MRP2 (ABCC2) and MRP3 (ABCC3) are key primary active transporters involved in anionic conjugate and drug extrusion from the human liver...
  23. Rost D, Mahner S, Sugiyama Y, Stremmel W. Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. Am J Physiol Gastrointest Liver Physiol. 2002;282:G720-6 pubmed
    Multidrug resistance-associated protein 3 (MRP3; symbol ABCC3), has been shown to mediate ATP-dependent transport of organic anions including 17beta-glucuronosyl estradiol, glucuronosyl bilirubin, monovalent, and sulfated bile salts...
  24. Konig J, Rost D, Cui Y, Keppler D. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology. 1999;29:1156-63 pubmed
    ..membrane is mediated by the apical MRP isoform, MRP2 (APMRP), also known as canalicular multispecific organic anion transporter (cMOAT)...
  25. Ruiz M, Villanueva S, Luquita M, Vore M, Mottino A, Catania V. Ethynylestradiol increases expression and activity of rat liver MRP3. Drug Metab Dispos. 2006;34:1030-4 pubmed
    ..wt. s.c., for 5 consecutive days) on the expression and activity of multidrug resistance-associated protein 3 (Mrp3) in rats. Western blotting analysis revealed decreased Mrp2 (-41%) and increased Mrp3 (+200%) expression by EE...
  26. Hardwick R, Fisher C, Street S, Canet M, Cherrington N. Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. Drug Metab Dispos. 2012;40:450-60 pubmed publisher
    ..The sinusoidal transporter Abcc3 was induced in MCD rats, which correlated with increased plasma concentrations of EZE-GLUC, regardless of dosing ..