Abcc2

Summary

Gene Symbol: Abcc2
Description: ATP binding cassette subfamily C member 2
Alias: Cmoat, Mrp2, cMRP, mrp, canalicular multispecific organic anion transporter 1, ATP-binding cassette sub-family C member 2, ATP-binding cassette, sub-family C (CFTR/MRP), member 2, ATP-binding cassette, subfamily C (CFTR/MRP), member 2, cMrp2/cMoat canalicular apical conjugate export pump, calicular multispecific organic anion transporter, canalicular multidrug resistance protein, multidrug resistance-associated protein 2
Species: rat
Products:     Abcc2

Top Publications

  1. Planchamp C, Hadengue A, Stieger B, Bourquin J, Vonlaufen A, Frossard J, et al. Function of both sinusoidal and canalicular transporters controls the concentration of organic anions within hepatocytes. Mol Pharmacol. 2007;71:1089-97 pubmed
    ..regulation of the sinusoidal organic anion transporting polypeptides (Oatps) and the canalicular multidrug resistance associated protein 2 (Mrp(2)) determines the hepatic concentrations of the organic anion gadolinium ..
  2. Ou Q, Qian X, Li D, Zhang Y, Pei X, Chen J, et al. Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions. Pediatr Res. 2016;79:589-95 pubmed publisher
    ..Serum biomarkers, liver histology, and the distribution of protein and mRNA expression of Mrp2 and Bsep were analyzed...
  3. Tomer G, Ananthanarayanan M, Weymann A, Balasubramanian N, Suchy F. Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2. Pediatr Res. 2003;53:288-94 pubmed
    ..that contribute to bile formation, the bile salt export pump (Bsep) and multidrug resistance protein-2 (Mrp2), have been cloned...
  4. de Waart D, Paulusma C, Kunne C, Oude Elferink R. Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006;26:362-8 pubmed
    ..We investigated the role of multidrug resistance-associated protein 2 (MRP2) in the transport of PGE(2)...
  5. Kosaka K, Watanabe T, Susukida T, Aoki S, Sekine S, Kume T, et al. Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats. Xenobiotica. 2015;45:556-62 pubmed publisher
    1. Raloxifene-6-glucuronide (R6G) is a substrate of rat multidrug resistance-associated protein 2 (Mrp2), a transporter responsible for biliary excretion of organic anions. 2...
  6. Zalups R, Bridges C. MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA. Toxicol Appl Pharmacol. 2009;235:10-7 pubmed publisher
    ..In the present study, we extended our previous studies by testing the hypothesis that MRP2 mediates the secretion of DMPS or DMSA S-conjugates of CH(3)Hg(+)...
  7. Dietrich C, Geier A, Salein N, Lammert F, Roeb E, Oude Elferink R, et al. Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Gastroenterology. 2004;126:1044-53 pubmed
    Multidrug resistance-associated protein 2 (MRP2), a transporter of organic anions in hepatocytes, renal epithelial cells, and enterocytes, is differentially regulated in liver and kidney during cholestasis, but little is known about its ..
  8. Mertens P, Martin I, Frye B, Rauen T, Strauch S, Pabst M, et al. Rat Mrp2 gene expression is regulated by an interleukin-1?-stimulated biphasic response with enhanced transcription and subcellular shuttling of YB-1. Eur J Cell Biol. 2012;91:533-41 pubmed publisher
    Expression of hepatobiliary transporters is decreased during endotoxemia. Reduction of Mrp2 is mediated by IL-1?-dependent signals but underlying mechanisms are still unclear...
  9. Itagaki S, Chiba M, Kobayashi M, Hirano T, Iseki K. Contribution of multidrug resistance-associated protein 2 to secretory intestinal transport of organic anions. Biol Pharm Bull. 2008;31:146-8 pubmed
    ..It has been reported that multidrug resistance-associated protein 2 (Mrp2) is expressed in the mucosal membrane of the epithelium of the small intestine and secretes various drugs into the ..

More Information

Publications62

  1. Hoblinger A, Grunhage F, Sauerbruch T, Lammert F. Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 Gene (MRP2/ABCC2) with susceptibility to bile duct cancer. Digestion. 2009;80:36-9 pubmed publisher
    Multidrug resistance-associated protein 2 (MRP2/ABCC2) is one of the ATP-binding cassette (ABC) transporters expressed on the apical membrane of hepatocytes and cholangiocytes...
  2. Li G, Pei Q, Gao Y, Liu K, Nie J, Han G, et al. Protective effects of hepatocellular canalicular conjugate export pump (Mrp2) on sodium arsenite-induced hepatic dysfunction in rats. Exp Toxicol Pathol. 2007;58:447-53 pubmed
    ..conjugate export pump, which has been identified as the canalicular isoform of the multidrug resistance protein 2 (Mrp2). It has been proved that Mrp2 can transport arsenite in vitro, but its effects in vivo are not clear...
  3. Toh S, Wada M, Uchiumi T, Inokuchi A, Makino Y, Horie Y, et al. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Am J Hum Genet. 1999;64:739-46 pubmed
    ..Previous studies of the defects in the human canalicular multispecific organic anion transporter gene (MRP2/cMOAT) in patients with DJS have suggested that the gene defects are responsible for DJS...
  4. Wu T, Zhang Q, Li J, Chen H, Wu J, Song H. Up-regulation of BSEP and MRP2 by Calculus Bovis administration in 17?-ethynylestradiol-induced cholestasis: Involvement of PI3K/Akt signaling pathway. J Ethnopharmacol. 2016;190:22-32 pubmed publisher
    ..Expression of bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP2) were studied by western blot and immunohistochemical assay...
  5. Miranda S, Lee J, Brouwer K, Wen Z, Smith P, Hawke R. Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2). Drug Metab Dispos. 2008;36:2219-26 pubmed publisher
    ..To determine the role of multidrug resistance-associated protein 2 (Mrp2) (Abcc2) in the biliary excretion of silymarin, the hepatobiliary disposition of the six major silymarin flavonolignans ..
  6. Micuda S, Fuksa L, Brcakova E, Osterreicher J, Cermanova J, Cibicek N, et al. Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone. J Gastroenterol Hepatol. 2008;23:e225-30 pubmed
    The present study was aimed to evaluate the hepatic zonation of multidrug resistance-associated protein 2 (mrp2), an important drug transporter, and its potential changes during the induction of its expression by known inducer, ..
  7. Zinchuk V, Zinchuk O, Akimaru K, Moriya F, Okada T. Ethanol consumption alters expression and colocalization of bile salt export pump and multidrug resistance protein 2 in the rat. Histochem Cell Biol. 2007;127:503-12 pubmed
    ..of bile salt export pump (Bsep), a major canalicular exporter of bile salts, and multidrug resistance protein 2 (Mrp2), a canalicular organic anion transporter, in the rat liver...
  8. Maeng H, Kim M, Jin H, Shin S, Tsuruo T, Kim S, et al. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Drug Metab Dispos. 2007;35:1996-2005 pubmed
    ..Taken together, these observations suggest that nitrosative stress leads to the up-regulation of the message for the efflux transporter and, ultimately, to the enhanced function, probably via a NF-kappaB-dependent mechanism...
  9. Crocenzi F, Mottino A, Cao J, Veggi L, Pozzi E, Vore M, et al. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Am J Physiol Gastrointest Liver Physiol. 2003;285:G449-59 pubmed
    Endocytic internalization of the multidrug resistance-associated protein 2 (Mrp2) was previously suggested to be involved in estradiol-17beta-D-glucuronide (E217G)-induced cholestasis...
  10. Parasrampuria R, Mehvar R. Divergent effects of nitric oxide donors on the biliary efflux transporters in isolated perfused rat livers: nitric oxide-independent inhibition of ABC transporters by sodium nitroprusside. Drug Metab Lett. 2011;5:64-72 pubmed
    ..the bile via the ABC efflux transporters P-glycoprotein (P-gp) and multidrug resistance-related protein type 2 (Mrp2), respectively...
  11. Sekine S, Ito K, Horie T. Oxidative stress and Mrp2 internalization. Free Radic Biol Med. 2006;40:2166-74 pubmed
    ..the internalization of multidrug resistance-associated protein 2/ATP-binding cassette transporter family 2 (Mrp2/Abcc2), a biliary transporter involved in bile-salt-independent bile flow, under ethacrynic acid (EA)-induced acute ..
  12. Mottino A, Hoffman T, Crocenzi F, Sanchez Pozzi E, Roma M, Vore M. Disruption of function and localization of tight junctional structures and Mrp2 in sustained estradiol-17beta-D-glucuronide-induced cholestasis. Am J Physiol Gastrointest Liver Physiol. 2007;293:G391-402 pubmed
    ..occludens-1 (ZO-1) and occludin and of the canalicular transporter multidrug resistance-associated protein-2 (Mrp2). An initial dose of E(2)17G (15 mumol/kg iv) followed by five subsequent doses of 7...
  13. Zamek Gliszczynski M, Goldstein K, Paulman A, Baker T, Ryan T. Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics. Drug Metab Dispos. 2013;41:1174-8 pubmed publisher
    Mdr1a-, Bcrp-, and Mrp2-knockout rats are a more practical species for absorption, distribution, metabolism, and excretion (ADME) studies than murine models and previously demonstrated expected alterations in the pharmacokinetics of ..
  14. Suzuki T, Zhao Y, Nadai M, Naruhashi K, Shimizu A, Takagi K, et al. Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats. Life Sci. 2006;79:455-61 pubmed
    ..exist in the expression and function of hepatic P-glycoprotein- and/or multidrug resistance-associated protein (Mrp2), we measured the hepatobiliary excretion of doxorubicin and their protein levels in male and female Sprague-Dawley ..
  15. Kudo A, Kashiwagi S, Kajimura M, Yoshimura Y, Uchida K, Arii S, et al. Kupffer cells alter organic anion transport through multidrug resistance protein 2 in the post-cold ischemic rat liver. Hepatology. 2004;39:1099-109 pubmed
    ..We examined whether intracellular relocalization of multidrug resistance protein-2 (Mrp2) occurred...
  16. Ellis L, Hawksworth G, Weaver R. ATP-dependent transport of statins by human and rat MRP2/Mrp2. Toxicol Appl Pharmacol. 2013;269:187-94 pubmed publisher
    Multidrug resistance associated protein-2, MRP2 (human), Mrp2 (rat) are an efflux transporter, responsible for the transport of numerous endogenous and xenobiotic compounds including taurocholate, methotrexate and ..
  17. Cantore M, Reinehr R, Sommerfeld A, Becker M, Haussinger D. The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane. J Biol Chem. 2011;286:45014-29 pubmed publisher
    In perfused rat liver, hyperosmolarity induces Mrp2- (Kubitz, R., D'urso, D., Keppler, D., and Häussinger, D. (1997) Gastroenterology 113, 1438-1442) and Bsep retrieval (Schmitt, M., Kubitz, R., Lizun, S., Wettstein, M...
  18. Maier Salamon A, Trauner G, Hiltscher R, Reznicek G, Kopp B, Thalhammer T, et al. Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: role of Mrp2 (Abcc2). J Pharm Sci. 2009;98:3839-49 pubmed publisher
    ..system of valerenic acid, a main active constituent of valerian, in isolated perfused livers from Wistar and Mrp2-deficient TR(-) rats...
  19. Noma B, Sasaki T, Fujimoto Y, Serikawa M, Kobayashi K, Inoue M, et al. Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer. Int J Oncol. 2008;33:1187-94 pubmed
    ..The aims of this study were to examine the expression of multidrug resistance-associated proteins (MRPs) MRP1, MRP2 and MRP3 and to evaluate the correlation between MRP2 expression and CDDP resistance in human pancreatic cancer...
  20. Naud J, Michaud J, Boisvert C, Desbiens K, Leblond F, Mitchell A, et al. Down-regulation of intestinal drug transporters in chronic renal failure in rats. J Pharmacol Exp Ther. 2007;320:978-85 pubmed
    ..in drug absorption [organic anion-transportingpolypeptide (Oatp)] and those implicated in drug extrusion (Pgp and MRP2)...
  21. Umapathy A, Li B, Donaldson P, Lim J. Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens. Invest Ophthalmol Vis Sci. 2015;56:5256-68 pubmed publisher
    ..reaction and Western blotting were used to screen for the presence of multidrug resistance-associated protein (Mrp) and organic anion transporting polypeptide (Oatp) isoforms, and immunohistochemistry used to localize Mrp isoforms...
  22. Barosso I, Zucchetti A, Miszczuk G, Boaglio A, Taborda D, Roma M, et al. EGFR participates downstream of ERα in estradiol-17β-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets. Arch Toxicol. 2016;90:891-903 pubmed publisher
    ..acute endocytic internalization of canalicular transporters, including multidrug resistance-associated protein 2 (Abcc2) in rat, generating cholestasis...
  23. Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, et al. Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1450-63 pubmed
    ..agents for cholestasis, the effects of ICKT or its ingredients on multidrug resistance-associated protein 2 (Mrp2/ MRP2)-mediated choleretic activity, as well as on antioxidative action, were investigated using rats and chimeric ..
  24. Potschka H, Fedrowitz M, Loscher W. Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity. J Pharmacol Exp Ther. 2003;306:124-31 pubmed
    ..More recently, the multidrug resistance protein MRP2 (ABCC2) has been found in the luminal surface of brain capillary endothelium of different species, including humans...
  25. Au A, Baba A, Azlan H, Norsa adah B, Ankathil R. Clinical impact of ABCC1 and ABCC2 genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients. J Clin Pharm Ther. 2014;39:685-90 pubmed publisher
    ..study was to investigate the association between genetic variations in drug efflux transporter ABCC1 (MRP1) and ABCC2 (MRP2) genes and response to IM in patients with CML...
  26. Notenboom S, Wouterse A, Peters B, Kuik L, Heemskerk S, Russel F, et al. Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure. J Pharmacol Exp Ther. 2006;318:1194-202 pubmed
    Multidrug resistance protein (MRP) 2 (MRP2; ABCC2), an organic anion transporter apically expressed in liver, kidney, and intestine, plays an important protective role through facilitating the efflux of potentially toxic compounds...
  27. Zamek Gliszczynski M, Bedwell D, Bao J, Higgins J. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Drug Metab Dispos. 2012;40:1825-33 pubmed publisher
    ..paclitaxel; breast cancer resistance protein (Bcrp): sulfasalazine; and multidrug resistance-associated protein 2 (Mrp2): carboxydichlorofluorescein] were studied systematically across SAGE P-gp, Bcrp, and Mrp2 knockout rats...
  28. Donner M, Topp S, Cebula P, Krienen A, Gehrmann T, Sommerfeld A, et al. HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion. Biol Chem. 2013;394:97-112 pubmed publisher
    ..05) and biliary taurocholate excretion from 45.9±13.81 ?mol/3 h to 1.87±0.46 ?mol/3 h (p<0.05). Mrp2, Bsep and Ntcp peak immunofluorescence in pericentral hepatocytes decreased to 79.0±2.6% (p<0.001), 80.6±8...
  29. Moriondo V, Marchini S, Di Gangi P, Ferrari M, Nascimbeni F, Rocchi E, et al. Role of Multidrug-Resistance Protein 2 in coproporphyrin transport: results from experimental studies in bile fistula rat models. Cell Mol Biol (Noisy-le-grand). 2009;55:70-8 pubmed
    ..obtained from animal and human models have suggested a possible role for Multidrug Resistance-associated Protein 2 (MRP2) and other MRPs in hepatocyte excretion of CP...
  30. Cheng Q, Aleksunes L, Manautou J, Cherrington N, Scheffer G, Yamasaki H, et al. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol Pharm. 2008;5:77-91 pubmed publisher
    ..was increased in livers of ob/ob mice, particularly with Mrp4 expression being elevated by at least 6-fold and Mrp2 expression at least 3-fold in livers of ob/ob mice...
  31. Wang D, Wei Y, Zhou Y, Zhang G, Zhang F, Li Y, et al. Pharmacokinetic variation of ofloxacin based on gender-related difference in the expression of multidrug resistance-associated protein (Abcc2/Mrp2) in rat kidney. Yao Xue Xue Bao. 2012;47:624-9 pubmed
    ..of ofloxacin based on gender-related difference in the expression of multidrug resistance-associated protein (Abcc2/Mrp2) in rat kidney...
  32. Hirsova P, Karlasova G, Dolezelova E, Cermanova J, Zagorova M, Kadova Z, et al. Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2. Toxicology. 2013;303:9-15 pubmed publisher
    ..the main glutathione transporter on the hepatocyte canalicular membrane, multidrug resistance-associated protein 2 (Mrp2), was significantly decreased at the protein level...
  33. Zhang J, Zhang M, Sun B, Li Y, Xu P, Liu C, et al. Hyperammonemia enhances the function and expression of P-glycoprotein and Mrp2 at the blood-brain barrier through NF-κB. J Neurochem. 2014;131:791-802 pubmed publisher
    ..reported to alter expression and activity of P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (Mrp2) at the blood-brain barrier (BBB)...
  34. Kojima H, Omoto Y, Hidaka H, Aoki T, Nakamura T, Kawabata T, et al. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat. Biochem Biophys Res Commun. 1992;186:398-404 pubmed
    ..These results indicate that plasma post-heparin DAO activity may be used as a marker of intestinal hypertrophy as well as ability to absorb dietary sterols. ..
  35. Fujiwara K, Shin M, Yoshizaki Y, Miyazaki T, Saita T. An in vivo role of Mrp2 in the rat hepatocytes by immunocytochemistry for amoxicillin using the transporter-deficient EHBR. J Mol Histol. 2012;43:371-8 pubmed publisher
    An in vivo role of the multidrug resistant-associated protein (Mrp2) in rat hepatocytes was examined by immunocytochemistry (ICC) for amoxicillin (AMPC) by the use of the transporter-deficient Eisai hyperbilirubinemic rats (EHBR)...
  36. Liu T, Meng Q, Wang C, Liu Q, Guo X, Sun H, et al. Changes in expression of renal Oat1, Oat3 and Mrp2 in cisplatin-induced acute renal failure after treatment of JBP485 in rats. Toxicol Appl Pharmacol. 2012;264:423-30 pubmed publisher
    ..on acute renal failure (ARF) induced by cisplatin is related to change in expression of renal Oat1, Oat3 and Mrp2 in rats...
  37. Hu Y, Sampson K, Xing L, Li N, Heyde B, Xie J, et al. Two branched polar groups and polar linker moieties of thiophene amide derivatives are essential for MRP2/ABCC2 recognition. Drug Metab Lett. 2010;4:254-61 pubmed
    ..rings forming a three-dimensional conformation is the determinant factor for multi-drug resistance protein 2 (Mrp2/Abcc2) interaction [1]...
  38. Watanabe M, Matsumoto N, Takeba Y, Kumai T, Tanaka M, Tatsunami S, et al. Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver. J Biomed Biotechnol. 2011;2011:502057 pubmed publisher
    ..of pravastatin (PRV) and the expression of both protein and mRNA of multidrug resistance-associated protein 2 (Mrp2) in the rat small intestine and liver. Eight-week-old male Sprague-Dawley rats were used in this study. OJ or a 0...
  39. Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, et al. Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. 2002;31:320-5 pubmed
    ..in Dubin-Johnson syndrome, which is caused by mutations in the multidrug resistance protein 2 (MRP2, gene symbol ABCC2), although this syndrome is not associated with overt liver injury...
  40. Zgheib N, Akra Ismail M, Aridi C, Mahfouz R, Abboud M, Solh H, et al. Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. Pharmacogenet Genomics. 2014;24:387-96 pubmed publisher
    ..genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and the MTX effect mainly MTHFR and TYMS, and to assess whether these ..
  41. Norimizu S, Kudo A, Kajimura M, Ishikawa K, Taniai H, Yamaguchi T, et al. Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-IXalpha into bile in the perfused rat liver. Antioxid Redox Signal. 2003;5:449-56 pubmed
    ..CO-mediated choleresis and increased excretion of organic anions appeared to be mediated by mrp2, because Eisai hyperbilirubinemia rats, which genetically lack the transporter, did not exhibit choleresis upon the ..
  42. Liu Y, Yin Y, Sheng Q, Lu X, Wang F, Lin Z, et al. Association of ABCC2 -24C>T polymorphism with high-dose methotrexate plasma concentrations and toxicities in childhood acute lymphoblastic leukemia. PLoS ONE. 2014;9:e82681 pubmed publisher
    ..ATP-binding cassette subfamily C member 2 (ABCC2) is important for excretion of MTX and its toxic metabolite...
  43. Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, et al. Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats. Anticancer Res. 2015;35:4681-9 pubmed
    We investigated whether hepatic multidrug resistance-associated protein 2 (ABCC2) is involved in the hepatobiliary excretion of regorafenib, a novel multi-kinase inhibitor, using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats ..
  44. Cherrington N, Estrada T, Frisk H, Canet M, Hardwick R, Dvorak B, et al. The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2013;304:G48-56 pubmed publisher
    ..rat and mouse models of NEC, levels of Cyp7a1, Cyp27a1, and the hepatic BA transporters Bsep, Ntcp, Oatp2, Oatp4, Mrp2, and Mrp3 were investigated...
  45. Shao Y, Huang J, Ma Y, Han M, Ma K, Qin H, et al. Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats. Can J Physiol Pharmacol. 2015;93:633-9 pubmed publisher
    ..Our results showed that in PI-IBS rats the expression of multidrug resistance protein 2 (Mrp2) was significantly decreased, while colonic enterochromaffin cell density and serum levels of 5-HT were all ..
  46. Mottino A, Crocenzi F, Pozzi E, Veggi L, Roma M, Vore M. Role of microtubules in estradiol-17beta-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity. Am J Physiol Gastrointest Liver Physiol. 2005;288:G327-36 pubmed
    ..inhibition of bile flow in the rat together with endocytic retrieval of multidrug resistance-associated protein 2 (Mrp2) from the canalicular membrane to intracellular structures...
  47. Reichard J, Doorn J, Simon F, Taylor M, Petersen D. Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal. Arch Biochem Biophys. 2003;411:243-50 pubmed
    ..In this investigation we characterize the multidrug resistance-associated protein 2 (MRP2) as the primary transmembrane transport protein in hepatocytes responsible for extracellular export of 4HNE-..
  48. Yu Q, Shu M, Dai J, Ma J, Yu Y, Liu D. [The mechanism of the increase of plasma bilirubin after hepatic ischemia-reperfusion in rats]. Zhonghua Gan Zang Bing Za Zhi. 2007;15:763-6 pubmed
    ..RT-PCR was used to analyze the expression of the multidrug resistance-associated protein 2 (MRP2) and mRNA. Immunohistochemistry was used to analyze the localization of MRP2 in the canalicular membrane...
  49. Nakano T, Sekine S, Ito K, Horie T. Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine. Drug Metab Dispos. 2009;37:1521-7 pubmed publisher
    The multidrug resistance-associated protein 2/ATP-binding cassette transporter family C2 (Mrp2/Abcc2) is an ATP-dependent export pump that mediates the transport of a variety of organic anions...
  50. Bridges C, Joshee L, Zalups R. MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. Toxicol Appl Pharmacol. 2011;251:50-8 pubmed publisher
    ..agents have been shown to promote extraction of mercuric ions via the multidrug resistance-associated protein 2 (MRP2)...
  51. Lewis L, Miller A, Owzar K, Bies R, Markova S, Jiang C, et al. The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance). Pharmacogenet Genomics. 2013;23:29-33 pubmed publisher
    Docetaxel-related neutropenia was associated with polymorphisms in the drug transporters ABCC2 and SLCO1B3 in Japanese cancer patients...
  52. Ibbotson K, Yell J, Ronaldson P. Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress. Fluids Barriers CNS. 2017;14:6 pubmed publisher
    ..Our goal was to investigate, in vivo, regulation of Abcc1, Abcc2, and Abcc4 mRNA expression (i.e...
  53. Arana M, Tocchetti G, Zecchinati F, Londero A, Dominguez C, Perdomo V, et al. Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats. Toxicology. 2017;390:22-31 pubmed publisher
    Multidrug resistance-associated protein 2 (Mrp2, ABCC2) and P-glycoprotein (P-gp, ABCB1) constitute essential components of the intestinal biochemical barrier that prevent incorporation of food contaminants, drugs or toxic metabolites ..