Abcb1b

Summary

Gene Symbol: Abcb1b
Description: ATP-binding cassette, subfamily B (MDR/TAP), member 1B
Alias: Abcb1, Mdr1, Pgy1, mdr1b, multidrug resistance protein 1, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1), ATP-binding cassette sub-family B member 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1), ATP-binding cassette, sub-family B (MDR/TAP), member 1B, ATP-binding cassette, subfamily B, member 1B, P-glycoprotein 1, P-glycoprotein/multidrug resistance 1
Species: rat
Products:     Abcb1b

Top Publications

  1. Potocnik U, Ferkolj I, Glavac D, Dean M. Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis. Genes Immun. 2004;5:530-9 pubmed
    We used coding and noncoding polymorphisms evenly spaced across the ABCB1/MDR1 gene to perform association analysis in Slovenian patients with inflammatory bowel diseases and to obtain haplotype structure and patterns of linkage ..
  2. Ronaldson P, Bendayan R. HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein. Mol Pharmacol. 2006;70:1087-98 pubmed
  3. Cutler L, Howes C, Deeks N, Buck T, Jeffrey P. Development of a P-glycoprotein knockout model in rodents to define species differences in its functional effect at the blood-brain barrier. J Pharm Sci. 2006;95:1944-53 pubmed
    ..This study establishes the optimal blood concentrations of GF120918 in relation to SB-487946, to achieve chemically induced P-gp knockout in rodents. ..
  4. Kameyama N, Arisawa S, Ueyama J, Kagota S, Shinozuka K, Hattori A, et al. Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes. Biochim Biophys Acta. 2008;1782:355-60 pubmed publisher
    ..and the roles of PKCalpha and the transcription factor NF-kappaB, we investigated the expression levels of Mdr1a, Mdr1b, Mdr2, Mrp2, Bcrp, Bsep, Oct1, Oat2, and Oat3 transporters, PKCalpha, IkappaB, and NF-kappaB in the liver of rats ..
  5. Naud J, Michaud J, Boisvert C, Desbiens K, Leblond F, Mitchell A, et al. Down-regulation of intestinal drug transporters in chronic renal failure in rats. J Pharmacol Exp Ther. 2007;320:978-85 pubmed
    ..This reduction could explain the increased bioavailability of drugs in CRF. ..
  6. Cermanova J, Fuksa L, Brcakova E, Hroch M, Kucera O, Kolouchova G, et al. Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats. Pharmacol Res. 2010;61:129-35 pubmed publisher
    ..aim of this study was to investigate the influence of AMD pretreatment on the main multidrug transporting proteins, Mdr1 and Mrp2, in the liver and kidney...
  7. Reichel V, Burghard S, John I, Huber O. P-glycoprotein and breast cancer resistance protein expression and function at the blood-brain barrier and blood-cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats. Brain Res. 2011;1370:238-45 pubmed publisher
    ..mellitus type 1 on expression and function of the ATP-binding cassette transport proteins P-glycoprotein (Pgp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) at the blood-brain barrier and the blood-cerebrospinal fluid ..
  8. Heemskerk S, van Koppen A, van den Broek L, Poelen G, Wouterse A, Dijkman H, et al. Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. Pflugers Arch. 2007;454:321-34 pubmed
    ..Gene expression of 20 ABC transporters was determined. After LPS(+), a clear up-regulation in Abca1, Abcb1/P-glycoprotein (P-gp), Abcb11/bile salt export pump (Bsep), and Abcc2/multidrug resistance protein (Mrp2) was ..
  9. Bauer B, Hartz A, Pekcec A, Toellner K, Miller D, Potschka H. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol Pharmacol. 2008;73:1444-53 pubmed
    ..Moreover, they provide insight into one mechanism that underlies drug resistance in epilepsy and possibly other central nervous system disorders. ..

More Information

Publications62

  1. Liu H, Xu X, Yang Z, Deng Y, Liu X, Xie L. Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats. Brain Res. 2006;1123:245-52 pubmed
    ..These results suggested that the function and expression of P-GP might be impaired in the BBB of STZ-induced diabetic rats. ..
  2. Vos T, Hooiveld G, Koning H, Childs S, Meijer D, Moshage H, et al. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology. 1998;28:1637-44 pubmed
    ..This was confirmed in isolated hepatocytes. In addition, mdr1b mRNA was strongly increased, whereas mdr1a and mdr2 mRNA did not change significantly...
  3. Yu C, Argyropoulos G, Zhang Y, Kastin A, Hsuchou H, Pan W. Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia. Cell Physiol Biochem. 2008;22:745-56 pubmed publisher
    ..RBE4) cells of BBB origin, the proinflammatory cytokine TNF mainly induced transcriptional upregulation of mdr1b, and to a lesser extent mdr1a, resulting in greater efflux of the substrates...
  4. Maeng H, Kim M, Jin H, Shin S, Tsuruo T, Kim S, et al. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Drug Metab Dispos. 2007;35:1996-2005 pubmed
    ..Taken together, these observations suggest that nitrosative stress leads to the up-regulation of the message for the efflux transporter and, ultimately, to the enhanced function, probably via a NF-kappaB-dependent mechanism...
  5. Iwanaga K, Arimune K, Miyazaki M, Shibano M, Taniguchi M, Baba K, et al. Effects of furanocoumarins in Kampo extract-based medicines on rat intestinal absorption of CYP3A and P-glycoprotein substrate drugs in vivo. Arch Pharm Res. 2012;35:1055-64 pubmed publisher
    ..Decreased intestinal absorption of talinolol might be caused, not by the inhibition of P-gp, but by the inhibition of organic anion transporting peptides by both Kampo extract medicines. ..
  6. Berezowski V, Landry C, Dehouck M, Cecchelli R, Fenart L. Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier. Brain Res. 2004;1018:1-9 pubmed
    ..The tissue distribution of the expression of these transporters and the contribution of the different cell populations are discussed. ..
  7. Soares R, Do T, Mabondzo A, Pons G, Chhun S. Ontogeny of ABC and SLC transporters in the microvessels of developing rat brain. Fundam Clin Pharmacol. 2016;30:107-16 pubmed publisher
    ..We detected statistically significant higher expression of Abcb1b and Slc16a1 genes, and lower expression of Abcb1a and Abcg2 genes between the post-natal day 14 (P14) and the ..
  8. Durk M, Chan G, Campos C, Peart J, Chow E, Lee E, et al. 1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells. J Neurochem. 2012;123:944-53 pubmed publisher
    Induction of the multidrug resistance protein 1 (MDR1)/P-glycoprotein (P-gp) by the vitamin D receptor (VDR) was investigated in isolated rat brain capillaries and rat (RBE4) and human (hCMEC/D3) brain microvessel endothelial cell lines...
  9. Lee W, Torchalski B, Kohistani N, Thevenod F. ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport. Toxicol Sci. 2011;121:343-56 pubmed publisher
    ..Multidrug resistance P-glycoprotein (MDR1, ABCB1) confers resistance to Cd(2+) apoptosis, and it has been hypothesized that ABCB1 can directly transport Cd(2+) as ..
  10. Cerveny L, Neumanova Z, Karbanova S, Havlova I, Staud F. Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs. J Pharm Pharmacol. 2016;68:84-92 pubmed publisher
    ..day, the placenta and maternal/fetal intestine, brain, kidneys and liver were sampled and analysed for Abcb1a, Abcb1b and Abcg2 expression; placental and newborns' weights were also monitored...
  11. Rigor R, Hawkins B, Miller D. Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. J Cereb Blood Flow Metab. 2010;30:1373-83 pubmed publisher
    ..Targeting PKCbeta(I) at the BBB may prove to be an effective strategy for enhancing the delivery of small molecule therapeutics to the brain. ..
  12. Kooij G, van Horssen J, de Lange E, Reijerkerk A, van der Pol S, Van het Hof B, et al. T lymphocytes impair P-glycoprotein function during neuroinflammation. J Autoimmun. 2010;34:416-25 pubmed publisher
    The ATP-binding cassette (ABC) transporter P-glycoprotein (P-gp; ABCB1) is highly expressed at the blood-brain barrier (BBB)...
  13. Kipp H, Arias I. Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. J Biol Chem. 2000;275:15917-25 pubmed
    ..particular, we compared membrane targeting of newly synthesized canalicular ABC (ATP-binding cassette) transporters MDR1, MDR2, and SPGP (sister of P-glycoprotein) with that of cCAM105...
  14. Ghanem C, Arias A, Novak A, Carpini G, Villanueva S, Blazquez A, et al. Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line. Biochem Pharmacol. 2011;81:244-50 pubmed publisher
    ..analgesic and antipyretic drug N-acetyl-p-aminophenol (acetaminophen; APAP) has been previously reported to affect MDR1 expression in rat liver...
  15. Walentinsson A, Helou K, Wallenius V, Hedrich H, Szpirer C, Levan G. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Cancer Res. 2001;61:8263-73 pubmed
    ..Taken together, our findings suggest that up-regulation of Cdk6 and/or Met may contribute to the development of endometrial cancers in the BDII rat. ..
  16. Singh R, Panduri J, Kumar D, Kumar D, Chandsana H, Ramakrishna R, et al. Evaluation of memory enhancing clinically available standardized extract of Bacopa monniera on P-glycoprotein and cytochrome P450 3A in Sprague-Dawley rats. PLoS ONE. 2013;8:e72517 pubmed publisher
    ..Significant increase in AUC and Cmax of carbamazepine (4 and 1.8 fold) and digoxin (1.3 and 1.2 fold), respectively following the BM pre-treatment confirmed the down regulation of CYP3A and Pgp. ..
  17. Shao Y, Wang C, Hong Z, Chen Y. Inhibition of p38 mitogen-activated protein kinase signaling reduces multidrug transporter activity and anti-epileptic drug resistance in refractory epileptic rats. J Neurochem. 2016;136:1096-105 pubmed publisher
    ..This in vivo study examined the effects of p38MAPK on the expression of P-gp and mdr1 in the rat brain and quantified antiepileptic drug (AED) concentrations in the hippocampal extracellular fluid...
  18. Geng J, Zhou D. [Coriaria lactone induces in vitro the overexpression of multidrug resistance P-glycoprotein in astrocyte from rat brain]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39:80-3 pubmed
    ..The expression of P-glycoprotein (Pgp), the protein product of multidrug resistance 1 (MDR1), was investigated with immunocytochemistry and image analysis...
  19. Deuchars K, Duthie M, Ling V. Identification of distinct P-glycoprotein gene sequences in rat. Biochim Biophys Acta. 1992;1130:157-65 pubmed
    ..We have also isolated a fourth clone which contains only a short, but highly conserved P-glycoprotein domain. This clone appears not be a member of the P-glycoprotein gene family, and its relationship to P-glycoprotein is unknown. ..
  20. Patel V, Dunn M, Sorokin A. Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2. J Biol Chem. 2002;277:38915-20 pubmed
    ..One of the several genes that were highly up-regulated by over expressed Cox-2 was MDR1. MDR1 or P-glycoprotein (P-gp), the product of the MDR1 gene, is implicated as the primary cause of multidrug ..
  21. Cannon R, Peart J, Hawkins B, Campos C, Miller D. Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. Proc Natl Acad Sci U S A. 2012;109:15930-5 pubmed
  22. Mercier C, Masseguin C, Roux F, Gabrion J, Scherrmann J. Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes. Brain Res. 2004;1021:32-40 pubmed
    P-glycoprotein (P-gp, ABCB1) and the multidrug resistance-associated protein 1 (Mrp1, ABCC1) are two ATP-driven pumps that mediate the export of organic anions from cells and may confer cellular resistance to many cytotoxic hydrophobic ..
  23. Teeter L, Estes M, Chan J, Atassi H, Sell S, Becker F, et al. Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Mol Carcinog. 1993;8:67-73 pubmed
    ..P-glycoproteins are encoded by three multidrug-resistance (mdr) genes in rodents, designated mdr1a (mdr3), mdr1b (mdr1), and mdr2. Only the first two genes are functionally related to multidrug resistance...
  24. Fujiwara K, Shin M, Miyazaki T. A probable relationship between characteristic accumulation of doxorubicin and P-glycoprotein transporter in rat liver. J Mol Histol. 2011;42:409-15 pubmed publisher
    ..This is supported by conventional electron microscopic studies, since no specific subcellular organelles such as lysosomes assemble in the vicinity of the bile capillaries of the hepatocytes. ..
  25. Trezise A, Romano P, Gill D, Hyde S, Sepulveda F, Buchwald M, et al. The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression. EMBO J. 1992;11:4291-303 pubmed
    The cystic fibrosis gene product, CFTR, and the multidrug resistance P-glycoprotein (encoded by the MDR1 gene) are structurally related proteins and both are associated with epithelial chloride channel activities...
  26. Ortiz D, Moseley J, Calderon G, Swift A, Li S, Arias I. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. J Biol Chem. 2004;279:32761-70 pubmed
    ATP-binding cassette (ABC)-type proteins are essential for bile formation in vertebrate liver. BSEP, MDR1, MDR2, and MRP2 ABC transporters are targeted to the apical (canalicular) membrane of hepatocytes where they execute ATP-dependent ..
  27. Brandt C, Bethmann K, Gastens A, Loscher W. The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiol Dis. 2006;24:202-11 pubmed
    ..These data demonstrate that inhibiting P-gp in epileptic rats with proven drug resistance counteracts resistance, providing the first proof-of-principle of the multidrug transporter hypothesis of medically refractory epilepsy. ..
  28. Budde T, Haney J, Bien S, Schwebe M, Riad A, Tschope C, et al. Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression. J Pharm Sci. 2011;100:3951-8 pubmed publisher
    ..Thereby, we could show a significant upregulation of abcb1a (162 ± 15% of control) and abcb1b (418 ± 110% of control) mRNA transcripts after 3 days...
  29. Kojima C, Qu W, Waalkes M, Himeno S, Sakurai T. Chronic exposure to methylated arsenicals stimulates arsenic excretion pathways and induces arsenic tolerance in rat liver cells. Toxicol Sci. 2006;91:70-81 pubmed
  30. Nassar T, Rom A, Nyska A, Benita S. A novel nanocapsule delivery system to overcome intestinal degradation and drug transport limited absorption of P-glycoprotein substrate drugs. Pharm Res. 2008;25:2019-29 pubmed publisher
    ..The overall results suggest that the novel nanodelivery system which does not alter the activity of the P-gp is a potential platform for intestinal transport of sensitive lipophilic molecules that are P-gp substrates. ..
  31. Zhang L, Lu L, Jin S, Jing X, Yao D, Hu N, et al. Tissue-specific alterations in expression and function of P-glycoprotein in streptozotocin-induced diabetic rats. Acta Pharmacol Sin. 2011;32:956-66 pubmed publisher
    ..In liver, the level was increased in 5-week diabetic rats, and decreased in 8-week diabetic rats. Abcb1b mRNA levels were increased in cerebral cortex, hippocampus and kidney, but reduced in liver and intestinal mucosa ..
  32. Gazzin S, Berengeno A, Strazielle N, Fazzari F, Raseni A, Ostrow J, et al. Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PLoS ONE. 2011;6:e16165 pubmed publisher
    Accumulation of unconjugated bilirubin (UCB) in the brain causes bilirubin encephalopathy. Pgp (ABCb1) and Mrp1 (ABCc1), highly expressed in the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) respectively, may ..
  33. Suzuki T, Zhao Y, Nadai M, Naruhashi K, Shimizu A, Takagi K, et al. Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats. Life Sci. 2006;79:455-61 pubmed
    ..These results suggest that gender-related differences exist in P-glycoprotein- and Mrp2-mediated hepatobiliary transport and that these two transporters may be regulated by sex hormones. ..
  34. Su L, Mruk D, Lui W, Lee W, Cheng C. P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK). Proc Natl Acad Sci U S A. 2011;108:19623-8 pubmed publisher
    ..These findings indicate that P-glycoprotein is involved in BTB restructuring during spermatogenesis but that P-glycoprotein-mediated restructuring does not "open up" the BTB to make it freely permeable to drugs...
  35. Kankesan J, Laconi E, Medline A, Thiessen J, Ling V, Rao P, et al. PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats. Anticancer Res. 2006;26:995-9 pubmed
    ..Collectively, this study indicates that PSC inhibited experimental colorectal carcinogenesis initiated with 1,2-DMH in rats. ..
  36. Zhang Z, Wang X, Wang S. Chemosensitization effects of simultaneous suppression of MDR1 and XIAP in multidrug resistant glioma cells. Med Oncol. 2008;25:367-73 pubmed publisher
    We studied the mechanisms involved in the drug resistance of C6/ADR and compared the reversal effects of XIAP and MDR1 ASO used in combination and separately...
  37. Mercier C, Declèves X, Masseguin C, Fragner P, Tardy M, Roux F, et al. P-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes. J Neurochem. 2003;87:820-30 pubmed
    ..Among the two P-gp genes expressed in rodents, mdr1a and mdr1b, a time- and dose-dependent increase in mdr1b mRNA levels was revealed by northern blot analysis...
  38. Tramonti G, Xie P, Wallner E, Danesh F, Kanwar Y. Expression and functional characteristics of tubular transporters: P-glycoprotein, PEPT1, and PEPT2 in renal mass reduction and diabetes. Am J Physiol Renal Physiol. 2006;291:F972-80 pubmed
  39. Campos C, Schroter C, Wang X, Miller D. ABC transporter function and regulation at the blood-spinal cord barrier. J Cereb Blood Flow Metab. 2012;32:1559-66 pubmed publisher
    ..These capillaries exhibited transport function and protein expression of P-glycoprotein (Abcb1), multidrug resistance protein 2 (Mrp2, Abcc2), and breast cancer-related protein (Bcrp, Abcg2)...
  40. Yu N, Zhang Y, Zhang K, Cheng Y, Ma H, Di Q. Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid. Neurochem Res. 2017;42:2167-2177 pubmed publisher
    ..Our results offer insights into the mechanism underlying the development of DRE using or not using CBZ treatment. ..
  41. Beghin D, Delongeas J, Claude N, Farinotti R, Forestier F, Gil S. Comparative effects of drugs on P-glycoprotein expression and activity using rat and human trophoblast models. Toxicol In Vitro. 2010;24:630-7 pubmed publisher
    ..Observation of this similar response between these two in vitro trophoblast models is promising for assessment between P-gp expression and activity of drugs towards placental function. ..
  42. Christiansen H, Batusic D, Saile B, Hermann R, Dudas J, Rave Frank M, et al. Identification of genes responsive to gamma radiation in rat hepatocytes and rat liver by cDNA array gene expression analysis. Radiat Res. 2006;165:318-25 pubmed
    ..Thus we identified genes that may be involved in liver steatosis after irradiation. The methods shown in this work should help to further clarify the consequences of radiation exposure in the liver. ..
  43. Zhang Z, Xu K, Bi Y, Yu G, Wang S, Qi X, et al. Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo. PLoS ONE. 2013;8:e70685 pubmed publisher
    ..These results indicate that LIUS could increase the toxicity sensitivity of glioma by down-regulating the expressions of P-gp and MRP1, which might be mediated by the PI3K/Akt/NF-?B pathway. ..
  44. Nakamura Y, Sato H, Motokura T. Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation. Int J Cancer. 2006;118:2448-54 pubmed
    ..Although ploidy status and Tp53 mutations did not correlate with MDR, we found that Abcb1/Mdr1, encoding P-glycoprotein (Pgp), was significantly upregulated after K-selection...
  45. Wang Y, Qin H, Zhang C, Huan F, Yan T, Zhang L. The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo. Molecules. 2015;21:E46 pubmed publisher
    ..In kidney, it only showed an upward trend. Abcb1b mRNA levels were increased in hippocampus, but decreased in cerebral cortex, liver and kidney...
  46. Koraichi F, Inoubli L, Lakhdari N, Meunier L, Vega A, Mauduit C, et al. Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis. Toxicology. 2013;310:29-38 pubmed publisher
    ..Dose-dependent and long term modulations of mRNA and protein levels of Abcb1, Abcc1, Abcg2, Abcc4 and Abcc5 were observed, along with Abcc4 protein cellular delocalization...
  47. Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, et al. Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. 2002;31:320-5 pubmed
    ..These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs...
  48. Assaraf M, Diaz Z, Liberman A, Miller W, Arvanitakis Z, Li Y, et al. Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. J Neuropathol Exp Neurol. 2007;66:389-98 pubmed
    ..We conclude that upregulation of EpoR in temporal cortical and hippocampal astrocytes is an early, potentially neuroprotective, event in the pathogenesis of sporadic AD. ..
  49. Parasrampuria R, Mehvar R. Divergent effects of nitric oxide donors on the biliary efflux transporters in isolated perfused rat livers: nitric oxide-independent inhibition of ABC transporters by sodium nitroprusside. Drug Metab Lett. 2011;5:64-72 pubmed
    ..The observed inhibitory effects of SNP on the functions of both P-gp and Mrp2 are via an NO-independent mechanism...
  50. Thews O, Gassner B, Kelleher D, Gekle M. Activity of drug efflux transporters in tumor cells under hypoxic conditions. Adv Exp Med Biol. 2008;614:157-64 pubmed publisher
    ..Instead, indirect effects of hypoxia leading to extracellular acidosis seem to have a much more pronounced effect on pGP activity. ..
  51. Pavek P, Staud F, Fendrich Z, Sklenarova H, Libra A, Novotna M, et al. Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. J Pharmacol Exp Ther. 2003;305:1239-50 pubmed
    ..Therefore, it seems plausible that pharmacokinetics of xenobiotics in the rat placental barrier could be controlled by P-gp in both directions. ..
  52. Al Shawi M, Polar M, Omote H, Figler R. Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein. J Biol Chem. 2003;278:52629-40 pubmed
    ..We used purified human Pgp (ABCB1, MDR1) expressed in Saccharomyces cerevisiae (Figler, R. A., Omote, H., Nakamoto, R. K., and Al-Shawi, M. K...
  53. Akashi T, Nishimura T, Takaki Y, Takahashi M, Shin B, Tomi M, et al. Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents. Reprod Toxicol. 2016;65:375-381 pubmed publisher
    The purpose of this study is to clarify the subcellular localizations of multidrug resistance protein 1 (MDR1)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 in the rodent placental SynT bilayer, i.e...