Abca2

Summary

Gene Symbol: Abca2
Description: ATP binding cassette subfamily A member 2
Alias: Abc2, ATP-binding cassette sub-family A member 2, ATP-binding cassette 2, ATP-binding cassette transporter 2, ATP-binding cassette, sub-family A (ABC1), member 2, ATP-binding cassette, subfamily A (ABC1), member 2
Species: rat
Products:     Abca2

Top Publications

  1. Broccardo C, Nieoullon V, Amin R, Masmejean F, Carta S, Tassi S, et al. ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain. J Neurochem. 2006;97:345-55 pubmed
    The notion that the ATP-binding cassette transporter-A2 (ABCA2) may be involved in brain sterol homeostasis and is associated with early onset Alzheimer's disease led us to explore its neural expression...
  2. Kaminski W, Piehler A, Püllmann K, Porsch Ozcurumez M, Duong C, Bared G, et al. Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun. 2001;281:249-58 pubmed
    ..Here we report the complete cDNA and the genomic organization of ABCA2, another member of the human ABC A transporter subfamily. The ABCA2 coding region is 7...
  3. Vulevic B, Chen Z, Boyd J, Davis W, Walsh E, Belinsky M, et al. Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2). Cancer Res. 2001;61:3339-47 pubmed
    We have isolated the full-length cDNA for human ATP-binding cassette, sub-family A, member 2 transporter (ABCA2). The ORF of this cDNA encodes a protein consisting of 2436 amino acids with apparent molecular weight of M(r) 270,000...
  4. Zhou C, Inagaki N, Pleasure S, Zhao L, Kikuyama S, Shioda S. ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination. J Comp Neurol. 2002;451:334-45 pubmed
    We examined developmental characteristics of the ATP-binding cassette transporter ABCA2 (or ABC2) -expressing cells in rat spinal cord and peripheral nerves...
  5. Tanaka Y, Yamada K, Zhou C, Ban N, Shioda S, Inagaki N. Temporal and spatial profiles of ABCA2-expressing oligodendrocytes in the developing rat brain. J Comp Neurol. 2003;455:353-67 pubmed
    b>ABCA2 protein belongs to the ABCA subclass of ATP-binding cassette (ABC) transporters proposed to exert critical functions in transmembrane transport of endogenous lipids...
  6. Davis W, Boyd J, Ile K, Tew K. Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. Biochim Biophys Acta. 2004;1683:89-100 pubmed
    We present evidence that the ATP binding-cassette transporter-2 (ABCA2) is a sterol-responsive gene that has a role in the trafficking of low-density lipoprotein-derived free cholesterol (LDL-FC)...
  7. Beljanski V, Soulika A, Tucker J, Townsend D, Davis W, Tew K. Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo. 2005;19:657-60 pubmed
    b>ABCA2 is a member of the ATP binding cassette transporter family with functional roles in cholesterol homeostasis and drug resistance.
  8. Michaki V, Guix F, Vennekens K, Munck S, Dingwall C, Davis J, et al. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-? production by altering Nicastrin maturation and intracellular localization. J Biol Chem. 2012;287:1100-11 pubmed publisher
    ..The ATP-binding cassette transporter-2 (Abca2), which plays a role in intracellular sterol trafficking, has been genetically linked to AD...
  9. Zhao L, Zhou C, Tanaka A, Nakata M, Hirabayashi T, Amachi T, et al. Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2. Biochem J. 2000;350 Pt 3:865-72 pubmed
    ..Here we report the cloning, molecular characterization and tissue distribution of ABC2/ABCA2, which belongs to the ABC1 subfamily. Rat ABC2 is a protein of 2434 amino acids that has 44.5%, 40.0% and 40...
  10. Davis W. The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism. Biochim Biophys Acta. 2014;1841:168-79 pubmed publisher
    ..The ABC "A" subfamily is comprised of 13 members and transport sterols, phospholipids and bile acids. ABCA2 is the most abundant ABC transporter in human and rodent brain with highest expression in oligodendrocytes, ..

Detail Information

Publications10

  1. Broccardo C, Nieoullon V, Amin R, Masmejean F, Carta S, Tassi S, et al. ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain. J Neurochem. 2006;97:345-55 pubmed
    The notion that the ATP-binding cassette transporter-A2 (ABCA2) may be involved in brain sterol homeostasis and is associated with early onset Alzheimer's disease led us to explore its neural expression...
  2. Kaminski W, Piehler A, Püllmann K, Porsch Ozcurumez M, Duong C, Bared G, et al. Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun. 2001;281:249-58 pubmed
    ..Here we report the complete cDNA and the genomic organization of ABCA2, another member of the human ABC A transporter subfamily. The ABCA2 coding region is 7...
  3. Vulevic B, Chen Z, Boyd J, Davis W, Walsh E, Belinsky M, et al. Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2). Cancer Res. 2001;61:3339-47 pubmed
    We have isolated the full-length cDNA for human ATP-binding cassette, sub-family A, member 2 transporter (ABCA2). The ORF of this cDNA encodes a protein consisting of 2436 amino acids with apparent molecular weight of M(r) 270,000...
  4. Zhou C, Inagaki N, Pleasure S, Zhao L, Kikuyama S, Shioda S. ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination. J Comp Neurol. 2002;451:334-45 pubmed
    We examined developmental characteristics of the ATP-binding cassette transporter ABCA2 (or ABC2) -expressing cells in rat spinal cord and peripheral nerves...
  5. Tanaka Y, Yamada K, Zhou C, Ban N, Shioda S, Inagaki N. Temporal and spatial profiles of ABCA2-expressing oligodendrocytes in the developing rat brain. J Comp Neurol. 2003;455:353-67 pubmed
    b>ABCA2 protein belongs to the ABCA subclass of ATP-binding cassette (ABC) transporters proposed to exert critical functions in transmembrane transport of endogenous lipids...
  6. Davis W, Boyd J, Ile K, Tew K. Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. Biochim Biophys Acta. 2004;1683:89-100 pubmed
    We present evidence that the ATP binding-cassette transporter-2 (ABCA2) is a sterol-responsive gene that has a role in the trafficking of low-density lipoprotein-derived free cholesterol (LDL-FC)...
  7. Beljanski V, Soulika A, Tucker J, Townsend D, Davis W, Tew K. Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo. 2005;19:657-60 pubmed
    b>ABCA2 is a member of the ATP binding cassette transporter family with functional roles in cholesterol homeostasis and drug resistance.
  8. Michaki V, Guix F, Vennekens K, Munck S, Dingwall C, Davis J, et al. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-? production by altering Nicastrin maturation and intracellular localization. J Biol Chem. 2012;287:1100-11 pubmed publisher
    ..The ATP-binding cassette transporter-2 (Abca2), which plays a role in intracellular sterol trafficking, has been genetically linked to AD...
  9. Zhao L, Zhou C, Tanaka A, Nakata M, Hirabayashi T, Amachi T, et al. Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2. Biochem J. 2000;350 Pt 3:865-72 pubmed
    ..Here we report the cloning, molecular characterization and tissue distribution of ABC2/ABCA2, which belongs to the ABC1 subfamily. Rat ABC2 is a protein of 2434 amino acids that has 44.5%, 40.0% and 40...
  10. Davis W. The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism. Biochim Biophys Acta. 2014;1841:168-79 pubmed publisher
    ..The ABC "A" subfamily is comprised of 13 members and transport sterols, phospholipids and bile acids. ABCA2 is the most abundant ABC transporter in human and rodent brain with highest expression in oligodendrocytes, ..