Abca1

Summary

Gene Symbol: Abca1
Description: ATP binding cassette subfamily A member 1
Alias: ATP-binding cassette sub-family A member 1, ATP-binding cassette, sub-family A (ABC1), member 1, ATP-binding cassette, subfamily A (ABC1), member 1
Species: rat
Products:     Abca1

Top Publications

  1. Lawn R, Wade D, Garvin M, Wang X, Schwartz K, Porter J, et al. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999;104:R25-31 pubmed
    ..Thus, ABC1 has the properties of a key protein in the cellular lipid removal pathway, as emphasized by the consequences of its defect in patients with Tangier disease...
  2. Brooks Wilson A, Marcil M, Clee S, Zhang L, Roomp K, van Dam M, et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet. 1999;22:336-45 pubmed
    ..This indicates that the protein encoded by ABC1 is a key gatekeeper influencing intracellular cholesterol transport, hence we have named it cholesterol efflux regulatory protein (CERP)...
  3. Wang N, Lan D, Chen W, Matsuura F, Tall A. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A. 2004;101:9774-9 pubmed
    ..The ATP-binding cassette transporter A1 (ABCA1) mediates efflux of cellular cholesterol to lipid-poor apolipoproteins but not to HDL particles that constitute ..
  4. Zeng L, Liao H, Liu Y, Lee T, Zhu M, Wang X, et al. Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J Biol Chem. 2004;279:48801-7 pubmed
    ATP-binding cassette transporter A1 (ABCA1) is a pivotal regulator of cholesterol efflux from cells to apolipoproteins, whereas sterol-responsive element-binding protein 2 (SREBP2) is the key protein regulating cholesterol synthesis and ..
  5. Wu Q, Sucheta S, Azhar S, Menon K. Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol tra. Endocrinology. 2003;144:2437-45 pubmed
    ..cells, HDL-stimulated efflux of cholesterol has been shown to be mediated by the ATP-binding cassette A1 (ABCA1) transporter. Its expression has not been documented in steroidogenic cells...
  6. Villarreal Molina M, Aguilar Salinas C, Rodriguez Cruz M, Riaño D, Villalobos Comparan M, Coral Vazquez R, et al. The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities. Diabetes. 2007;56:1881-7 pubmed
    Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it is expressed in various tissues, where it may have different functions...
  7. Liu M, Chung S, Shelness G, Parks J. Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:1035-1043 pubmed publisher
    ATP binding cassette transporter A1 (ABCA1) is a membrane transporter that facilitates nascent HDL formation...
  8. Machado J, Iborra R, Fusco F, Castilho G, Pinto R, Machado Lima A, et al. N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1. Atherosclerosis. 2014;237:343-52 pubmed publisher
    ..NAC may contribute to attenuate the deleterious effects of CKD-albumin on lipid accumulation in macrophages helping to prevent atherogenesis in CKD. ..
  9. Iborra R, Machado Lima A, Castilho G, Nunes V, Abdalla D, Nakandakare E, et al. Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. Lipids Health Dis. 2011;10:172 pubmed publisher

More Information

Publications62

  1. Bared S, Buechler C, Boettcher A, Dayoub R, Sigruener A, Grandl M, et al. Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Mol Biol Cell. 2004;15:5399-407 pubmed
    The ATP-binding cassette transporter A1 (ABCA1) facilitates the cellular release of cholesterol and choline-phospholipids to apolipoprotein A-I (apoA-I) and several studies indicate that vesicular transport is associated with ABCA1 ..
  2. Francone O, Subbaiah P, Van Tol A, Royer L, Haghpassand M. Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry. 2003;42:8569-78 pubmed
    Recent studies have demonstrated that the ATP-binding cassette transporter A1 (ABCA1) facilitates the efflux of phospholipids and cholesterol to apoprotein acceptors, leading to the synthesis of HDL...
  3. Maric J, Kiss R, Franklin V, Marcel Y. Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem. 2005;280:39942-9 pubmed
    Hepatocytes, which are the main site of apolipoprotein (apo)A-I and ATP-binding cassette transporter A1 (ABCA1) expression, are also the main source of circulating high density lipoprotein...
  4. Chao W, Tsai S, Lin Y, Lin W, Yang V. Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation. Biochem Biophys Res Commun. 2005;332:743-9 pubmed
    The goal of this study was to investigate the cellular localization and the interaction between caveolin-1 and ABCA1 in cholesterol-loaded aortic endothelial cells after HDL incubation...
  5. Boone L, Lagor W, Moya M, Niesen M, Rothblat G, Ness G. Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter. Atherosclerosis. 2011;218:77-82 pubmed publisher
    ..The goal of this study was to examine the effects of thyroid hormone status on the ability of serum to accept cellular cholesterol...
  6. Clee S, Kastelein J, van Dam M, Marcil M, Roomp K, Zwarts K, et al. Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes. J Clin Invest. 2000;106:1263-70 pubmed
    We and others have recently identified mutations in the ABCA1 gene as the underlying cause of Tangier disease (TD) and of a dominantly inherited form of familial hypoalphalipoproteinemia (FHA) associated with reduced cholesterol efflux...
  7. Fu Y, Mukhamedova N, Ip S, D Souza W, Henley K, DiTommaso T, et al. ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 2013;18:225-38 pubmed publisher
    ..Abca12 deficiency caused a reduction in the abundance of Abca1, Abcg1, and Lxr?. Overexpression of Lxr? reversed the effects...
  8. Wein S, Fauroux M, Laffitte J, de Nadai P, Guaïni C, Pons F, et al. Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa. Biochem Pharmacol. 2004;67:1195-202 pubmed
    ..Taken together, our results show that annexin 1 secretion appears to share the efflux properties of ABC-transporter substrates...
  9. Neufeld E, Stonik J, Demosky S, Knapper C, Combs C, Cooney A, et al. The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J Biol Chem. 2004;279:15571-8 pubmed
    We have previously established that the ABCA1 transporter, which plays a critical role in the lipidation of extracellular apolipoprotein acceptors, traffics between late endocytic vesicles and the cell surface (Neufeld, E. B., Remaley, A...
  10. Lv Y, Tang Y, Peng J, Zhao G, Yang J, Yao F, et al. MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. Atherosclerosis. 2014;236:215-26 pubmed publisher
    ..Here, we have identified miR-19b binding to the 3'UTR of ATP-binding cassette transporter A1 (ABCA1) transporters, and further determined the potential roles of this novel interaction in atherogenesis...
  11. Hirsch Reinshagen V, Zhou S, Burgess B, Bernier L, McIsaac S, Chan J, et al. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem. 2004;279:41197-207 pubmed
    b>ABCA1 is a cholesterol transporter that is widely expressed throughout the body...
  12. Cho K, Kim H, Kamanna V, Vaziri N. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010;1800:6-15 pubmed publisher
    ..Present study sought to determine efficacy of niacin supplementation on renal tissue lipid metabolism in CRF...
  13. Xue X, Shi F, Chen T, Wei W, Zhou X, Chen L. Inhibition of ERK1/2 improves lipid balance in rat macrophages via ABCA1/G1 and CD36. Mol Med Rep. 2016;13:1533-40 pubmed publisher
    ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1), and macrophage scavenger receptor, cluster of differentiation (CD)36, function as key mediators of cholesterol efflux and influx from macrophages...
  14. Bates S, Tao J, Yu K, Borok Z, Crandall E, Collins H, et al. Expression and biological activity of ABCA1 in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2008;38:283-92 pubmed
    ..The processes may involve the ATP-binding cassette transporter A1 (ABCA1), a transport protein shown to be crucial in apolipoprotein A-I (apoA-I)-mediated mobilization of cellular ..
  15. Ghanbari Niaki A, Khabazian B, Hossaini Kakhak S, Rahbarizadeh F, Hedayati M. Treadmill exercise enhances ABCA1 expression in rat liver. Biochem Biophys Res Commun. 2007;361:841-6 pubmed
    ..b>ABCA1 is a member of this family which plays a crucial role in plasma HDL-C remodeling...
  16. Vedhachalam C, Narayanaswami V, Neto N, Forte T, Phillips M, Lund Katz S, et al. The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry. 2007;46:2583-93 pubmed
    ..of human apoE that mediate cellular cholesterol efflux and HDL assembly via ATP-binding cassette transporter A1 (ABCA1)...
  17. Hamon Y, Broccardo C, Chambenoit O, Luciani M, Toti F, Chaslin S, et al. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol. 2000;2:399-406 pubmed
    ..Transient local exposure of anionic phospholipids in the outer membrane leaflet may be sufficient to alter the general properties of the membrane and thus influence discrete physiological functions...
  18. Quazi F, Molday R. Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants. J Biol Chem. 2013;288:34414-26 pubmed publisher
    b>ABCA1, ABCA7, and ABCA4 are members of the ABCA subfamily of ATP-binding cassette transporters that share extensive sequence and structural similarity...
  19. Chen J, Gao J, Yang J, Zhang Y, Wang L. Effect of triptolide on the regulation of ATP‑binding cassette transporter A1 expression in lipopolysaccharide‑induced acute lung injury of rats. Mol Med Rep. 2014;10:3015-20 pubmed publisher
    The aim of this study was to investigate the effect of triptolide on ATP‑binding cassette transporter A1 (ABCA1) expression in lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in rats...
  20. Kamtchueng Simo O, Ikhlef S, Berrougui H, Khalil A. Advanced glycation end products affect cholesterol homeostasis by impairing ABCA1 expression on macrophages. Can J Physiol Pharmacol. 2017;95:977-984 pubmed publisher
    ..5% increase, P < 0.003) and reduced ABCA1 protein expression and the capacity of macrophages to liberate cholesterol (69.1% decrease, P < 0.0001)...
  21. Maitra U, Parks J, Li L. An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol. 2009;29:5989-97 pubmed publisher
    ATP-binding cassette transporter A1 (ABCA1) plays a central role in promoting cholesterol efflux from macrophages, thereby reducing the risk of foam cell formation and atherosclerosis...
  22. Singaraja R, Bocher V, James E, Clee S, Zhang L, Leavitt B, et al. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1. J Biol Chem. 2001;276:33969-79 pubmed
    By using BAC transgenic mice, we have shown that increased human ABCA1 protein expression results in a significant increase in cholesterol efflux in different tissues and marked elevation in high density lipoprotein (HDL)-cholesterol ..
  23. Wang M, Kiss R, Franklin V, McBride H, Whitman S, Marcel Y. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res. 2007;48:633-45 pubmed
    ..b>ABCA1-mediated cholesterol efflux to apolipoprotein A-I (apoA-I) was much greater for AcLDL-loaded macrophages compared ..
  24. Sporstøl M, Mousavi S, Eskild W, Roos N, Berg T. ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. BMC Mol Biol. 2007;8:5 pubmed
    Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport...
  25. Guo L, Hu W, Lian J, Ji W, Deng T, Qian M, et al. Anti-hyperlipidemic properties of CM108 (a flavone derivative) in vitro and in vivo. Eur J Pharmacol. 2006;551:80-6 pubmed
    ..in the formation and function of HDL, such as apolipoprotein (apo) A-I and ATP binding cassette transporter A1 (ABCA1)...
  26. Katzov H, Chalmers K, Palmgren J, Andreasen N, Johansson B, Cairns N, et al. Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism. Hum Mutat. 2004;23:358-67 pubmed
    ..The gene encoding the ATP-binding cassette A1 transporter (ABCA1) resides within proximity of previously identified linkage peaks and represents a plausible biological candidate ..
  27. McNeish J, Aiello R, Guyot D, Turi T, Gabel C, Aldinger C, et al. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc Natl Acad Sci U S A. 2000;97:4245-50 pubmed
  28. Guan J, Tamasawa N, Murakami H, Matsui J, Yamato K, Suda T. Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. Tohoku J Exp Med. 2003;201:251-9 pubmed
    ..The levels of mRNAs for liver X receptor alpha (LXRalpha), ATP-binding cassette A1 (ABCA1), PPARalpha and cholesterol 7alpha-hydroxylase (CYP7A) in the liver were analyzed by northern blotting...
  29. Lin Y, Lin C, Kuo C, Yang V. ABCA1 modulates the oligomerization and Golgi exit of caveolin-1 during HDL-mediated cholesterol efflux in aortic endothelial cells. Biochem Biophys Res Commun. 2009;382:189-95 pubmed publisher
    ..the authors have shown that the molecular interaction between caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) is associated with the high-density lipoprotein (HDL)-mediated cholesterol efflux pathway in aortic endothelial ..
  30. Ohashi R, Mu H, Wang X, Yao Q, Chen C. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. QJM. 2005;98:845-56 pubmed
    ..is removed from macrophages in the subintima of the vessel wall by ATP-binding membrane cassette transporter A1 (ABCA1) or by other mechanisms, including passive diffusion, scavenger receptor B1 (SR-B1), caveolins and sterol 27-..
  31. Tian M, Zhang X, Wang L, Li Y. Curcumin induces ABCA1 expression and apolipoprotein A-I-mediated cholesterol transmembrane in the chronic cerebral hypoperfusion aging rats. Am J Chin Med. 2013;41:1027-42 pubmed publisher
    ..The pathway of the liver X receptor-? (LXR-?)/retinoic X receptor-? (RXR-?)/ABCA1 plays a vital role in lipoprotein metabolism. Curcumin, a kind of phenolic compound, has been widely used...
  32. Hoekstra M, Out R, Kruijt J, Van Eck M, Van Berkel T. Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells. J Hepatol. 2005;42:400-7 pubmed
    ..Kupffer cells, however, showed a highly adaptive response with a 2- to 9-fold induction of SR-BI, ABCA1, and ABCG5/G8, and an 82-fold induction in CYP7A1 mRNA expression, respectively...
  33. Chen W, Sun Y, Welch C, Gorelik A, Leventhal A, Tabas I, et al. Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes. J Biol Chem. 2001;276:43564-9 pubmed
    Recently, ATP-binding cassette transporter A1 (ABCA1), the defective molecule in Tangier disease, has been shown to stimulate phospholipid and cholesterol efflux to apolipoprotein A-I (apoA-I); however, little is known concerning the ..
  34. Nonomura K, Arai Y, Mitani H, Abe Dohmae S, Yokoyama S. Insulin down-regulates specific activity of ATP-binding cassette transporter A1 for high density lipoprotein biogenesis through its specific phosphorylation. Atherosclerosis. 2011;216:334-41 pubmed publisher
    ..direct effects of insulin on HDL biosynthesis focusing on the activity of ATP-binding cassette transporter A1 (ABCA1) in culture cells and in experimental animals...
  35. Johnson A, Yabu J, Hanson S, Shah V, Zager R. Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expression. Am J Pathol. 2003;162:283-91 pubmed
    ..SR-B1 (a CE influx protein), ABCA1 (a FC exporter), and HMG CoA reductase protein/mRNA levels were also assessed...
  36. Bortnick A, Favari E, Tao J, Francone O, Reilly M, Zhang Y, et al. Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2003;285:L869-78 pubmed
    ATP-binding cassette transporter A1 (ABCA1) promotes transfer of cholesterol and phospholipid from cells to lipid-free serum apolipoproteins...
  37. Nofer J, Herminghaus G, Brodde M, Morgenstern E, Rust S, Engel T, et al. Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). J Biol Chem. 2004;279:34032-7 pubmed
    ATP binding cassette transporter A1 (ABCA1) is involved in regulation of intracellular lipid trafficking and export of cholesterol from cells to high density lipoproteins...
  38. Lin S, Zhou C, Neufeld E, Wang Y, Xu S, Lu L, et al. BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ATP-binding cassette transporter A-1 trafficking and function. Arterioscler Thromb Vasc Biol. 2013;33:e31-8 pubmed publisher
    ..localization and intracellular trafficking are essential for the function of ATP-binding cassette transporter A-1 (ABCA1). However, regulation of these activities is still largely unknown...
  39. Yan P, Li S, Duang C, Mei Z, Tan X, Si T, et al. [Mechanisms of foam cell formation in smooth muscle cell derived from bone marrow stem cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1250-2 pubmed
    ..To establish a model of smooth muscle cells differentiated from bone mesenchymal stem cells (BMSC-SMCs) in vitro and explore the relationship between scavenger receptors A (SR-A) and caveolin-1...
  40. Li J, Murao K, Imachi H, Masugata H, Iwama H, Tada S, et al. Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway. J Cell Mol Med. 2010;14:1083-7 pubmed publisher
    ATP-binding cassette transporter A1 (ABCA1) in pancreatic beta cells influences insulin secretion and glucose homeostasis...
  41. Villarreal Molina M, Flores Dorantes M, Arellano Campos O, Villalobos Comparan M, Rodriguez Cruz M, Miliar Garcia A, et al. Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Diabetes. 2008;57:509-13 pubmed
    The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos...
  42. Hirayama T, Honda A, Matsuzaki Y, Miyazaki T, Ikegami T, Doy M, et al. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hepatology. 2006;44:602-11 pubmed
    ..Protein and mRNA expression of the ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1) was markedly higher in tumors than in livers...
  43. Nishiuchi Y, Murao K, Imachi H, Nishiuchi T, Iwama H, Ishida T. Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate. Atherosclerosis. 2010;212:418-25 pubmed publisher
    ..However, the role of PREB in SMCs is not clearly understood. The ATP-binding cassette transporter A1 (ABCA1) regulates lipid efflux from peripheral cells to apolipoproteins...
  44. Chung S, Gebre A, Seo J, Shelness G, Parks J. A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion. J Lipid Res. 2010;51:729-42 pubmed publisher
    In Tangier disease, absence of ATP binding cassette transporter A1 (ABCA1) results in reduced plasma HDL and elevated triglyceride (TG) levels...
  45. Szakacs G, Langmann T, Ozvegy C, Orso E, Schmitz G, Varadi A, et al. Characterization of the ATPase cycle of human ABCA1: implications for its function as a regulator rather than an active transporter. Biochem Biophys Res Commun. 2001;288:1258-64 pubmed
    b>ABCA1 plays a key role in cellular cholesterol and phospholipid traffic. To explore the biochemical properties of this membrane protein we applied a Baculovirus-insect cell expression system...
  46. Fitzgerald M, Morris A, Rhee J, Andersson L, Mendez A, Freeman M. Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem. 2002;277:33178-87 pubmed
    The ABCA1 transporter contains two large domains into which many of the genetic mutations in individuals with Tangier disease fall...
  47. Choi H, Rahmani M, Wong B, Allahverdian S, McManus B, Pickering J, et al. ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells. Circulation. 2009;119:3223-31 pubmed publisher
    ..The purpose of this study was to examine the expression and activity of ATP-binding cassette transporter A1 (ABCA1) in model intimal and medial arterial SMCs, in human atherosclerotic coronary artery intimal and medial layers, ..
  48. Shichiri M, Takanezawa Y, Rotzoll D, Yoshida Y, Kokubu T, Ueda K, et al. ATP-binding cassette transporter A1 is involved in hepatic alpha-tocopherol secretion. J Nutr Biochem. 2010;21:451-6 pubmed publisher
    ..First, addition of apolipoprotein A-I (apoA-I), a direct acceptor of the ATP-binding cassette transporter A1 (ABCA1)-secreted lipids, increased alpha-tocopherol secretion in a dose-dependent manner...
  49. Lee T, Lin C, Tsai J, Wu Y, Su K, Lu K, et al. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci. 2009;84:97-104 pubmed publisher
    ..SR-A and CD36), while the cholesterol efflux is regulated by SR-BI, ATP-binding cassette transporter-A1 (ABCA1) and ABCG1...
  50. Wang X, Collins H, Ranalletta M, Fuki I, Billheimer J, Rothblat G, et al. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest. 2007;117:2216-24 pubmed
    Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular acceptors in vitro and influence atherosclerosis in mice, but ..
  51. Linsel Nitschke P, Jehle A, Shan J, Cao G, Bacic D, Lan D, et al. Potential role of ABCA7 in cellular lipid efflux to apoA-I. J Lipid Res. 2005;46:86-92 pubmed
    ABCA7 is homologous to ABCA1 and has recently been shown in cell culture to bind apolipoprotein A-I (apoA-I) and to promote the efflux of phospholipids. However, it is not known if ABCA7 promotes lipid efflux in vivo...
  52. Li X, Ji L, Li Y, Zhang Y. [The effect of soy isoflavones on ATP binding cassette A1 expression level in rats without ovaries with atherosclerotic plaque]. Zhonghua Yu Fang Yi Xue Za Zhi. 2009;43:895-9 pubmed
    To study the effect of soy isoflavones (SI) on ATP binding cassette A1 (ABCA1) expression in rats without ovary with atherosclerosis.
  53. Morizawa Y, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, et al. Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nat Commun. 2017;8:28 pubmed publisher
    ..Phagocytic astrocytes upregulate ABCA1 and its pathway molecules, MEGF10 and GULP1, which are required for phagocytosis, and upregulation of ABCA1 alone ..