Gene Symbol: TGFB1
Description: transforming growth factor beta-1
Alias: transforming growth factor beta-1
Species: rabbit
Products:     TGFB1

Top Publications

  1. Gonzalez C, Auw Yang K, Schwab J, Fitzsimmons J, Reinholz M, Resch Z, et al. Transforming growth factor-beta1 modulates insulin-like growth factor binding protein-4 expression and proteolysis in cultured periosteal explants. Growth Horm IGF Res. 2010;20:81-6 pubmed publisher
    ..This study demonstrates that TGF-beta1 modulates the expression of IGFBP-4 and PAPP-A in cultured periosteal explants. ..
  2. Wang Y, Huang X, Tang Y, Lin H, Zhou N. Effects of panax notoginseng saponins on the osteogenic differentiation of rabbit bone mesenchymal stem cells through TGF-?1 signaling pathway. BMC Complement Altern Med. 2016;16:319 pubmed publisher
    ..05). It was shown that silencing TGF-?1 gene could interrupt the osteogenic effects of PNS. PNS may have a promoting effect on osteogenic differentiation of rabbits' BMSCs in vitro by up-regulating the gene expression of TGF-?1. ..
  3. Zhang F, Dang Y, Li Y, Hao Q, Li R, Qi X. Cardiac Contractility Modulation Attenuate Myocardial Fibrosis by Inhibiting TGF-?1/Smad3 Signaling Pathway in a Rabbit Model of Chronic Heart Failure. Cell Physiol Biochem. 2016;39:294-302 pubmed publisher
    ..CCM therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-?1/Smad3 signaling pathway in CHF rabbits. ..
  4. Friedberg M, Cho M, Li J, Assad R, Sun M, Rohailla S, et al. Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased transforming growth factor-?1 signaling and is abrogated by angiotensin receptor blockade. Am J Respir Cell Mol Biol. 2013;49:1019-28 pubmed publisher
    ..Adverse ventricular-ventricular interactions induced by isolated RV afterload appear to be mediated through TGF-?1-CTGF and ET-1 pathways. ..
  5. Morigele M, Shao Z, Zhang Z, Kaige M, Zhang Y, Qiang W, et al. TGF-?1 induces a nucleus pulposus-like phenotype in Notch 1 knockdown rabbit bone marrow mesenchymal stem cells. Cell Biol Int. 2013;37:820-5 pubmed publisher
    ..01), and higher levels of collagen II mRNA and protein than control cells (P < 0.001). Thus knockdown of Notch1 expression in MSCs may be useful in the treatment of intervertebral disc degeneration. ..
  6. Abramov Y, Hirsch E, Ilievski V, Goldberg R, Botros S, Sand P. Transforming growth factor ? 1 gene expression during vaginal vs cutaneous surgical woundexpression during vaginal vs cutaneous surgical wound healing in the rabbit. Int Urogynecol J. 2013;24:671-5 pubmed publisher
    ..b>Transforming growth factor beta 1 (TGF-?1) is a principal mediator of wound repair in dermal tissue...
  7. Koplin S, Su L, Salamat S, Torrealba J, McCarthy J, MITCHELL J, et al. Distraction osteogenesis-induced muscle fibrosis may not be associated with TGF-?1. J Pediatr Orthop. 2011;31:413-20 pubmed publisher
    ..We conclude that TGF-?1 may not be the primary mediator of muscle fibrosis in distraction osteogenesis. Injection of suramin may not prevent contracture formation after distraction osteogenesis. ..
  8. Swanson E, Ohno T, Abdollahian D, Garrett C, Rousseau B. Effects of raised-intensity phonation on inflammatory mediator gene expression in normal rabbit vocal fold. Otolaryngol Head Neck Surg. 2010;143:567-72 pubmed publisher
    ..The long-term goal of these studies is to advance understanding of the molecular and cellular events underlying phonation-related tissue alterations...
  9. Abramov Y, Hirsch E, Ilievski V, Goldberg R, Sand P. Transforming growth factor beta1 gene expression during vaginal wound healing in a rabbit menopause model. BJOG. 2013;120:251-256 pubmed publisher
    ..Oophorectomised rabbits show protracted incisional vaginal wound healing associated with increased TGF?1 gene transcription. ..

More Information


  1. Zhang Y, Qiu L, Li M. [Effects of radix astragali on expression of transforming growth factor ? 1 and Smad 3 signal pathway in hypertrophic scar of rabbit]. Zhonghua Shao Shang Za Zhi. 2010;26:366-70 pubmed
    ..Its inhibition effect is drug concentration and duration dependent. The drug may be considered as a potential agent to prevent hypertrophic scar. ..
  2. Kwon Y, Lee J, Moon E, Chung Y, Kim O, Kim H. Anabolic effects of Peniel 2000, a peptide that regulates TGF-?1 signaling on intervertebral disc degeneration. Spine (Phila Pa 1976). 2013;38:E49-58 pubmed publisher
    ..01). A novel peptide, P2K, regulating TGF-?1 signaling had an anabolic effect on bovine IVD cells and rabbit degenerated discs. The results suggest that P2K has considerable potential as a treatment of degenerative disc disease...
  3. Liu K, Fan X, Zhang L, Wen Q, Feng J, Chen F, et al. Effects of recombinant human interleukin-10 on Treg cells, IL-10 and TGF-? in transplantation of rabbit skin. Mol Med Rep. 2014;9:639-44 pubmed publisher
    ..Thus, the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-?. ..
  4. Tsai T, Sun M, Ho T, Ma H, Liu M, Tsao Y. Notch prevents transforming growth factor-beta-assisted epithelial-mesenchymal transition in cultured limbal progenitor cells through the induction of Smad7. Mol Vis. 2014;20:522-34 pubmed
  5. Vuckovic A, Herber Jonat S, Flemmer A, Ruehl I, Votino C, Segers V, et al. Increased TGF-β: a drawback of tracheal occlusion in human and experimental congenital diaphragmatic hernia?. Am J Physiol Lung Cell Mol Physiol. 2016;310:L311-27 pubmed publisher
    ..Whether this might influence postnatal development of sustainably ventilated lungs remains to be determined. ..
  6. Salma U, Xue M, Ali Sheikh M, Guan X, Xu B, Zhang A, et al. Role of Transforming Growth Factor-?1 and Smads Signaling Pathway in Intrauterine Adhesion. Mediators Inflamm. 2016;2016:4158287 pubmed publisher
    ..05). Our study suggested that TGF-?1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA. ..
  7. Kapur N, Bian C, Lin E, Deming C, Sperry J, Hansen B, et al. Inhibition of transforming growth factor-? restores endothelial thromboresistance in vein grafts. J Vasc Surg. 2011;54:1117-1123.e1 pubmed publisher
    ..Systemic administration of an anti-TGF-? antibody effectively prevented TM downregulation and preserved local thromboresistance without negative effect on VG remodeling. ..
  8. Zeng W, Chen W, Leng X, He J, Ma H. [Angiotensin-(1-7) reduced postangioplasty vascular fibrosis in abdominal aorta of rabbits]. Zhonghua Xin Xue Guan Bing Za Zhi. 2010;38:531-8 pubmed
    ..ANG-(1-7) attenuates postangioplasty collagen synthesis in rabbits possibly through down-regulating the expression of TGF-beta1 and inhibiting the activation of Smad2 pathway. ..
  9. Yin F, Cai J, Zen W, Wei Y, Zhou W, Yuan F, et al. Cartilage Regeneration of Adipose-Derived Stem Cells in the TGF-β1-Immobilized PLGA-Gelatin Scaffold. Stem Cell Rev. 2015;11:453-9 pubmed publisher
  10. Yang H, Cao C, Wu C, Yuan C, Gu Q, Shi Q, et al. TGF-βl Suppresses Inflammation in Cell Therapy for Intervertebral Disc Degeneration. Sci Rep. 2015;5:13254 pubmed publisher
  11. Chen D, Zhang Z, Cao J, Zhang D, Jia B. [Effect of glucosamine hydrochloride capsules on articular cartilage of rabbit knee joint in osteoarthritis]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010;24:287-91 pubmed pathologic changes with HE staining and graded by Mankin's scale, the expression level of transforming growth factor beta 1 (TGF-beta 1) and interleukin 1 beta (IL-1 beta) were detected by immunohistochemical staining...
  12. Jiang Z, Tao M, Omalley K, Wang D, Ozaki C, Berceli S. Established neointimal hyperplasia in vein grafts expands via TGF-beta-mediated progressive fibrosis. Am J Physiol Heart Circ Physiol. 2009;297:H1200-7 pubmed publisher
    ..The modulation of late TGF-beta/CTGF signaling may offer a novel therapeutic strategy to improve the long-term VG durability...