Gene Symbol: PPARG
Description: peroxisome proliferator activated receptor gamma
Alias: NR1C3, peroxisome proliferator-activated receptor gamma, PPAR gamma 1, PPAR gamma 3, PPAR-gamma, nuclear receptor subfamily 1 group C member 3, peroxisome proliferator activated receptor gamma-1
Michael L, Lazar M, Mendelson C. Peroxisome proliferator-activated receptor gamma1 expression is induced during cyclic adenosine monophosphate-stimulated differentiation of alveolar type II pneumonocytes. Endocrinology. 1997;138:3695-703 pubmed
..In view of the role of PPARgamma in adipocyte differentiation and lipid homeostasis, we postulate that PPARgamma1 induction by cAMP plays a role in the differentiation and expression of lipogenic enzymes in lung type II cells. ..
Guan Y, Zhang Y, Davis L, Breyer M. Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans. Am J Physiol. 1997;273:F1013-22 pubmed
..acid (8-S-HETE), leukotriene B4 (LTB4), and hypolipidemic fibrates activate PPAR alpha, whereas PPAR gamma is activated by prostaglandin metabolites...
Yang J, Zhao S, Li J, Dong S. Effect of niacin on adipocyte leptin in hypercholesterolemic rabbits. Cardiovasc Pathol. 2008;17:219-25 pubmed publisher
..69 and r=-.63, respectively, P<.01). Niacin can reduce serum level and adipose mRNA expression of leptin and up-regulate PPARgamma and CD36 mRNA expression in hypercholesterolemic rabbits. ..
Yasuda S, Kobayashi H, Iwasa M, Kawamura I, Sumi S, Narentuoya B, et al
. Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2009;296:H1558-65 pubmed publisher
..Pioglitazone may be a novel strategy for the treatment of diabetes mellitus with coronary artery disease...
Yang P, Li Y, Li J, Qin L, LI X. Up-regulating PPAR-? expression and NO concentration, and down-regulating PAI-1 concentration in a rabbit atherosclerotic model: the possible antiatherogenic and antithrombotic effects of atorvastatin. Int J Cardiol. 2010;139:213-7 pubmed publisher
Zeng X, Li X, Wen H. Telmisartan protects against microvascular dysfunction during myocardial ischemia/reperfusion injury by activation of peroxisome proliferator-activated receptor ?. BMC Cardiovasc Disord. 2013;13:39 pubmed publisher
..myocardial ischemia/reperfusion (I/R) injury by activating the peroxisome proliferator-activated receptor gamma (PPARG) pathway...
Li J, Li Y, Wang Y, Liu M, Zhao G. Preventive effects of siRNA targeting PPAR? gene on steroid-induced osteonecrosis in rabbits. Connect Tissue Res. 2014;55:322-30 pubmed publisher
..The inhibition of bone-marrow adipogenesis and concomitant enhancement of osteogenesis with RNAi may provide a novel approach to the prevention of steroid-induced osteonecrosis. ..
Cao H, Qin L, Huang K. [Effects of Tongxinluo on MMP-3, 9 and PPARgamma expressions in atherosclerotic rabbits]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:1887-9 pubmed
..01). Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma, which might be the mechanism of its anti-atherosclerotic effect. ..
Zerani M, Maranesi M, Brecchia G, Gobbetti A, Boiti C, Parillo F. Evidence for a luteotropic role of peroxisome proliferator-activated receptor gamma: expression and in vitro effects on enzymatic and hormonal activities in corpora lutea of pseudopregnant rabbits. Biol Reprod. 2013;88:62 pubmed publisher
..These results indicate that PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 down-regulation and 3beta-HSD up-regulation, with a consequent PGF2alpha decrease and progesterone increase...