Gene Symbol: NOS3
Description: nitric oxide synthase 3
Alias: eNOS, nitric oxide synthase, endothelial, endothelial nitric oxide synthase NOS3, nitric oxide synthase 3 (endothelial cell)
Shi Y, Pritchard K, Holman P, Rafiee P, Griffith O, Kalyanaraman B, et al
. Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. Free Radic Biol Med. 2000;29:695-703 pubmed
..Ribonuclease protection assays revealed that chronic hypoxia did not alter NOS transcript levels for NOS1, NOS2, or NOS3. The most abundant transcript was NOS3. Western analysis revealed NOS3 was the only isoform detected...
Wan L, Xia J, Ye D, Liu J, Chen J, Wang G. Effects of quercetin on gene and protein expression of NOX and NOS after myocardial ischemia and reperfusion in rabbit. Cardiovasc Ther. 2009;27:28-33 pubmed publisher
Previous studies have suggested that reactive oxygen species (ROS), endothelial nitric oxide synthase (eNOS), and inducible nitric oxide synthase (iNOS) are involved in the pathophysiology of myocardial ischemia-reperfusion injury (MIRI)...
Yasuda S, Kobayashi H, Iwasa M, Kawamura I, Sumi S, Narentuoya B, et al
. Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2009;296:H1558-65 pubmed publisher
..Western blotting was performed to assess levels of Akt and phospho-Akt and phospho-endothelial NOS (eNOS) in the myocardium following reperfusion...
Marrachelli V, Miranda F, Centeno J, Salom J, Torregrosa G, Jover Mengual T, et al
. Role of NO-synthases and cyclooxygenases in the hyperreactivity of male rabbit carotid artery to testosterone under experimental diabetes. Pharmacol Res. 2010;61:62-70 pubmed publisher
..In arteries from diabetic rabbits, eNOS, iNOS and COX-2 expression and testosterone induced release of prostacyclin resulted enhanced in comparison with ..
Sedoris K, Gozal E, Ovechkin A, Theile A, Roberts A. Interplay of endothelial and inducible nitric oxide synthases modulates the vascular response to ischaemia-reperfusion in the rabbit lung. Acta Physiol (Oxf). 2012;204:331-43 pubmed publisher
Vladic N, Ge Z, Leucker T, Brzezinska A, Du J, Shi Y, et al
. Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2011;301:H2130-9 pubmed publisher
..6 ± 0.2 to 10.2 ± 0.3 pmol/mg protein, respectively), Hsp90-endothelial nitric oxide synthase (eNOS) association (coimmunoprecipitation and Western blotting in mice; 4.0 ± 0.3 to 5.4 ± 0...
Khan H, Kusakabe K, Wakitani S, Hiyama M, Takeshita A, Kiso Y. Expression and localization of NO synthase isoenzymes (iNOS and eNOS) in development of the rabbit placenta. J Reprod Dev. 2012;58:231-6 pubmed
..Here, we attempted to clarify the expression and localization of inducible and endothelial NOS (iNOS and eNOS) in the developing rabbit placenta...
Nieminen T, Toivanen P, Laakkonen J, Heikura T, Kaikkonen M, Airenne K, et al
. Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity. Cardiovasc Res. 2015;107:267-76 pubmed publisher
..VEGFR2 activation was not affected by Slit2, but eNOS phosphorylation was diminished...
Figueroa H, Cifuentes J, Lozano M, Alvarado C, Cabezas C, Eixarch E, et al
. Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction. Prenat Diagn. 2016;36:628-35 pubmed publisher
..We describe significant deregulation of vascular activity and oxidative damage in kidneys of fetal rabbits that have been exposed to restriction of the uterine circulation. © 2016 John Wiley & Sons, Ltd. ..