Gene Symbol: MMP3
Description: matrix metallopeptidase 3
Alias: stromelysin-1, MMP-3, SL-1, matrix metallopeptidase 3 (stromelysin 1, progelatinase), matrix metalloproteinase 3, transin-1
Fini M, Karmilowicz M, Ruby P, Beeman A, Borges K, Brinckerhoff C. Cloning of a complementary DNA for rabbit proactivator. A metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase. Arthritis Rheum. 1987;30:1254-64 pubmed
..Our data suggest the existence of coordinately regulated metalloproteinases that are important in the modulation of connective tissue metabolism. ..
Whitham S, Murphy G, Angel P, Rahmsdorf H, Smith B, Lyons A, et al
. Comparison of human stromelysin and collagenase by cloning and sequence analysis. Biochem J. 1986;240:913-6 pubmed
Zhao J, Fan X, Zhang Q, Sun F, Li X, Xiong C, et al
. Chitosan-plasmid DNA nanoparticles encoding small hairpin RNA targeting MMP-3 and -13 to inhibit the expression of dedifferentiation related genes in expanded chondrocytes. J Biomed Mater Res A. 2014;102:373-80 pubmed publisher
..The results indicated that chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage. ..
Attia E, Bohnert K, Brown H, Bhargava M, Hannafin J. Characterization of total and active matrix metalloproteinases-1, -3, and -13 synthesized and secreted by anterior cruciate ligament fibroblasts in three-dimensional collagen gels. Tissue Eng Part A. 2014;20:171-7 pubmed publisher
..This system will now permit the study of externally applied cyclic and static strains, strain deprivation, and the potential combined role of the cytoskeleton and MMPs in matrix turnover in ligaments. ..
Cao H, Qin L, Huang K. [Effects of Tongxinluo on MMP-3, 9 and PPARgamma expressions in atherosclerotic rabbits]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:1887-9 pubmed
..01). Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma, which might be the mechanism of its anti-atherosclerotic effect. ..
Sanchez Ramos C, Vega J, del Valle M, Fernandez Balbuena A, Bonnin Arias C, Benitez del Castillo J. Role of metalloproteases in retinal degeneration induced by violet and blue light. Adv Exp Med Biol. 2010;664:159-64 pubmed publisher
..Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some MMPs. This alteration could indicate damage to the extracellular matrix and have detrimental effects on the retina...
Hua G, Haiping Z, Baorong H, Dingjun H. Effect of ulinastatin on the expression of iNOS, MMP-2, and MMP-3 in degenerated nucleus pulposus cells of rabbits. Connect Tissue Res. 2013;54:29-33 pubmed publisher
..It suggests that ulinastatin may potentially be useful for clinical therapy of intervertebral disc degeneration. ..
Shi J, Zhang C, Yi Z, Lan C. Explore the variation of MMP3, JNK, p38 MAPKs, and autophagy at the early stage of osteoarthritis. IUBMB Life. 2016;68:293-302 pubmed publisher
..To reveal the mechanism and the effect of JNK and p38 MAPKs on matrix metalloproteinase 3 (MMP3) and autophagy in OA, the study established OA model in rabbits, used the measurement of the ..