matrix metalloproteinase 9


Gene Symbol: matrix metalloproteinase 9
Description: matrix metallopeptidase 9
Alias: matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, GELB, MMP-9, Preproform of 92-kDa type IV collagenase (MMP-9): N-terminal, gelatinase B, matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Species: rabbit
Products:     matrix metalloproteinase 9

Top Publications

  1. Fini M, Bartlett J, Matsubara M, Rinehart W, Mody M, Girard M, et al. The rabbit gene for 92-kDa matrix metalloproteinase. Role of AP1 and AP2 in cell type-specific transcription. J Biol Chem. 1994;269:28620-8 pubmed
    We isolated the rabbit gene for the 92-kDa matrix metalloproteinase, gelatinase B, and sequenced 1802 contiguous bases covering the first three exons and 522 bases of DNA upstream of the start site for transcription...
  2. Tezuka K, Nemoto K, Tezuka Y, Sato T, Ikeda Y, Kobori M, et al. Identification of matrix metalloproteinase 9 in rabbit osteoclasts. J Biol Chem. 1994;269:15006-9 pubmed
    ..of one such clone, F17, was found to share significant similarity with the sequences of human and mouse matrix metalloproteinase 9 (MMP-9) cDNA...
  3. Gordon G, Ledee D, Feuer W, Fini M. Cytokines and signaling pathways regulating matrix metalloproteinase-9 (MMP-9) expression in corneal epithelial cells. J Cell Physiol. 2009;221:402-11 pubmed publisher
    ..Inhibition of the ERK pathway did not have an effect on MMP-9 mediated expression in either the treated or untreated co-transfected cells...
  4. Cao H, Qin L, Huang K. [Effects of Tongxinluo on MMP-3, 9 and PPARgamma expressions in atherosclerotic rabbits]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:1887-9 pubmed
    ..01). Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma, which might be the mechanism of its anti-atherosclerotic effect. ..
  5. Sanchez Ramos C, Vega J, del Valle M, Fernandez Balbuena A, Bonnin Arias C, Benitez del Castillo J. Role of metalloproteases in retinal degeneration induced by violet and blue light. Adv Exp Med Biol. 2010;664:159-64 pubmed publisher
    ..Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some MMPs. This alteration could indicate damage to the extracellular matrix and have detrimental effects on the retina...
  6. Shen Q, Zhang Q, Tian R, Xia Y, Xu T, Xia G. [Relationship between expression of MMP-9 and presyrinx state of experimental syringomyelia of rabbits]. Zhonghua Yi Xue Za Zhi. 2010;90:2461-5 pubmed
    ..01). In the model of experimental syringomyelia, MMP-9 plays an important role in causing edema in presyrinx state. Thus doxycycline may be used to prevent and treat syringomyelia. ..
  7. Karadimas S, Klironomos G, Papachristou D, Papanikolaou S, Papadaki E, Gatzounis G. Immunohistochemical profile of NF-?B/p50, NF-?B/p65, MMP-9, MMP-2, and u-PA in experimental cervical spondylotic myelopathy. Spine (Phila Pa 1976). 2013;38:4-10 pubmed publisher
    ..There is a strong correlation between the immunoexpression of NF-?B/p50, NF-?B/p65, MMP-2, MMP-9, u-PA, and CSM. ..
  8. Shi Y, Xu T, Li L, Chen X. Over-expression of VEGF and MMP-9 in residual tumor cells of hepatocellular carcinoma after embolization with lipidol. J Huazhong Univ Sci Technolog Med Sci. 2013;33:90-95 pubmed publisher
  9. Liu Y, Zhang Y, Dai D, Xu Z. Expression of NF-?B, MCP-1 and MMP-9 in a Cerebral Aneurysm Rabbit Model. Can J Neurol Sci. 2014;41:200-5 pubmed
    We explored the early expression of NF-?B, MCP-1 and -MMP 9 in a rabbit carotid aneurysm model, and investigated the possible mechanism of aneurysm. twenty four adult new Zealand rabbits were divided into four groups...

More Information


  1. Wu Z, Zhang Z, Nie S, Yuan J, Yang Y. Activity of matrix metalloproteinases 2 and 9 in cultured rabbit corneal epithelium cells stimulated by tumor necrosis factor alpha. Genet Mol Res. 2015;14:6360-8 pubmed publisher
    ..This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases, and could play an important role in the prevention and treatment of corneal inflammatory diseases. ..
  2. Ruddy J, Jones J, Stroud R, Mukherjee R, Spinale F, Ikonomidis J. Differential effect of wall tension on matrix metalloproteinase promoter activation in the thoracic aorta. J Surg Res. 2010;160:333-9 pubmed publisher
    ..Using unique transgenic constructs with homology to human MMP promoters, this study demonstrated that a physiologically relevant mechanical stimulus was sufficient to differentially induce MMP promoter activation. ..
  3. Qiu Q, Liu Y, Song Q, Ge Y, Hong G, Lu Z, et al. [Effects of hemoperfusion on oxidative stress, matrix metalloproteinases and their inhibitors in acute paraquat poisoning rabbits]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012;30:89-96 pubmed
    ..So HP treatment could play a role in rescuing the PQ poisoning and protecting the organs function. ..
  4. Wu G, Sun S, Long X, Wang L, Ren S. Early stage minimally invasive procedures reduce perihematomal MMP-9 and blood-brain barrier disruption in a rabbit model of intracerebral hemorrhage. Neurol Res. 2013;35:649-58 pubmed publisher
    ..The optimal time window of performing MI procedures for the intracerebral hematoma evacuation might be within 6-12 hours after hemorrhage. ..