Gene Symbol: LOC100328915
Description: cytochrome b5
Alias: CYB5, CYB5A, cytochrome b5
Species: rabbit

Top Publications

  1. Takematsu H, Kozutsumi Y, Suzuki A, Kawasaki T. Molecular cloning of rabbit cytochrome b5 genes: evidence for the occurrence of two separate genes encoding the soluble and microsomal forms. Biochem Biophys Res Commun. 1992;185:845-51 pubmed
    The rabbit genomic segments for the soluble cytochrome b5 (b5) and microsomal b5 were amplified and isolated, respectively, by means of the polymerase chain reaction using primers corresponding to various portions of the open reading ..
  2. Ozols J. Structure of cytochrome b5 and its topology in the microsomal membrane. Biochim Biophys Acta. 1989;997:121-30 pubmed
    The complete amino acid sequence of human and chicken liver microsomal cytochrome b5 was determined...
  3. Tsugita A, Kobayashi M, Tani S, Kyo S, Rashid M. Comparative study of the primary structures of cytochrome b5 from four species. Proc Natl Acad Sci U S A. 1970;67:442-7 pubmed
    ..Results for bovine cytochrome b(5) differ significantly from those previously reported for calf cytochrome b(5). ..
  4. Ozols J. Amino acid sequence of rabbit liver microsomal cytochrome b5. J Biol Chem. 1970;245:4863-74 pubmed
  5. Tsugita A, Kobayashi M, Kajihara T, Hagihara B. Primary structure of rabbit liver cytochrome b5. J Biochem. 1968;64:727-30 pubmed
  6. Takagaki Y, Gerber G, Nihei K, Khorana H. Amino acid sequence of the membranous segment of rabbit liver cytochrome b5. Methodology for separation of hydrophobic peptides. J Biol Chem. 1980;255:1536-41 pubmed
    The primary structure of the membranous segment of rabbit liver cytochrome b5 has been determined to be as follows: (Formula: see text), New methods were developed for the separation of peptide fragments...
  7. Banci L, Bertini I, Rosato A, Scacchieri S. Solution structure of oxidized microsomal rabbit cytochrome b5. Factors determining the heterogeneous binding of the heme. Eur J Biochem. 2000;267:755-66 pubmed
    b>Cytochrome b5 is heterogeneous in solution because of the presence of two isomers (A and B), differing in the rotation of the heme plane around the axis defined by the alpha and gamma meso protons...
  8. Sulc M, Ječmen T, Snajdrová R, Novak P, Martinek V, Hodek P, et al. Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations. Neuro Endocrinol Lett. 2012;33 Suppl 3:41-7 pubmed
    The cytochrome P450 (P450) and cytochrome b5 are membrane hemoproteins composing together with flavoprotein NADPH:P450 reductase a mixed function oxidase (MFO) system...
  9. Ahuja S, Jahr N, Im S, Vivekanandan S, Popovych N, Le Clair S, et al. A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data. J Biol Chem. 2013;288:22080-95 pubmed publisher
    Microsomal cytochrome b5 (cytb5) is a membrane-bound protein that modulates the catalytic activity of its redox partner, cytochrome P4502B4 (cytP450)...

More Information


  1. Zhang M, Huang R, Im S, Waskell L, Ramamoorthy A. Effects of membrane mimetics on cytochrome P450-cytochrome b5 interactions characterized by NMR spectroscopy. J Biol Chem. 2015;290:12705-18 pubmed publisher
    ..whose catalytic activities require two electrons to be sequentially delivered from its redox partners: cytochrome b5 (cytb5) and cytochrome P450 reductase, both of which are membrane proteins...
  2. Pearl N, Wilcoxen J, Im S, Kunz R, Darty J, Britt R, et al. Protonation of the Hydroperoxo Intermediate of Cytochrome P450 2B4 Is Slower in the Presence of Cytochrome P450 Reductase Than in the Presence of Cytochrome b5. Biochemistry. 2016;55:6558-6567 pubmed
    ..the two electrons can be provided by cytochrome P450 reductase, the second electron can also be donated by cytochrome b5 (b5). The steady-state activity of P450 2B4 is increased up to 10-fold by b5...
  3. Kondo K, Tajima S, Sato R, Narita K. Primary structure of the membrane-binding segment of rabbit cytochrome b5. J Biochem. 1979;86:1119-28 pubmed
    The primary structure of the membrane-binding segment of rabbit cytochrome b5 has been determined...
  4. Dariush N, Fisher C, Steggles A. The nucleotide sequence of rabbit liver cytochrome b5 mRNA. Protein Seq Data Anal. 1988;1:351-3 pubmed
    ..we have screened a rabbit liver cDNA library in lambda gt11 and isolated a 1000 bp DNA clone corresponding to cytochrome b5 mRNA. The clone contains the complete coding region and long 5' and 3' non-translated regions...