Gene Symbol: LEP
Doyon C, Drouin G, Trudeau V, Moon T. Molecular evolution of leptin. Gen Comp Endocrinol. 2001;124:188-98 pubmed publisher
b>Leptin, a hormone produced mainly by adipocytes, is involved in the regulation of food intake, metabolism, and reproduction. The objective of this study was to determine the evolutionary relationships of leptin genes...
Yang J, Wang Z, Zhao X, Xu B, Ren Y, Tian H. Natural selection and adaptive evolution of leptin in the ochotona family driven by the cold environmental stress. PLoS ONE. 2008;3:e1472 pubmed publisher
..Variations in energy metabolism are remarkable for them living in cold environments. Leptin, an adipocyte-derived hormone, plays important roles in energy homeostasis.
Yang J, Zhao S, Li J, Dong S. Effect of niacin on adipocyte leptin in hypercholesterolemic rabbits. Cardiovasc Pathol. 2008;17:219-25 pubmed publisher
b>Leptin may play an important role in the development of atherosclerosis...
Yan H, Zhang H, Fu P, Liu B, Jin W, Duan S, et al
. Leptin's effect on accelerated fracture healing after traumatic brain injury. Neurol Res. 2013;35:537-44 pubmed publisher
..as follows: (1) blood and cerebrospinal fluid (CSF) were drawn on days 1, 3, and 7 to demonstrate changes in serum leptin, growth hormone (GH), insulin-like growth factor 1 (IGF-1), and CSF leptin; (2) bone defection was created by ..
Koch E, Hue Beauvais C, Galio L, Solomon G, Gertler A, Révillon F, et al
. Leptin gene in rabbit: cloning and expression in mammary epithelial cells during pregnancy and lactation. Physiol Genomics. 2013;45:645-52 pubmed publisher
b>Leptin is known as a cytokine mostly produced by fat cells and implicated in regulation of energy metabolism and food intake but has also been shown to be involved in many physiological mechanisms such as tissue metabolism and cell ..
Prior L, Davern P, Burke S, Lim K, Armitage J, Head G. Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits. Hypertension. 2014;63:338-45 pubmed publisher
..pressure and renal sympathetic nerve activity, responses to stress, and sensitivity to central administration of leptin and ghrelin...