Research Topics

Genomes and Genes

HTR1B

Summary

Gene Symbol: HTR1B
Description: 5-hydroxytryptamine receptor 1B
Alias: 5-HT1-LIKE, 5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT-1D-beta, 5-HT1B, 5-HT1D beta receptor, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, serotonin 1D beta receptor, serotonin receptor 1B
Species: rabbit

Top Publications

  1. Harwood G, Lockyer M, Giles H, Fairweather N. Cloning and characterisation of the rabbit 5-HT1D alpha and 5-HT1D beta receptors. FEBS Lett. 1995;377:73-6 pubmed
    ..However, sumatriptan had a lower affinity for both the rabbit receptors compared to their human counterparts. This may be accounted for by differences between the primary amino acid sequences of these species homologues. ..
  2. Bard J, Kucharewicz S, Zgombick J, Weinshank R, Branchek T, Cohen M. Differences in ligand binding profiles between cloned rabbit and human 5-HT1D alpha and 5-HT1D beta receptors: ketanserin and methiothepin distinguish rabbit 5-HT1D receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 1996;354:237-44 pubmed
    ..human 5-HT1D alpha) similarities in their ligand binding profiles. These data suggest that 5-HT1D-mediated responses in rabbit preparations may provide information relevant to the pharmacology of the 5-HT1D receptor subtypes in humans. ..