Gene Symbol: ATP1A1
Description: ATPase Na+/K+ transporting subunit alpha 1
Alias: sodium/potassium-transporting ATPase subunit alpha-1, ATPase, Na+/K+ transporting, alpha 1 polypeptide, Na(+)/K(+) ATPase alpha-1 subunit, Na+/K+ -ATPase alpha 1 subunit, Na/K ATPase alpha 1 subunit, sodium pump subunit alpha-1
Fransen P, Hendrickx J, Brutsaert D, Sys S. Distribution and role of Na(+)/K(+) ATPase in endocardial endothelium. Cardiovasc Res. 2001;52:487-99 pubmed
..Accordingly, the endocardial endothelial alpha(1) isoform of Na(+)/K(+) ATPase may contribute to blood-heart barrier properties of this endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. ..
Bartolommei G, Gramigni E, Tadini Buoninsegni F, Santini G, Moncelli M. Confining the sodium pump in a phosphoenzyme form: the effect of lead(II) ions. Biophys J. 2010;99:2087-96 pubmed publisher
..In particular, under conditions that promote enzyme phosphorylation, Pb(2+) ions are able to confine the Na(+),K(+)-ATPase into a phosphorylated E(2) state...
Saha P, Manoharan P, Arthur S, Sundaram S, Kekuda R, Sundaram U. Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine. Biochim Biophys Acta. 2015;1848:702-11 pubmed publisher
..Therefore, altered localization of Na-K-ATPase as a result of transcriptional down-regulation of ankyrin-G mediates the down-regulation of Na-K-ATPase activity during chronic intestinal inflammation. ..
Garcia A, Liu C, Cornelius F, Clarke R, Rasmussen H. Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion. Biophys J. 2016;110:1099-109 pubmed publisher
..We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect of conformation-dependent Î²1 pump subunit glutathionylation, not restricted subsarcolemmal diffusion of Na(+). ..
Apell H, Hitzler T, Schreiber G. Modulation of the Na,K-ATPase by Magnesium Ions. Biochemistry. 2017;56:1005-1016 pubmed publisher
..Therefore, stopped-flow experiments could be performed to gain the first insight into the Na+ binding kinetics on the cytoplasmic side by Mg2+ concentration jump experiments. ..