Gene Symbol: PRRSVgp2
Description: cysteine protease/serine protease
Alias: cysteine protease/serine protease, ORF1a polyprotein
Species: Porcine reproductive and respiratory syndrome virus
Allende R, Lewis T, Lu Z, Rock D, Kutish G, Ali A, et al
. North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. J Gen Virol. 1999;80 ( Pt 2):307-15 pubmed
..Major differences were found in the region encoding the non-structural part of the ORF1a polyprotein, which shared only 47% amino acid identity over 2503 residues of the six non-structural proteins (Nsps) ..
Ziebuhr J, Snijder E, Gorbalenya A. Virus-encoded proteinases and proteolytic processing in the Nidovirales. J Gen Virol. 2000;81:853-79 pubmed publisher
Wei Z, Tian D, Sun L, Lin T, Gao F, Liu R, et al
. Influence of N-linked glycosylation of minor proteins of porcine reproductive and respiratory syndrome virus on infectious virus recovery and receptor interaction. Virology. 2012;429:1-11 pubmed publisher
..The study further revealed that none of the N-glycosylation sites in the minor proteins is critical for the susceptibility of mutants to neutralizing antibody. ..
Das P, Dinh P, Ansari I, de Lima M, Osorio F, Pattnaik A. The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163. J Virol. 2010;84:1731-40 pubmed publisher
Sun Z, Chen Z, Lawson S, Fang Y. The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions. J Virol. 2010;84:7832-46 pubmed publisher
..This study represents a fundamental step in elucidating the role of nsp2 in PRRS pathogenesis and provides an important insight in future modified live-virus vaccine development...
Chen Z, Li M, He Q, Du J, Zhou L, Ge X, et al
. The amino acid at residue 155 in nonstructural protein 4 of porcine reproductive and respiratory syndrome virus contributes to its inhibitory effect for interferon-? transcription in vitro. Virus Res. 2014;189:226-34 pubmed publisher
..Our findings suggest that the nucleus-localized NSP4 of PRRSV participates in the modulation of the host type I IFNs system, and also provide novel insight for understanding the pathogenesis of the Chinese HP-PRRSV. ..
Huang C, Zhang Q, Guo X, Yu Z, Xu A, Tang J, et al
. Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-?B essential modulator. J Virol. 2014;88:10934-45 pubmed publisher
..The data presented here may help us to better understand PRRSV pathogenesis. ..